{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:20:17Z","timestamp":1775244017418,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002141","name":"Public Health England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Mycology Case Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.mmcr.2021.03.005","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T17:28:14Z","timestamp":1616088494000},"page":"39-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement"],"prefix":"10.1016","volume":"32","author":[{"given":"R.P.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Farrugia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Leask","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Khalsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Melia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mmcr.2021.03.005_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11908-007-0066-4","article-title":"Zygomycosis: an emerging fungal infection with new options for management","volume":"9","author":"Kauffman","year":"2007","journal-title":"Curr. Infect. Dis. Rep."},{"issue":"5","key":"10.1016\/j.mmcr.2021.03.005_bib2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/432579","article-title":"Epidemiology and outcome of zygomycosis: a review of 929 reported cases","volume":"41","author":"Roden","year":"2005","journal-title":"Clin. Infect. Dis."},{"issue":"S3","key":"10.1016\/j.mmcr.2021.03.005_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1469-0691.12371","article-title":"ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013","volume":"20","author":"Cornely","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"issue":"3","key":"10.1016\/j.mmcr.2021.03.005_bib4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.diabet.2012.01.002","article-title":"Diabetes and mucormycosis: a complex interplay","volume":"38","author":"Rammaert","year":"2012","journal-title":"Diabetes Metab."},{"issue":"12","key":"10.1016\/j.mmcr.2021.03.005_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028425","article-title":"Mould routine identification in the clinical laboratory by matrix-assisted laser desorption ionization time-of-flight mass spectrometry","volume":"6","author":"Cassagne","year":"2011","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.mmcr.2021.03.005_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/590004","article-title":"Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis","volume":"47","author":"Chamilos","year":"2008","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.mmcr.2021.03.005_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/TP.0b013e3181dde8fc","article-title":"Rhino-orbital-cerebral zygomycosis in solid organ transplant recipients","volume":"90","author":"Sun","year":"2010","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.mmcr.2021.03.005_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cmi.2018.07.011","article-title":"The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports","volume":"25","author":"Jeong","year":"2019","journal-title":"Clin. Microbiol. Infect. [Internet]"},{"issue":"3","key":"10.1016\/j.mmcr.2021.03.005_bib9","first-page":"231","article-title":"Rhino-orbito-cerebral mucormycosis. A retrospective analysis of clinical features and treatment outcomes","volume":"51","author":"Nithyanandam","year":"2003","journal-title":"Indian J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.mmcr.2021.03.005_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1128\/CMR.13.2.236","article-title":"Zygomycetes in human disease","volume":"13","author":"Ribes","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.mmcr.2021.03.005_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7457269","article-title":"Role of adaptive and innate immunity in type 2 diabetes mellitus","volume":"2018","author":"Zhou","year":"2018","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.mmcr.2021.03.005_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1086\/505969","article-title":"Prospective study of amphotericin B formulations in immunocompromised patients in 4 European countries","author":"Ullmann","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.mmcr.2021.03.005_bib13","first-page":"1289","article-title":"Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high \u2013 loading dose regimen with standard dosing ( AmBiLoad trial )","volume":"44","author":"Cornely","year":"2007"},{"issue":"SUPPL. 1","key":"10.1016\/j.mmcr.2021.03.005_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/cid\/cir885","article-title":"Combination therapy for mucormycosis: why, what, and how?","volume":"54","author":"Spellberg","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.mmcr.2021.03.005_bib15","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2147\/TCRM.S90335","article-title":"Role of isavuconazole in the treatment of invasive fungal infections","volume":"12","author":"Wilson","year":"2016","journal-title":"Therapeut. Clin. Risk Manag."},{"issue":"7","key":"10.1016\/j.mmcr.2021.03.005_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00585-18","article-title":"Isavuconazole concentration in real-world practice: consistency with results from clinical trials","volume":"62","author":"Andes","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.mmcr.2021.03.005_bib17","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/mmy\/myaa022","article-title":"Lessons from isavuconazole therapeutic drug monitoring at a United Kingdom Reference Center","volume":"58","author":"Borman","year":"2020","journal-title":"Med. Mycol."},{"key":"10.1016\/j.mmcr.2021.03.005_bib18","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2147\/DDDT.S145545","article-title":"Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy","volume":"12","author":"Jenks","year":"2018","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Medical Mycology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211753921000142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211753921000142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T18:02:47Z","timestamp":1761933767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211753921000142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":18,"alternative-id":["S2211753921000142"],"URL":"https:\/\/doi.org\/10.1016\/j.mmcr.2021.03.005","relation":{},"ISSN":["2211-7539"],"issn-type":[{"value":"2211-7539","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement","name":"articletitle","label":"Article Title"},{"value":"Medical Mycology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mmcr.2021.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology.","name":"copyright","label":"Copyright"}]}}