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Ther."},{"key":"10.1016\/j.mocell.2026.100343_bib87","first-page":"183","article-title":"Explainability, transparency and black box challenges of AI in radiology: impact on patient care in cardiovascular radiology","volume":"55","author":"Marey","year":"2024","journal-title":"Egypt.\u00a0J.\u00a0Radiol.\u00a0Nucl.\u00a0Med."},{"key":"10.1016\/j.mocell.2026.100343_bib88","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.nbd.2011.12.040","article-title":"Animal models of the non-motor features of Parkinson's disease","volume":"46","author":"McDowell","year":"2012","journal-title":"Neurobiol Dis."},{"key":"10.1016\/j.mocell.2026.100343_bib89","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3233\/JPD-240272","article-title":"Parkinson's disease drug therapies in the clinical trial pipeline: 2024 update","volume":"14","author":"McFarthing","year":"2024","journal-title":"J. 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Med."},{"key":"10.1016\/j.mocell.2026.100343_bib97","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00002826-200305000-00010","article-title":"Optimizing levodopa pharmacokinetics: intestinal infusion versus oral sustained-release tablets","volume":"26","author":"Nyholm","year":"2003","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.mocell.2026.100343_bib98","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/mds.27115","article-title":"Past, present, and future of Parkinson's disease: a special essay on the 200th Anniversary of the Shaking Palsy","volume":"32","author":"Obeso","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.mocell.2026.100343_bib99","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1056\/NEJMct1208070","article-title":"Deep-brain stimulation for Parkinson's disease","volume":"367","author":"Okun","year":"2012","journal-title":"N.\u00a0Engl. J. 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Med."},{"key":"10.1016\/j.mocell.2026.100343_bib103","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mocell.2026.100343_bib104","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/jnnp.39.2.184","article-title":"Bromocriptine treatment in Parkinson's disease","volume":"39","author":"Parkes","year":"1976","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.mocell.2026.100343_bib105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1176\/jnp.14.2.223","article-title":"An essay on the shaking palsy. 1817","volume":"14","author":"Parkinson","year":"2002","journal-title":"J.\u00a0Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.mocell.2026.100343_bib106","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1056\/NEJM198911163212004","article-title":"Effect of deprenyl on the progression of disability in early Parkinson's disease","volume":"321","author":"ParkinsonStudyGroup","year":"1989","journal-title":"N. Engl. J.\u00a0Med."},{"key":"10.1016\/j.mocell.2026.100343_bib107","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.parkreldis.2020.08.010","article-title":"Multimodal dopamine transporter (DAT) imaging and magnetic resonance imaging (MRI) to characterise early Parkinson's disease","volume":"79","author":"Porter","year":"2020","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.mocell.2026.100343_bib108","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson's disease: a systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.mocell.2026.100343_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27278","article-title":"Human protein-protein interaction networks: a\u00a0topological comparison review","volume":"10","author":"Ramos","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.mocell.2026.100343_bib110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12967-023-03876-3","article-title":"DeepMPF: deep learning framework for predicting drug-target interactions based on multi-modal representation with meta-path semantic analysis","volume":"21","author":"Ren","year":"2023","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.mocell.2026.100343_bib111","doi-asserted-by":"crossref","first-page":"W449","DOI":"10.1093\/nar\/gkaa379","article-title":"NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data","volume":"48","author":"Reynisson","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mocell.2026.100343_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5607\/en.2011.20.1.1","article-title":"MAO-inhibitors in Parkinson's disease","volume":"20","author":"Riederer","year":"2011","journal-title":"Exp.\u00a0Neurobiol."},{"key":"10.1016\/j.mocell.2026.100343_bib113","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1212\/WNL.29.12.1584","article-title":"Levodopa with benserazide or carbidopa in Parkinson disease","volume":"29","author":"Rinne","year":"1979","journal-title":"Neurology"},{"key":"10.1016\/j.mocell.2026.100343_bib114","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nbd.2017.04.004","article-title":"Alpha-synuclein: pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease","volume":"109","author":"Rocha","year":"2018","journal-title":"Neurobiol. 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Neurol."},{"key":"10.1016\/j.mocell.2026.100343_bib118","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/mds.23732","article-title":"Etiology and pathogenesis of Parkinson's disease","volume":"26","author":"Schapira","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.mocell.2026.100343_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105580","article-title":"Multi-omic insights into Parkinson's disease: from genetic associations to functional mechanisms","volume":"163","author":"Schilder","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mocell.2026.100343_bib120","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. 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Image Anal."},{"key":"10.1016\/j.mocell.2026.100343_bib125","article-title":"A review on omics-based biomarkers discovery for Alzheimer's disease from the bioinformatics perspectives: statistical approach vs machine learning approach","volume":"139","author":"Tan","year":"2021","journal-title":"Comput.\u00a0Biol. 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