{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:53:03Z","timestamp":1793116383798,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal Armed Forces India"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.mjafi.2024.11.002","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T16:11:29Z","timestamp":1734624689000},"page":"714-722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The spectrum of cytogenetics and clinical profile in Robertsonian translocations: An experience of two decades from tertiary referral center in India"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-0564","authenticated-orcid":false,"given":"Krishna Kumar","family":"Maharjan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-2047","authenticated-orcid":false,"given":"Paresh","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel P.","family":"Oommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mathai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiji","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurien Anil","family":"Kuruvila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumita","family":"Danda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-2174","authenticated-orcid":false,"given":"Vivi M.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mjafi.2024.11.002_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1399-0004.1975.tb01498.x","article-title":"A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities","volume":"8","author":"Hamerton","year":"1975","journal-title":"Clin Genet"},{"issue":"1","key":"10.1016\/j.mjafi.2024.11.002_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01213097","article-title":"Chromosome abnormalities found among 34910 newborn children: results from a 13-year incidence study in Arhus, Denmark","volume":"87","author":"Nielsen","year":"1991","journal-title":"Hum Genet"},{"issue":"4","key":"10.1016\/j.mjafi.2024.11.002_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejmg.2009.03.015","article-title":"Array analysis and karyotyping: workflow consequences based on a retrospective study of 36,325 patients with idiopathic developmental delay in the Netherlands","volume":"52","author":"Hochstenbach","year":"2009","journal-title":"Eur J Med Genet"},{"issue":"1","key":"10.1016\/j.mjafi.2024.11.002_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000512676","article-title":"Prevalence and phenotypic impact of robertsonian translocations","volume":"12","author":"Poot","year":"2021","journal-title":"Mol Syndromol"},{"issue":"2","key":"10.1016\/j.mjafi.2024.11.002_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jmor.1050270202","article-title":"Chromosome studies. I. Taxonomic relationships shown in the chromosomes of tettigidae and acrididae: V-shaped chromosomes and their significance in acrididae, locustidae, and gryllidae: chromosomes and variation","volume":"27","author":"Robertson","year":"1916","journal-title":"J Morphol"},{"key":"10.1016\/j.mjafi.2024.11.002_bib6","series-title":"Gardner and Sutherland's Chromosome Abnormalities and Genetic Counselling","year":"2018"},{"key":"10.1016\/j.mjafi.2024.11.002_bib7","series-title":"The Principles of Clinical Cytogenetics [Internet]","year":"2013"},{"issue":"6","key":"10.1016\/j.mjafi.2024.11.002_bib8","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1086\/344662","article-title":"Parental origin and timing of de novo Robertsonian translocation formation","volume":"71","author":"Bandyopadhyay","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.mjafi.2024.11.002_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1469-1809.1989.tb01121.x","article-title":"The nonrandom participation of human acrocentric chromosomes in Robertsonian translocations","volume":"53","author":"Therman","year":"1989","journal-title":"Ann Hum Genet"},{"issue":"5","key":"10.1016\/j.mjafi.2024.11.002_bib10","first-page":"995","article-title":"De novo balanced chromosome rearrangements and extra marker chromosomes identified at prenatal diagnosis: clinical significance and distribution of breakpoints","volume":"49","author":"Warburton","year":"1991","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1016\/j.mjafi.2024.11.002_bib11","article-title":"Robertsonian translocations: an overview of 872 Robertsonian translocations identified in a diagnostic laboratory in China","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.mjafi.2024.11.002_bib12","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/aje\/kwy266","article-title":"Mortality and cancer incidence in carriers of balanced robertsonian translocations: a national cohort study","volume":"188","author":"Schoemaker","year":"2019","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.mjafi.2024.11.002_bib13","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s43032-023-01398-3","article-title":"A retrospective analysis of robertsonian translocations from a single center in China","volume":"31","author":"Lu","year":"2023","journal-title":"Reprod Sci"},{"issue":"1\u20133","key":"10.1016\/j.mjafi.2024.11.002_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/09723757.2010.11886090","article-title":"Cytogenetic evaluation of Down syndrome: a review of 1020 referral cases","volume":"10","author":"Chandra","year":"2010","journal-title":"Int J Hum Genet"},{"issue":"2","key":"10.1016\/j.mjafi.2024.11.002_bib15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.rbmo.2012.04.004","article-title":"Chromosomal aberrations in 2000 couples of Indian ethnicity with reproductive failure","volume":"25","author":"Gada","year":"2012","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"10.1016\/j.mjafi.2024.11.002_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1447-0756.2012.01905.x","article-title":"Reproductive outcome of couples with recurrent miscarriage and balanced chromosomal abnormalities","volume":"39","author":"Kochhar","year":"2013","journal-title":"J Obstet Gynaecol Res"},{"issue":"4","key":"10.1016\/j.mjafi.2024.11.002_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4103\/0971-6866.124369","article-title":"Chromosomal abnormalities in couples with repeated fetal loss: an Indian retrospective study","volume":"19","author":"Sheth","year":"2013","journal-title":"Indian J Hum Genet"},{"key":"10.1016\/j.mjafi.2024.11.002_bib18","series-title":"The AGT Cytogenetics Laboratory Manual [Internet]","first-page":"87","article-title":"Peripheral blood cytogenetic methods","author":"Lawce","year":"2017"},{"key":"10.1016\/j.mjafi.2024.11.002_bib19","series-title":"An International System for Human Cytogenomic Nomenclature (ISCN)","year":"2020"},{"issue":"6","key":"10.1016\/j.mjafi.2024.11.002_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jcma.2013.02.007","article-title":"Robertsonian translocations: an overview of a 30-year experience in a single tertiary medical center in Taiwan","volume":"76","author":"Chang","year":"2013","journal-title":"J Chin Med Assoc"},{"issue":"4","key":"10.1016\/j.mjafi.2024.11.002_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5045\/br.2020.2020255","article-title":"Changing the frequency and spectra of chromosomal aberrations in Korean patients with acute leukemia in a tertiary care hospital","volume":"55","author":"Park","year":"2020","journal-title":"Blood research"},{"issue":"3","key":"10.1016\/j.mjafi.2024.11.002_bib22","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.rbmo.2022.05.019","article-title":"Robertsonian translocation (13;14) and its clinical manifestations: a literature review","volume":"45","author":"Tun\u00e7","year":"2022","journal-title":"Reprod Biomed Online"},{"issue":"5","key":"10.1016\/j.mjafi.2024.11.002_bib23","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/ajmg.a.35248","article-title":"Cytogenetic and epidemiological findings in Down syndrome: England and wales 1989-2009","volume":"158A","author":"Morris","year":"2012","journal-title":"Am J Med Genet A"},{"issue":"6","key":"10.1016\/j.mjafi.2024.11.002_bib24","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.arcmed.2015.08.001","article-title":"Cytogenetic profile in 1,921 cases of trisomy 21 syndrome","volume":"46","author":"Flores-Ram\u00edrez","year":"2015","journal-title":"Arch Med Res"},{"issue":"5","key":"10.1016\/j.mjafi.2024.11.002_bib25","first-page":"1108","article-title":"Sex ratio in normal and disomic sperm: evidence that the extra chromosome 21 preferentially segregates with the Y chromosome","volume":"59","author":"Griffin","year":"1996","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1016\/j.mjafi.2024.11.002_bib26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1534\/genetics.120.303656","article-title":"The interchromosomal effect: different meanings for different organisms","volume":"216","author":"Miller","year":"2020","journal-title":"Genetics"},{"issue":"10","key":"10.1016\/j.mjafi.2024.11.002_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003025","article-title":"Embryos of robertsonian translocation carriers exhibit a mitotic interchromosomal effect that enhances genetic instability during early development","volume":"8","author":"Alfarawati","year":"2012","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.mjafi.2024.11.002_bib28","first-page":"65","article-title":"Robertsonian and balanced reciprocal translocation in both child and mother with a history of recurrent abortions","volume":"21","author":"Poornima","year":"2020","journal-title":"J Reproduction Infertil"},{"issue":"4","key":"10.1016\/j.mjafi.2024.11.002_bib29","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1399-0004.1991.tb03028.x","article-title":"Prader-Willi syndrome and Robertsonian translocations involving chromosome 15","volume":"39","author":"Casamassima","year":"1991","journal-title":"Clin Genet"}],"container-title":["Medical Journal Armed Forces India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0377123724002478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0377123724002478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T20:12:00Z","timestamp":1762027920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0377123724002478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0377123724002478"],"URL":"https:\/\/doi.org\/10.1016\/j.mjafi.2024.11.002","relation":{},"ISSN":["0377-1237"],"issn-type":[{"value":"0377-1237","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The spectrum of cytogenetics and clinical profile in Robertsonian translocations: An experience of two decades from tertiary referral center in India","name":"articletitle","label":"Article Title"},{"value":"Medical Journal Armed Forces India","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mjafi.2024.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Director General, Armed Forces Medical Services. Published by Elsevier, a division of RELX India Pvt. Ltd.","name":"copyright","label":"Copyright"}]}}