{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:09:14Z","timestamp":1785438554176,"version":"3.56.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Development"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.mod.2019.103556","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T21:18:34Z","timestamp":1558387114000},"page":"103556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Single origin of the epithelium of the human middle ear"],"prefix":"10.1016","volume":"158","author":[{"given":"Huibert F.","family":"van Waegeningh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenna A.","family":"Ebbens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"van Spronsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-8307","authenticated-orcid":false,"given":"Roelof-Jan","family":"Oostra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mod.2019.103556_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139939","article-title":"A unique expression of keratin 14 in a subset of trophoblast cells","volume":"10","author":"Abou-Kheir","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mod.2019.103556_bb0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/00016488209130880","article-title":"Middle ear mucosa in newborn infants. A topographical and microanatomical study","volume":"93","author":"Akaan-Penttila","year":"1982","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.mod.2019.103556_bb0015","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/000348947308200225","article-title":"Distribution and density of goblet cells in the normal adult human middle ear","volume":"82","author":"Bak-Pedersen","year":"1973","journal-title":"The Annals of Otology, Rhinology, and Laryngology"},{"key":"10.1016\/j.mod.2019.103556_bb0020","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1017\/S0022215100075502","article-title":"Ultrastructure of normal and pathological middle ear mucosa","volume":"86","author":"Bremond","year":"1972","journal-title":"J. Laryngol. Otol."},{"issue":"7998","key":"10.1016\/j.mod.2019.103556_bb0025","article-title":"A role for E-cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells","volume":"6","author":"Campbell","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mod.2019.103556_bb0030","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1288\/00005537-195610000-00004","article-title":"The significance and fate of the mesenchyme of the middle ear","volume":"66","author":"Clements","year":"1956","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mod.2019.103556_bb0035","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF02885012","article-title":"I. Abtheilung: Allgeraeine Morphologie der Schlundspalten beim Menschen. Entwicklnng des Mittelohrraumes und des \u00e4usseren Geh\u00f6rganges","volume":"59","author":"Hammar","year":"1902","journal-title":"Arch. Mikrosk. Anat."},{"key":"10.1016\/j.mod.2019.103556_bb0040","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1177\/000348947007900620","article-title":"Ultrastructure of the normal mucosa in the human middle ear, mastoid cavities, and eustachian tube","volume":"79","author":"Hentzer","year":"1970","journal-title":"The Annals of otology, rhinology, and laryngology"},{"key":"10.1016\/j.mod.2019.103556_bb0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/00016488409122876","article-title":"Ultrastructure of the middle ear mucosa","volume":"414","author":"Hentzer","year":"1984","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.mod.2019.103556_bb0050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S0022215100093920","article-title":"The fine surface view of the human adult eustachian tube","volume":"97","author":"Hiraide","year":"1983","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.mod.2019.103556_bb0055","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.yexcr.2007.03.040","article-title":"Novel functions of vimentin in cell adhesion, migration, and signaling","volume":"313","author":"Ivaska","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"Suppl. 4","key":"10.1016\/j.mod.2019.103556_bb0060","first-page":"S1","article-title":"A new theory on the pathogenesis of acquired cholesteatoma: mucosal traction","volume":"125","author":"Jackler","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mod.2019.103556_bb0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1001\/archotol.1973.00780020006002","article-title":"Distribution of mucus-secreting cells in normal middle ear mucosa","volume":"98","author":"Lim","year":"1973","journal-title":"Archives of otolaryngology (Chicago, Ill. : 1960)"},{"key":"10.1016\/j.mod.2019.103556_bb0070","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.mao.0000247822.06022.07","article-title":"Aeration of Prussak's space is independent of the supradiaphragmatic epitympanic compartments","volume":"28","author":"Palva","year":"2007","journal-title":"Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology"},{"key":"10.1016\/j.mod.2019.103556_bb0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archotol.1966.00760030139005","article-title":"Middle ear mucosa","volume":"84","author":"Sade","year":"1966","journal-title":"Archives of otolaryngology (Chicago, Ill. : 1960)"},{"key":"10.1016\/j.mod.2019.103556_bb0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S0022215100054906","article-title":"The pneumatization of the temporal bone: a new concept","volume":"73","author":"Schwarzbart","year":"1959","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.mod.2019.103556_bb0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/000348947208100205","article-title":"Distribution of ciliated cells in the human middle ear. Electron and light microscopic observations","volume":"81","author":"Shimada","year":"1972","journal-title":"The Annals of otology, rhinology, and laryngology"},{"key":"10.1016\/j.mod.2019.103556_bb0090","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1126\/science.1232862","article-title":"Dual origin of the epithelium of the mammalian middle ear","volume":"339","author":"Thompson","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.mod.2019.103556_bb0095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000063124","article-title":"Fetal development of the human tympanic ossicular chain articulations","volume":"171","author":"Whyte","year":"2002","journal-title":"Cells Tissues Organs"}],"container-title":["Mechanisms of Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477318301692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925477318301692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:21:17Z","timestamp":1760419277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925477318301692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":19,"alternative-id":["S0925477318301692"],"URL":"https:\/\/doi.org\/10.1016\/j.mod.2019.103556","relation":{},"ISSN":["0925-4773"],"issn-type":[{"value":"0925-4773","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single origin of the epithelium of the human middle ear","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mod.2019.103556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103556"}}