{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:50:16Z","timestamp":1791579016501,"version":"4.3.4"},"reference-count":189,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF CAREER MCB-2237117"],"award-info":[{"award-number":["NSF CAREER MCB-2237117"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NHLBI R01HL183792"],"award-info":[{"award-number":["NHLBI R01HL183792"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.mito.2026.102222","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:46:33Z","timestamp":1791330393000},"page":"102222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mitochondrial calcium and ROS: present understanding and future directions"],"prefix":"10.1016","volume":"92","author":[{"given":"Chloe I.","family":"Roth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa C.","family":"Vadovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keeler J.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Raftu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skyler","family":"Shaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jada G.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason N.","family":"Bazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 2","key":"10.1016\/j.mito.2026.102222_bb0005","doi-asserted-by":"crossref","first-page":"S413","DOI":"10.3233\/JAD-2010-100465","article-title":"Calcium and mitochondrial reactive oxygen species generation: how to read the facts","volume":"20","author":"Adam-Vizi","year":"2010","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.mito.2026.102222_bb0010","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuron.2016.12.034","article-title":"Transient opening of the mitochondrial permeability transition pore induces microdomain calcium transients in astrocyte processes","volume":"93","author":"Agarwal","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.mito.2026.102222_bb0015","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1172\/JCI25371","article-title":"The mitochondrial origin of postischemic arrhythmias","volume":"115","author":"Akar","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mito.2026.102222_bb0020","doi-asserted-by":"crossref","first-page":"10580","DOI":"10.1073\/pnas.1401591111","article-title":"An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore","volume":"111","author":"Alavian","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0025","first-page":"C465","article-title":"Molecular nature and physiological role of the mitochondrial calcium uniporter channel","volume":"320","author":"Alevriadou","year":"2021","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.mito.2026.102222_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/bj2390019","article-title":"The reversible Ca2+\u2212induced permeabilization of rat liver mitochondria","volume":"239","author":"Al-Nasser","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2026.102222_bb0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13041-025-01272-0","article-title":"Primary cortical neurons precipitate and extrude large mitochondria-associated calcium-phosphate sheets with a bone-precursor-like ultrastructure","volume":"19","author":"Anderson","year":"2026","journal-title":"Mol. Brain"},{"key":"10.1016\/j.mito.2026.102222_bb0040","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cmet.2011.05.014","article-title":"Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging","volume":"14","author":"Andersson","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.mito.2026.102222_bb0045","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s10541-005-0102-7","article-title":"Mitochondrial metabolism of reactive oxygen species","volume":"70","author":"Andreyev","year":"2005","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.mito.2026.102222_bb0050","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1134\/S0006297915050028","article-title":"Mitochondrial ROS metabolism: 10 years later","volume":"80","author":"Andreyev","year":"2015","journal-title":"Biochemistry. Biokhimiia"},{"key":"10.1016\/j.mito.2026.102222_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167300","article-title":"Real-time fluorescence measurements of ROS and [Ca2+] in ischemic \/ Reperfused rat hearts: detectable increases occur only after mitochondrial pore opening and are attenuated by ischemic preconditioning","volume":"11","author":"Andrienko","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2026.102222_bb0060","doi-asserted-by":"crossref","first-page":"44735","DOI":"10.1074\/jbc.M302673200","article-title":"Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes","volume":"278","author":"Aon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0065","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1073\/pnas.0307156101","article-title":"Percolation and criticality in a mitochondrial network","volume":"101","author":"Aon","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0070","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/nm.3735","article-title":"Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity","volume":"20","author":"Arruda","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0075","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102222_bb0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-0716-0676-6_11","article-title":"Electrophysiological methods for detection of membrane leakage and Hemifission by dynamin 1","volume":"2159","author":"Bashkirov","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111899","article-title":"The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria","volume":"42","author":"Bassot","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.mito.2026.102222_bb0090","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.bpj.2017.08.018","article-title":"Analysis of a functional dimer model of ubiquinol cytochrome c oxidoreductase","volume":"113","author":"Bazil","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.mito.2026.102222_bb0095","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.freeradbiomed.2014.08.023","article-title":"Determining the origins of superoxide and hydrogen peroxide in the mammalian NADH:ubiquinone oxidoreductase","volume":"77","author":"Bazil","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0100","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.bpj.2015.09.036","article-title":"Catalytic coupling of oxidative phosphorylation, ATP demand, and reactive oxygen species generation","volume":"110","author":"Bazil","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.mito.2026.102222_bb0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00769534","article-title":"Properties of the inner membrane anion channel in intact mitochondria","volume":"24","author":"Beavis","year":"1992","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.mito.2026.102222_bb0110","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.tem.2026.02.010","article-title":"Energy constraint on human health","volume":"37","author":"Behnke","year":"2026","journal-title":"Trends Endocrinol"},{"key":"10.1016\/j.mito.2026.102222_bb0115","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1742-4658.2006.05213.x","article-title":"The mitochondrial permeability transition from in vitro artifact to disease target","volume":"273","author":"Bernardi","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.mito.2026.102222_bb0120","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1111\/febs.16254","article-title":"The mitochondrial permeability transition: recent progress and open questions","volume":"289","author":"Bernardi","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.mito.2026.102222_bb0125","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mito.2026.102222_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.101119","article-title":"Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts","volume":"3","author":"Booth","year":"2022","journal-title":"STAR Protoc"},{"key":"10.1016\/j.mito.2026.102222_bb0135","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a038802","article-title":"Fundamentals of cellular calcium signaling: a primer","volume":"12","author":"Bootman","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0140","doi-asserted-by":"crossref","first-page":"19282","DOI":"10.1016\/S0021-9258(18)38955-5","article-title":"108-pS channel in brown fat mitochondria might be identical to the inner membrane anion channel","volume":"272","author":"Borecky","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mito.2022.01.006","article-title":"Targeting the mitochondrial permeability transition pore for drug discovery: challenges and opportunities","volume":"63","author":"Boyenle","year":"2022","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2026.102222_bb0150","doi-asserted-by":"crossref","first-page":"11150","DOI":"10.1073\/pnas.1514284112","article-title":"The growing importance of mitochondrial calcium in health and disease","volume":"112","author":"Boyman","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0155","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1172\/JCI88241","article-title":"Axial tubule junctions control rapid calcium signaling in atria","volume":"126","author":"Brandenburg","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mito.2026.102222_bb0160","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1073\/pnas.48.11.1928","article-title":"Active transport of inorganic phosphate and magnesium ions by beef heart mitochondria","volume":"48","author":"Brierley","year":"1962","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0165","first-page":"C817","article-title":"Calcium, ATP, and ROS: a mitochondrial love-hate triangle","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.mito.2026.102222_bb0170","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0002-8703(52)90128-2","article-title":"The Krebs cycle in human cardiac muscle","volume":"44","author":"Burdette","year":"1952","journal-title":"Am. Heart J."},{"key":"10.1016\/j.mito.2026.102222_bb0175","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bbabio.2010.03.024","article-title":"The fateful encounter of mitochondria with calcium: how did it happen?","volume":"1797","author":"Carafoli","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102222_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102719","article-title":"The mitochondrial permeability transition pore in ca(2+) homeostasis","volume":"111","author":"Carraro","year":"2023","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2026.102222_bb0185","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41580-024-00820-1","article-title":"The roles of mitochondria in global and local intracellular calcium signalling","volume":"26","author":"Cartes-Saavedra","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0190","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0891-5849(94)00166-H","article-title":"Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria","volume":"18","author":"Castilho","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0195","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0891-5849(94)00166-H","article-title":"Permeabilization of the inner mitochondrial-membrane by Ca2+ ions is stimulated by T-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria","volume":"18","author":"Castilho","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0200","first-page":"65","article-title":"The respiratory chain and oxidative phosphorylation","volume":"17","author":"Chance","year":"1956","journal-title":"Adv. Enzymol. Relat. Subj. Biochem."},{"key":"10.1016\/j.mito.2026.102222_bb0205","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fcvm.2016.00036","article-title":"Mitochondrial ROS versus ER ROS: which comes first in myocardial calcium dysregulation?","volume":"3","author":"Chaube","year":"2016","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0210","article-title":"Dialogue between mitochondria and endoplasmic reticulum-potential therapeutic targets for age-related cardiovascular diseases","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mito.2026.102222_bb0215","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.8235594","article-title":"Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle","volume":"262","author":"Cheng","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.mito.2026.102222_bb0220","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1432-1033.1996.0623w.x","article-title":"The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites","volume":"238","author":"Chernyak","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mito.2026.102222_bb0225","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1038\/nmicrobiol.2016.50","article-title":"The hemifusion structure induced by influenza virus haemagglutinin is determined by physical properties of the target membranes","volume":"1","author":"Chlanda","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.mito.2026.102222_bb0230","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102222_bb0235","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.91.2351.77","article-title":"Particulate components of Normal and tumor cells","volume":"91","author":"Claude","year":"1940","journal-title":"Science"},{"key":"10.1016\/j.mito.2026.102222_bb0240","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.80.1.19","article-title":"The constitution of mitochondria and microsomes, and the distribution of nucleic acid in the cytoplasm of a leukemic cell","volume":"80","author":"Claude","year":"1944","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0245","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1084\/jem.84.1.61","article-title":"Fractionation of mammalian liver cells by differential centrifugation; experimental procedures and results","volume":"84","author":"Claude","year":"1946","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0250","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tibs.2016.01.001","article-title":"Mitochondrial cristae: where beauty meets functionality","volume":"41","author":"Cogliati","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mito.2026.102222_bb0255","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1529\/biophysj.104.041749","article-title":"A mitochondrial oscillator dependent on reactive oxygen species","volume":"87","author":"Cortassa","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.mito.2026.102222_bb0260","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1074\/jbc.271.12.6746","article-title":"Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites","volume":"271","author":"Costantini","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0265","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.bbabio.2009.06.004","article-title":"SR\/ER-mitochondrial local communication: calcium and ROS","volume":"1787","author":"Csordas","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102222_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1336416","article-title":"Neither too much nor too little: mitochondrial calcium concentration as a balance between physiological and pathological conditions","volume":"10","author":"D\u2019Angelo","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.mito.2026.102222_bb0275","doi-asserted-by":"crossref","first-page":"23327","DOI":"10.1074\/jbc.273.36.23327","article-title":"Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain","volume":"273","author":"del Arco","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.mito.2026.102222_bb0280","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1042\/bj3450725","article-title":"Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues","volume":"345","author":"Del Arco","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2026.102222_bb0285","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1073\/pnas.47.11.1744","article-title":"Calcium uptake by rat kidney mitochondria","volume":"47","author":"Deluca","year":"1961","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0290","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.ph.52.030190.002315","article-title":"Ca2+ as a second messenger within mitochondria of the heart and other tissues","volume":"52","author":"Denton","year":"1990","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mito.2026.102222_bb0295","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yjmcc.2012.07.015","article-title":"SR and mitochondria: calcium cross-talk between kissing cousins","volume":"55","author":"Dorn","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.mito.2026.102222_bb0300","doi-asserted-by":"crossref","first-page":"27850","DOI":"10.1074\/jbc.M110.101196","article-title":"Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin\/peroxiredoxin system","volume":"285","author":"Drechsel","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mito.2026.102222_bb0305","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1469-7793.2000.00057.x","article-title":"Mitochondria and calcium: from cell signalling to cell death","volume":"529","author":"Duchen","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.mito.2026.102222_bb0310","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mito.2020.01.005","article-title":"Calcium overload decreases net free radical emission in cardiac mitochondria","volume":"51","author":"Duong","year":"2020","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2026.102222_bb0315","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqab050","article-title":"Identifying site-specific superoxide and hydrogen peroxide production rates from the mitochondrial electron transport system using a computational strategy","volume":"2","author":"Duong","year":"2021","journal-title":"Function"},{"key":"10.1016\/j.mito.2026.102222_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/cells12091273","article-title":"The mitochondrial permeability transition pore-current knowledge of its structure, function, and regulation, and optimized methods for evaluating its functional state","volume":"12","author":"Endlicher","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.mito.2026.102222_bb0325","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0143-4160(94)90053-1","article-title":"The Ca2+-induced permeability transition pore is involved in Ca2+-induced mitochondrial oscillations. A study on permeabilised Ehrlich ascites tumour cells","volume":"15","author":"Evtodienko Yu","year":"1994","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2026.102222_bb0330","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2741\/3303","article-title":"Crosstalk signaling between mitochondrial Ca2+ and ROS","volume":"14","author":"Feissner","year":"2009","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.mito.2026.102222_bb0335","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<74::AID-CYTO10>3.0.CO;2-V","article-title":"Is chloromethyl-X-rosamine useful in measuring mitochondrial transmembrane potential?","volume":"31","author":"Ferlini","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.mito.2026.102222_bb0340","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/1873-3468.13427","article-title":"Mitochondrial ca(2+) concentrations in live cells: quantification methods and discrepancies","volume":"593","author":"Fernandez-Sanz","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mito.2026.102222_bb0345","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIRCRESAHA.116.305484","article-title":"The ins and outs of mitochondrial calcium","volume":"116","author":"Finkel","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.mito.2026.102222_bb0350","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ceca.2010.07.001","article-title":"Monitoring mitochondrial [ca(2+)] dynamics with rhod-2, ratiometric pericam and aequorin","volume":"48","author":"Fonteriz","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2026.102222_bb0355","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1073\/pnas.1432962100","article-title":"Shape bistability of a membrane neck: a toggle switch to control vesicle content release","volume":"100","author":"Frolov","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0360","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/j.cmet.2025.09.005","article-title":"Mitochondrial sodium-calcium exchange-can TMEM65 do it alone?","volume":"37","author":"Garbincius","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.mito.2026.102222_bb0365","doi-asserted-by":"crossref","first-page":"10507","DOI":"10.1074\/jbc.RL120.014342","article-title":"Reply to Rutter et al.: the roles of cytosolic and intramitochondrial ca(2+) and the mitochondrial ca(2+)-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation","volume":"295","author":"Gellerich","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0370","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1006\/bbrc.2001.6214","article-title":"Calcium-dependent oxidation of thioredoxin during cellular growth initiation","volume":"290","author":"Gitler","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2026.102222_bb0375","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1021\/bi2018909","article-title":"Role of mitochondrial Ca2+ in the regulation of cellular energetics","volume":"51","author":"Glancy","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.mito.2026.102222_bb0380","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1161\/CIRCULATIONAHA.120.048183","article-title":"Redox-resistant SERCA [Sarco(endo)plasmic reticulum calcium ATPase] attenuates oxidant-stimulated mitochondrial calcium and apoptosis in cardiac myocytes and pressure overload-induced myocardial failure in mice","volume":"142","author":"Goodman","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.mito.2026.102222_bb0385","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","article-title":"Calcium and ROS: a mutual interplay","volume":"6","author":"G\u00f6rlach","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0390","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0003-9861(66)90036-1","article-title":"The mitochondrial electron transfer chain","volume":"116","author":"Green","year":"1966","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mito.2026.102222_bb0395","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2008.04.021","article-title":"Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition","volume":"45","author":"Hansson","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0400","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0003-9861(79)90372-2","article-title":"The Ca2+\u2212induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site","volume":"195","author":"Haworth","year":"1979","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mito.2026.102222_bb0405","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF01870239","article-title":"Allosteric inhibition of the Ca2+\u2212activated hydrophilic channel of the mitochondrial inner membrane by nucleotides","volume":"54","author":"Haworth","year":"1980","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0410","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.243324","article-title":"Safety factors as a \u2018design\u2019 principle of animal form and function: an historical perspective","volume":"224","author":"Hicks","year":"2021","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0415","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0021-9258(17)41175-6","article-title":"The distribution of cytochrome oxidase and succinoxidase in the cytoplasm of the mammalian liver cell","volume":"165","author":"Hogeboom","year":"1946","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0420","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0021-9258(19)52749-1","article-title":"Cytochemical studies of mammalian tissues; isolation of intact mitochondria from rat liver; some biochemical properties of mitochondria and submicroscopic particulate material","volume":"172","author":"Hogeboom","year":"1948","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0425","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13054-024-05069-w","article-title":"Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives","volume":"28","author":"Hu","year":"2024","journal-title":"Crit. Care"},{"key":"10.1016\/j.mito.2026.102222_bb0430","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0003-9861(79)90371-0","article-title":"The Ca2+\u2212induced membrane transition in mitochondria. I. The protective mechanisms","volume":"195","author":"Hunter","year":"1979","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mito.2026.102222_bb0435","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/0003-9861(79)90373-4","article-title":"The Ca2+\u2212induced membrane transition in mitochondria. III. Transitional Ca2+ release","volume":"195","author":"Hunter","year":"1979","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mito.2026.102222_bb0440","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1016\/S0021-9258(17)33220-9","article-title":"Relationship between configuration, function, and permeability in calcium-treated mitochondria","volume":"251","author":"Hunter","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0445","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10863-016-9672-x","article-title":"Mitochondrial ca(2+) and regulation of the permeability transition pore","volume":"49","author":"Hurst","year":"2017","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.mito.2026.102222_bb0450","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-5793(94)00615-6","article-title":"Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling","volume":"348","author":"Ichas","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mito.2026.102222_bb0455","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-5793(94)00615-6","article-title":"Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling","volume":"348","author":"Ichas","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mito.2026.102222_bb0460","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.mito.2009.02.001","article-title":"NDUFS4: creation of a mouse model mimicking a complex I disorder","volume":"9","author":"Ingraham","year":"2009","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2026.102222_bb0465","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/BJ20081981","article-title":"Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi","volume":"418","author":"Irigoin","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2026.102222_bb0470","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/jcs.115.6.1175","article-title":"Mitochondrial oxidative stress and cell death in astrocytes--requirement for stored Ca2+ and sustained opening of the permeability transition pore","volume":"115","author":"Jacobson","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mito.2026.102222_bb0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2017.07.009","article-title":"Association between ROS production, swelling and the respirasome integrity in cardiac mitochondria","volume":"630","author":"Jang","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mito.2026.102222_bb0480","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2013.00076","article-title":"Mitochondrial permeability transition and cell death: the role of cyclophilin d","volume":"4","author":"Javadov","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mito.2026.102222_bb0485","first-page":"35","article-title":"Myocardial metabolic markers of total ischemia in vitro","volume":"57","author":"Kakinuma","year":"1994","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.mito.2026.102222_bb0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2011.09.030","article-title":"Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations","volume":"52","author":"Kalyanaraman","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0495","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrm4039","article-title":"The molecular era of the mitochondrial calcium uniporter","volume":"16","author":"Kamer","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0500","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1073\/pnas.90.4.1374","article-title":"Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands","volume":"90","author":"Kinnally","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0505","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ceca.2016.03.004","article-title":"ROS and intracellular ion channels","volume":"60","author":"Kiselyov","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2026.102222_bb0510","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.bbabio.2008.05.004","article-title":"H2O2 generation is decreased by calcium in isolated brain mitochondria","volume":"1777","author":"Komary","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102222_bb0515","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1089\/dna.2019.5347","article-title":"Mitochondrial and nuclear DNA oxidative damage in physiological and pathological aging","volume":"39","author":"Kowalska","year":"2020","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0520","first-page":"C141","article-title":"Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state","volume":"269","author":"Kowaltowski","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.mito.2026.102222_bb0525","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bbabio.2005.05.009","article-title":"Comparative kinetic analysis reveals that inducer-specific ion release precedes the mitochondrial permeability transition","volume":"1708","author":"Krasnikov","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102222_bb0530","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/bj0540107","article-title":"Oxidative phosphorylation","volume":"54","author":"Krebs","year":"1953","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2026.102222_bb0535","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/0006-291X(63)90377-2","article-title":"Respiration-dependent accumulation of inorganic phosphate and ca ions by rat liver mitochondria","volume":"10","author":"Lehninger","year":"1963","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2026.102222_bb0540","doi-asserted-by":"crossref","DOI":"10.3390\/cells14201579","article-title":"TRIC-A facilitates sarcoplasmic reticulum-mitochondrial ca(2+) Signaling crosstalk in cardiomyocytes","volume":"14","author":"Li","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.mito.2026.102222_bb0545","series-title":"Calcium concentration microdomains","first-page":"17","author":"Llin\u00e1s","year":"1997"},{"key":"10.1016\/j.mito.2026.102222_bb0550","doi-asserted-by":"crossref","first-page":"15611","DOI":"10.1074\/jbc.M113.533653","article-title":"Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin\/peroxiredoxin (Trx\/Prx) system","volume":"289","author":"Lopert","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0555","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/CIRCRESAHA.115.308093","article-title":"Individual cardiac mitochondria undergo rare transient permeability transition pore openings","volume":"118","author":"Lu","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.mito.2026.102222_bb0560","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1016\/j.bpj.2023.07.030","article-title":"Nanoscale details of mitochondrial constriction revealed by cryoelectron tomography","volume":"122","author":"Mageswaran","year":"2023","journal-title":"Biophys. J."},{"key":"10.1016\/j.mito.2026.102222_bb0565","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2017.00139","article-title":"Structure, activity regulation, and role of the mitochondrial calcium uniporter in health and disease","volume":"7","author":"Mammucari","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mito.2026.102222_bb0570","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00424-018-2123-2","article-title":"Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models","volume":"470","author":"Mammucari","year":"2018","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.mito.2026.102222_bb0575","doi-asserted-by":"crossref","first-page":"15262","DOI":"10.1074\/jbc.RA120.014483","article-title":"Computationally modeling mammalian succinate dehydrogenase kinetics identifies the origins and primary determinants of ROS production","volume":"295","author":"Manhas","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0580","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.248534","article-title":"Endoplasmic reticulum-mitochondria signaling in neurons and neurodegenerative diseases","volume":"135","author":"Markovinovic","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mito.2026.102222_bb0585","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00220763","article-title":"The role of Ca2+ ions in the regulation of intramitochondrial metabolism and energy production in rat heart","volume":"89","author":"McCormack","year":"1989","journal-title":"Mol. Cell. Biochem."},{"issue":"Pt 3","key":"10.1016\/j.mito.2026.102222_bb0590","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1042\/bst0210793","article-title":"The role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in mammalian tissues","volume":"21","author":"McCormack","year":"1993","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mito.2026.102222_bb0595","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/physrev.1990.70.2.391","article-title":"Role of calcium ions in regulation of mammalian intramitochondrial metabolism","volume":"70","author":"McCormack","year":"1990","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mito.2026.102222_bb0600","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bst0200153","article-title":"Mitochondrial Ca2+ transport and the role of matrix Ca2+ in mammalian tissues","volume":"20","author":"McCormack","year":"1992","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mito.2026.102222_bb0605","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/191144a0","article-title":"Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism","volume":"191","author":"Mitchell","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102222_bb0610","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1469-185X.1966.tb01501.x","article-title":"Chemiosmotic coupling in oxidative and photosynthetic phosphorylation","volume":"41","author":"Mitchell","year":"1966","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.mito.2026.102222_bb0615","series-title":"David Keilin\u2019s Respiratory Chain Concept and its Chemiosmotic Consequences, Nobel Lecture","author":"Mitchell","year":"1978"},{"key":"10.1016\/j.mito.2026.102222_bb0620","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/213137a0","article-title":"Chemiosmotic hypothesis of oxidative phosphorylation","volume":"213","author":"Mitchell","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102222_bb0625","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1021\/bi00067a039","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation","volume":"32","author":"Nicolli","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.mito.2026.102222_bb0630","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuint.2007.02.008","article-title":"The mitochondrial permeability transition in neurologic disease","volume":"50","author":"Norenberg","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mito.2026.102222_bb0635","doi-asserted-by":"crossref","unstructured":"Pak, V.V., Ezerina, D., Lyublinskaya, O.G., Pedre, B., Tyurin-Kuzmin, P.A., Mishina, N.M., Thauvin, M., Young, D., Wahni, K., Martinez Gache, S.A., Demidovich, A.D., Ermakova, Y.G., Maslova, Y.D., Shokhina, A.G., Eroglu, E., Bilan, D.S., Bogeski, I., Michel, T., Vriz, S., Messens, J., Belousov, V.V., 2020. Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function. Cell Metab. 31, 642\u2013653 e646.","DOI":"10.1016\/j.cmet.2020.02.003"},{"key":"10.1016\/j.mito.2026.102222_bb0640","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.15723.1","article-title":"Recent advances in the molecular mechanism of mitochondrial calcium uptake","volume":"7","author":"Pallafacchina","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.mito.2026.102222_bb0645","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1093\/emboj\/20.18.5060","article-title":"Citrin and aralar1 are ca(2+)-stimulated aspartate\/glutamate transporters in mitochondria","volume":"20","author":"Palmieri","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.mito.2026.102222_bb0650","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39441","article-title":"The role of scaffold reshaping and disassembly in dynamin driven membrane fission","volume":"7","author":"Pannuzzo","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.mito.2026.102222_bb0655","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0891-5849(92)90176-H","article-title":"Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue","volume":"13","author":"Paraidathathu","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0660","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0300-483X(94)90209-7","article-title":"Modulation of rat heart mitochondrial function and the production of reactive oxygen by vitamin E deficiency","volume":"90","author":"Paraidathathu","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.mito.2026.102222_bb0665","doi-asserted-by":"crossref","first-page":"eaax9484","DOI":"10.1126\/sciadv.aax9484","article-title":"High-resolution cryo-EM structures of respiratory complex I: mechanism, assembly, and disease","volume":"5","author":"Parey","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mito.2026.102222_bb0670","article-title":"Astrocytic Nrf2 mediates the neuroprotective and anti-inflammatory effects of nootkatone in an MPTP-induced Parkinson\u2019s disease mouse model","volume":"12","author":"Park","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.mito.2026.102222_bb0675","doi-asserted-by":"crossref","first-page":"31041","DOI":"10.1016\/S0021-9258(18)47387-5","article-title":"Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone","volume":"269","author":"Pastorino","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0680","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303713120","article-title":"The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore","volume":"120","author":"Pekson","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0685","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0021-9258(18)54034-5","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+","volume":"268","author":"Petronilli","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0690","doi-asserted-by":"crossref","first-page":"16638","DOI":"10.1016\/S0021-9258(19)89437-1","article-title":"The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents","volume":"269","author":"Petronilli","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0695","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.146.3642.347","article-title":"Strong inference: certain systematic methods of scientific thinking may produce much more rapid progress than others","volume":"146","author":"Platt","year":"1964","journal-title":"Science"},{"key":"10.1016\/j.mito.2026.102222_bb0700","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1182\/bloodadvances.2020002847","article-title":"Mitochondrial dynamics and reactive oxygen species initiate thrombopoiesis from mature megakaryocytes","volume":"5","author":"Poirault-Chassac","year":"2021","journal-title":"Blood Adv."},{"issue":"Suppl. 6","key":"10.1016\/j.mito.2026.102222_bb0705","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/sj.ijo.0800937","article-title":"Indirect measurement of mitochondrial proton leak and its application","volume":"23","author":"Porter","year":"1999","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.mito.2026.102222_bb0710","first-page":"142","article-title":"Swelling of isolated mitochondria of the liver and their susceptibility to physicochemical influences","volume":"11","author":"Raaflaub","year":"1953","journal-title":"Helv. Physiol. Pharmacol. Acta"},{"key":"10.1016\/j.mito.2026.102222_bb0715","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10495-021-01668-y","article-title":"Ca(2+) overload- and ROS-associated mitochondrial dysfunction contributes to delta-tocotrienol-mediated paraptosis in melanoma cells","volume":"26","author":"Raimondi","year":"2021","journal-title":"Apoptosis"},{"key":"10.1016\/j.mito.2026.102222_bb0720","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ceb.2004.09.012","article-title":"Misfolded proteins, endoplasmic reticulum stress and neurodegeneration","volume":"16","author":"Rao","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0725","article-title":"The unfolded protein response: an overview","volume":"10","author":"Read","year":"2021","journal-title":"Biol.-Basel"},{"key":"10.1016\/j.mito.2026.102222_bb0730","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1089\/ars.2020.8231","article-title":"Endoplasmic reticulum-mitochondria contacts modulate reactive oxygen species-mediated Signaling and oxidative stress in brain disorders: the key role of Sigma-1 receptor","volume":"37","author":"Resende","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mito.2026.102222_bb0735","doi-asserted-by":"crossref","first-page":"9869","DOI":"10.1074\/jbc.RA118.003647","article-title":"Control of mitochondrial superoxide production by reverse electron transport at complex I","volume":"293","author":"Robb","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0740","article-title":"Atad3 is essential for mitochondrial permeability transition pore opening and cardiac ischemia reperfusion injury","author":"Robichaux","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mito.2026.102222_bb0745","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2511890122","article-title":"In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment","volume":"122","author":"Rose","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mito.2026.102222_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2021.102356","article-title":"VDAC regulation of mitochondrial calcium flux: from channel biophysics to disease","volume":"94","author":"Rosencrans","year":"2021","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2026.102222_bb0755","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/acel.12650","article-title":"The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore","volume":"16","author":"Rottenberg","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.mito.2026.102222_bb0760","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1074\/jbc.L120.013975","article-title":"The roles of cytosolic and intramitochondrial ca(2+) and the mitochondrial ca(2+)-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation","volume":"295","author":"Rutter","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0765","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1534-5807(01)00116-2","article-title":"A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis","volume":"2","author":"Scorrano","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mito.2026.102222_bb0770","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/bj0530557","article-title":"The effect of tonicity of the medium on the respiratory and phosphorylative activity of heart-muscle sarcosomes","volume":"53","author":"Slater","year":"1953","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2026.102222_bb0775","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1085\/jgp.201711814","article-title":"Ambiguous interactions between diastolic and SR ca(2+) in the regulation of cardiac ca(2+) release","volume":"149","author":"Sobie","year":"2017","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.mito.2026.102222_bb0780","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/330498a0","article-title":"Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel","volume":"330","author":"Sorgato","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102222_bb0785","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/342555a0","article-title":"Patch clamp studies of single cell-fusion events mediated by a viral fusion protein","volume":"342","author":"Spruce","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102222_bb0790","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0006-8993(96)01271-1","article-title":"Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice","volume":"749","author":"Sriram","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.mito.2026.102222_bb0795","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1471-4159.2002.01153.x","article-title":"Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax","volume":"83","author":"Starkov","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2026.102222_bb0800","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1471-4159.2002.01153.x","article-title":"Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax","volume":"83","author":"Starkov","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2026.102222_bb0805","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10863-014-9581-9","article-title":"Scavenging of H2O2 by mouse brain mitochondria","volume":"46","author":"Starkov","year":"2014","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.mito.2026.102222_bb0810","doi-asserted-by":"crossref","DOI":"10.3390\/app11052071","article-title":"Modeling the effects of calcium overload on mitochondrial ultrastructural remodeling","volume":"11","author":"Strubbe-Rivera","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.mito.2026.102222_bb0815","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41598-020-80398-8","article-title":"The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function","volume":"11","author":"Strubbe-Rivera","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mito.2026.102222_bb0820","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1016\/S0021-9258(19)50677-9","article-title":"Modulation of the mitochondrial megachannel by divalent cations and protons","volume":"267","author":"Szab\u00f3","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0825","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1074\/jbc.RA119.011902","article-title":"Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply","volume":"295","author":"Szibor","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0830","article-title":"A perspective on the future of heart failure research","volume":"15","author":"Vadovsky","year":"2026","journal-title":"J Mol Cell Cardiol Plus"},{"key":"10.1016\/j.mito.2026.102222_bb0835","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/S0021-9258(19)73805-8","article-title":"Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation","volume":"237","author":"Vasington","year":"1962","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0840","doi-asserted-by":"crossref","DOI":"10.3390\/biom12121891","article-title":"Calcium overload and mitochondrial metabolism","volume":"12","author":"Walkon","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.mito.2026.102222_bb0845","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1089\/ars.2016.6739","article-title":"Mitochondrial flash: integrative reactive oxygen species and pH signals in cell and organelle biology","volume":"25","author":"Wang","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mito.2026.102222_bb0850","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29929","article-title":"3D visualization of mitochondrial solid-phase calcium stores in whole cells","volume":"6","author":"Wolf","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.mito.2026.102222_bb0855","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00033.2020","article-title":"Calcium-release channels: structure and function of IP(3) receptors and ryanodine receptors","volume":"102","author":"Woll","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mito.2026.102222_bb0860","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41467-023-36096-w","article-title":"CryoET reveals organelle phenotypes in Huntington disease patient iPSC-derived and mouse primary neurons","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mito.2026.102222_bb0865","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.str.2025.07.010","article-title":"Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells","volume":"33","author":"Wu","year":"2025","journal-title":"Structure"},{"key":"10.1016\/j.mito.2026.102222_bb0870","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.mito.2026.102222_bb0875","article-title":"Understanding the dynamics of the transient and permanent opening events of the mitochondrial permeability transition pore with a novel stochastic model","volume":"12","author":"Yalamanchili","year":"2022","journal-title":"Membranes (Basel)"},{"key":"10.1016\/j.mito.2026.102222_bb0880","article-title":"Rapidly blocking the calcium overload\/ROS production feedback loop to alleviate acute kidney injury via microenvironment-responsive BAPTA-AM\/BAC co-delivery Nanosystem","volume":"19","author":"Yan","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.mito.2026.102222_bb0885","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17030327","article-title":"Endoplasmic reticulum stress and associated ROS","volume":"17","author":"Zeeshan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mito.2026.102222_bb0890","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.celrep.2018.04.104","article-title":"Accumulation of succinate in cardiac ischemia primarily occurs via canonical Krebs cycle activity","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.mito.2026.102222_bb0895","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2705","article-title":"Measuring mitochondrial ROS in mammalian cells with a genetically encoded protein sensor","volume":"8","author":"Zhang","year":"2018","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.mito.2026.102222_bb0900","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s41556-025-01721-x","article-title":"TMEM65 functions as the mitochondrial Na(+)\/ca(2+) exchanger","volume":"27","author":"Zhang","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0905","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0910","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1059576","article-title":"The role of mitochondria-associated membranes mediated ROS on NLRP3 inflammasome in cardiovascular diseases","volume":"9","author":"Zhao","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0915","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/abio.1997.2391","article-title":"A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases","volume":"253","author":"Zhou","year":"1997","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mito.2026.102222_bb0920","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000657","article-title":"A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network","volume":"6","author":"Zhou","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.mito.2026.102222_bb0925","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.freeradbiomed.2007.11.013","article-title":"Cytochrome c-mediated oxidation of hydroethidine and Mito-hydroethidine in mitochondria: identification of homo- and heterodimers","volume":"44","author":"Zielonka","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0930","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1074\/jbc.M308143200","article-title":"Respiration-dependent removal of exogenous H2O2 in brain mitochondria: inhibition by Ca2+","volume":"279","author":"Zoccarato","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102222_bb0935","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","article-title":"Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes","volume":"192","author":"Zorov","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mito.2026.102222_bb0940","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","article-title":"Mitochondrial ROS-induced ROS release: an update and review","volume":"1757","author":"Zorov","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102222_bb0945","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724926001121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724926001121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:10:23Z","timestamp":1791576623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724926001121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":189,"alternative-id":["S1567724926001121"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2026.102222","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial calcium and ROS: present understanding and future directions","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2026.102222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102222"}}