{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:05:07Z","timestamp":1776823507043,"version":"3.51.2"},"reference-count":49,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1811,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Development"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.mod.2008.04.006","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T07:22:31Z","timestamp":1209885751000},"page":"687-699","source":"Crossref","is-referenced-by-count":57,"title":["Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species"],"prefix":"10.1016","volume":"125","author":[{"given":"Tiffany A.","family":"Heanue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilis","family":"Pachnis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mod.2008.04.006_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF00213811","article-title":"Evidence for 5-HT-containing intrinsic neurons in the teleost intestine","volume":"230","author":"Anderson","year":"1983","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mod.2008.04.006_bib2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1053\/j.gastro.2006.01.002","article-title":"The cell adhesion molecule l1 is required for chain migration of neural crest cells in the developing mouse gut","volume":"130","author":"Anderson","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mod.2008.04.006_bib3","doi-asserted-by":"crossref","first-page":"17644","DOI":"10.1074\/jbc.271.30.17644","article-title":"A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins","volume":"271","author":"Asai","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2008.04.006_bib4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/hmg\/4.8.1381","article-title":"Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease","volume":"4","author":"Attie","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mod.2008.04.006_bib5","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/(SICI)1097-4695(19971120)33:6<749::AID-NEU4>3.0.CO;2-9","article-title":"Expression of c-ret in the zebrafish embryo: potential roles in motoneuronal development","volume":"33","author":"Bisgrove","year":"1997","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.mod.2008.04.006_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1073\/pnas.97.1.268","article-title":"A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus","volume":"97","author":"Bolk","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mod.2008.04.006_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1399-0004.2004.00319.x","article-title":"Studying the genetics of Hirschsprung\u2019s disease: unraveling an oligogenic disorder","volume":"67","author":"Brooks","year":"2005","journal-title":"Clin. Genet."},{"key":"10.1016\/j.mod.2008.04.006_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000059341","article-title":"Conservation of RET proto-oncogene splicing variants and implications for RET isoform function","volume":"95","author":"Carter","year":"2001","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.mod.2008.04.006_bib9","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1101\/gad.205001","article-title":"Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis","volume":"15","author":"de Graaff","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.mod.2008.04.006_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ydbio.2005.08.040","article-title":"The pattern of neural crest advance in the cecum and colon","volume":"287","author":"Druckenbrod","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2008.04.006_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1242\/dev.122.1.349","article-title":"Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts","volume":"122","author":"Durbec","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.mod.2008.04.006_bib12","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1242\/dev.128.21.4113","article-title":"Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates","volume":"128","author":"Dutton","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.mod.2008.04.006_bib13","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.mod.2004.12.008","article-title":"Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent","volume":"122","author":"Elworthy","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.mod.2008.04.006_bib14","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/genetics\/151.4.1531","article-title":"Preservation of duplicate genes by complementary, degenerative mutations","volume":"151","author":"Force","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.mod.2008.04.006_bib15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cytogfr.2005.02.002","article-title":"Fibroblast growth factor homologous factors: evolution, structure, and function","volume":"16","author":"Goldfarb","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.mod.2008.04.006_bib16","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1086\/342774","article-title":"A rare haplotype of the RET proto-oncogene is a risk-modifying allele in hirschsprung disease","volume":"71","author":"Griseri","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mod.2008.04.006_bib17","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1073\/pnas.0602152103","article-title":"Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes","volume":"103","author":"Heanue","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mod.2008.04.006_bib18","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrn2137","article-title":"Enteric nervous system development and Hirschsprung\u2019s disease advances in genetic and stem cell studies","volume":"8","author":"Heanue","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mod.2008.04.006_bib19","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/hmg\/5.10.1577","article-title":"Mechanism of ret dysfunction by Hirschsprung mutations affecting its extracellular domain","volume":"5","author":"Iwashita","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mod.2008.04.006_bib20","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature03025","article-title":"Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype","volume":"431","author":"Jaillon","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mod.2008.04.006_bib21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1101\/gad.1387206","article-title":"Critical and distinct roles for key RET tyrosine docking sites in renal development","volume":"20","author":"Jain","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.mod.2008.04.006_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mod.2008.04.006_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/dvdy.21033","article-title":"Genetic screen for mutations affecting development and function of the enteric nervous system","volume":"236","author":"Kuhlman","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mod.2008.04.006_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nn1827","article-title":"Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration","volume":"10","author":"Maness","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mod.2008.04.006_bib25","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.onc.1201048","article-title":"The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis","volume":"14","author":"Marcos-Gutierrez","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.mod.2008.04.006_bib26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10024-001-0142-y","article-title":"Enteric nervous system: development and developmental disturbances \u2013 part 1","volume":"5","author":"Newgreen","year":"2002","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.mod.2008.04.006_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10024-002-0002-4","article-title":"Enteric nervous system: development and developmental disturbances \u2013 part 2","volume":"5","author":"Newgreen","year":"2002","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.mod.2008.04.006_bib28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ydbio.2005.07.013","article-title":"Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis","volume":"286","author":"Ng","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2008.04.006_bib29","series-title":"Evolution by Gene Duplication","author":"Ohno","year":"1970"},{"key":"10.1016\/j.mod.2008.04.006_bib30","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1242\/dev.02215","article-title":"Lessen encodes a zebrafish trap 100 required for enteric nervous system development","volume":"133","author":"Pietsch","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.mod.2008.04.006_bib31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.tig.2006.09.005","article-title":"Current concepts in RET-related genetics, signaling and therapeutics","volume":"22","author":"Plaza-Menacho","year":"2006","journal-title":"Trends Genet."},{"key":"10.1016\/j.mod.2008.04.006_bib32","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mod.2008.04.006_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-70956-7_1","article-title":"The CRMP family of proteins and their role in Sema3A signaling","volume":"600","author":"Schmidt","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mod.2008.04.006_bib34","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/367380a0","article-title":"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret","volume":"367","author":"Schuchardt","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.mod.2008.04.006_bib35","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.modgep.2005.03.009","article-title":"Expression of collapsin response mediator proteins in the nervous system of embryonic zebrafish","volume":"5","author":"Schweitzer","year":"2005","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.mod.2008.04.006_bib36","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1006\/dbio.2000.0145","article-title":"Functional analysis of zebrafish GDNF","volume":"231","author":"Shepherd","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2008.04.006_bib37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1242\/dev.00912","article-title":"Roles for GFRalpha1 receptors in zebrafish enteric nervous system development","volume":"131","author":"Shepherd","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.mod.2008.04.006_bib38","first-page":"97","article-title":"Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line","volume":"5","author":"Tahira","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/j.mod.2008.04.006_bib39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1359-6101(01)00012-0","article-title":"The GDNF\/RET signaling pathway and human diseases","volume":"12","author":"Takahashi","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.mod.2008.04.006_bib40","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1242\/dev.126.12.2785","article-title":"Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system","volume":"126","author":"Taraviras","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.mod.2008.04.006_bib41","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1242\/dev.119.4.1203","article-title":"Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos","volume":"119","author":"Thisse","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.mod.2008.04.006_bib42","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/jnr.490420413","article-title":"Zebrafish neurons express two L1-related molecules during early axonogenesis","volume":"42","author":"Tongiorgi","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mod.2008.04.006_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mod.2004.10.009","article-title":"Intestinal growth and differentiation in zebrafish","volume":"122","author":"Wallace","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.mod.2008.04.006_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0012-1606(02)00034-9","article-title":"Unique and conserved aspects of gut development in zebrafish","volume":"255","author":"Wallace","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2008.04.006_bib45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00233560","article-title":"Fluorescent histochemistry of the teleost gut: evidence for the presence of serotonergic neurones","volume":"197","author":"Watson","year":"1979","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mod.2008.04.006_bib46","series-title":"The Zebrafish Book","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.mod.2008.04.006_bib47","doi-asserted-by":"crossref","first-page":"9661","DOI":"10.1128\/MCB.25.21.9661-9673.2005","article-title":"Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform","volume":"25","author":"Wong","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mod.2008.04.006_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ydbio.2004.03.015","article-title":"Dynamics of neural crest-derived cell migration in the embryonic mouse gut","volume":"270","author":"Young","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2008.04.006_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10448","article-title":"Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine","volume":"456","author":"Young","year":"2003","journal-title":"J. Comp. Neurol."}],"container-title":["Mechanisms of Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477308000610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477308000610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T17:54:03Z","timestamp":1631210043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925477308000610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0925477308000610"],"URL":"https:\/\/doi.org\/10.1016\/j.mod.2008.04.006","relation":{},"ISSN":["0925-4773"],"issn-type":[{"value":"0925-4773","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}