{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:28:25Z","timestamp":1786814905426,"version":"build-2736575974"},"reference-count":87,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2024-00411768"],"award-info":[{"award-number":["RS-2024-00411768"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["NRF-2022R1A2C1091644"],"award-info":[{"award-number":["NRF-2022R1A2C1091644"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2024-00438368"],"award-info":[{"award-number":["RS-2024-00438368"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002582","name":"Gwangju Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2024-00512909"],"award-info":[{"award-number":["RS-2024-00512909"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecules and Cells"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.mocell.2025.100241","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T12:02:20Z","timestamp":1749816140000},"page":"100241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Building blocks for lung regeneration: Stem cells and niches"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1710-3935","authenticated-orcid":false,"given":"Hyeyoung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7265-4867","authenticated-orcid":false,"given":"Chae Won","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3621-1928","authenticated-orcid":false,"given":"Woo Ram","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8941-117X","authenticated-orcid":false,"given":"Ji Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Yeon","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-0929","authenticated-orcid":false,"given":"Jinwook","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mocell.2025.100241_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1983","article-title":"Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis","volume":"6","author":"Adams","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mocell.2025.100241_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023139","article-title":"Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair","volume":"6","author":"Al Alam","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mocell.2025.100241_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41385-021-00480-w","article-title":"The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity","volume":"15","author":"Bain","year":"2022","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.mocell.2025.100241_bib4","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82998","article-title":"The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures","volume":"12","author":"Balazova","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.mocell.2025.100241_bib5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1242\/dev.140103","article-title":"Lung organoids: current uses and future promise","volume":"144","author":"Barkauskas","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.mocell.2025.100241_bib6","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1172\/JCI68782","article-title":"Type 2 alveolar cells are stem cells in adult lung","volume":"123","author":"Barkauskas","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mocell.2025.100241_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-022-04552-0","article-title":"Human distal airways contain a multipotent secretory cell that can regenerate alveoli","volume":"604","author":"Basil","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2877-5","article-title":"Exuberant fibroblast activity compromises lung function via ADAMTS4","volume":"587","author":"Boyd","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib9","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/ncb3510","article-title":"A three-dimensional model of human lung development and disease from pluripotent stem cells","volume":"19","author":"Chen","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mocell.2025.100241_bib10","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.stem.2020.06.020","article-title":"Inflammatory\u00a0signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration","volume":"27","author":"Choi","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib11","doi-asserted-by":"crossref","DOI":"10.1242\/dev.163014","article-title":"Niche-mediated BMP\/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation","volume":"145","author":"Chung","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.mocell.2025.100241_bib12","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1164\/rccm.201408-1492PP","article-title":"Airway basal cells the \u201csmoking gun\u201d of chronic obstructive pulmonary disease","volume":"190","author":"Crystal","year":"2014","journal-title":"Am. J. Resp. Crit. Care"},{"key":"10.1016\/j.mocell.2025.100241_bib13","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1172\/JCI36498","article-title":"CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury","volume":"119","author":"D'Alessio","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mocell.2025.100241_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.celrep.2014.12.017","article-title":"Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung","volume":"10","author":"Danahay","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.mocell.2025.100241_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41586-021-03570-8","article-title":"COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets","volume":"595","author":"Delorey","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cell.2011.10.003","article-title":"Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization","volume":"147","author":"Ding","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib17","article-title":"SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice","volume":"14","author":"Dinnon","year":"2022","journal-title":"Sci.\u00a0Transl.\u00a0Med."},{"key":"10.1016\/j.mocell.2025.100241_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05098","article-title":"In vitro generation of human pluripotent stem cell derived lung organoids","volume":"4","author":"Dye","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.mocell.2025.100241_bib19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2020.01.009","article-title":"Epithelial Vegfa specifies a distinct endothelial population in the mouse lung","volume":"52","author":"Ellis","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.mocell.2025.100241_bib21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.stem.2025.01.011","article-title":"Sustained NF-kappaB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation","volume":"32","author":"England","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib22","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/j.celrep.2019.02.046","article-title":"Dlk1-mediated temporal regulation of notch signaling is required for differentiation of alveolar type II to type I cells during repair","volume":"26","author":"Finn","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.mocell.2025.100241_bib23","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1074\/jbc.M109.070326","article-title":"Beta-catenin\/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells","volume":"285","author":"Flozak","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mocell.2025.100241_bib24","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.celrep.2016.11.001","article-title":"Emergence of a wave of Wnt signaling that regulates lung alveologenesis by controlling epithelial self-renewal and differentiation","volume":"17","author":"Frank","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.mocell.2025.100241_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41586-020-2822-7","article-title":"Capillary cell-type specialization in the alveolus","volume":"586","author":"Gillich","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1972","article-title":"Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis","volume":"6","author":"Habermann","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mocell.2025.100241_bib27","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41586-024-07113-9","article-title":"An atlas of epithelial cell states and plasticity in lung adenocarcinoma","volume":"627","author":"Han","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib28","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/s41586-023-06423-8","article-title":"Mitochondrial integrated stress response controls lung epithelial cell fate","volume":"620","author":"Han","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-023-05874-3","article-title":"Lung adenocarcinoma promotion by air pollutants","volume":"616","author":"Hill","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.stem.2017.08.014","article-title":"Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells","volume":"21","author":"Jacob","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.ado5561","article-title":"An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung","volume":"386","author":"Jones","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.mocell.2025.100241_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-022-04541-3","article-title":"Human distal lung maps and lineage hierarchies reveal a bipotent progenitor","volume":"604","author":"Kadur Lakshminarasimha Murthy","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib33","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221462","article-title":"Regulation of the alveolar regenerative niche by amphiregulin-producing regulatory T cells","volume":"220","author":"Kaiser","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mocell.2025.100241_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111828","article-title":"Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung","volume":"41","author":"Kawasaki","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.mocell.2025.100241_bib35","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41556-020-0542-8","article-title":"Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis","volume":"22","author":"Kobayashi","year":"2020","journal-title":"Nat.\u00a0Cell Biol."},{"key":"10.1016\/j.mocell.2025.100241_bib36","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.stem.2023.10.001","article-title":"Transitional cell states sculpt tissue topology during lung regeneration","volume":"30","author":"Konkimalla","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib37","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.3389\/fimmu.2020.01722","article-title":"Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury","volume":"11","author":"Kumar","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mocell.2025.100241_bib38","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1172\/JCI125014","article-title":"Yap\/Taz regulate alveolar regeneration and resolution of lung inflammation","volume":"129","author":"LaCanna","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mocell.2025.100241_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/jmcb\/mju046","article-title":"Hippo\/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung","volume":"7","author":"Lange","year":"2015","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.mocell.2025.100241_bib40","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2013.12.039","article-title":"Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis","volume":"156","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib41","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.4049\/jimmunol.177.10.7155","article-title":"Lipopolysaccharide-activated CD4+CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death","volume":"177","author":"Lewkowicz","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.mocell.2025.100241_bib42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cellimm.2018.02.001","article-title":"The interstitial macrophage: a long-neglected piece in the puzzle of lung immunity","volume":"330","author":"Liegeois","year":"2018","journal-title":"Cell Immunol."},{"key":"10.1016\/j.mocell.2025.100241_bib43","article-title":"IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury","volume":"4","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.mocell.2025.100241_bib44","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41588-019-0346-6","article-title":"Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction","volume":"51","author":"Liu","year":"2019","journal-title":"Nat.\u00a0Genet."},{"key":"10.1016\/j.mocell.2025.100241_bib45","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.celrep.2016.07.020","article-title":"MAPK-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration","volume":"16","author":"Liu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.mocell.2025.100241_bib46","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.stem.2017.03.001","article-title":"Efficient derivation of functional human airway epithelium from pluripotent stem cells via temporal regulation of Wnt signaling","volume":"20","author":"McCauley","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-021-03569-1","article-title":"A molecular single-cell lung atlas of lethal COVID-19","volume":"595","author":"Melms","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-018-0393-7","article-title":"A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","volume":"560","author":"Montoro","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib49","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1038\/s44318-024-00113-5","article-title":"Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis","volume":"43","author":"Moye","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.mocell.2025.100241_bib50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat.\u00a0Rev. Immunol."},{"key":"10.1016\/j.mocell.2025.100241_bib51","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.aam6603","article-title":"Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells","volume":"359","author":"Nabhan","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.mocell.2025.100241_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53072","article-title":"Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury","volume":"9","author":"Niethamer","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.mocell.2025.100241_bib53","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s40139-017-0137-7","article-title":"Lung organoids and their use to study cell-cell interaction","volume":"5","author":"Nikolic","year":"2017","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.mocell.2025.100241_bib54","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1158\/2159-8290.CD-16-1154","article-title":"Personalized in vitro and in vivo cancer models to guide precision medicine","volume":"7","author":"Pauli","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.mocell.2025.100241_bib55","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41586-018-0394-6","article-title":"A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte","volume":"560","author":"Plasschaert","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib56","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib57","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib58","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.immuni.2018.07.015","article-title":"Regulatory T cells promote macrophage efferocytosis during inflammation resolution","volume":"49","author":"Proto","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.mocell.2025.100241_bib59","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature17040","article-title":"Angiocrine functions of organ-specific endothelial cells","volume":"529","author":"Rafii","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib60","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib61","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1242\/dmm.006031","article-title":"Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling","volume":"3","author":"Rock","year":"2010","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.mocell.2025.100241_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.ado1227","article-title":"Recruited atypical Ly6G(+) macrophages license alveolar regeneration after lung injury","volume":"9","author":"Ruscitti","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.mocell.2025.100241_bib63","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100300","article-title":"Long-term expanding human airway organoids for disease modeling","volume":"38","author":"Sachs","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.mocell.2025.100241_bib64","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102099","article-title":"Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo","volume":"38","author":"Salwig","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.mocell.2025.100241_bib65","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1242\/dev.079590","article-title":"In vitro organogenesis in three dimensions: self-organising stem cells","volume":"139","author":"Sasai","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.mocell.2025.100241_bib66","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrm3873","article-title":"Three-dimensional organotypic culture: experimental models of mammalian biology and disease","volume":"15","author":"Shamir","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mocell.2025.100241_bib67","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/s41467-020-17358-3","article-title":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mocell.2025.100241_bib68","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/j.stemcr.2021.10.015","article-title":"Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids","volume":"16","author":"Suezawa","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mocell.2025.100241_bib69","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1165\/rcmb.2023-0292LE","article-title":"Single-cell transcriptomes, lineage, and differentiation of functional airway microfold cells","volume":"69","author":"Surve","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mocell.2025.100241_bib70","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/stem.3423","article-title":"Characterization in mice of the resident mesenchymal niche maintaining AT2 stem cell proliferation in homeostasis and disease","volume":"39","author":"Taghizadeh","year":"2021","journal-title":"Stem Cells"},{"key":"10.1016\/j.mocell.2025.100241_bib71","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.stem.2022.07.006","article-title":"Wound healing, fibroblast heterogeneity, and fibrosis","volume":"29","author":"Talbott","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib72","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature12777","article-title":"Dedifferentiation of committed epithelial cells into stem cells in vivo","volume":"503","author":"Tata","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib73","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ar.1092290308","article-title":"The proximal border of the human respiratory unit, as shown by scanning and transmission electron microscopy and light microscopical cytochemistry","volume":"229","author":"ten Have-Opbroek","year":"1991","journal-title":"Anat.\u00a0Rec."},{"key":"10.1016\/j.mocell.2025.100241_bib74","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/s41467-020-15647-5","article-title":"Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis","volume":"11","author":"Tsukui","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mocell.2025.100241_bib75","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-024-07660-1","article-title":"Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis","volume":"631","author":"Tsukui","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1165\/rcmb.2019-0188OC","article-title":"Exposure to cigarette smoke enhances the stemness of alveolar type 2 cells","volume":"63","author":"Tsutsumi","year":"2020","journal-title":"Am. J.\u00a0Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mocell.2025.100241_bib77","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2020.01.009","article-title":"Epithelial vegfa specifies a distinct endothelial population in the mouse lung","volume":"52","author":"Vila Ellis","year":"2020","journal-title":"Dev. Cell."},{"key":"10.1016\/j.mocell.2025.100241_bib78","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq2509","article-title":"Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae","volume":"387","author":"Wei","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.mocell.2025.100241_bib79","first-page":"375","article-title":"What makes a good lung?","volume":"139","author":"Weibel","year":"2009","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.mocell.2025.100241_bib80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2019.11.027","article-title":"Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells","volume":"180","author":"Wu","year":"2020","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.mocell.2025.100241_bib81","article-title":"The role of immune cells in the pathogenesis of idiopathic pulmonary fibrosis","volume":"59","author":"Xu","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.mocell.2025.100241_bib82","first-page":"54","article-title":"The development and plasticity of alveolar type 1 cells","volume":"143","author":"Yang","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.mocell.2025.100241_bib83","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12931-022-01996-w","article-title":"Impaired AT2 to AT1 cell transition in PM2.5-induced mouse model of chronic obstructive pulmonary disease","volume":"23","author":"Yu","year":"2022","journal-title":"Respir.\u00a0Res."},{"key":"10.1016\/j.mocell.2025.100241_bib84","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature25786","article-title":"Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor","volume":"555","author":"Zacharias","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mocell.2025.100241_bib85","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.cell.2017.07.034","article-title":"Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung","volume":"170","author":"Zepp","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mocell.2025.100241_bib86","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pccm.2023.10.007","article-title":"Epithelial stem cells and niches in lung alveolar regeneration and diseases","volume":"2","author":"Zhang","year":"2024","journal-title":"Chin. Med. J. Pulm. Crit. Care Med."},{"key":"10.1016\/j.mocell.2025.100241_bib87","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1186\/s12967-023-04782-4","article-title":"Role of IL-33-ST2 pathway in regulating inflammation: current evidence and future perspectives","volume":"21","author":"Zhou","year":"2023","journal-title":"J.\u00a0Transl. Med."}],"container-title":["Molecules and Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847825000652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847825000652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T13:51:09Z","timestamp":1752846669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1016847825000652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":87,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1016847825000652"],"URL":"https:\/\/doi.org\/10.1016\/j.mocell.2025.100241","relation":{},"ISSN":["1016-8478"],"issn-type":[{"value":"1016-8478","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Building blocks for lung regeneration: Stem cells and niches","name":"articletitle","label":"Article Title"},{"value":"Molecules and Cells","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mocell.2025.100241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Korean Society for Molecular and Cellular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100241"}}