{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:14:25Z","timestamp":1793744065415,"version":"4.6.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.modpat.2025.100743","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T08:06:51Z","timestamp":1740470811000},"page":"100743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prostate Ductal Adenocarcinoma Revisited: Clinicopathological and Genomic Characterization Identifies Heterogenous Group of Diseases with Implications for Patient Management"],"prefix":"10.1016","volume":"38","author":[{"given":"Qi","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas M.","family":"Khanshour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Bhanvadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit K.","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-6823","authenticated-orcid":false,"given":"Rajal B.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.modpat.2025.100743_bib1","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1097\/00000478-199912000-00004","article-title":"Ductal adenocarcinoma of the prostate diagnosed on needle biopsy: correlation with clinical and radical prostatectomy findings and progression","volume":"23","author":"Brinker","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2025.100743_bib2","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/1097-0142(196710)20:10<1715::AID-CNCR2820201022>3.0.CO;2-E","article-title":"Endometrial carcinoma of proxtatic utricle (uterus masculinus)","volume":"20","author":"Melicow","year":"1967","journal-title":"Cancer"},{"key":"10.1016\/j.modpat.2025.100743_bib3","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/1097-0142(19910415)67:8<2118::AID-CNCR2820670818>3.0.CO;2-G","article-title":"Prostatic duct adenocarcinoma. Findings at radical prostatectomy","volume":"67","author":"Christensen","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.modpat.2025.100743_bib4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PAS.0000000000000530","article-title":"The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system","volume":"40","author":"Epstein","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2025.100743_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41585-021-00447-3","article-title":"Optimizing the diagnosis and management of ductal prostate cancer","volume":"18","author":"Ranasinghe","year":"2021","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.modpat.2025.100743_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/modpathol.2008.236","article-title":"TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas","volume":"22","author":"Lotan","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2025.100743_bib7","article-title":"Genomic characterization of prostatic ductal adenocarcinoma identifies a high prevalence of DNA repair gene mutations","volume":"3","author":"Schweizer","year":"2019","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.modpat.2025.100743_bib8","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/pros.24304","article-title":"Ductal and acinar components of mixed prostatic adenocarcinoma frequently have a common clonal origin","volume":"82","author":"Lindh","year":"2022","journal-title":"Prostate"},{"key":"10.1016\/j.modpat.2025.100743_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.euf.2017.12.003","article-title":"Integrative genomic analysis of coincident cancer foci implicates CTNNB1 and PTEN alterations in ductal prostate cancer","volume":"5","author":"Gillard","year":"2019","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.modpat.2025.100743_bib10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1464-410X.2009.08812.x","article-title":"Ductal adenocarcinoma of the prostate diagnosed on transurethral biopsy or resection is not always indicative of aggressive disease: implications for clinical management","volume":"105","author":"Aydin","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.modpat.2025.100743_bib11","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/s41379-022-01093-9","article-title":"Enrichment of \"cribriform\" morphologies (intraductal and cribriform adenocarcinoma) and genomic alterations in radiorecurrent prostate cancer","volume":"35","author":"Shah","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2025.100743_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/PAS.0000000000000289","article-title":"Metastatic prostate adenocarcinoma to the penis: a series of 29 cases with a predilection for ductal adenocarcinoma","volume":"39","author":"Ellis","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2025.100743_bib13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/his.12382","article-title":"Diagnostic criteria for ductal adenocarcinoma of the prostate: interobserver variability among 20 expert uropathologists","volume":"65","author":"Seipel","year":"2014","journal-title":"Histopathology"},{"key":"10.1016\/j.modpat.2025.100743_bib14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1309\/PCND-T3N0-5K01-D454","article-title":"The morphologic spectrum of metastatic prostatic adenocarcinoma to the lung: special emphasis on histologic features overlapping with other pulmonary neoplasms","volume":"117","author":"Copeland","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.modpat.2025.100743_bib15","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2015.05.001","article-title":"Integrative clinical genomics of advanced prostate cancer","volume":"161","author":"Robinson","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.modpat.2025.100743_bib16","article-title":"Integrative molecular analysis of patients with advanced and metastatic cancer","volume":"3","author":"Sailer","year":"2019","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.modpat.2025.100743_bib17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.eururo.2020.12.040","article-title":"The mutational landscape of metastatic castration-sensitive prostate cancer: the spectrum theory revisited","volume":"80","author":"Deek","year":"2021","journal-title":"Eur Urol"},{"key":"10.1016\/j.modpat.2025.100743_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13671","article-title":"Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories","volume":"8","author":"Taylor","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.modpat.2025.100743_bib19","first-page":"808","article-title":"PARP inhibitors in prostate cancer: practical guidance for busy clinicians","volume":"18","author":"VanderWeele","year":"2020","journal-title":"Clin Adv Hematol Oncol"},{"key":"10.1016\/j.modpat.2025.100743_bib20","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.1002\/cam4.5573","article-title":"Genomic analysis of aggressive ductal adenocarcinoma of the prostate","volume":"12","author":"Kobayashi","year":"2023","journal-title":"Cancer Med"},{"key":"10.1016\/j.modpat.2025.100743_bib21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1158\/2159-8290.CD-17-0867","article-title":"Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth","volume":"8","author":"Pearson","year":"2018","journal-title":"Cancer Discov"},{"key":"10.1016\/j.modpat.2025.100743_bib22","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/modpathol.2009.79","article-title":"Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma","volume":"22","author":"Han","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2025.100743_bib23","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41391-019-0145-2","article-title":"Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer","volume":"22","author":"Krook","year":"2019","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.modpat.2025.100743_bib24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00535-020-01735-2","article-title":"Molecular detection and clinicopathological characteristics of advanced\/recurrent biliary tract carcinomas harboring the FGFR2 rearrangements: a prospective observational study (PRELUDE Study)","volume":"56","author":"Maruki","year":"2021","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.modpat.2025.100743_bib25","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1053\/j.gastro.2019.02.037","article-title":"Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or used as biomarkers","volume":"156","author":"Singhi","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.modpat.2025.100743_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eururo.2018.11.045","article-title":"Compound genomic alterations of TP53, PTEN, and RB1 tumor suppressors in localized and metastatic prostate cancer","volume":"76","author":"Hamid","year":"2019","journal-title":"Eur Urol"},{"key":"10.1016\/j.modpat.2025.100743_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107669","article-title":"Combined TP53 and RB1 loss promotes prostate cancer resistance to a spectrum of therapeutics and confers vulnerability to replication stress","volume":"31","author":"Nyquist","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.modpat.2025.100743_bib28","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1242\/dev.01917","article-title":"Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation","volume":"132","author":"Gao","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.modpat.2025.100743_bib29","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0022-5347(17)61430-7","article-title":"Endometrial carcinoma of uterus masculinus (prostatic utricle). Report of 6 cases","volume":"106","author":"Melicow","year":"1971","journal-title":"J Urol"},{"key":"10.1016\/j.modpat.2025.100743_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/1097-0142(197308)32:2<402::AID-CNCR2820320218>3.0.CO;2-Q","article-title":"Prostatic adenocarcinoma of ductal origin","volume":"32","author":"Dube","year":"1973","journal-title":"Cancer"},{"key":"10.1016\/j.modpat.2025.100743_bib31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5858\/arpa.2020-0015-RA","article-title":"The 2019 Genitourinary Pathology Society (GUPS) white paper on contemporary grading of prostate cancer","volume":"145","author":"Epstein","year":"2021","journal-title":"Arch Pathol Lab Med"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225000390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225000390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T11:36:09Z","timestamp":1750246569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395225000390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0893395225000390"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100743","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prostate Ductal Adenocarcinoma Revisited: Clinicopathological and Genomic Characterization Identifies Heterogenous Group of Diseases with Implications for Patient Management","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100743"}}