{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:18:53Z","timestamp":1793053133912,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal Armed Forces India"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.mjafi.2024.04.013","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T11:44:46Z","timestamp":1716810286000},"page":"449-457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinico-immunological evaluation of use of omega-3 fatty acids as nutraceutical approach in management of patients with chronic periodontitis: A randomized clinical trial"],"prefix":"10.1016","volume":"80","author":[{"given":"T.","family":"Prasanth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Saravanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S.","family":"Satisha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.B.","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.A.","family":"Bahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mjafi.2024.04.013_bib1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1902\/annals.1996.1.1.821","article-title":"Periodontal diseases: pathogenesis","volume":"1","author":"Offenbacher","year":"1996","journal-title":"Ann Periodontol"},{"issue":"3","key":"10.1016\/j.mjafi.2024.04.013_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1590\/1678-775720140259","article-title":"Host response mechanisms in periodontal diseases","volume":"23","author":"Silva","year":"2015","journal-title":"J Appl Oral Sci"},{"issue":"1","key":"10.1016\/j.mjafi.2024.04.013_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/annals.1996.1.1.443","article-title":"Non-surgical pocket therapy: mechanical","volume":"1","author":"Cobb","year":"1996","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.mjafi.2024.04.013_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","article-title":"Association between periodontal pathogens and systemic disease","volume":"42","author":"Bui","year":"2019","journal-title":"Biomed J"},{"key":"10.1016\/j.mjafi.2024.04.013_bib5","article-title":"n-3 fatty acid intake and periodontal disease","volume":"27","author":"Kaye","year":"2010","journal-title":"J Am Diet Assoc"},{"issue":"suppl 6","key":"10.1016\/j.mjafi.2024.04.013_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1600-051X.2005.00785.x","article-title":"Host response modulation in the management of periodontal diseases","volume":"32","author":"Salvi","year":"2005","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.mjafi.2024.04.013_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5051\/jpis.2014.44.1.25","article-title":"Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double blind, palcebo- controlled, clinical trial","volume":"44","author":"Deore","year":"2014","journal-title":"J Periodontal Implant Sci"},{"key":"10.1016\/j.mjafi.2024.04.013_bib8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1902\/jop.2012.120171","article-title":"Serum levels of long-chain polyunsaturated fatty acids in patients with periodontal disease","volume":"84","author":"Figueredo","year":"2013","journal-title":"J Periodontol"},{"key":"10.1016\/j.mjafi.2024.04.013_bib9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0765.1991.tb01649.x","article-title":"The role of inflammatory mediators in the pathogenesis of periodontal disease","volume":"26","author":"Page","year":"1991","journal-title":"J Periodont Res"},{"key":"10.1016\/j.mjafi.2024.04.013_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3892\/etm.2014.1724","article-title":"Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6","volume":"8","author":"Reis","year":"2014","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.mjafi.2024.04.013_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35046196","article-title":"Bone versus immune system","volume":"408","author":"Arron","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mjafi.2024.04.013_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-051X.2008.01354.x","article-title":"New directions in host modulation for the management of periodontal disease: commentary","volume":"36","author":"Bhatavadekar","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"2","key":"10.1016\/j.mjafi.2024.04.013_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-0765.2008.01108.x","article-title":"Effect of dietary omega-3 polyunsaturated fatty acids on experimental periodontitis in the mouse","volume":"44","author":"Bendyk","year":"2009","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.mjafi.2024.04.013_bib14","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/jre.12434","article-title":"Dietary supplementation with low-dose omega-3 fatty acids reduces salivary tumor necrosis factor-a levels in patients with chronic periodontitis: a randomized controlled clinical study","volume":"52","author":"Keskiner","year":"2017","journal-title":"J Periodont Res"},{"key":"10.1016\/j.mjafi.2024.04.013_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1590\/0103-6440201801702","article-title":"Omega 3 fatty acids reduce the triglyceride levels in rats with apical periodontitis","volume":"29","author":"Azuma","year":"2018","journal-title":"Braz Dent J"},{"key":"10.1016\/j.mjafi.2024.04.013_bib16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/0022034514541125","article-title":"Docosahexaenoic acid and periodontitis in adults: a randomized controlled trial","volume":"93","author":"Naqvi","year":"2014","journal-title":"J Dent Res"},{"key":"10.1016\/j.mjafi.2024.04.013_bib17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1753-4887.2010.00287.x","article-title":"Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids","volume":"68","author":"Wall","year":"2010","journal-title":"Nutr Rev"},{"key":"10.1016\/j.mjafi.2024.04.013_bib18","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1073\/pnas.0334211100","article-title":"Differential effects of prostaglandin derived from \u03c9-6 and \u03c9-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion","volume":"100","author":"Bagga","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.mjafi.2024.04.013_bib19","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/jcpe.13680","article-title":"The effect of omega-3 fatty acids on active periodontal therapy: a systematic review and meta-analysis","volume":"49","author":"Van Ravensteijn","year":"2022","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.mjafi.2024.04.013_bib20","first-page":"327","article-title":"Effect of omega-3 fatty acids on chronic periodontitis patients in postmenopausal women: a randomized controlled clinical study","volume":"4","author":"Elgendy","year":"2018","journal-title":"Oral Health Prev Dent"},{"issue":"1","key":"10.1016\/j.mjafi.2024.04.013_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jobcr.2021.10.005","article-title":"Role of adjunct use of omega 3 fatty acids in periodontal therapy of periodontitis. A systematic review and meta-analysis","volume":"12","author":"Chatterjee","year":"2022","journal-title":"J Oral Biol Cranio Res"},{"issue":"1","key":"10.1016\/j.mjafi.2024.04.013_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5051\/jpis.2014.44.1.25","article-title":"Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial","volume":"44","author":"Deore","year":"2014","journal-title":"J Perio Implant Sci"},{"issue":"11","key":"10.1016\/j.mjafi.2024.04.013_bib23","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1902\/jop.2010.090628","article-title":"Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin","volume":"81","author":"El-Sharkawy","year":"2010","journal-title":"J Periodontol"},{"key":"10.1016\/j.mjafi.2024.04.013_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-0765.2010.01336.x","article-title":"The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study)","volume":"46","author":"Elkhouli","year":"2011","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.mjafi.2024.04.013_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/ijdr.IJDR_647_18","article-title":"Efficacy of omega 3 fatty acid as an adjunct in the management of chronic periodontitis: a randomized controlled trial","volume":"31","author":"Kujur","year":"2020","journal-title":"Indian J Dent Res"},{"key":"10.1016\/j.mjafi.2024.04.013_bib26","first-page":"8","article-title":"Omega-3 as an adjunctive to non surgical treatment of chronic periodontitis patients","volume":"13","author":"Salman","year":"2014","journal-title":"ISOR J Dental Med Sci"},{"issue":"9","key":"10.1016\/j.mjafi.2024.04.013_bib27","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.3390\/nu12092614","article-title":"Omega-3 polyunsaturated fatty acids EPA and DHA as an adjunct to non-surgical treatment of periodontitis: a randomized clinical trial","volume":"12","author":"Sta\u0144do","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.mjafi.2024.04.013_bib28","doi-asserted-by":"crossref","first-page":"386","DOI":"10.4103\/jisp.jisp_16_16","article-title":"Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1 \u03b2 levels in patients with chronic periodontitis: a clinico-immunological study","volume":"21","author":"Umrania","year":"2017","journal-title":"J Indian Soc Periodontol"},{"key":"10.1016\/j.mjafi.2024.04.013_bib29","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/jre.12257","article-title":"Effect of omega 3 fatty acids plus low-dose aspirin on both clinical and biochemical profile of patients with chronic periodontitis and type 2 diabetes: a randomized double blind placebo-controlled study","volume":"50","author":"Elwakeel","year":"2015","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.mjafi.2024.04.013_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.ATV.0000057393.97337.AE","article-title":"Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association","volume":"23","author":"Kris-Etherton","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Medical Journal Armed Forces India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0377123724000571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0377123724000571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T18:42:36Z","timestamp":1719945756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0377123724000571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0377123724000571"],"URL":"https:\/\/doi.org\/10.1016\/j.mjafi.2024.04.013","relation":{},"ISSN":["0377-1237"],"issn-type":[{"value":"0377-1237","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinico-immunological evaluation of use of omega-3 fatty acids as nutraceutical approach in management of patients with chronic periodontitis: A randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Medical Journal Armed Forces India","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mjafi.2024.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Director General, Armed Forces Medical Services. Published by Elsevier, a division of RELX India Pvt. Ltd.","name":"copyright","label":"Copyright"}]}}