{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:50:30Z","timestamp":1791319830481,"version":"4.3.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":265,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100025294","name":"Research Ireland","doi-asserted-by":"publisher","award":["13\/RC\/2073_P2"],"award-info":[{"award-number":["13\/RC\/2073_P2"]}],"id":[{"id":"10.13039\/501100025294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025294","name":"Research Ireland","doi-asserted-by":"publisher","award":["23\/RC\/12208"],"award-info":[{"award-number":["23\/RC\/12208"]}],"id":[{"id":"10.13039\/501100025294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Military Medical Research"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.mmr.2026.100070","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:38:25Z","timestamp":1790689105000},"page":"100070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycosylation as a design component of biomaterials in implant design"],"prefix":"10.1016","volume":"13","author":[{"given":"Abhay","family":"Pandit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mmr.2026.100070_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/glycob\/cww086","article-title":"Biological roles of glycans","volume":"27","author":"Varki","year":"2017","journal-title":"Glycobiology"},{"key":"10.1016\/j.mmr.2026.100070_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121585","article-title":"Therapeutic potential of targeting galectins \u2013 a biomaterials-focused perspective","volume":"286","author":"Martin-Salda\u00f1a","year":"2022","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.mmr.2026.100070_bib3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","article-title":"Glycosylation in health and disease","volume":"15","author":"Reily","year":"2019","journal-title":"Nat Rev Nephrol"},{"issue":"4","key":"10.1016\/j.mmr.2026.100070_bib4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.molmed.2022.01.004","article-title":"Role and therapeutic implications of protein glycosylation in neuroinflammation","volume":"28","author":"Rebelo","year":"2022","journal-title":"Trends Mol Med"},{"issue":"1","key":"10.1016\/j.mmr.2026.100070_bib5","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgad439","article-title":"Changes in tissue protein N-glycosylation and associated molecular signature occur in the human Parkinsonian brain in a region-specific manner","volume":"3","author":"Rebelo","year":"2024","journal-title":"PNAS Nexus"},{"issue":"1","key":"10.1016\/j.mmr.2026.100070_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12974-021-02163-6","article-title":"Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain","volume":"18","author":"Rebelo","year":"2021","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.mmr.2026.100070_bib7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.22203\/eCM.v041a26","article-title":"The role of altered glycosylation in human nucleus pulposus cells in inflammation and degeneration","volume":"41","author":"Joyce","year":"2021","journal-title":"Eur Cell Mater"},{"issue":"6","key":"10.1016\/j.mmr.2026.100070_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202506669","article-title":"Inhibition of hypersialylation in human intervertebral disc degeneration modulates inflammation and metabolism","volume":"13","author":"Joyce","year":"2026","journal-title":"Adv Sci"},{"issue":"4","key":"10.1016\/j.mmr.2026.100070_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaq0597","article-title":"Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury","volume":"4","author":"Mohd Isa","year":"2018","journal-title":"Sci Adv"},{"issue":"10","key":"10.1016\/j.mmr.2026.100070_bib10","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1039\/C9BM00964G","article-title":"The sulfation of biomimetic glycosaminoglycan substrates controls binding of growth factors and subsequent neural and glial cell growth","volume":"7","author":"Malaeb","year":"2019","journal-title":"Biomater Sci"},{"issue":"386","key":"10.1016\/j.mmr.2026.100070_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai9044","article-title":"Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice","volume":"9","author":"Lohmann","year":"2017","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.mmr.2026.100070_bib12","doi-asserted-by":"crossref","DOI":"10.1098\/rsfs.2018.0080","article-title":"Synthetic glycoscapes: addressing the structural and functional complexity of the glycocalyx","volume":"9","author":"Purcell","year":"2019","journal-title":"Interface Focus"},{"issue":"9","key":"10.1016\/j.mmr.2026.100070_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.70148","article-title":"Profiling the glycosignature of commercial pepsin-soluble type I collagen preparations: a multimodal lectin strategy reveals latent batch variability","volume":"114","author":"El-Melegy","year":"2026","journal-title":"J Biomed Mater Res A"},{"issue":"5","key":"10.1016\/j.mmr.2026.100070_bib14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/19420862.2018.1466767","article-title":"The \u2018less-is-more\u2019 in therapeutic antibodies: afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity","volume":"10","author":"Pereira","year":"2018","journal-title":"MAbs"},{"issue":"7","key":"10.1016\/j.mmr.2026.100070_bib15","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1021\/acs.biomac.0c00387","article-title":"Glycan-functionalized collagen hydrogels modulate the glycoenvironment of a neuronal primary culture","volume":"21","author":"Rebelo","year":"2020","journal-title":"Biomacromolecules"},{"issue":"2","key":"10.1016\/j.mmr.2026.100070_bib16","article-title":"Sweet tailoring of glyco-modulatory extracellular matrix-inspired biomaterials to target neuroinflammation","volume":"2","author":"Rebelo","year":"2021","journal-title":"Cell Rep Phys Sci"},{"issue":"1","key":"10.1016\/j.mmr.2026.100070_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41392-021-00512-8","article-title":"Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties","volume":"6","author":"Joyce","year":"2021","journal-title":"Signal Transduct Target Ther"}],"container-title":["Military Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2054936926001020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2054936926001020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:57:04Z","timestamp":1791316624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2054936926001020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2054936926001020"],"URL":"https:\/\/doi.org\/10.1016\/j.mmr.2026.100070","relation":{},"ISSN":["2054-9369"],"issn-type":[{"value":"2054-9369","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycosylation as a design component of biomaterials in implant design","name":"articletitle","label":"Article Title"},{"value":"Military Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mmr.2026.100070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}],"article-number":"100070"}}