{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:04:05Z","timestamp":1779782645075,"version":"3.53.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100016345","name":"Renmin Hospital of Wuhan University","doi-asserted-by":"publisher","award":["JCRCWL-2022-004"],"award-info":[{"award-number":["JCRCWL-2022-004"]}],"id":[{"id":"10.13039\/501100016345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018570","name":"Special Project of Central Government for Local Science and Technology Development of Hubei Province","doi-asserted-by":"publisher","award":["2020ZYYD006"],"award-info":[{"award-number":["2020ZYYD006"]}],"id":[{"id":"10.13039\/501100018570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.modpat.2025.100814","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T19:28:43Z","timestamp":1749756523000},"page":"100814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Cellular Patterns Predicting Lymph Node Status Helps Personalized Management of Stage T1 Esophageal Squamous Cell Carcinoma"],"prefix":"10.1016","volume":"38","author":[{"given":"Hangjia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangli","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbiao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyutian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2544-6266","authenticated-orcid":false,"given":"Yongshun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.modpat.2025.100814_bib1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12943-023-01839-2","article-title":"Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma","volume":"22","author":"An","year":"2023","journal-title":"Mol Cancer"},{"issue":"8","key":"10.1016\/j.modpat.2025.100814_bib2","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.14309\/ajg.0000000000002257","article-title":"Radiotherapy improves survival of patients with lymphovascular invasion in pT1b esophageal squamous cell cancer after endoscopic submucosal dissection","volume":"118","author":"Yang","year":"2023","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.modpat.2025.100814_bib3","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1097\/SLA.0000000000003450","article-title":"A clinical nomogram for predicting node-positive disease in esophageal cancer","volume":"273","author":"Semenkovich","year":"2021","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.modpat.2025.100814_bib4","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/SLA.0000000000001557","article-title":"The prevalence of overall and initial lymph node metastases in clinical T1N0 thoracic esophageal cancer: from the results of JCOG0502, a prospective multicenter study","volume":"264","author":"Akutsu","year":"2016","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.modpat.2025.100814_bib5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/bjs.11487","article-title":"Minimally invasive oesophagectomy with extended lymph node dissection and thoracic duct resection for early-stage oesophageal squamous cell carcinoma","volume":"107","author":"Matsuda","year":"2020","journal-title":"Br J Surg"},{"issue":"1","key":"10.1016\/j.modpat.2025.100814_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cgh.2018.04.038","article-title":"Outcomes of endoscopic submucosal dissection vs esophagectomy for T1 esophageal squamous cell carcinoma in a real-world cohort","volume":"17","author":"Zhang","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.modpat.2025.100814_bib7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1056\/NEJMoa1805101","article-title":"Hybrid minimally invasive esophagectomy for esophageal cancer","volume":"380","author":"Mariette","year":"2019","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.modpat.2025.100814_bib8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/bjs.11128","article-title":"Meta-analysis of risk factors and complications associated with atrial fibrillation after oesophagectomy","volume":"106","author":"Schizas","year":"2019","journal-title":"Br J Surg"},{"issue":"3","key":"10.1016\/j.modpat.2025.100814_bib9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/SLA.0000000000005093","article-title":"Esophagectomy complications impact long-term survival: a National Cancer Database analysis","volume":"277","author":"Sachidananda","year":"2023","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.modpat.2025.100814_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/bjs.8973","article-title":"Impact of postoperative morbidity on long-term survival after oesophagectomy","volume":"100","author":"Hii","year":"2013","journal-title":"Br J Surg"},{"issue":"6","key":"10.1016\/j.modpat.2025.100814_bib11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2023.02.021","article-title":"Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes","volume":"186","author":"Rahim","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.modpat.2025.100814_bib12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/JS9.0000000000000774","article-title":"Impact of lymphadenectomy extent on immunotherapy efficacy in postresectional recurred non-small cell lung cancer: a multi-institutional retrospective cohort study","volume":"110","author":"Deng","year":"2024","journal-title":"Int J Surg"},{"issue":"1","key":"10.1016\/j.modpat.2025.100814_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1155","article-title":"Multiplex immunofluorescence and single-cell transcriptomic profiling reveal the spatial cell interaction networks in the non-small cell lung cancer microenvironment","volume":"13","author":"Peng","year":"2023","journal-title":"Clin Transl Med"},{"issue":"2","key":"10.1016\/j.modpat.2025.100814_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S1470-2045(23)00560-0","article-title":"Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II-III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis","volume":"25","author":"Frei","year":"2024","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.modpat.2025.100814_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40880-019-0427-z","article-title":"The immune landscape of esophageal cancer","volume":"39","author":"Huang","year":"2019","journal-title":"Cancer Commun (Lond)"},{"key":"10.1016\/j.modpat.2025.100814_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.48","article-title":"Oesophageal cancer","volume":"3","author":"Smyth","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.modpat.2025.100814_bib17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.modpat.2025.100814_bib18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1055\/a-2245-7235","article-title":"Endoscopic submucosal dissection for early esophageal squamous cell carcinoma: long-term results from a Western cohort","volume":"56","author":"Beaufort","year":"2024","journal-title":"Endoscopy"},{"issue":"7","key":"10.1016\/j.modpat.2025.100814_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1001\/jamasurg.2021.1555","article-title":"Intrathoracic vs cervical anastomosis after totally or hybrid minimally invasive esophagectomy for esophageal cancer: a randomized clinical trial","volume":"156","author":"van Workum","year":"2021","journal-title":"JAMA Surg"},{"issue":"1","key":"10.1016\/j.modpat.2025.100814_bib20","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1097\/SLA.0000000000003829","article-title":"Assessment of health related quality of life and digestive symptoms in long-term, disease free survivors after esophagectomy","volume":"275","author":"Boshier","year":"2022","journal-title":"Ann Surg"},{"issue":"9","key":"10.1016\/j.modpat.2025.100814_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41581-023-00733-w","article-title":"Regulatory T cells in autoimmune kidney diseases and transplantation","volume":"19","author":"Mikami","year":"2023","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"10.1016\/j.modpat.2025.100814_bib22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41571-019-0175-7","article-title":"Regulatory T cells in cancer immunosuppression\u2014implications for anticancer therapy","volume":"16","author":"Togashi","year":"2019","journal-title":"Nat Rev Clin Oncol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:31:50Z","timestamp":1779780710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395225001103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0893395225001103"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100814","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune Cellular Patterns Predicting Lymph Node Status Helps Personalized Management of Stage T1 Esophageal Squamous Cell Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100814"}}