{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:39:35Z","timestamp":1768070375160,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Grant-in-Aid for challenging Exploratory Research","award":["24659810"],"award-info":[{"award-number":["24659810"]}]},{"name":"Grant-in-Aid for challenging Exploratory Research","award":["26462777"],"award-info":[{"award-number":["26462777"]}]},{"name":"Grant for Promotion of Niigata University Research Projects","award":["23C049"],"award-info":[{"award-number":["23C049"]}]},{"name":"Grant for Promotion of Niigata University Research Projects","award":["24C037"],"award-info":[{"award-number":["24C037"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Development"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.mod.2016.01.002","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T21:02:06Z","timestamp":1453496526000},"page":"18-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["The glycogen metabolism via Akt signaling is important for the secretion of enamel matrix in tooth development"],"prefix":"10.1016","volume":"139","author":[{"given":"Hiroko","family":"Ida-Yonemochi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Otsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemitsu","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mod.2016.01.002_bb0005","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1093\/carcin\/13.12.2329","article-title":"Sequential changes in glycogen content, expression of glucose transporters and enzymic patterns during development of clear\/acidophilic cell tumors in rat kidney","volume":"13","author":"Ahn","year":"1992","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mod.2016.01.002_bb0010","doi-asserted-by":"crossref","first-page":"264","DOI":"10.5357\/koubyou.60.264","article-title":"Production of monoclonal antibody that recognizes glycogen and its application for immunohistochemistry","volume":"60","author":"Baba","year":"1993","journal-title":"Kokubyo Gakkai Zasshi"},{"key":"10.1016\/j.mod.2016.01.002_bb0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(05)80085-6","article-title":"Role of insulin-like growth factors in embryonic and postnatal growth","volume":"75","author":"Baker","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mod.2016.01.002_bb0020","first-page":"192","article-title":"Glycogen storage disease type Ib: a paediatric case report","volume":"7","author":"Bartoli","year":"2006","journal-title":"Eur. J. Paediatr. Dent."},{"key":"10.1016\/j.mod.2016.01.002_bb0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0074-7696(08)62719-9","article-title":"Histochemistry of ossification","volume":"11","author":"Cabrini","year":"1961","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.mod.2016.01.002_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.archoralbio.2004.11.012","article-title":"IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes","volume":"50","author":"Cat\u00f3n","year":"2005","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.mod.2016.01.002_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044258","article-title":"Ambient pH controls glycogen levels by regulating glycogen synthase gene expression in Neurospora crassa. New insights into the pH signaling pathway","volume":"7","author":"Cupertino","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mod.2016.01.002_bb0040","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.bbagen.2012.12.016","article-title":"The conserved role of the AKT\/GSK3 axis in cell survival and glycogen metabolism in Rhipicephalus (Boophilus) microplus embryo tick cell line BME26","volume":"1830","author":"de Abreu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mod.2016.01.002_bb0045","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ar.1092420304","article-title":"Relationships between endothelial cells, pericytes, and osteoblasts during bone formation in the sheep femur following implantation of tricalciumphosphate-ceramic","volume":"242","author":"Decker","year":"1995","journal-title":"Anat. Rec."},{"key":"10.1016\/j.mod.2016.01.002_bb0050","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.cmet.2012.10.017","article-title":"Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells","volume":"16","author":"Favaro","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.mod.2016.01.002_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1679\/aohc.67.1","article-title":"New perspectives on tooth development and the dental stem cell niche","volume":"67","author":"Harada","year":"2004","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.mod.2016.01.002_bb0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1083\/jcb.147.1.105","article-title":"Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling","volume":"147","author":"Harada","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mod.2016.01.002_bb0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbrc.2005.12.053","article-title":"Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling","volume":"340","author":"Harada","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mod.2016.01.002_bb0070","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ydbio.2011.12.020","article-title":"Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars","volume":"363","author":"Ida-Yonemochi","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2016.01.002_bb0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/08977199308991572","article-title":"Expression and regulation of insulin-like growth factor-I in the rat incisor","volume":"8","author":"Joseph","year":"1993","journal-title":"Growth Factors"},{"key":"10.1016\/j.mod.2016.01.002_bb0080","first-page":"267","article-title":"Insulin-like growth factor-I receptor in the cell biology of the ameloblast: an immunohistochemical study on the rat incisor","volume":"8","author":"Joseph","year":"1994","journal-title":"Epithelial Cell Biol."},{"key":"10.1016\/j.mod.2016.01.002_bb0085","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1152\/ajpcell.00218.2010","article-title":"Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation","volume":"299","author":"Josephsen","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mod.2016.01.002_bb0090","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/03008200290000637","article-title":"Establishment of dental epithelial cell line (HAT-7) and the cell differentiation dependent on Notch signaling pathway","volume":"43","author":"Kawano","year":"2002","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.mod.2016.01.002_bb0095","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1242\/jcs.01738","article-title":"A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation","volume":"118","author":"Matoba","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mod.2016.01.002_bb0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ydbio.2008.09.004","article-title":"Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation","volume":"324","author":"Matoba","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2016.01.002_bb0105","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1447-073X.2007.00182.x","article-title":"Temporary accumulation of glycogen in the epithelial cells of the developing mouse submandibular gland","volume":"82","author":"Matsuura","year":"2007","journal-title":"Anat. Sci. Int."},{"key":"10.1016\/j.mod.2016.01.002_bb0110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.archoralbio.2004.12.006","article-title":"In vitro differentiation of dental epithelial progenitor cells through epithelial-mesenchymal interactions","volume":"50","author":"Morotomi","year":"2005","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.mod.2016.01.002_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fnene.2012.00003","article-title":"Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular level","volume":"4","author":"Obel","year":"2012","journal-title":"Front. Neuroenerg."},{"key":"10.1016\/j.mod.2016.01.002_bb0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s004410051355","article-title":"Developmental regulation and ultrastructure of glycogen deposits during murine tooth morphogenesis","volume":"297","author":"Ohshima","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mod.2016.01.002_bb0125","series-title":"Tooth Enamel IV","first-page":"146","article-title":"The SER-Golgi system in the secretory ameloblasts: its three dimensional structure and function","author":"Ozawa","year":"1984"},{"key":"10.1016\/j.mod.2016.01.002_bb0130","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gad.1089403","article-title":"Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2","volume":"17","author":"Peng","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.mod.2016.01.002_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009644","article-title":"Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1","volume":"5","author":"Pescador","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mod.2016.01.002_bb0140","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/BJ20111416","article-title":"Glycogen and its metabolism: some new developments and old themes","volume":"441","author":"Roach","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.mod.2016.01.002_bb0145","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2106\/00004623-195840050-00010","article-title":"Histochemical studies on glycogen in normal ossification and calcification","volume":"40","author":"Schajowicz","year":"1958","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.mod.2016.01.002_bb0150","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0022-5320(71)90015-3","article-title":"Distribution of glycogen in osteoblasts of the fetal rat","volume":"36","author":"Scott","year":"1971","journal-title":"J. Ultrastruct. Res."},{"key":"10.1016\/j.mod.2016.01.002_bb0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.spen.2006.06.007","article-title":"Glycogen storage disease: clinical, biochemical, and molecular heterogeneity","volume":"13","author":"Shin","year":"2006","journal-title":"Semin. Pediatr. Neurol."},{"key":"10.1016\/j.mod.2016.01.002_bb0160","article-title":"Effect of vitronectin bound to insulin-like growth factor-I and insulin-like growth factor binding protein-3 on porcine enamel organ-derived epithelial cells","volume":"386282","author":"Shinohara","year":"2012","journal-title":"Int. J. Dent."},{"key":"10.1016\/j.mod.2016.01.002_bb0165","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0012-1606(76)90163-9","article-title":"Epithelial\u2013mesenchyme interactions during odontogenesis. IV. Morphological evidence for direct heterotypic cell\u2013cell contacts","volume":"50","author":"Slavkin","year":"1976","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mod.2016.01.002_bb0170","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/10454411980090020101","article-title":"Cellular and chemical events during enamel maturation","volume":"9","author":"Smith","year":"1998","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.mod.2016.01.002_bb0175","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3892\/ijmm.2015.2118","article-title":"Thymosin beta 4 is associated with RUNX2 expression through the Smad and Akt signaling pathways in mouse dental epithelial cells","volume":"35","author":"Someya","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mod.2016.01.002_bb0180","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/03008209809017047","article-title":"Induction of amelogenin and ameloblastin by insulin and insulin-like growth factors (IGF-I and IGF-II) during embryonic mouse tooth development in vitro","volume":"38","author":"Takahashi","year":"1998","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.mod.2016.01.002_bb0185","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.stem.2012.10.011","article-title":"Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells","volume":"12","author":"Takubo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mod.2016.01.002_bb0190","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1242\/jcs.00410","article-title":"Epithelial\u2013mesenchymal signalling regulating tooth morphogenesis","volume":"116","author":"Thesleff","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mod.2016.01.002_bb0195","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1152\/ajpregu.00681.2006","article-title":"Glycogen phosphorylase in glycogen-rich cells is involved in the energy supply for ion regulation in fish gill epithelia","volume":"293","author":"Tseng","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mod.2016.01.002_bb0200","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00315983","article-title":"Immunochemical and immunohistochem- ical studies, using antisera against porcine 25kDa amelogenin, 89kDa enamelin and the 13\u201317kDa nonamelogenins, on immature enamel of the pig and rat","volume":"96","author":"Uchida","year":"1991","journal-title":"Histochemistry"},{"key":"10.1016\/j.mod.2016.01.002_bb0205","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1679\/aohc.54.527","article-title":"Immunocyto- chemical and immunochemical detection of a 32kDa non- amelogenin and related proteins in porcine tooth germs","volume":"54","author":"Uchida","year":"1991","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.mod.2016.01.002_bb0210","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.neuroscience.2008.09.058","article-title":"Robust glycogen shunt activity in astrocytes: effects of glutamatergic and adrenergic agents","volume":"158","author":"Walls","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.mod.2016.01.002_bb0215","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","article-title":"Glucose uptake and runx2 synergize to orchestrate osteoblast differentiation and bone formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mod.2016.01.002_bb0220","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s00436-002-0733-1","article-title":"Ultrastructure of smooth muscle, gap junctions and glycogen distribution in Taenia solium tapeworms from experimentally infected hamsters","volume":"89","author":"Willms","year":"2003","journal-title":"Parasitol. Res."}],"container-title":["Mechanisms of Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477316300028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477316300028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T08:34:46Z","timestamp":1600072486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925477316300028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":44,"alternative-id":["S0925477316300028"],"URL":"https:\/\/doi.org\/10.1016\/j.mod.2016.01.002","relation":{},"ISSN":["0925-4773"],"issn-type":[{"value":"0925-4773","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The glycogen metabolism via Akt signaling is important for the secretion of enamel matrix in tooth development","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mod.2016.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}