{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:44:12Z","timestamp":1793353452979,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010905","name":"Illumina Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.modpat.2024.100625","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:43:27Z","timestamp":1727279007000},"page":"100625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["DNA Methylation Profiling of Salivary Gland Tumors Supports and Expands Conventional Classification"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-3794","authenticated-orcid":false,"given":"Philipp","family":"Jurmeister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Leitheiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Pay\u00e1","family":"Capilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana H.","family":"Mochmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yauheniya","family":"Zhdanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstanze","family":"Schleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar Calderon","family":"Chimal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kumbrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Harter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Preni\u00dfl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefer","family":"Elezkurtaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Brcic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Deigendesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Hench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"F\u00f6rsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben","family":"Breimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"van Engen van Grunsven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben","family":"Lassche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"van Herpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matija","family":"Snuderl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Robert","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Capper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Klauschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ihrler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.modpat.2024.100625_bib1","article-title":"Head and Neck Tumours","year":"2022","journal-title":"[Internet; beta version ahead of print]. International Agency for Research on Cancer"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12105-022-01420-1","article-title":"Update from the 5th edition of the World Health Organization classification of head and neck tumors: salivary glands","volume":"16","author":"Sk\u00e1lov\u00e1","year":"2022","journal-title":"Head Neck Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100625_bib3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/PAS.0000000000001218","article-title":"Misinterpreted myoepithelial carcinoma of salivary gland: a challenging and potentially significant pitfall","volume":"43","author":"Xu","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100625_bib4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/his.14421","article-title":"Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult?","volume":"79","author":"Ihrler","year":"2021","journal-title":"Histopathology"},{"issue":"5","key":"10.1016\/j.modpat.2024.100625_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/gcc.23020","article-title":"Fusion-positive salivary gland carcinomas","volume":"61","author":"Sk\u00e1lov\u00e1","year":"2022","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"10.1016\/j.modpat.2024.100625_bib6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/PAS.0b013e3181d9efcc","article-title":"Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity","volume":"34","author":"Sk\u00e1lov\u00e1","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100625_bib7","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/his.13281","article-title":"MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma","volume":"71","author":"Fujii","year":"2017","journal-title":"Histopathology"},{"issue":"7697","key":"10.1016\/j.modpat.2024.100625_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib9","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1038\/s41467-022-34815-3","article-title":"DNA methylation-based classification of sinonasal tumors","volume":"13","author":"Jurmeister","year":"2022","journal-title":"Nat Commun"},{"issue":"509","key":"10.1016\/j.modpat.2024.100625_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw8513","article-title":"Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases","volume":"11","author":"Jurmeister","year":"2019","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41467-020-20603-4","article-title":"Sarcoma classification by DNA methylation profiling","volume":"12","author":"Koelsche","year":"2021","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.modpat.2024.100625_bib12","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1186\/gb-2014-15-4-r54","article-title":"DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns","volume":"15","author":"Lokk","year":"2014","journal-title":"Genome Biol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1158\/1541-7786.MCR-17-0636","article-title":"Integrative epigenetic and gene expression analysis of renal tumor progression to metastasis","volume":"17","author":"Nam","year":"2019","journal-title":"Mol Cancer Res"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib14","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1038\/ncomms9699","article-title":"A\u00a0CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma","volume":"6","author":"Wei","year":"2015","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.modpat.2024.100625_bib15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/path.5845","article-title":"Machine learning models predict the primary sites of head and neck squamous cell carcinoma metastases based on DNA methylation","volume":"256","author":"Leitheiser","year":"2022","journal-title":"J\u00a0Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13059-015-0644-y","article-title":"Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin","volume":"16","author":"Vandiver","year":"2015","journal-title":"Genome Biol"},{"key":"10.1016\/j.modpat.2024.100625_bib17","author":"Hovestadt"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/path.5808","article-title":"Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location-dependent patterns of genetic and epigenetic alterations","volume":"256","author":"Jurmeister","year":"2022","journal-title":"J\u00a0Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1186\/1471-2164-13-591","article-title":"Copynumber: efficient algorithms for single- and multi-track copy number segmentation","volume":"13","author":"Nilsen","year":"2012","journal-title":"BMC Genomics"},{"issue":"10","key":"10.1016\/j.modpat.2024.100625_bib20","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2164-14-293","article-title":"A\u00a0data-driven approach to preprocessing Illumina 450K methylation array data","volume":"14","author":"Pidsley","year":"2013","journal-title":"BMC Genomics"},{"issue":"19","key":"10.1016\/j.modpat.2024.100625_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab637","article-title":"Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate","volume":"49","author":"Peters","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8935-8-6","article-title":"De novo identification of differentially methylated regions in the human genome","volume":"8","author":"Peters","year":"2015","journal-title":"Epigenetics Chromatin"},{"issue":"4","key":"10.1016\/j.modpat.2024.100625_bib24","article-title":"Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes","volume":"45","author":"Zhou","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.modpat.2024.100625_bib25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41596-019-0251-6","article-title":"Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data","volume":"15","author":"Maros","year":"2020","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib26","first-page":"1","article-title":"Elastic net regularization paths for all generalized linear models","volume":"106","author":"Tay","year":"2023","journal-title":"J\u00a0Stat Softw"},{"issue":"4","key":"10.1016\/j.modpat.2024.100625_bib27","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/PAS.0000000000001431","article-title":"Histologic classification and molecular signature of polymorphous adenocarcinoma (PAC) and cribriform adenocarcinoma of salivary gland (CASG)","volume":"44","author":"Xu","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2024.100625_bib28","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1097\/PAS.0b013e31821e1f54","article-title":"Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity","volume":"35","author":"Sk\u00e1lov\u00e1","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2024.100625_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2559.1999.00792.x","article-title":"Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue","volume":"35","author":"Michael","year":"1999","journal-title":"Histopathology"},{"issue":"8","key":"10.1016\/j.modpat.2024.100625_bib30","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/PAS.0000000000000883","article-title":"Newly described entities in salivary gland pathology","volume":"41","author":"Sk\u00e1lov\u00e1","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2024.100625_bib31","article-title":"Head and Neck Tumours","year":"2022","journal-title":"International Agency for Research on Cancer"},{"issue":"1","key":"10.1016\/j.modpat.2024.100625_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/dc.20954","article-title":"Pleomorphic adenoma with predominant plasmocytoid myoepithelial cells: a diagnostic pitfall in aspiration cytology. Case report and review of the literature","volume":"37","author":"Pusztaszeri","year":"2009","journal-title":"Diagn Cytopathol"},{"issue":"7","key":"10.1016\/j.modpat.2024.100625_bib33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/gcc.20881","article-title":"EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland","volume":"50","author":"Antonescu","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"issue":"2","key":"10.1016\/j.modpat.2024.100625_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/modpathol.2012.154","article-title":"Genomic profiles and CRTC1\u2013MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma","volume":"26","author":"Jee","year":"2013","journal-title":"Mod Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395224002059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395224002059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T05:24:10Z","timestamp":1734499450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395224002059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0893395224002059"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2024.100625","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA Methylation Profiling of Salivary Gland Tumors Supports and Expands Conventional Classification","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2024.100625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}],"article-number":"100625"}}