{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:49:04Z","timestamp":1780145344827,"version":"3.54.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U2CCA271891"],"award-info":[{"award-number":["U2CCA271891"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA008748 S5"],"award-info":[{"award-number":["P30CA008748 S5"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["RO1 CA260628"],"award-info":[{"award-number":["RO1 CA260628"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50 CA228991"],"award-info":[{"award-number":["P50 CA228991"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.modpat.2024.100629","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T15:38:12Z","timestamp":1728488292000},"page":"100629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Early Genetic Divergence of High-Grade Carcinomas Originating from Low-Grade Serous Ovarian Neoplasms"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7220-3996","authenticated-orcid":false,"given":"M. Herman","family":"Chui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brant","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Vang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie-Ming","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.modpat.2024.100629_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/PAP.0b013e3181b4fffa","article-title":"Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems","volume":"16","author":"Vang","year":"2009","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.modpat.2024.100629_bib2","series-title":"Female Genital Tumours","year":"2020"},{"issue":"2","key":"10.1016\/j.modpat.2024.100629_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100629_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/path.5219","article-title":"Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions","volume":"248","author":"Wu","year":"2019","journal-title":"J\u00a0Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100629_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/path.5545","article-title":"Genomic analysis of low-grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities","volume":"253","author":"Cheasley","year":"2021","journal-title":"J\u00a0Pathol"},{"issue":"20","key":"10.1016\/j.modpat.2024.100629_bib6","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1158\/1078-0432.CCR-21-4183","article-title":"MAPK pathway genetic alterations are associated with prolonged overall survival in low-grade serous ovarian carcinoma","volume":"28","author":"Manning-Geist","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"3","key":"10.1016\/j.modpat.2024.100629_bib7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/PAS.0b013e31823732a9","article-title":"Low-grade ovarian serous neoplasms (low-grade serous carcinoma and serous borderline tumor) associated with high-grade serous carcinoma or undifferentiated carcinoma: report of a series of cases of an unusual phenomenon","volume":"36","author":"Boyd","year":"2012","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100629_bib8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/PGP.0b013e31824ae6f2","article-title":"Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: a report of 3 cases","volume":"31","author":"Garg","year":"2012","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"10.1016\/j.modpat.2024.100629_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.pgp.0000130049.19643.f6","article-title":"Early recurrence of ovarian serous borderline tumor as high-grade carcinoma: a report of two cases","volume":"23","author":"Parker","year":"2004","journal-title":"Int J Gynecol Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2024.100629_bib10","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2559.2009.03283.x","article-title":"High-grade serous carcinoma arising in a low-grade serous carcinoma and micropapillary serous borderline tumour of the ovary in a 23-year-old woman","volume":"54","author":"Quddus","year":"2009","journal-title":"Histopathology"},{"issue":"7","key":"10.1016\/j.modpat.2024.100629_bib11","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/PAS.0b013e31802cbbe9","article-title":"The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis","volume":"31","author":"Dehari","year":"2007","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.1016\/j.modpat.2024.100629_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/his.13796","article-title":"Somatic genetic alterations in synchronous and metachronous low-grade serous tumours and high-grade carcinomas of the adnexa","volume":"74","author":"Murali","year":"2019","journal-title":"Histopathology"},{"issue":"11","key":"10.1016\/j.modpat.2024.100629_bib13","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1097\/PAS.0000000000001325","article-title":"Clinicopathologic and molecular features of paired cases of metachronous ovarian serous borderline tumor and subsequent serous carcinoma","volume":"43","author":"Chui","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100629_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/(SICI)1097-0142(19980301)82:5<893::AID-CNCR14>3.0.CO;2-W","article-title":"Toward the\u00a0development of a universal grading system for ovarian epithelial carcinoma: testing of a proposed system in a series of 461 patients with\u00a0uniform treatment and follow-up","volume":"82","author":"Shimizu","year":"1998","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.modpat.2024.100629_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/PAS.0000000000001419","article-title":"Clinicopathologic, immunohistochemical, and molecular characteristics of ovarian serous carcinoma with mixed morphologic features of high-grade and low-grade serous carcinoma","volume":"44","author":"Zarei","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2024.100629_bib16","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1097\/PAS.0b013e3181a24354","article-title":"Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis","volume":"33","author":"Ayhan","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2024.100629_bib17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41379-020-00648-y","article-title":"Characterization of TP53-wildtype tubo-ovarian high-grade serous carcinomas: rare exceptions to the binary classification of ovarian serous carcinoma","volume":"34","author":"Chui","year":"2021","journal-title":"Mod Pathol"},{"issue":"4","key":"10.1016\/j.modpat.2024.100629_bib18","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00000478-200404000-00009","article-title":"Grading ovarian serous carcinoma using a two-tier system","volume":"28","author":"Malpica","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2024.100629_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/path.5353","article-title":"Oncogenic BRAF and KRAS mutations in endosalpingiosis","volume":"250","author":"Chui","year":"2020","journal-title":"J\u00a0Pathol"},{"issue":"16","key":"10.1016\/j.modpat.2024.100629_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw520","article-title":"FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing","volume":"44","author":"Shen","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.modpat.2024.100629_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ajpath.2020.09.006","article-title":"The origin of ovarian cancer species and precancerous landscape","volume":"191","author":"Shih","year":"2021","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100629_bib22","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A\u00a0genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.modpat.2024.100629_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/PAS.0000000000000824","article-title":"Long-term behavior of serous borderline tumors subdivided into atypical proliferative tumors and noninvasive low-grade carcinomas: a population-based clinicopathologic study of 942 cases","volume":"41","author":"Vang","year":"2017","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100629_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/path.4293","article-title":"Mutational analysis of BRAF and KRAS in ovarian serous borderline (atypical proliferative) tumours and associated peritoneal implants","volume":"232","author":"Ardighieri","year":"2014","journal-title":"J\u00a0Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2024.100629_bib25","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.celrep.2019.07.001","article-title":"Integrated analysis of TP53 gene and pathway alterations in The Cancer Genome Atlas","volume":"28","author":"Donehower","year":"2019","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.modpat.2024.100629_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.4230","article-title":"Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling","volume":"231","author":"Bashashati","year":"2013","journal-title":"J\u00a0Pathol"},{"issue":"1","key":"10.1016\/j.modpat.2024.100629_bib27","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-017-00962-1","article-title":"High grade serous ovarian carcinomas originate in the fallopian tube","volume":"8","author":"Labidi-Galy","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.modpat.2024.100629_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2019.10.014","article-title":"Liquid biopsy in ovarian cancer using circulating tumor DNA and cells: Ready for prime time?","volume":"468","author":"Asante","year":"2020","journal-title":"Cancer Lett"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395224002096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395224002096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T02:38:31Z","timestamp":1767235111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395224002096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0893395224002096"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2024.100629","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Genetic Divergence of High-Grade Carcinomas Originating from Low-Grade Serous Ovarian Neoplasms","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2024.100629","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100629"}}