{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:02:34Z","timestamp":1792598554941,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.modpat.2023.100194","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T19:25:59Z","timestamp":1682277959000},"page":"100194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Biallelic ELOC-Inactivated Renal Cell Carcinoma: Molecular Features Supporting Classification as a Distinct Entity"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-5816","authenticated-orcid":false,"given":"Aashil A.","family":"Batavia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Rutishauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Sobottka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schraml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niko","family":"Beerenwinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Moch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.modpat.2023.100194_bib1","first-page":"950","article-title":"Re: international variations and trends in renal cell carcinoma incidence and mortality","volume":"194","author":"Laguna","year":"2015","journal-title":"J\u00a0Urol"},{"issue":"5","key":"10.1016\/j.modpat.2023.100194_bib2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.eururo.2022.06.016","article-title":"The 2022 World Health Organization classification of tumours of the urinary system and male genital organs\u2014part A: renal, penile, and testicular tumours","volume":"82","author":"Moch","year":"2022","journal-title":"Eur Urol"},{"issue":"10","key":"10.1016\/j.modpat.2023.100194_bib3","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1002\/ijc.24642","article-title":"Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays","volume":"125","author":"Chen","year":"2009","journal-title":"Int J Cancer"},{"issue":"7456","key":"10.1016\/j.modpat.2023.100194_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature12222","article-title":"Comprehensive molecular characterization of clear cell renal cell carcinoma","volume":"499","year":"2013","journal-title":"Nature"},{"issue":"6733","key":"10.1016\/j.modpat.2023.100194_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.modpat.2023.100194_bib6","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1172\/JCI67230","article-title":"HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations","volume":"123","author":"Semenza","year":"2013","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"10.1016\/j.modpat.2023.100194_bib7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/his.13749","article-title":"Clear cell renal cell carcinoma with wild-type von Hippel-Lindau gene: a non-existent or new tumour entity?","volume":"74","author":"Batavia","year":"2019","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.modpat.2023.100194_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2018.03.043","article-title":"Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal","volume":"173","author":"Turajlic","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.modpat.2023.100194_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cell.2019.12.026","article-title":"Integrated proteogenomic characterization of clear cell renal cell carcinoma","volume":"180","author":"Clark","year":"2020","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.modpat.2023.100194_bib10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/ng.2699","article-title":"Integrated molecular analysis of clear-cell renal cell carcinoma","volume":"45","author":"Sato","year":"2013","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.modpat.2023.100194_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.euf.2019.11.013","article-title":"Putative drivers of aggressiveness in TCEB1-mutant renal cell carcinoma: an emerging entity with a variable clinical course","volume":"7","author":"DiNatale","year":"2021","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.modpat.2023.100194_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1186\/s12885-016-2688-0","article-title":"Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance","volume":"16","author":"Razafinjatovo","year":"2016","journal-title":"BMC Cancer"},{"issue":"16","key":"10.1016\/j.modpat.2023.100194_bib13","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1158\/0008-5472.CAN-11-0757","article-title":"VHL gene mutations and their effects on hypoxia inducible factor HIF\u03b1: identification of potential driver and passenger mutations","volume":"71","author":"Rechsteiner","year":"2011","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.modpat.2023.100194_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41241-016-0007-3","article-title":"Utilization of the oncoscan microarray assay in cancer diagnostics","volume":"37","author":"Jung","year":"2017","journal-title":"Appl Cancer Res"},{"issue":"39","key":"10.1016\/j.modpat.2023.100194_bib15","doi-asserted-by":"crossref","first-page":"16910","DOI":"10.1073\/pnas.1009843107","article-title":"Allele-specific copy number analysis of tumors","volume":"107","author":"Van Loo","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.modpat.2023.100194_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1868-7083-5-16","article-title":"Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma","volume":"5","author":"Ricketts","year":"2013","journal-title":"Clin Epigenetics"},{"issue":"7","key":"10.1016\/j.modpat.2023.100194_bib17","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein-protein docking approach based on biochemical or biophysical information","volume":"125","author":"Dominguez","year":"2003","journal-title":"J\u00a0Am Chem Soc"},{"issue":"13","key":"10.1016\/j.modpat.2023.100194_bib18","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J\u00a0Comput Chem"},{"issue":"43","key":"10.1016\/j.modpat.2023.100194_bib19","doi-asserted-by":"crossref","first-page":"27444","DOI":"10.1074\/jbc.272.43.27444","article-title":"Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein","volume":"272","author":"Takagi","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.modpat.2023.100194_bib20","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.12688\/f1000research.17456.1","article-title":"pdb-tools: a swiss army knife for molecular structures","volume":"7","author":"Rodrigues","year":"2018","journal-title":"F1000Res"},{"issue":"8","key":"10.1016\/j.modpat.2023.100194_bib21","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/pmic.201100463","article-title":"Using iRT, a normalized retention time for more targeted measurement of peptides","volume":"12","author":"Escher","year":"2012","journal-title":"Proteomics"},{"issue":"12","key":"10.1016\/j.modpat.2023.100194_bib22","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1074\/mcp.RA117.000314","article-title":"Optimization of experimental parameters in data-independent mass spectrometry significantly increases depth and reproducibility of results","volume":"16","author":"Bruderer","year":"2017","journal-title":"Mol Cell Proteomics"},{"issue":"10","key":"10.1016\/j.modpat.2023.100194_bib23","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1373\/clinchem.2008.108175","article-title":"High-abundance polypeptides of the human plasma proteome comprising the top 4 logs of polypeptide abundance","volume":"54","author":"Hortin","year":"2008","journal-title":"Clin Chem"},{"issue":"7484","key":"10.1016\/j.modpat.2023.100194_bib24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature12912","article-title":"Discovery and saturation analysis of cancer genes across 21 tumour types","volume":"505","author":"Lawrence","year":"2014","journal-title":"Nature"},{"issue":"5413","key":"10.1016\/j.modpat.2023.100194_bib25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.284.5413.455","article-title":"Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function","volume":"284","author":"Stebbins","year":"1999","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.modpat.2023.100194_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/PAS.0000000000001422","article-title":"\u201cRenal cell carcinoma with leiomyomatous stroma\u201d harbor somatic mutations of TSC1, TSC2, MTOR, and\/or ELOC (TCEB1): clinicopathologic and molecular characterization of 18 sporadic tumors supports a distinct entity","volume":"44","author":"Shah","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.modpat.2023.100194_bib27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/PAP.0000000000000337","article-title":"Renal cell carcinoma with fibromyomatous stroma\u2014the whole story","volume":"29","author":"Shah","year":"2022","journal-title":"Adv Anat Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2023.100194_bib28","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/modpathol.2015.6","article-title":"TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype","volume":"28","author":"Hakimi","year":"2015","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2023.100194_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1158\/2159-8290.CD-21-1094","article-title":"A\u00a0summary of the inaugural WHO classification of pediatric tumors: transitioning from the optical into the molecular era","volume":"12","author":"Pfister","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.modpat.2023.100194_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/srep31128","article-title":"VHLdb: a database of von Hippel-Lindau protein interactors and mutations","volume":"6","author":"Tabaro","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.modpat.2023.100194_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pathol.2019.04.006","article-title":"Renal cell carcinomas with a mesenchymal stromal component: what do we know so far?","volume":"51","author":"Williamson","year":"2019","journal-title":"Pathology"},{"key":"10.1016\/j.modpat.2023.100194_bib32","series-title":"WHO Classification of Tumors: Urinary and Male Genital Tumors","first-page":"76","author":"Argani","year":"2022"},{"issue":"11","key":"10.1016\/j.modpat.2023.100194_bib33","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/modpathol.2017.72","article-title":"Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database","volume":"30","author":"Favazza","year":"2017","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2023.100194_bib34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.anndiagpath.2015.11.003","article-title":"Clear cell papillary renal cell carcinoma, renal angiomyoadenomatous tumor, and renal cell carcinoma with leiomyomatous stroma relationship of 3 types of renal tumors: a review","volume":"21","author":"Hes","year":"2016","journal-title":"Ann Diagn Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2023.100194_bib35","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/PAS.0000000000001255","article-title":"Genetic underpinnings of renal cell carcinoma with leiomyomatous stroma","volume":"43","author":"Parilla","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.modpat.2023.100194_bib36","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/PAI.0000000000000410","article-title":"Renal cell carcinoma with leiomyomatous stroma: a group of tumors with indistinguishable histopathologic features, but 2 distinct genetic profiles: next-generation sequencing analysis of 6 cases negative for aberrations related to the VHL gene","volume":"26","author":"Petersson","year":"2018","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"10","key":"10.1016\/j.modpat.2023.100194_bib37","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.5858\/arpa.2016-0218-RA","article-title":"Morphologic, molecular, and taxonomic evolution of renal cell carcinoma: a conceptual perspective with emphasis on updates to the 2016 World Health Organization classification","volume":"140","author":"Udager","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"9","key":"10.1016\/j.modpat.2023.100194_bib38","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/PAS.0000000000001111","article-title":"Eosinophilic solid and cystic (ESC) renal cell carcinomas harbor TSC mutations: molecular analysis supports an expanding clinicopathologic spectrum","volume":"42","author":"Palsgrove","year":"2018","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"10.1016\/j.modpat.2023.100194_bib39","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/PAS.0000000000001067","article-title":"Are sporadic eosinophilic solid and cystic renal cell carcinomas characterized by somatic tuberous sclerosis gene mutations?","volume":"42","author":"Parilla","year":"2018","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.1016\/j.modpat.2023.100194_bib40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.eururo.2018.06.007","article-title":"Somatic bi-allelic loss of TSC genes in eosinophilic solid and cystic renal cell carcinoma","volume":"74","author":"Mehra","year":"2018","journal-title":"Eur Urol"},{"issue":"6","key":"10.1016\/j.modpat.2023.100194_bib41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00428-018-2456-4","article-title":"\u201cHigh-grade oncocytic renal tumor\u201d: morphologic, immunohistochemical, and molecular genetic study of 14 cases","volume":"473","author":"He","year":"2018","journal-title":"Virchows Arch"},{"issue":"1","key":"10.1016\/j.modpat.2023.100194_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/PAS.0000000000001170","article-title":"Somatic mutations of TSC2 or MTOR characterize a morphologically distinct subset of sporadic renal cell carcinoma with eosinophilic and vacuolated cytoplasm","volume":"43","author":"Chen","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2023.100194_bib43","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/his.14663","article-title":"Eosinophilic solid and cystic renal cell carcinoma and renal cell carcinomas with TFEB alterations: a comparative study","volume":"81","author":"Lobo","year":"2022","journal-title":"Histopathology"},{"issue":"11","key":"10.1016\/j.modpat.2023.100194_bib44","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/PAS.0000000000001955","article-title":"TSC\/MTOR-associated eosinophilic renal tumors exhibit a heterogeneous clinicopathologic spectrum: a targeted next-generation sequencing and gene expression profiling study","volume":"46","author":"Xia","year":"2022","journal-title":"Am J Surg Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395223000996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395223000996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:24:25Z","timestamp":1760232265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395223000996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0893395223000996"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2023.100194","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biallelic ELOC-Inactivated Renal Cell Carcinoma: Molecular Features Supporting Classification as a Distinct Entity","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2023.100194","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}],"article-number":"100194"}}