{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:33:27Z","timestamp":1787924007329,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.modpat.2025.100852","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:47:56Z","timestamp":1753426076000},"page":"100852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Magnetic Resonance Imaging (MRI)\u2013Adapted Prostate Cancer Risk Tool Incorporating Cribriform and Intraductal Carcinoma"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1363-2127","authenticated-orcid":false,"given":"Ngoc-Nhu Jennifer","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lajkosz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Bernardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyi Bellinda","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hollemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Kroon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Fleshner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert J.L.H.","family":"van Leenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Iczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodorus H.","family":"van der Kwast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle R.","family":"Downes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.modpat.2025.100852_bib1","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1097\/01.ju.0000158155.33890.e7","article-title":"The University of California, San Francisco Cancer of the Prostate Risk Assessment score: a straightforward and reliable preoperative predictor of disease recurrence after radical prostatectomy","volume":"173","author":"Cooperberg","year":"2005","journal-title":"J Urol"},{"issue":"8","key":"10.1016\/j.modpat.2025.100852_bib2","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1097\/PAS.0000000000001497","article-title":"The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma","volume":"44","author":"van Leenders","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"10.1016\/j.modpat.2025.100852_bib3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1056\/NEJMoa1910038","article-title":"MRI-targeted, systematic, and combined biopsy for prostate cancer diagnosis","volume":"382","author":"Ahdoot","year":"2020","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.modpat.2025.100852_bib4","first-page":"E227","article-title":"Target prostate biopsies: how best to report in synoptic format?","volume":"16","author":"Downes","year":"2022","journal-title":"Can Urol Assoc J"},{"issue":"10","key":"10.1016\/j.modpat.2025.100852_bib5","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jclinpath-2018-205093","article-title":"Contemporary prostate biopsy reporting: insights from a survey of clinicians' use of pathology data","volume":"71","author":"Varma","year":"2018","journal-title":"J Clin Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2025.100852_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/1078-1439(95)00066-6","article-title":"Interobserver consistency of digital rectal examination in clinical staging of localized prostatic carcinoma","volume":"1","author":"Angulo","year":"1995","journal-title":"Urol Oncol"},{"issue":"740","key":"10.1016\/j.modpat.2025.100852_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3399\/bjgp24X736677","article-title":"Is the digital rectal exam any good as a prostate cancer screening test?","volume":"74","author":"Kirby","year":"2024","journal-title":"Br J Gen Pract"},{"issue":"8","key":"10.1016\/j.modpat.2025.100852_bib8","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.humpath.2014.03.011","article-title":"Clinicopathological analysis of intraductal proliferative lesions of prostate: intraductal carcinoma of prostate, high-grade prostatic intraepithelial neoplasia, and atypical cribriform lesion","volume":"45","author":"Miyai","year":"2014","journal-title":"Hum Pathol"},{"issue":"6","key":"10.1016\/j.modpat.2025.100852_bib9","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/modpathol.2016.49","article-title":"Disease-specific survival of patients with invasive cribriform and intraductal prostate cancer at diagnostic biopsy","volume":"29","author":"Kweldam","year":"2016","journal-title":"Mod Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2025.100852_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/modpathol.2017.29","article-title":"Presence of invasive cribriform or intraductal growth at biopsy outperforms percentage grade 4 in predicting outcome of Gleason score 3+4=7 prostate cancer","volume":"30","author":"Kweldam","year":"2017","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2025.100852_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.humpath.2020.02.004","article-title":"Gleason pattern 4 with cribriform morphology on biopsy is associated with adverse clinicopathological findings in a prospective radical prostatectomy cohort","volume":"98","author":"Haffner","year":"2020","journal-title":"Hum Pathol"},{"key":"10.1016\/j.modpat.2025.100852_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.humpath.2023.01.008","article-title":"Cribriform pattern and intraductal carcinoma of the prostate can have a clinicopathological impact, regardless of their percentage and\/or number of cores","volume":"135","author":"Okubo","year":"2023","journal-title":"Hum Pathol"},{"issue":"7","key":"10.1016\/j.modpat.2025.100852_bib13","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/his.14658","article-title":"Large and small cribriform architecture have similar adverse clinical outcome on prostate cancer biopsies","volume":"80","author":"Rijstenberg","year":"2022","journal-title":"Histopathology"},{"issue":"11","key":"10.1016\/j.modpat.2025.100852_bib14","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/s41379-022-01111-w","article-title":"Impact of cribriform pattern 4 and intraductal prostatic carcinoma on National Comprehensive Cancer Network (NCCN) and Cancer of Prostate Risk Assessment (CAPRA) patient stratification","volume":"35","author":"Yu","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2025.100852_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clgc.2023.07.013","article-title":"Addition of cribriform and intraductal carcinoma presence to prostate biopsy reporting strengthens pretreatment risk stratification using CAPRA and NCCN tools","volume":"22","author":"Downes","year":"2024","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.modpat.2025.100852_bib16","article-title":"Addition of cribriform pattern 4 and intraductal prostatic carcinoma into the CAPRA-S tool improves post-radical prostatectomy patient stratification in a multi-institutional cohort","volume":"20","author":"Nguyen","year":"2024","journal-title":"J Clin Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2025.100852_bib17","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1097\/PAS.0000000000001728","article-title":"ISUP consensus definition of cribriform pattern prostate cancer","volume":"45","author":"van der Kwast","year":"2021","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1016\/j.modpat.2025.100852_bib18","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/modpathol.3800702","article-title":"Intraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance","volume":"19","author":"Guo","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2025.100852_bib19","series-title":"WHO Classification of Tumours Editorial Board. Urinary and Male Genital Tumours [Internet]","article-title":"Intraductal carcinoma of the prostate","author":"Zhou","year":"2022"},{"issue":"2","key":"10.1016\/j.modpat.2025.100852_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/JU.0000000000003486","article-title":"Stability of prognostic estimation using the CAPRA score incorporating imaging-based vs physical exam-based staging","volume":"210","author":"Chang","year":"2023","journal-title":"J Urol"},{"issue":"2","key":"10.1016\/j.modpat.2025.100852_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.eururo.2019.09.027","article-title":"Predicting prostate cancer death with different pretreatment risk stratification tools: a head-to-head comparison in a nationwide cohort study","volume":"77","author":"Zelic","year":"2020","journal-title":"Eur Urol"},{"issue":"1","key":"10.1016\/j.modpat.2025.100852_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.juro.2018.01.081","article-title":"Role of magnetic resonance imaging targeted biopsy in detection of prostate cancer harboring adverse pathological features of intraductal carcinoma and invasive cribriform carcinoma","volume":"200","author":"Prendeville","year":"2018","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.modpat.2025.100852_bib23","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.231948","article-title":"Comparison of multiparametric MRI-targeted and systematic biopsies for detection of cribriform and intraductal carcinoma prostate cancer","volume":"312","author":"Ghai","year":"2024","journal-title":"Radiology"},{"key":"10.1016\/j.modpat.2025.100852_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.humpath.2018.03.005","article-title":"Defining the optimal method for reporting prostate cancer grade and tumor extent on magnetic resonance\/ultrasound fusion-targeted biopsies","volume":"76","author":"Gordetsky","year":"2018","journal-title":"Hum Pathol"},{"issue":"4","key":"10.1016\/j.modpat.2025.100852_bib25","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.euf.2021.04.016","article-title":"Computationally derived cribriform area index from prostate cancer hematoxylin and eosin images is associated with biochemical recurrence following radical prostatectomy and is most prognostic in Gleason grade group 2","volume":"7","author":"Leo","year":"2021","journal-title":"Eur Urol Focus"},{"issue":"5","key":"10.1016\/j.modpat.2025.100852_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.7086","article-title":"Significance of the cribriform morphology area ratio for biochemical recurrence in Gleason score 4 + 4 prostate cancer patients following robot-assisted radical prostatectomy","volume":"13","author":"Shimodaira","year":"2024","journal-title":"Cancer Med"},{"issue":"3","key":"10.1016\/j.modpat.2025.100852_bib27","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/his.13747","article-title":"Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set","volume":"74","author":"Masoomian","year":"2019","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.modpat.2025.100852_bib28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/his.13893","article-title":"Concordance of cribriform architecture in matched prostate cancer biopsy and radical prostatectomy specimens","volume":"75","author":"Hollemans","year":"2019","journal-title":"Histopathology"},{"issue":"10","key":"10.1016\/j.modpat.2025.100852_bib29","doi-asserted-by":"crossref","first-page":"452.e1","DOI":"10.1016\/j.urolonc.2022.07.012","article-title":"Sensitivity of multiparametric MRI and targeted biopsy for detection of adverse pathologies (cribriform gleason pattern 4 and intraductal carcinoma): correlation of detected and missed prostate cancer foci with whole mount histopathology","volume":"40","author":"Cai","year":"2022","journal-title":"Urol Oncol"},{"issue":"1","key":"10.1016\/j.modpat.2025.100852_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.euf.2023.08.010","article-title":"Limitations of prostate biopsy in detection of cribriform and intraductal prostate cancer","volume":"10","author":"Bernardino","year":"2024","journal-title":"Eur Urol Focus"}],"updated-by":[{"DOI":"10.1016\/j.modpat.2025.100893","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000}}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T07:17:57Z","timestamp":1765955877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395225001498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0893395225001498"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100852","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetic Resonance Imaging (MRI)\u2013Adapted Prostate Cancer Risk Tool Incorporating Cribriform and Intraductal Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100852"}}