{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:10:33Z","timestamp":1785521433113,"version":"3.56.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"4-5","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL018645"],"award-info":[{"award-number":["HL018645"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nathan Shock Center of Excellence in the Basic Biology of Aging","award":["AG013280"],"award-info":[{"award-number":["AG013280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Development"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.mod.2013.01.001","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T03:57:03Z","timestamp":1358999823000},"page":"272-289","source":"Crossref","is-referenced-by-count":35,"title":["Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults"],"prefix":"10.1016","volume":"130","author":[{"given":"Carole L.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Gough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy A.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina K.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Wight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine W.","family":"Raines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mod.2013.01.001_b0005","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/pr1009806","article-title":"Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves","volume":"10","author":"Angel","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mod.2013.01.001_b0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ydbio.2009.04.032","article-title":"BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis","volume":"331","author":"Beppu","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0015","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/385729a0","article-title":"A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells","volume":"385","author":"Black","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mod.2013.01.001_b0020","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1128\/MCB.00406-09","article-title":"Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling","volume":"29","author":"Bozkulak","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0025","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1098\/rstb.2007.2130","article-title":"Valvulogenesis: the moving target","volume":"362","author":"Butcher","year":"2007","journal-title":"Philos. Trans. R. Soc. London B. Biol. Sci."},{"key":"10.1016\/j.mod.2013.01.001_b0030","doi-asserted-by":"crossref","first-page":"e13433","DOI":"10.1371\/journal.pone.0013433","article-title":"The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation","volume":"5","author":"Canault","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mod.2013.01.001_b0035","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1084\/jem.20092366","article-title":"Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice","volume":"207","author":"Chalaris","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mod.2013.01.001_b0040","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/73528","article-title":"Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis","volume":"24","author":"Chen","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mod.2013.01.001_b0045","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/CIRCRESAHA.109.201566","article-title":"Heart valve development: regulatory networks in development and disease","volume":"105","author":"Combs","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0050","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCRESAHA.109.196469","article-title":"VEGF and RANKL regulation of NFATc1 in heart valve development","volume":"105","author":"Combs","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/32419","article-title":"Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum","volume":"392","author":"de la Pompa","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mod.2013.01.001_b0060","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.RES.0000141429.13560.cb","article-title":"Lineage and morphogenetic analysis of the cardiac valves","volume":"95","author":"de Lange","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.90284.2008","article-title":"Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles","volume":"35","author":"de Lange","year":"2008","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.mod.2013.01.001_b0070","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bdra.20809","article-title":"What chick and mouse models have taught us about the role of the endocardium in congenital heart disease","volume":"91","author":"DeLaughter","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.mod.2013.01.001_b0075","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ydbio.2011.06.041","article-title":"Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease","volume":"357","author":"Dupuis","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0080","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nn.2794","article-title":"SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis","volume":"14","author":"Esteve","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mod.2013.01.001_b0085","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/72835","article-title":"A role for smad6 in development and homeostasis of the cardiovascular system","volume":"24","author":"Galvin","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mod.2013.01.001_b0090","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1084\/jem.20091990","article-title":"ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo","volume":"207","author":"Gibb","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mod.2013.01.001_b0095","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.1003318","article-title":"ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2\/site 3 cleavage products of Notch","volume":"186","author":"Gibb","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.mod.2013.01.001_b0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbrc.2009.01.013","article-title":"ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis","volume":"380","author":"Gooz","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mod.2013.01.001_b0105","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1097-2765(03)00386-1","article-title":"Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta\/ALK5 signaling","volume":"12","author":"Goumans","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mod.2013.01.001_b0110","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/emboj\/21.7.1743","article-title":"Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors","volume":"21","author":"Goumans","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.mod.2013.01.001_b0115","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.4049\/jimmunol.0901188","article-title":"Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages","volume":"184","author":"Hakozaki","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.mod.2013.01.001_b0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1534\/genetics.109.113167","article-title":"The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17","volume":"185","author":"Hassemer","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.mod.2013.01.001_b0125","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ar.a.20332","article-title":"Hyaluronan and its receptor CD44 in the heart of newborn and adult rats","volume":"288","author":"Hellstrom","year":"2006","journal-title":"Anat. Rec. A Discov. Mol. Cell. Evol. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0130","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.RES.83.5.523","article-title":"Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart","volume":"83","author":"Henderson","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrg2279","article-title":"The multifaceted role of Notch in cardiac development and disease","volume":"9","author":"High","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mod.2013.01.001_b0140","doi-asserted-by":"crossref","first-page":"H2480","DOI":"10.1152\/ajpheart.91431.2007","article-title":"Mouse heart valve structure and function: echocardiographic and morphometric analyses from the fetus through the aged adult","volume":"294","author":"Hinton","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mod.2013.01.001_b0145","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/01.RES.0000224114.65109.4e","article-title":"Extracellular matrix remodeling and organization in developing and diseased aortic valves","volume":"98","author":"Hinton","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0150","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-physiol-012110-142145","article-title":"Heart valve structure and function in development and disease","volume":"73","author":"Hinton","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mod.2013.01.001_b0155","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.4049\/jimmunol.179.5.2686","article-title":"Cutting edge: TNF-alpha-converting enzyme (TACE\/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock","volume":"179","author":"Horiuchi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.mod.2013.01.001_b0160","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ydbio.2005.05.004","article-title":"Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2","volume":"283","author":"Horiuchi","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1247\/csf.31.1","article-title":"ErbB and HB-EGF signaling in heart development and function","volume":"31","author":"Iwamoto","year":"2006","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.mod.2013.01.001_b0170","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1242\/dev.048926","article-title":"HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans","volume":"137","author":"Iwamoto","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.mod.2013.01.001_b0175","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1073\/pnas.0537588100","article-title":"Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function","volume":"100","author":"Iwamoto","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mod.2013.01.001_b0180","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1093\/emboj\/cdg264","article-title":"Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling","volume":"22","author":"Jackson","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.mod.2013.01.001_b0185","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1172\/JCI44244","article-title":"Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves","volume":"121","author":"Jain","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mod.2013.01.001_b0190","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/dvdy.20838","article-title":"Proteolytic cleavage of versican during cardiac cushion morphogenesis","volume":"235","author":"Kern","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mod.2013.01.001_b0195","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.matbio.2010.01.005","article-title":"Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies","volume":"29","author":"Kern","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0200","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/dbio.2000.0106","article-title":"Tie2-Cre transgenic mice. a new model for endothelial cell-lineage analysis in vivo","volume":"230","author":"Kisanuki","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0205","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ydbio.2006.10.037","article-title":"Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart","volume":"303","author":"Komatsu","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0210","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.193.6.741","article-title":"Conditional vascular cell adhesion molecule 1 deletion in mice. impaired lymphocyte migration to bone marrow","volume":"193","author":"Koni","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mod.2013.01.001_b0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/MCB.23.1.55-61.2003","article-title":"Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice. involvement of Meltrin alpha in adipogenesis and myogenesis","volume":"23","author":"Kurisaki","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ydbio.2003.10.021","article-title":"Essential roles of Meltrin beta (ADAM19) in heart development","volume":"267","author":"Kurohara","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0225","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.matbio.2009.07.007","article-title":"ADAM17 co-purifies with TIMP-3 and modulates endothelial invasion responses in three-dimensional collagen matrices","volume":"28","author":"Kwak","year":"2009","journal-title":"Matrix Biol. J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0230","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ydbio.2006.01.017","article-title":"NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K","volume":"292","author":"Lange","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0235","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1161\/01.CIR.0000034049.61181.F3","article-title":"Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice","volume":"106","author":"Liao","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.mod.2013.01.001_b0240","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1387\/ijdb.103210jl","article-title":"ADAM17 overexpression promotes angiogenesis by increasing blood vessel sprouting and pericyte number during brain microvessel development","volume":"55","author":"Lin","year":"2011","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0245","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molcel.2009.06.018","article-title":"TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling","volume":"35","author":"Liu","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mod.2013.01.001_b0250","doi-asserted-by":"crossref","first-page":"H2082","DOI":"10.1152\/ajpheart.00747.2009","article-title":"The bHLH transcription factor CHF1\/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload","volume":"298","author":"Liu","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mod.2013.01.001_b0255","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/bdra.20810","article-title":"Extracellular matrix and heart development. Birt","volume":"91","author":"Lockhart","year":"2011","journal-title":"Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.mod.2013.01.001_b0260","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1161\/CIRCRESAHA.112.279109","article-title":"Formation of the collateral circulation is regulated by vascular endothelial growth factor-a and a disintegrin and metalloprotease family members 10 and 17","volume":"111","author":"Lucitti","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0265","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ncomms1332","article-title":"TRAF6 ubiquitinates TGFbeta type I receptor to promote its cleavage and nuclear translocation in cancer","volume":"2","author":"Mu","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mod.2013.01.001_b0270","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.immuni.2012.01.005","article-title":"Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis","volume":"36","author":"Murthy","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.mod.2013.01.001_b0275","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2006.09.060","article-title":"Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation","volume":"350","author":"Nanba","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mod.2013.01.001_b0280","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1073\/pnas.97.6.2626","article-title":"Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis","volume":"97","author":"Oh","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mod.2013.01.001_b0285","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-5793(99)00929-1","article-title":"The sensitivity of versican from rabbit lung to gelatinase A (MMP-2) and B (MMP-9) and its involvement in the development of hydraulic lung edema","volume":"456","author":"Passi","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mod.2013.01.001_b0290","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0074-7696(05)43005-3","article-title":"Cell biology of cardiac cushion development","volume":"243","author":"Person","year":"2005","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.mod.2013.01.001_b0295","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.282.5392.1281","article-title":"An essential role for ectodomain shedding in mammalian development","volume":"282","author":"Peschon","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mod.2013.01.001_b0300","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/32426","article-title":"The transcription factor NF-ATc is essential for cardiac valve formation","volume":"392","author":"Ranger","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mod.2013.01.001_b0305","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.200307137","article-title":"Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands","volume":"164","author":"Sahin","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0310","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1074\/jbc.M009737200","article-title":"Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4","volume":"276","author":"Sandy","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2013.01.001_b0315","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1161\/CIRCULATIONAHA.108.805911","article-title":"Evolving concepts of cardiac valve dynamics: the continuum of development, functional structure, pathobiology, and tissue engineering","volume":"118","author":"Schoen","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.mod.2013.01.001_b0320","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/abbi.1996.9854","article-title":"Genistein selectively inhibits platelet-derived growth factor-stimulated versican biosynthesis in monkey arterial smooth muscle cells","volume":"339","author":"Schonherr","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mod.2013.01.001_b0325","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00109-003-0456-5","article-title":"Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling","volume":"81","author":"Schroeder","year":"2003","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.mod.2013.01.001_b0330","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/labinvest.3700376","article-title":"Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development","volume":"86","author":"Seki","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.mod.2013.01.001_b0335","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1083\/jcb.200411155","article-title":"Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis","volume":"169","author":"Shen","year":"2005","journal-title":"J. cell Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0340","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0012-1606(03)00315-4","article-title":"TACE is required for fetal murine cardiac development and modeling","volume":"261","author":"Shi","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0345","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/dvdy.21725","article-title":"Origin and fate of cardiac mesenchyme","volume":"237","author":"Snarr","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mod.2013.01.001_b0350","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ydbio.2008.07.038","article-title":"Signaling via the Tgf-beta type I receptor Alk5 in heart development","volume":"322","author":"Sridurongrit","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0355","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.carpath.2011.01.002","article-title":"Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix","volume":"21","author":"Stephens","year":"2012","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.mod.2013.01.001_b0360","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1128\/MCB.25.6.2191-2199.2005","article-title":"Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon","volume":"25","author":"Tadano","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0365","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1182\/blood-2010-11-321406","article-title":"Adam17-dependent shedding limits early neutrophil influx, but does not alter early monocyte recruitment to inflammatory sites","volume":"118","author":"Tang","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.mod.2013.01.001_b0370","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/dbio.1993.1032","article-title":"CD44 positive macrophages take up hyaluronan during lung development","volume":"155","author":"Underhill","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0375","doi-asserted-by":"crossref","first-page":"31018","DOI":"10.1074\/jbc.M109.006775","article-title":"Metalloprotease ADAM10 is required for Notch1 site 2 cleavage","volume":"284","author":"van Tetering","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mod.2013.01.001_b0380","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0385","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1242\/dev.055210","article-title":"The disintegrin\/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling","volume":"138","author":"Weber","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.mod.2013.01.001_b0390","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1128\/MCB.22.5.1537-1544.2002","article-title":"Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life","volume":"22","author":"Weskamp","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0395","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/CIRCRESAHA.109.207415","article-title":"Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes","volume":"106","author":"Weskamp","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0400","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0955-0674(02)00375-7","article-title":"Versican: a versatile extracellular matrix proteoglycan in cell biology","volume":"14","author":"Wight","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0405","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1083\/jcb.67.3.660","article-title":"Proteoglycans in primate arteries. I. Ultrastructural localization and distribution in the intima","volume":"67","author":"Wight","year":"1975","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0410","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1165\/rcmb.2003-0380OC","article-title":"Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblasts","volume":"31","author":"Wilkinson","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0415","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/CIRCRESAHA.111.245035","article-title":"Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation","volume":"109","author":"Wu","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0420","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI200317700","article-title":"Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy","volume":"112","author":"Yamamoto","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mod.2013.01.001_b0425","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.200307035","article-title":"Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities","volume":"163","author":"Yamazaki","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0430","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/dvdy.22549","article-title":"The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling","volume":"240","author":"Yu","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mod.2013.01.001_b0435","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1002\/dvdy.22391","article-title":"Adam10 is essential for early embryonic cardiovascular development","volume":"239","author":"Zhang","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mod.2013.01.001_b0440","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/CIRCRESAHA.110.225318","article-title":"The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation","volume":"107","author":"Zhang","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.mod.2013.01.001_b0445","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/dbio.2001.0176","article-title":"Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis","volume":"232","author":"Zhao","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2013.01.001_b0450","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1128\/MCB.24.1.96-104.2004","article-title":"Essential role for ADAM19 in cardiovascular morphogenesis","volume":"24","author":"Zhou","year":"2004","journal-title":"Mol. Cell. Biol."}],"container-title":["Mechanisms of Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477313000038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477313000038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T03:22:19Z","timestamp":1539919339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925477313000038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":90,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0925477313000038"],"URL":"https:\/\/doi.org\/10.1016\/j.mod.2013.01.001","relation":{},"ISSN":["0925-4773"],"issn-type":[{"value":"0925-4773","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}