{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:19:54Z","timestamp":1792433994997,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.modpat.2024.100440","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T10:03:19Z","timestamp":1706436199000},"page":"100440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Follicular Lymphoma Presenting With Symptomatic Bone Involvement: A Clinicopathologic and Molecular Analysis of 16 Cases"],"prefix":"10.1016","volume":"37","author":[{"given":"Rossella","family":"Sarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Bisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Guey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Missiaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cairoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Omoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Letovanec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Hasserjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-516X","authenticated-orcid":false,"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.modpat.2024.100440_bib1","series-title":"WHO Classification of Soft Tissue and Bone Tumours","year":"2020"},{"key":"10.1016\/j.modpat.2024.100440_bib2","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2017"},{"issue":"11","key":"10.1016\/j.modpat.2024.100440_bib3","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.5858\/133.11.1868","article-title":"Primary bone lymphoma","volume":"133","author":"Bhagavathi","year":"2009","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"10.1016\/j.modpat.2024.100440_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/10428190500272705","article-title":"Primary non-Hodgkin's lymphoma of bone: a rare disorder with high frequency of T-cell phenotype in southern Taiwan","volume":"47","author":"Hsieh","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1016\/j.modpat.2024.100440_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00432-004-0641-0","article-title":"Primary multifocal osseous Hodgkin disease: a case report and review of the literature","volume":"131","author":"Gebert","year":"2005","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"issue":"7","key":"10.1016\/j.modpat.2024.100440_bib6","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00000478-199007000-00006","article-title":"Malignant lymphoma involving the mandible. Clinical, morphologic, and immunohistochemical study of 17 cases","volume":"14","author":"Pileri","year":"1990","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"10.1016\/j.modpat.2024.100440_bib7","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/00000478-200011000-00003","article-title":"Precursor B-cell lymphoblastic lymphoma: a predominantly extranodal tumor with low propensity for leukemic involvement","volume":"24","author":"Lin","year":"2000","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2024.100440_bib8","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.3109\/10428194.2013.853298","article-title":"The clinical features, management and prognosis of primary and secondary indolent lymphoma of the bone: a retrospective study of the International Extranodal Lymphoma Study Group (IELSG #14 study)","volume":"55","author":"Govi","year":"2014","journal-title":"Leuk Lymphoma"},{"issue":"8","key":"10.1016\/j.modpat.2024.100440_bib9","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1200\/JCO.1988.6.8.1280","article-title":"Skeletal complications in hairy cell leukemia: diagnosis and therapy","volume":"6","author":"Lembersky","year":"1988","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100440_bib10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ajh.21929","article-title":"Hairy cell leukemia presenting as a cranial mass","volume":"86","author":"Chaudhry","year":"2011","journal-title":"Am J Hematol"},{"issue":"12","key":"10.1016\/j.modpat.2024.100440_bib11","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1038\/sj.leu.2401582","article-title":"Primary non-Hodgkin's lymphoma of bone: a clinicopathological investigation of 60 cases","volume":"13","author":"Heyning","year":"1999","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.modpat.2024.100440_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/10428190903308007","article-title":"Primary bone lymphoma--the University of Miami experience","volume":"51","author":"Alencar","year":"2010","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1016\/j.modpat.2024.100440_bib13","first-page":"280","article-title":"Primary bone lymphoma: experience with 52 patients","volume":"88","author":"Zinzani","year":"2003","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.modpat.2024.100440_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41572-019-0132-x","article-title":"Follicular lymphoma","volume":"5","author":"Carbone","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"10.1016\/j.modpat.2024.100440_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00277-007-0433-0","article-title":"Extranodal follicular lymphoma exclusively featured by diffuse pattern originating from multiple vertebral bones","volume":"87","author":"Tabata","year":"2008","journal-title":"Ann Hematol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100440_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/bjh.12841","article-title":"Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience","volume":"166","author":"Wu","year":"2014","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.modpat.2024.100440_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ctrv.2015.02.001","article-title":"Primary and secondary bone lymphomas","volume":"41","author":"Messina","year":"2015","journal-title":"Cancer Treat Rev"},{"issue":"1A","key":"10.1016\/j.modpat.2024.100440_bib18","first-page":"325","article-title":"Primary lymphomas of bone","volume":"26","author":"Kitsoulis","year":"2006","journal-title":"Anticancer Res"},{"issue":"12","key":"10.1016\/j.modpat.2024.100440_bib19","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1002\/cncr.21930","article-title":"Primary bone lymphoma: treatment results and prognostic factors with long-term follow-up of 82 patients","volume":"106","author":"Beal","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.modpat.2024.100440_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2016.07.028","article-title":"Primary lymphoma of bone in the pediatric and young adult population","volume":"60","author":"Chisholm","year":"2017","journal-title":"Hum Pathol"},{"key":"10.1016\/j.modpat.2024.100440_bib21","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1186\/1471-2407-14-900","article-title":"Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas","volume":"14","author":"Wu","year":"2014","journal-title":"BMC Cancer"},{"issue":"11","key":"10.1016\/j.modpat.2024.100440_bib22","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1080\/0284186X.2019.1643918","article-title":"Incidence of solid cancer in patients with follicular lymphoma","volume":"58","author":"Sorigue","year":"2019","journal-title":"Acta Oncol"},{"issue":"9","key":"10.1016\/j.modpat.2024.100440_bib23","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.clml.2017.06.028","article-title":"Risk of second primary malignancies in patients with follicular lymphoma: a United States population-based study","volume":"17","author":"Giri","year":"2017","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.modpat.2024.100440_bib24","series-title":"Atlas of Tumor Pathology Series IV.s","first-page":"231","article-title":"Tumors of the Bones and Joints","author":"Unni","year":"2005"},{"issue":"9","key":"10.1016\/j.modpat.2024.100440_bib25","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1097\/00000478-200309000-00011","article-title":"Diffuse large B-cell lymphoma of bone: an analysis of differentiation-associated antigens with clinical correlation","volume":"27","author":"de Leval","year":"2003","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"10.1016\/j.modpat.2024.100440_bib26","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/jcp.2008.063156","article-title":"Primary lymphoma of bone: extranodal lymphoma with favourable survival independent of germinal centre, post-germinal centre or indeterminate phenotype","volume":"62","author":"Heyning","year":"2009","journal-title":"J\u00a0Clin Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2024.100440_bib27","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/bjh.12714","article-title":"Clinical features, management and prognosis of multifocal primary bone lymphoma: a retrospective study of the international extranodal lymphoma study group (the IELSG 14 study)","volume":"164","author":"Messina","year":"2014","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.modpat.2024.100440_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1634\/theoncologist.2013-0249","article-title":"Clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-cell lymphoma of the bone (the IELSG-14 study)","volume":"19","author":"Bruno Ventre","year":"2014","journal-title":"Oncologist"},{"issue":"10","key":"10.1016\/j.modpat.2024.100440_bib29","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1097\/PAS.0b013e3181b314ce","article-title":"Primary bone diffuse large B-cell lymphoma: clinicopathologic study of 21 cases and review of literature","volume":"33","author":"Bhagavathi","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2024.100440_bib30","first-page":"814","article-title":"Primary bone lymphoma: a clinicopathological retrospective study of 28 patients in a single institution","volume":"16","author":"Nasiri","year":"2011","journal-title":"J\u00a0Res Med Sci"},{"issue":"2","key":"10.1016\/j.modpat.2024.100440_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00428-013-1519-9","article-title":"The density of CD8+ T-cell infiltration and expression of BCL2 predicts outcome of primary diffuse large B-cell lymphoma of bone","volume":"464","author":"Rajnai","year":"2014","journal-title":"Virchows Arch"},{"issue":"10","key":"10.1016\/j.modpat.2024.100440_bib32","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1097\/PAS.0000000000000923","article-title":"Primary bone lymphoma exhibits a favorable prognosis and distinct gene expression signatures resembling diffuse large B-cell lymphoma derived from centrocytes in the germinal center","volume":"41","author":"Li","year":"2017","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1016\/j.modpat.2024.100440_bib33","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/jcp.2010.078915","article-title":"Array-based comparative genomic hybridisation analysis reveals recurrent chromosomal alterations in primary diffuse large B cell lymphoma of bone","volume":"63","author":"Heyning","year":"2010","journal-title":"J\u00a0Clin Pathol"},{"issue":"10","key":"10.1016\/j.modpat.2024.100440_bib34","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/modpathol.3880425","article-title":"An immunophenotypic and molecular study of primary large B-cell lymphoma of bone","volume":"14","author":"Huebner-Chan","year":"2001","journal-title":"Mod Pathol"},{"issue":"9","key":"10.1016\/j.modpat.2024.100440_bib35","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.humpath.2008.01.004","article-title":"Primary diffuse large B-cell lymphomas of the bone: prognostic relevance of protein expression and clinical factors","volume":"39","author":"Adams","year":"2008","journal-title":"Hum Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2024.100440_bib36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/PAS.0b013e31823ea106","article-title":"Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-Hodgkin lymphomas","volume":"36","author":"Martinez","year":"2012","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"10.1016\/j.modpat.2024.100440_bib37","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.humpath.2014.02.010","article-title":"Low-grade B-cell lymphoma presenting primarily in the bone marrow","volume":"45","author":"Iwatani","year":"2014","journal-title":"Hum Pathol"},{"issue":"10","key":"10.1016\/j.modpat.2024.100440_bib38","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1172\/JCI63186","article-title":"Pathogenesis of follicular lymphoma","volume":"122","author":"Kridel","year":"2012","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"10.1016\/j.modpat.2024.100440_bib39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.celrep.2013.12.027","article-title":"Genetics of follicular lymphoma transformation","volume":"6","author":"Pasqualucci","year":"2014","journal-title":"Cell Rep"},{"issue":"7360","key":"10.1016\/j.modpat.2024.100440_bib40","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","article-title":"Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma","volume":"476","author":"Morin","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.modpat.2024.100440_bib41","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nrc.2017.127","article-title":"From genetics to the clinic: a translational perspective on follicular lymphoma","volume":"18","author":"Huet","year":"2018","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.modpat.2024.100440_bib42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1182\/blood-2017-08-737361","article-title":"Chromatin modifying gene mutations in follicular lymphoma","volume":"131","author":"Green","year":"2018","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.modpat.2024.100440_bib43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/leu.2011.266","article-title":"High rate of TNFRSF14 gene alterations related to 1p36 region in de novo follicular lymphoma and impact on prognosis","volume":"26","author":"Launay","year":"2012","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.modpat.2024.100440_bib44","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ng.2856","article-title":"Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma","volume":"46","author":"Okosun","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.modpat.2024.100440_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fmed.2019.00044","article-title":"Unraveling tumor heterogeneity in an apparently monolithic disease: BCL2 and other players in the genetic landscape of nodal follicular lymphoma","volume":"6","author":"Magnoli","year":"2019","journal-title":"Front Med (Lausanne)"},{"issue":"6","key":"10.1016\/j.modpat.2024.100440_bib46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ajh.24701","article-title":"BCL2 mutations do not confer adverse prognosis in follicular lymphoma patients treated with rituximab","volume":"92","author":"Huet","year":"2017","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100440_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41408-023-00847-1","article-title":"Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era","volume":"13","author":"Correia","year":"2023","journal-title":"Blood Cancer J"},{"issue":"8","key":"10.1016\/j.modpat.2024.100440_bib48","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1182\/blood-2008-05-154013","article-title":"The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival","volume":"112","author":"O'Shea","year":"2008","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.modpat.2024.100440_bib49","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S1470-2045(15)00169-2","article-title":"Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry","volume":"16","author":"Pastore","year":"2015","journal-title":"Lancet Oncol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395224000206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395224000206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:59:00Z","timestamp":1762315140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395224000206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0893395224000206"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2024.100440","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Follicular Lymphoma Presenting With Symptomatic Bone Involvement: A Clinicopathologic and Molecular Analysis of 16 Cases","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2024.100440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100440"}}