{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:53:42Z","timestamp":1789350822687,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1293,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"crossref","award":["SC-094-PP-03"],"award-info":[{"award-number":["SC-094-PP-03"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Development"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.mod.2009.10.004","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T05:07:30Z","timestamp":1256274450000},"page":"82-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Matriptase\/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation"],"prefix":"10.1016","volume":"127","author":[{"given":"Sheau-Ling","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Roller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Gyung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongeun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mod.2009.10.004_bib1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1742-4658.2005.05094.x","article-title":"Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1\/angiomodulin\/mac25)","volume":"273","author":"Ahmed","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.mod.2009.10.004_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO;2-Z","article-title":"The urokinase-type plasminogen activator system in cancer metastasis: a review","volume":"72","author":"Andreasen","year":"1997","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mod.2009.10.004_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1023\/A:1020985632550","article-title":"Deregulated activation of matriptase in breast cancer cells","volume":"19","author":"Benaud","year":"2002","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.mod.2009.10.004_bib4","doi-asserted-by":"crossref","first-page":"10539","DOI":"10.1074\/jbc.M109064200","article-title":"Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase","volume":"277","author":"Benaud","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib5","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.1038\/sj.onc.1208582","article-title":"Adhesion signaling by a novel mitotic substrate of src kinases","volume":"24","author":"Bhatt","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.mod.2009.10.004_bib6","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1073\/pnas.0606514104","article-title":"Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway","volume":"104","author":"Bhatt","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mod.2009.10.004_bib7","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1083\/jcb.131.6.1573","article-title":"Hepatocyte growth factor\/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells","volume":"131","author":"Birnkmann","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2009.10.004_bib8","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/376768a0","article-title":"Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud","volume":"376","author":"Bladt","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.mod.2009.10.004_bib9","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1016\/S0021-9258(18)83255-0","article-title":"Plamnimogen activators in the mouse mammary gland. Decreased expression during lactation","volume":"264","author":"Busso","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib10","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/jnr.10799","article-title":"Hepatocyte growth factor stimulates cell motility in cultures of the striatal progenitor cells ST14A","volume":"74","author":"Cacci","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mod.2009.10.004_bib11","doi-asserted-by":"crossref","first-page":"44581","DOI":"10.1074\/jbc.M107059200","article-title":"N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease","volume":"276","author":"Cho","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib12","series-title":"Advances in Cancer Research","first-page":"139","article-title":"Plasminogen activators, tissue degradation, and cancer","author":"Dano","year":"1985"},{"key":"10.1016\/j.mod.2009.10.004_bib13","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2741\/2698","article-title":"MT-SP1 proteolysis and regulation of cell\u2013microenvironment interactions","volume":"1","author":"Darragh","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.mod.2009.10.004_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1574-6968.1998.tb12905.x","article-title":"Cloning of the 52-kDa chitinase gene from Serratia marcescens KCTC2172 and its proteolytic cleavage into an active 35-kDa enzyme","volume":"160","author":"Gal","year":"1998","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.mod.2009.10.004_bib15","first-page":"227","article-title":"Hepatocyte growth factor\u2013scatter factor: mitogen, motogen and Met","volume":"3","author":"Gherardi","year":"1991","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mod.2009.10.004_bib16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrm1714","article-title":"Information networks in the mammary gland","volume":"6","author":"Hennighausen","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mod.2009.10.004_bib100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/BF00204976","article-title":"Hepatocyte growth factor\/scatter factor-Met signaling in tumorigenicity and invasion\/metastasis","volume":"74","author":"Jeffers","year":"1996","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.mod.2009.10.004_bib17","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1349-7006.2006.00328.x","article-title":"Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis","volume":"97","author":"Jin","year":"2006","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mod.2009.10.004_bib18","first-page":"1101","article-title":"Tissue microarray analysis of hepatocyte growth factor\/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer","volume":"63","author":"Kang","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.mod.2009.10.004_bib19","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1182\/blood-2006-02-001073","article-title":"Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase","volume":"108","author":"Kilpatrick","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.mod.2009.10.004_bib20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s002510050515","article-title":"Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains","volume":"49","author":"Kim","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/j.mod.2009.10.004_bib21","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.febslet.2005.01.085","article-title":"Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2","volume":"579","author":"Kirchhofer","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mod.2009.10.004_bib22","doi-asserted-by":"crossref","first-page":"C40","DOI":"10.1152\/ajpcell.00351.2005","article-title":"Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells","volume":"291","author":"Kiyomiya","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mod.2009.10.004_bib23","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1210\/endo.141.10.7697","article-title":"Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells","volume":"141","author":"Lee","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.mod.2009.10.004_bib24","doi-asserted-by":"crossref","first-page":"36720","DOI":"10.1074\/jbc.M007802200","article-title":"Activation of hepatocyte growth factor and urokinase\/plasminogen activator by matriptase, an epithelial membrane serine protease","volume":"275","author":"Lee","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib101","doi-asserted-by":"crossref","first-page":"C95","DOI":"10.1152\/ajpcell.00611.2006","article-title":"Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain","volume":"293","author":"Lee","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mod.2009.10.004_bib25","doi-asserted-by":"crossref","first-page":"18237","DOI":"10.1074\/jbc.274.26.18237","article-title":"Purification and characterization of a complex containing matriptase and Kunitz-type serine protease inhibitor from human milk","volume":"274","author":"Lin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib26","doi-asserted-by":"crossref","first-page":"36714","DOI":"10.1074\/jbc.M705521200","article-title":"Autosomal Ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice","volume":"282","author":"List","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib27","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2353\/ajpath.2006.051071","article-title":"Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis","volume":"168","author":"List","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mod.2009.10.004_bib28","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/S0960-894X(01)00493-0","article-title":"Synthesis and evaluation of sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matripase","volume":"11","author":"Long","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.mod.2009.10.004_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1006\/jmbi.1999.2891","article-title":"High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds","volume":"290","author":"Luckett","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mod.2009.10.004_bib30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1152\/physrev.1993.73.1.161","article-title":"Biology and biochemistry of proteinases in tumor invasion","volume":"73","author":"Mignatti","year":"1993","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mod.2009.10.004_bib31","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0092-8674(91)90115-F","article-title":"Induction of epithelial tubular morphogenesis in vitro by fibroblast derived soluble factors","volume":"66","author":"Montesano","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.mod.2009.10.004_bib32","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1002\/j.1460-2075.1992.tb05588.x","article-title":"Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor\/scatter factor","volume":"11","author":"Naldini","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.mod.2009.10.004_bib33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1074\/jbc.270.2.603","article-title":"Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction","volume":"270","author":"Naldini","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib34","doi-asserted-by":"crossref","first-page":"32941","DOI":"10.1074\/jbc.C600208200","article-title":"Evidence for a matriptase\u2013prostasin proteolytic cascade regulating terminal epidermal differentiation","volume":"281","author":"Netzel-Arnett","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib35","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1083\/jcb.143.2.533","article-title":"Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis","volume":"143","author":"Niemann","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2009.10.004_bib36","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1242\/dev.121.9.2897","article-title":"HGF\/SF: a potent cytokine for mammary growth, morphogenesis and development","volume":"121","author":"Niranjan","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.mod.2009.10.004_bib37","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9440(10)64081-3","article-title":"Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo","volume":"158","author":"Oberst","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mod.2009.10.004_bib38","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1177\/002215540305100805","article-title":"Characterization of matriptase expression in normal human tissues","volume":"51","author":"Oberst","year":"2003","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.mod.2009.10.004_bib39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bone.2005.12.006","article-title":"Involvement of hepatocyte growth factor in the development of bone metastasis of a mouse mammary cancer cell line, BALB\/c-MC","volume":"39","author":"Ono","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.mod.2009.10.004_bib40","first-page":"215","article-title":"HGF\/SF in angiogenesis","volume":"212","author":"Rosen","year":"1997","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.mod.2009.10.004_bib41","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/373699a0","article-title":"Scatter factor\/hepatocyte growth factor is essential for liver development","volume":"373","author":"Schmidt","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.mod.2009.10.004_bib42","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.ATV.0000258862.61067.14","article-title":"Membrane-type serine protease-1\/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis","volume":"27","author":"Seitz","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mod.2009.10.004_bib43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1432-1033.1995.tb20463.x","article-title":"Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XII and hepatocyte growth factor activator","volume":"229","author":"Shimomura","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mod.2009.10.004_bib44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/327239a0","article-title":"Scatter factor is a fibroblast-derived modulator of epithelial cell mobility","volume":"327","author":"Stoker","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.mod.2009.10.004_bib45","doi-asserted-by":"crossref","first-page":"26333","DOI":"10.1074\/jbc.M002941200","article-title":"Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates","volume":"275","author":"Takeuchi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2009.10.004_bib46","doi-asserted-by":"crossref","first-page":"11054","DOI":"10.1073\/pnas.96.20.11054","article-title":"Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue","volume":"96","author":"Takeuchi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mod.2009.10.004_bib47","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000050604","article-title":"Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention","volume":"22","author":"Tanimoto","year":"2001","journal-title":"Tumor Biol."},{"key":"10.1016\/j.mod.2009.10.004_bib48","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/373702a0","article-title":"Placental defect and embryonic lethality in mice lacking hepatocyte growth factor\/scatter factor","volume":"373","author":"Uehara","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.mod.2009.10.004_bib49","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1091\/mbc.6.10.1287","article-title":"Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development","volume":"6","author":"Witty","year":"1995","journal-title":"Mol. Biol. Cell"}],"container-title":["Mechanisms of Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477309014749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477309014749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:20:53Z","timestamp":1760419253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925477309014749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":51,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0925477309014749"],"URL":"https:\/\/doi.org\/10.1016\/j.mod.2009.10.004","relation":{},"ISSN":["0925-4773"],"issn-type":[{"value":"0925-4773","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matriptase\/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mod.2009.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}