{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:04:25Z","timestamp":1789596265730,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.modpat.2023.100142","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T02:15:32Z","timestamp":1676859332000},"page":"100142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Testicular Juvenile Granulosa Cell Tumors Demonstrate Recurrent Loss of Chromosome 10 and Absence of Molecular Alterations Described in Ovarian Counterparts"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-6731","authenticated-orcid":false,"given":"Katrina","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette M.","family":"Sholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara O.","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M.","family":"Cornejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Kravtsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan C.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad T.","family":"Idrees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Ulbright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-5911","authenticated-orcid":false,"given":"Andr\u00e9s M.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.modpat.2023.100142_bib1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1097\/PAS.0000000000000450","article-title":"Juvenile granulosa cell tumors of the testis: a clinicopathologic study of 70 cases with emphasis on its wide morphologic spectrum","volume":"39","author":"Kao","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2023.100142_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00000478-198502000-00003","article-title":"Juvenile granulosa cell tumor of the infantile testis. A report of 14 cases","volume":"9","author":"Lawrence","year":"1985","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"10.1016\/j.modpat.2023.100142_bib3","first-page":"1129","article-title":"Juvenile granulosa cell tumor of the testis","volume":"112","author":"Nistal","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.modpat.2023.100142_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1824-7288-38-67","article-title":"Juvenile granulosa cell tumor of the testis: prenatal diagnosis and prescrotal approach","volume":"38","author":"Bulotta","year":"2012","journal-title":"Ital J Pediatr"},{"issue":"10","key":"10.1016\/j.modpat.2023.100142_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/00000478-198510000-00005","article-title":"Juvenile granulosa cell tumor\u2014another neoplasm associated with abnormal chromosomes and ambiguous genitalia. A report of three cases","volume":"9","author":"Young","year":"1985","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2023.100142_bib6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00000478-198608000-00008","article-title":"Congenital testicular juvenile granulosa cell tumor in a neonate with X\/XY mosaicism","volume":"10","author":"Raju","year":"1986","journal-title":"Am J Surg Pathol"},{"issue":"19","key":"10.1016\/j.modpat.2023.100142_bib7","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87062","article-title":"Institutional implementation of clinical tumor profiling on an unselected cancer population","volume":"1","author":"Sholl","year":"2016","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.modpat.2023.100142_bib8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.5858\/arpa.2016-0527-OA","article-title":"Validation of OncoPanel: a targeted next-generation sequencing assay for the detection of somatic variants in cancer","volume":"141","author":"Garcia","year":"2017","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"10.1016\/j.modpat.2023.100142_bib9","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1093\/nar\/gku1211","article-title":"BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers","volume":"43","author":"Abo","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.modpat.2023.100142_bib10","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1038\/s41379-018-0091-x","article-title":"Validation of a targeted next-generation sequencing approach to detect mismatch repair deficiency in colorectal adenocarcinoma","volume":"31","author":"Papke","year":"2018","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2023.100142_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/gcc.22690","article-title":"Targeted RNA sequencing: a routine ancillary technique in the diagnosis of bone and soft tissue neoplasms","volume":"58","author":"Dickson","year":"2019","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"10.1016\/j.modpat.2023.100142_bib12","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv1234","article-title":"Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data","volume":"44","author":"Liu","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.modpat.2023.100142_bib13","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/bioinformatics\/btv710","article-title":"Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications","volume":"32","author":"Chen","year":"2016","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.modpat.2023.100142_bib14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2350\/09-04-0638-CR.1","article-title":"Congenital intra-abdominal bilateral juvenile granulosa cell tumors of the testis associated with constitutional loss of material from chromosome 4","volume":"14","author":"Yu","year":"2011","journal-title":"Pediatr Dev Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2023.100142_bib15","first-page":"1057","article-title":"Juvenile granulosa cell (sex cord-stromal) tumor of fetal testis","volume":"129","author":"Crump","year":"1983","journal-title":"J\u00a0Urol"},{"issue":"4","key":"10.1016\/j.modpat.2023.100142_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/15513819309048227","article-title":"Juvenile granulosa cell tumor of the testis: a comparative immunohistochemical study with normal infantile gonads","volume":"13","author":"Groisman","year":"1993","journal-title":"Pediatr Pathol"},{"issue":"3","key":"10.1016\/j.modpat.2023.100142_bib17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/15513819609168683","article-title":"Testicular sex cord-stromal tumors in children: clinicopathologic study of sixteen children with review of the literature","volume":"16","author":"Goswitz","year":"1996","journal-title":"Pediatr Pathol Lab Med"},{"issue":"4","key":"10.1016\/j.modpat.2023.100142_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF01092753","article-title":"Testicular juvenile granulosa cell and Sertoli cell tumours: a clinicopathological study of 29 cases from the Kiel Paediatric Tumour Registry","volume":"430","author":"Harms","year":"1997","journal-title":"Virchows Arch"},{"issue":"8","key":"10.1016\/j.modpat.2023.100142_bib19","first-page":"774","article-title":"Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors","volume":"11","author":"Iczkowski","year":"1998","journal-title":"Mod Pathol"},{"issue":"10","key":"10.1016\/j.modpat.2023.100142_bib20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/PAS.0000000000001704","article-title":"Immunohistochemical characterization of 120 testicular sex cord-stromal tumors with an emphasis on the diagnostic utility of SOX9, FOXL2, and SF-1","volume":"45","author":"Lau","year":"2021","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2023.100142_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00000478-198209000-00002","article-title":"Granulosa tumors of the ovary in children: a clinical and pathologic study of 32 cases","volume":"6","author":"Zaloudek","year":"1982","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.modpat.2023.100142_bib22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/gyno.1997.4695","article-title":"Juvenile granulosa cell tumors of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study","volume":"65","author":"Calaminus","year":"1997","journal-title":"Gynecol Oncol"},{"issue":"8","key":"10.1016\/j.modpat.2023.100142_bib23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00000478-198408000-00002","article-title":"Juvenile granulosa cell tumor of the ovary. A clinicopathological analysis of 125 cases","volume":"8","author":"Young","year":"1984","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2023.100142_bib24","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1200\/JCO.1988.6.6.990","article-title":"Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases","volume":"6","author":"Vassal","year":"1988","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.modpat.2023.100142_bib25","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1210\/jc.2005-2710","article-title":"Activating mutations of the stimulatory G protein in juvenile ovarian granulosa cell tumors: a new prognostic factor?","volume":"91","author":"Kalfa","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6236","key":"10.1016\/j.modpat.2023.100142_bib26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/340692a0","article-title":"GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours","volume":"340","author":"Landis","year":"1989","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.modpat.2023.100142_bib27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ebiom.2015.03.002","article-title":"A\u00a0hot-spot of in-frame duplications activates the oncoprotein AKT1 in juvenile granulosa cell tumors","volume":"2","author":"Bessi\u00e8re","year":"2015","journal-title":"EBioMedicine"},{"issue":"23","key":"10.1016\/j.modpat.2023.100142_bib28","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1093\/hmg\/ddv373","article-title":"Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads","volume":"24","author":"Auguste","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.modpat.2023.100142_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1001\/jama.2009.1022","article-title":"Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas","volume":"302","author":"Yadav","year":"2009","journal-title":"JAMA"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395223000479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395223000479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:23:47Z","timestamp":1760232227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395223000479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0893395223000479"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2023.100142","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testicular Juvenile Granulosa Cell Tumors Demonstrate Recurrent Loss of Chromosome 10 and Absence of Molecular Alterations Described in Ovarian Counterparts","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2023.100142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100142"}}