{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:21:41Z","timestamp":1790896901476,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002632","name":"Hallym University","doi-asserted-by":"publisher","award":["HRF-202402-009"],"award-info":[{"award-number":["HRF-202402-009"]}],"id":[{"id":"10.13039\/501100002632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecules and Cells"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.mocell.2025.100247","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T10:17:21Z","timestamp":1750587441000},"page":"100247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optogenetics to biomolecular phase separation in neurodegenerative diseases"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3993-3572","authenticated-orcid":false,"given":"Kyung Hwan","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8252-6203","authenticated-orcid":false,"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","article-title":"Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates","volume":"176","author":"Alberti","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.mocell.2025.100247_bib2","doi-asserted-by":"crossref","unstructured":"Aldewachi, H., Al-Zidan, R.N., Conner, M.T., and Salman, M.M. (2021). High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases. Bioengineering (Basel), 8(2), 30. https:\/\/doi.org\/10.3390\/bioengineering8020030","DOI":"10.3390\/bioengineering8020030"},{"issue":"5700","key":"10.1016\/j.mocell.2025.100247_bib3","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1126\/science.1102506","article-title":"Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting","volume":"306","author":"Ando","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.mocell.2025.100247_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/srep42971","article-title":"Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools","volume":"7","author":"Arinkin","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib5","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/s41467-020-14815-x","article-title":"Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons","volume":"11","author":"Asakawa","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.mocell.2025.100247_bib6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuron.2013.02.004","article-title":"Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD\/ALS","volume":"77","author":"Ash","year":"2013","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.mocell.2025.100247_bib7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.molcel.2018.07.032","article-title":"mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington\u2019s disease","volume":"71","author":"Ast","year":"2018","journal-title":"Mol.\u00a0Cell"},{"key":"10.1016\/j.mocell.2025.100247_bib8","first-page":"423","article-title":"Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?","volume":"9","author":"Aulas","year":"2015","journal-title":"Front.\u00a0Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.mocell.2025.100247_bib9","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.jmb.2020.03.004","article-title":"Liquid-liquid phase separation and its mechanistic role in pathological protein aggregation","volume":"432","author":"Babinchak","year":"2020","journal-title":"J.\u00a0Mol. Biol."},{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001578","article-title":"A light-inducible protein clustering system for in vivo analysis of alpha-synuclein aggregation in Parkinson disease","volume":"20","author":"Berard","year":"2022","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.mocell.2025.100247_bib11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.tcb.2018.02.004","article-title":"Protein phase separation: a new phase in cell biology","volume":"28","author":"Boeynaems","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.mocell.2025.100247_bib12","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.cell.2018.10.048","article-title":"Mapping local and global liquid phase behavior in living cells using photo-oligomerizable seeds","volume":"175","author":"Bracha","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib13","first-page":"6717","article-title":"Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag","volume":"15","author":"Brumbaugh-Reed","year":"2024","journal-title":"Nat.\u00a0Commun."},{"issue":"4","key":"10.1016\/j.mocell.2025.100247_bib14","first-page":"301","article-title":"Prion-like transmission of protein aggregates in neurodegenerative diseases","volume":"11","author":"Brundin","year":"2010","journal-title":"Nat.\u00a0Rev.\u00a0Mol.\u00a0Cell Biol."},{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib15","first-page":"249","article-title":"Optogenetic protein clustering and signaling activation in mammalian cells","volume":"10","author":"Bugaj","year":"2013","journal-title":"Nat.\u00a0Methods"},{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.mocell.2025.100247_bib17","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.bpj.2023.10.009","article-title":"Condensate interfaces can accelerate protein aggregation","volume":"123","author":"Choi","year":"2024","journal-title":"Biophys. J."},{"issue":"12","key":"10.1016\/j.mocell.2025.100247_bib18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41582-023-00883-2","article-title":"Tau-targeting therapies for Alzheimer disease: current status and future directions","volume":"19","author":"Congdon","year":"2023","journal-title":"Nat.\u00a0Rev. Neurol."},{"issue":"9","key":"10.1016\/j.mocell.2025.100247_bib19","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nn.4091","article-title":"Optogenetics: 10 years of microbial opsins in neuroscience","volume":"18","author":"Deisseroth","year":"2015","journal-title":"Nat.\u00a0Neurosci."},{"issue":"6","key":"10.1016\/j.mocell.2025.100247_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrneurol.2014.78","article-title":"The role of FUS gene variants in neurodegenerative diseases","volume":"10","author":"Deng","year":"2014","journal-title":"Nat.\u00a0Rev. Neurol."},{"issue":"5334","key":"10.1016\/j.mocell.2025.100247_bib21","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.mocell.2025.100247_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cels.2018.05.002","article-title":"Protein phase separation provides long-term memory of transient spatial stimuli","volume":"6","author":"Dine","year":"2018","journal-title":"Cell Syst."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41467-017-00648-8","article-title":"Understanding CRY2 interactions for optical control of intracellular signaling","volume":"8","author":"Duan","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mocell.2025.100247_bib24","doi-asserted-by":"crossref","unstructured":"Gendron, T.F., and Petrucelli, L. (2018). Disease mechanisms of C9ORF72 repeat expansions. Cold Spring Harb. Perspect. Med. 8(4), 2018, a024224. https:\/\/doi.org\/10.1101\/cshperspect.a024224","DOI":"10.1101\/cshperspect.a024224"},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-4-8","article-title":"The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease","volume":"4","author":"Golde","year":"2009","journal-title":"Mol.\u00a0Neurodegener."},{"issue":"22","key":"10.1016\/j.mocell.2025.100247_bib26","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1016\/j.molcel.2022.09.031","article-title":"Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding","volume":"82","author":"Gropp","year":"2022","journal-title":"Mol.\u00a0Cell"},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1073\/pnas.1417910112","article-title":"Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins","volume":"112","author":"Guntas","year":"2015","journal-title":"Proc.\u00a0Natl. Acad.\u00a0Sci."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib28","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41380-021-01296-7","article-title":"Brain regions susceptible to alpha-synuclein spreading","volume":"27","author":"Guo","year":"2022","journal-title":"Mol.\u00a0Psychiatry"},{"issue":"10","key":"10.1016\/j.mocell.2025.100247_bib29","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/hmg\/ddp099","article-title":"SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans","volume":"18","author":"Guthrie","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cell.2024.11.038","article-title":"Long somatic DNA-repeat expansion drives neurodegeneration in Huntington\u2019s disease","volume":"188","author":"Handsaker","year":"2025","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.mocell.2025.100247_bib31","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1042\/BCJ20160499","article-title":"RNA-binding proteins with prion-like domains in health and disease","volume":"474","author":"Harrison","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.mocell.2025.100247_bib32","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3389\/fnins.2019.01154","article-title":"The beta amyloid dysfunction (BAD) hypothesis for Alzheimer's disease","volume":"13","author":"Hillen","year":"2019","journal-title":"Front. Neurosci."},{"issue":"10","key":"10.1016\/j.mocell.2025.100247_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110937","article-title":"C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology","volume":"27","author":"Hodgson","year":"2024","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib34","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s42003-024-06840-z","article-title":"Live-cell visualization of tau aggregation in human neurons","volume":"7","author":"Hurtle","year":"2024","journal-title":"Commun. Biol."},{"issue":"7465","key":"10.1016\/j.mocell.2025.100247_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases","volume":"501","author":"Jucker","year":"2013","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.mocell.2025.100247_bib36","first-page":"591","article-title":"A bacterial phytochrome-based optogenetic system controllable with near-infrared light","volume":"13","author":"Kaberniuk","year":"2016","journal-title":"Nat.\u00a0Methods"},{"issue":"12","key":"10.1016\/j.mocell.2025.100247_bib37","first-page":"973","article-title":"Rapid blue-light\u2013mediated induction of protein interactions in living cells","volume":"7","author":"Kennedy","year":"2010","journal-title":"Nat.\u00a0Methods"},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib38","first-page":"7551","article-title":"TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types","volume":"8","author":"Khalfallah","year":"2018","journal-title":"Sci.\u00a0Rep."},{"issue":"7","key":"10.1016\/j.mocell.2025.100247_bib39","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.stem.2023.05.015","article-title":"Advanced human iPSC-based preclinical model for Parkinson\u2019s disease with optogenetic alpha-synuclein aggregation","volume":"30","author":"Kim","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"16","key":"10.1016\/j.mocell.2025.100247_bib40","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/hmg\/ddm143","article-title":"SUT-1 enables tau-induced neurotoxicity in C. elegans","volume":"16","author":"Kraemer","year":"2007","journal-title":"Hum.\u00a0Mol. Genet."},{"issue":"R1","key":"10.1016\/j.mocell.2025.100247_bib41","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","article-title":"TDP-43 and FUS\/TLS: emerging roles in RNA processing and neurodegeneration","volume":"19","author":"Lagier-Tourenne","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib42","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1038\/s41467-024-47442-x","article-title":"Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.mocell.2025.100247_bib43","article-title":"Transcellular transmission and molecular heterogeneity of aggregation-prone proteins in neurodegenerative diseases","volume":"47","author":"Lee","year":"2024","journal-title":"Mol.\u00a0Cells"},{"key":"10.1016\/j.mocell.2025.100247_bib44","article-title":"Red light optogenetics in neuroscience","volume":"15","author":"Lehtinen","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib45","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1083\/jcb.201302044","article-title":"Stress granules as crucibles of ALS pathogenesis","volume":"201","author":"Li","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.mocell.2025.100247_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52589","article-title":"Application of optogenetic Amyloid-beta distinguishes between metabolic and physical damages in neurodegeneration","volume":"9","author":"Lim","year":"2020","journal-title":"Elife"},{"issue":"5907","key":"10.1016\/j.mocell.2025.100247_bib47","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1126\/science.1163927","article-title":"Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis","volume":"322","author":"Liu","year":"2008","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.mocell.2025.100247_bib48","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mocell.2025.100247_bib49","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neuron.2019.01.048","article-title":"RNA binding antagonizes neurotoxic phase transitions of TDP-43","volume":"102","author":"Mann","year":"2019","journal-title":"Neuron"},{"issue":"24","key":"10.1016\/j.mocell.2025.100247_bib50","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1016\/j.cell.2024.09.037","article-title":"RNA G-quadruplexes form scaffolds that promote neuropathological alpha-synuclein aggregation","volume":"187","author":"Matsuo","year":"2024","journal-title":"Cell"},{"issue":"6125","key":"10.1016\/j.mocell.2025.100247_bib51","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.1232927","article-title":"The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD\/ALS","volume":"339","author":"Mori","year":"2013","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.mocell.2025.100247_bib52","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41588-024-02054-5","article-title":"In vivo CRISPR\u2013Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington\u2019s disease","volume":"57","author":"Mouro Pinto","year":"2025","journal-title":"Nat.\u00a0Genet."},{"key":"10.1016\/j.mocell.2025.100247_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105078","article-title":"Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo","volume":"146","author":"Otte","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib54","first-page":"30","article-title":"Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2","volume":"8","author":"Park","year":"2017","journal-title":"Nat.\u00a0Commun."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40035-025-00480-x","article-title":"Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans","volume":"14","author":"Park","year":"2025","journal-title":"Transl. Neurodegener."},{"issue":"11","key":"10.1016\/j.mocell.2025.100247_bib56","first-page":"845","article-title":"Cellular and pathological functions of tau","volume":"25","author":"Parra Bravo","year":"2024","journal-title":"Nat.\u00a0Rev.\u00a0Mol.\u00a0Cell Biol."},{"issue":"10","key":"10.1016\/j.mocell.2025.100247_bib57","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1021\/bi047545g","article-title":"Role of structural plasticity in signal transduction by the cryptochrome blue-light photoreceptor","volume":"44","author":"Partch","year":"2005","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41531-023-00618-6","article-title":"Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson\u2019s disease","volume":"10","author":"Prymaczok","year":"2024","journal-title":"npj Parkinsons Dis."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nn.3584","article-title":"State of play in amyotrophic lateral sclerosis genetics","volume":"17","author":"Renton","year":"2014","journal-title":"Nat.\u00a0Neurosci."},{"issue":"6025","key":"10.1016\/j.mocell.2025.100247_bib60","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.1200660","article-title":"Perception of UV-B by the Arabidopsis UVR8 protein","volume":"332","author":"Rizzini","year":"2011","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib61","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1474-4422(14)70233-9","article-title":"C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.mocell.2025.100247_bib63","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nchem.2889","article-title":"Structure-based inhibitors of tau aggregation","volume":"10","author":"Seidler","year":"2018","journal-title":"Nat.\u00a0Chem."},{"issue":"6","key":"10.1016\/j.mocell.2025.100247_bib64","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"10","key":"10.1016\/j.mocell.2025.100247_bib65","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/nbt734","article-title":"A light-switchable gene promoter system","volume":"20","author":"Shimizu-Sato","year":"2002","journal-title":"Nat.\u00a0Biotechnol."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib66","doi-asserted-by":"crossref","first-page":"6","DOI":"10.14348\/molcells.2021.0204","article-title":"Rich phase separation behavior of biomolecules","volume":"45","author":"Shin","year":"2022","journal-title":"Mol.\u00a0Cells"},{"issue":"1-2","key":"10.1016\/j.mocell.2025.100247_bib67","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cell.2016.11.054","article-title":"Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets","volume":"168","author":"Shin","year":"2017","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.mocell.2025.100247_bib68","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.str.2024.06.018","article-title":"Intracellular tau fragment droplets serve as seeds for tau fibrils","volume":"32","author":"Soeda","year":"2024","journal-title":"Structure"},{"issue":"6645","key":"10.1016\/j.mocell.2025.100247_bib69","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.mocell.2025.100247_bib70","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/biom11071014","article-title":"Prion-like proteins in phase separation and their link to disease","volume":"11","author":"Sprunger","year":"2021","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.mocell.2025.100247_bib71","first-page":"379","article-title":"TULIPs: tunable, light-controlled interacting protein tags for cell biology","volume":"9","author":"Strickland","year":"2012","journal-title":"Nat.\u00a0Methods"},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib72","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13024-020-00397-1","article-title":"The role of TDP-43 mislocalization in amyotrophic lateral sclerosis","volume":"15","author":"Suk","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mocell.2025.100247_bib73","first-page":"4925","article-title":"An optimized optogenetic clustering tool for probing protein interaction and function","volume":"5","author":"Taslimi","year":"2014","journal-title":"Nat.\u00a0Commun."},{"issue":"6","key":"10.1016\/j.mocell.2025.100247_bib74","first-page":"425","article-title":"Optimized second-generation CRY2\u2013CIB dimerizers and photoactivatable Cre recombinase","volume":"12","author":"Taslimi","year":"2016","journal-title":"Nat.\u00a0Chem.\u00a0Biol."},{"key":"10.1016\/j.mocell.2025.100247_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/srep15348","article-title":"Light-induced cell damage in live-cell super-resolution microscopy","volume":"5","author":"W\u00e4ldchen","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib76","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat.\u00a0Rev.\u00a0Neurosci."},{"issue":"6310","key":"10.1016\/j.mocell.2025.100247_bib77","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1126\/science.aaf9030","article-title":"Photoactivation and inactivation of Arabidopsis cryptochrome 2","volume":"354","author":"Wang","year":"2016","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.mocell.2025.100247_bib78","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.mocell.2025.100247_bib79","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuron.2021.11.003","article-title":"Opto-vTrap, an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission, and behavior","volume":"110","author":"Won","year":"2022","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mocell.2025.100247_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm.4269","article-title":"\u03b1-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies","volume":"23","author":"Wong","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.mocell.2025.100247_bib81","article-title":"\u201cPrion-like\u201d seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders","volume":"18","author":"Zampar","year":"2024","journal-title":"Front.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.mocell.2025.100247_bib82","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s40478-024-01914-9","article-title":"Decoding TDP-43: the molecular chameleon of neurodegenerative diseases","volume":"12","author":"Zeng","year":"2024","journal-title":"Acta Neuropathol.\u00a0Commun."},{"key":"10.1016\/j.mocell.2025.100247_bib83","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39578","article-title":"Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology","volume":"8","author":"Zhang","year":"2019","journal-title":"Elife"},{"issue":"11","key":"10.1016\/j.mocell.2025.100247_bib84","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006054","article-title":"The proline-rich domain promotes Tau liquid-liquid phase separation in cells","volume":"219","author":"Zhang","year":"2020","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.mocell.2025.100247_bib85","first-page":"818","article-title":"RNA-binding proteins in amyotrophic lateral sclerosis","volume":"41","author":"Zhao","year":"2018","journal-title":"Mol.\u00a0Cells"},{"issue":"4","key":"10.1016\/j.mocell.2025.100247_bib86","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cbpa.2013.05.031","article-title":"Photoswitchable fluorescent proteins: ten years of colorful chemistry and exciting applications","volume":"17","author":"Zhou","year":"2013","journal-title":"Curr.\u00a0Opin. Chem. Biol."},{"issue":"27","key":"10.1016\/j.mocell.2025.100247_bib87","doi-asserted-by":"crossref","first-page":"7012","DOI":"10.1021\/bi8007017","article-title":"Light activation of the LOV protein vivid generates a rapidly exchanging dimer","volume":"47","author":"Zoltowski","year":"2008","journal-title":"Biochemistry"},{"issue":"5827","key":"10.1016\/j.mocell.2025.100247_bib88","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1126\/science.1137128","article-title":"Conformational switching in the fungal light sensor vivid","volume":"316","author":"Zoltowski","year":"2007","journal-title":"Science"}],"container-title":["Molecules and Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847825000718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847825000718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:20:54Z","timestamp":1762352454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1016847825000718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":88,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1016847825000718"],"URL":"https:\/\/doi.org\/10.1016\/j.mocell.2025.100247","relation":{},"ISSN":["1016-8478"],"issn-type":[{"value":"1016-8478","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optogenetics to biomolecular phase separation in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Molecules and Cells","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mocell.2025.100247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Korean Society for Molecular and Cellular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100247"}}