{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:41:59Z","timestamp":1789594919822,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":469,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.modpat.2022.100011","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T16:07:20Z","timestamp":1673280440000},"page":"100011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of COL1A1\/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion)"],"prefix":"10.1016","volume":"36","author":[{"given":"Yu-Chien","family":"Kao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Han","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolin H.","family":"Nord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim H.","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Wei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chih-Hsueh Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.M.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7739-5934","authenticated-orcid":false,"given":"Jen-Chieh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.modpat.2022.100011_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00000478-198304000-00003","article-title":"Bizarre parosteal osteochondromatous proliferations of the hands and feet","volume":"7","author":"Nora","year":"1983","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"10.1016\/j.modpat.2022.100011_bib2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/00000478-199307000-00006","article-title":"Bizarre parosteal osteochondromatous proliferation of bone (Nora\u2019s lesion)","volume":"17","author":"Meneses","year":"1993","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2022.100011_bib3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/01.pas.0000126642.61690.d6","article-title":"Distinct chromosomal rearrangements in subungual (Dupuytren) exostosis and bizarre parosteal osteochondromatous proliferation (Nora lesion)","volume":"28","author":"Zambrano","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2022.100011_bib4","first-page":"138","article-title":"Bizarre parosteal osteochondromatous proliferation: 16 cases with a focus on histologic variability","volume":"15","author":"Cocks","year":"2018","journal-title":"J\u00a0Orthop"},{"issue":"5","key":"10.1016\/j.modpat.2022.100011_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00241768","article-title":"Proliferative periosteal processes of phalanges: a unitary hypothesis","volume":"21","author":"Yuen","year":"1992","journal-title":"Skeletal Radiol"},{"issue":"9","key":"10.1016\/j.modpat.2022.100011_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.humpath.2004.02.008","article-title":"Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora\u2019s lesion)","volume":"35","author":"Nilsson","year":"2004","journal-title":"Hum Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2022.100011_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00428-005-1266-7","article-title":"Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation","volume":"447","author":"Endo","year":"2005","journal-title":"Virchows Arch"},{"issue":"3","key":"10.1016\/j.modpat.2022.100011_bib8","first-page":"285","article-title":"Bizarre parosteal osteochondromatous proliferation (Nora\u2019s lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis","volume":"41","author":"Kuruvilla","year":"2011","journal-title":"Ann Clin Lab Sci"},{"issue":"6","key":"10.1016\/j.modpat.2022.100011_bib9","doi-asserted-by":"crossref","first-page":"690.e7","DOI":"10.1053\/j.jfas.2009.06.012","article-title":"Bizarre parosteal osteochondromatous proliferation of the metatarsal: a pediatric case report and archival review","volume":"48","author":"Teoh","year":"2009","journal-title":"J\u00a0Foot Ankle Surg"},{"issue":"11","key":"10.1016\/j.modpat.2022.100011_bib10","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s00256-011-1173-8","article-title":"Bizarre parosteal osteochondromatous proliferation with an inversion of chromosome 7","volume":"40","author":"Sakamoto","year":"2011","journal-title":"Skeletal Radiol"},{"issue":"7","key":"10.1016\/j.modpat.2022.100011_bib11","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s11999-011-1898-7","article-title":"Bizarre parosteal osteochondromatous proliferation: a locally aggressive benign tumor","volume":"469","author":"Joseph","year":"2011","journal-title":"Clin Orthop Relat Res"},{"issue":"11","key":"10.1016\/j.modpat.2022.100011_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cancergen.2013.11.004","article-title":"Bizarre parosteal osteochondromatous proliferation: a new cytogenetic subgroup characterized by inversion of chromosome 7","volume":"206","author":"Broehm","year":"2013","journal-title":"Cancer Genet"},{"issue":"5","key":"10.1016\/j.modpat.2022.100011_bib13","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s41379-019-0416-4","article-title":"Frequent overexpression of klotho in fusion-negative phosphaturic mesenchymal tumors with tumorigenic implications","volume":"33","author":"Lee","year":"2020","journal-title":"Mod Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2022.100011_bib14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/ng.2927","article-title":"GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma","volume":"46","author":"Nord","year":"2014","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.modpat.2022.100011_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/PAS.0000000000001742","article-title":"Cytokeratin-positive malignant tumor in the abdomen with EWSR1\/FUS-CREB fusion: a clinicopathologic study of 8 cases","volume":"46","author":"Shibayama","year":"2022","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2022.100011_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.modpat.2022.100011_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"12","key":"10.1016\/j.modpat.2022.100011_bib18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"1","key":"10.1016\/j.modpat.2022.100011_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"3","key":"10.1016\/j.modpat.2022.100011_bib20","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jaad.2010.06.020","article-title":"Dermatofibrosarcoma protuberans: a clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors","volume":"65","author":"Llombart","year":"2011","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"12","key":"10.1016\/j.modpat.2022.100011_bib21","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/jamadermatol.2015.2389","article-title":"A\u00a0novel chromosomal translocation associated with COL1A2-PDGFB gene fusion in dermatofibrosarcoma protuberans: PDGF expression as a new diagnostic tool","volume":"151","author":"Nakamura","year":"2015","journal-title":"JAMA Dermatol"},{"issue":"21","key":"10.1016\/j.modpat.2022.100011_bib22","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/sj.onc.1208506","article-title":"Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes","volume":"24","author":"Oliveira","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.modpat.2022.100011_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.anndiagpath.2018.06.009","article-title":"COL1A1 is a fusion partner of USP6 in myositis ossificans\u2014FISH analysis of six cases","volume":"36","author":"Flucke","year":"2018","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.modpat.2022.100011_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.humpath.2019.02.009","article-title":"Fibro-osseous pseudotumor of digits and myositis ossificans show consistent COL1A1-USP6 rearrangement: a clinicopathological and genetic study of 27 cases","volume":"88","author":"\u0160vajdler","year":"2019","journal-title":"Hum Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2022.100011_bib25","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/his.14268","article-title":"Clinicopathological and molecular haracterization of USP6-rearranged soft tissue neoplasms: the evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity","volume":"78","author":"Wang","year":"2021","journal-title":"Histopathology"},{"issue":"17","key":"10.1016\/j.modpat.2022.100011_bib26","first-page":"4869","article-title":"PLAG1 fusion oncogenes in lipoblastoma","volume":"60","author":"Hibbard","year":"2000","journal-title":"Cancer Res"},{"issue":"8","key":"10.1016\/j.modpat.2022.100011_bib27","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/ng.2668","article-title":"Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma","volume":"45","author":"Tarpey","year":"2013","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.modpat.2022.100011_bib28","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/ijc.21586","article-title":"Rearrangement of the COL12A1 and COL4A5 genes in subungual exostosis: molecular cytogenetic delineation of the tumor-specific translocation t(X;6)(q13-14;q22)","volume":"118","author":"Storlazzi","year":"2006","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.modpat.2022.100011_bib29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/(SICI)1098-2264(199902)24:2<162::AID-GCC11>3.0.CO;2-7","article-title":"Clonal chromosome abnormalities in a so-called Dupuytren\u2019s subungual exostosis","volume":"24","author":"Dal Cin","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"issue":"2","key":"10.1016\/j.modpat.2022.100011_bib30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ijc.25353","article-title":"The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4","volume":"128","author":"Mertens","year":"2011","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.modpat.2022.100011_bib31","first-page":"258","article-title":"LncRNA LINC-PINT inhibits cancer cell proliferation, invasion, and migration in osteosarcoma by downregulating miRNA-21","volume":"34","author":"Liu","year":"2019","journal-title":"Cancer Biother Radiopharm"},{"key":"10.1016\/j.modpat.2022.100011_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112127","article-title":"Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) as a novel prognosis indicator and therapeutic target in cancer","volume":"143","author":"He","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"13","key":"10.1016\/j.modpat.2022.100011_bib33","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.3390\/ijms22136768","article-title":"Expression and function of C1orf132 long-noncoding RNA in breast cancer cell lines and tissues","volume":"22","author":"Shafaroudi","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.modpat.2022.100011_bib34","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13059-017-1331-y","article-title":"The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element","volume":"18","author":"Mar\u00edn-B\u00e9jar","year":"2017","journal-title":"Genome Biol"},{"issue":"3","key":"10.1016\/j.modpat.2022.100011_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/path.4730","article-title":"Recurrent MALAT1-GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma","volume":"239","author":"Spans","year":"2016","journal-title":"J\u00a0Pathol"},{"issue":"10","key":"10.1016\/j.modpat.2022.100011_bib36","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/modpathol.2017.68","article-title":"Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene","volume":"30","author":"Graham","year":"2017","journal-title":"Mod Pathol"},{"issue":"4","key":"10.1016\/j.modpat.2022.100011_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/PAS.0000000000001408","article-title":"Clinicopathologic and molecular analysis of the TFEB fusion variant reveals new members of TFEB translocation renal cell carcinomas (RCCs): expanding the genomic spectrum","volume":"44","author":"Xia","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.1016\/j.modpat.2022.100011_bib38","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41379-020-00713-6","article-title":"TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1","volume":"34","author":"Cali\u00f2","year":"2021","journal-title":"Mod Pathol"},{"issue":"11","key":"10.1016\/j.modpat.2022.100011_bib39","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1097\/PAS.0000000000001531","article-title":"A\u00a0molecular reappraisal of glomus tumors and related pericytic neoplasms with emphasis on NOTCH-gene fusions","volume":"44","author":"Agaram","year":"2020","journal-title":"Am J Surg Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222000114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222000114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:13:53Z","timestamp":1760213633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222000114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0893395222000114"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2022.100011","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of COL1A1\/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion)","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2022.100011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100011"}}