{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:11:59Z","timestamp":1789549919289,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"1-4","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":539,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22791798"],"award-info":[{"award-number":["22791798"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["18300106"],"award-info":[{"award-number":["18300106"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["23592748"],"award-info":[{"award-number":["23592748"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Development"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.mod.2012.02.002","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T06:40:52Z","timestamp":1330152052000},"page":"38-50","source":"Crossref","is-referenced-by-count":46,"title":["Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development"],"prefix":"10.1016","volume":"129","author":[{"given":"Ryo","family":"Aizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahiro","family":"Iimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Kassai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Tsukasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gou","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiko","family":"Tachikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matsuo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsu","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Kamijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mod.2012.02.002_b0005","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1371\/journal.pgen.0020216","article-title":"Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis","volume":"2","author":"Bandyopadhyay","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mod.2012.02.002_b0010","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1242\/dev.036418","article-title":"A BMP-Shh negative-feedback loop restricts Shh expression during limb development","volume":"136","author":"Bastida","year":"2009","journal-title":"Development"},{"issue":"Pt 2","key":"10.1016\/j.mod.2012.02.002_b0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/0264-6021:3480241","article-title":"Rho GTPases and their effector proteins","volume":"348","author":"Bishop","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.mod.2012.02.002_b0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0092-8674(04)00003-0","article-title":"Rho and Rac take center stage","volume":"116","author":"Burridge","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mod.2012.02.002_b0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.cellbio.17.1.87","article-title":"Patterning mechanisms controlling vertebrate limb development","volume":"17","author":"Capdevila","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0030","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.mod.2012.02.002_b0035","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0960-9822(00)00571-6","article-title":"Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability","volume":"10","author":"Chen","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0040","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/(SICI)1097-010X(19981215)282:6<691::AID-JEZ5>3.0.CO;2-S","article-title":"Shaping limbs by apoptosis","volume":"282","author":"Chen","year":"1998","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.mod.2012.02.002_b0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/joca.1999.0306","article-title":"Cellular interactions and signaling in cartilage development","volume":"8","author":"DeLise","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.mod.2012.02.002_b0050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(95)90487-5","article-title":"Toward a molecular understanding of skeletal development","volume":"80","author":"Erlebacher","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mod.2012.02.002_b0055","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.mod.2012.02.002_b0060","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/dvdy.20916","article-title":"Birth and death of cells in limb development: a mapping study","volume":"235","author":"Fernandez-Teran","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mod.2012.02.002_b0065","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1469-7580.2003.00136.x","article-title":"Regulation of myogenic differentiation in the developing limb bud","volume":"202","author":"Francis-West","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.mod.2012.02.002_b0070","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/MCB.26.2.592-604.2006","article-title":"Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes","volume":"26","author":"Furusawa","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0075","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mod.2012.02.002_b0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<138::AID-BIES5>3.0.CO;2-4","article-title":"All for one and one for all: condensations and the initiation of skeletal development","volume":"22","author":"Hall","year":"2000","journal-title":"BioEssays"},{"key":"10.1016\/j.mod.2012.02.002_b0085","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1242\/dev.045203","article-title":"SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification","volume":"137","author":"Hattori","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.mod.2012.02.002_b0090","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrm2476","article-title":"Mammalian Rho GTPases: new insights into their functions from in vivo studies","volume":"9","author":"Heasman","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0095","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1440-169X.2010.01246.x","article-title":"Interdigital cell death function and regulation: new insights on an old programmed cell death model","volume":"53","author":"Hernandez-Martinez","year":"2011","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.mod.2012.02.002_b0100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0925-4773(97)00065-8","article-title":"Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene","volume":"65","author":"Houzelstein","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.mod.2012.02.002_b0105","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1172\/JCI39650","article-title":"Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL\/M-CSF signaling and osteoclast polarization","volume":"120","author":"Ito","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mod.2012.02.002_b0110","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01654","article-title":"The complexities of skeletal biology","volume":"423","author":"Karsenty","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mod.2012.02.002_b0115","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mod.2012.02.002_b0120","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.cub.2006.05.057","article-title":"CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility","volume":"16","author":"LaLonde","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gene.10092","article-title":"Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer","volume":"33","author":"Logan","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.mod.2012.02.002_b0130","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ydbio.2009.01.004","article-title":"In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth","volume":"327","author":"Maatouk","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0135","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1242\/dev.124.6.1109","article-title":"Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development","volume":"124","author":"Macias","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.mod.2012.02.002_b0140","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1074\/jbc.R110.200329","article-title":"Signaling role of Cdc42 in regulating mammalian physiology","volume":"286","author":"Melendez","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2012.02.002_b0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/dbio.1998.9129","article-title":"Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud","volume":"206","author":"Merino","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0150","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrg1001","article-title":"Pattern formation: old models out on a limb","volume":"4","author":"Niswander","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mod.2012.02.002_b0155","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1469-7580.2003.00145.x","article-title":"Tendon morphogenesis in the developing avian limb: plasticity of fetal tendon fibroblasts","volume":"202","author":"Oldfield","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.mod.2012.02.002_b0160","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ydbio.2006.03.013","article-title":"BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning","volume":"295","author":"Ovchinnikov","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0165","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1242\/dev.128.22.4463","article-title":"BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb","volume":"128","author":"Pizette","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.mod.2012.02.002_b0170","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1440-169X.2007.00946.x","article-title":"Bone morphogenetic protein signaling in limb outgrowth and patterning","volume":"49","author":"Robert","year":"2007","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.mod.2012.02.002_b0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/75973","article-title":"High-efficiency deleter mice show that FLPe is an alternative to Cre\u2013loxP","volume":"25","author":"Rodriguez","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mod.2012.02.002_b0180","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1242\/dev.01613","article-title":"Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb","volume":"132","author":"Sagai","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.mod.2012.02.002_b0185","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ajhg.2011.07.009","article-title":"Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams\u2013Oliver syndrome","volume":"89","author":"Shaheen","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mod.2012.02.002_b0190","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/bdrc.20057","article-title":"Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate","volume":"75","author":"Shapiro","year":"2005","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.mod.2012.02.002_b0195","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mod.2012.02.002_b0200","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ajhg.2011.04.013","article-title":"Gain-of-function mutations of ARHGAP31, a Cdc42\/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies","volume":"88","author":"Southgate","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mod.2012.02.002_b0205","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1083\/jcb.200611031","article-title":"TGF-beta signaling is essential for joint morphogenesis","volume":"177","author":"Spagnoli","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0210","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2009.09.014","article-title":"Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development","volume":"335","author":"Suzuki","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0215","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ajmg.10774","article-title":"Molecular basis of vertebrate limb patterning","volume":"112","author":"Tickle","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.mod.2012.02.002_b0220","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1359\/JBMR.050113","article-title":"Rac1\/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis","volume":"20","author":"Wang","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mod.2012.02.002_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.21110","article-title":"Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions","volume":"213","author":"Woods","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mod.2012.02.002_b0230","doi-asserted-by":"crossref","first-page":"23500","DOI":"10.1074\/jbc.M700680200","article-title":"Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis","volume":"282","author":"Woods","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2012.02.002_b0235","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.4049\/jimmunol.175.9.5708","article-title":"Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13","volume":"175","author":"Yamada","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.mod.2012.02.002_b0240","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.99.1.115","article-title":"Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeleton","volume":"99","author":"Zanetti","year":"1984","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2012.02.002_b0245","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1002\/jbmr.502","article-title":"The critical role of the epidermal growth factor receptor in endochondral ossification","volume":"26","author":"Zhang","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mod.2012.02.002_b0250","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1101\/gad.11.17.2191","article-title":"Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage","volume":"11","author":"Zou","year":"1997","journal-title":"Genes Dev."}],"container-title":["Mechanisms of Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477312000093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477312000093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T18:37:14Z","timestamp":1640889434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925477312000093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":50,"journal-issue":{"issue":"1-4","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0925477312000093"],"URL":"https:\/\/doi.org\/10.1016\/j.mod.2012.02.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.716447808.791852808","asserted-by":"object"}]},"ISSN":["0925-4773"],"issn-type":[{"value":"0925-4773","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}