{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:44:19Z","timestamp":1793043859991,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["5\\u00D71000"],"award-info":[{"award-number":["5\\u00D71000"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["20229B28P"],"award-info":[{"award-number":["20229B28P"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["21267"],"award-info":[{"award-number":["21267"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.modpat.2025.100854","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T23:25:24Z","timestamp":1753745124000},"page":"100854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Prognostic Correlates of the Reticulin-Collagen-Osteosclerosis Score in Primary Myelofibrosis"],"prefix":"10.1016","volume":"38","author":[{"given":"Raffaella","family":"Santi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-5462","authenticated-orcid":false,"given":"Giacomo","family":"Coltro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Atanasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Cicogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe G.","family":"Loscocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Capecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Boldrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pescia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-0730","authenticated-orcid":false,"given":"Alessandro M.","family":"Vannucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Gianelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.modpat.2025.100854_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ajh.26857","article-title":"Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Tefferi","year":"2023","journal-title":"Am J Hematol"},{"issue":"7","key":"10.1016\/j.modpat.2025.100854_bib2","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.modpat.2025.100854_bib3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ajh.26751","article-title":"The international consensus classification of myeloid neoplasms and acute Leukemias: myeloproliferative neoplasms","volume":"98","author":"Thiele","year":"2023","journal-title":"Am J Hematol"},{"issue":"2","key":"10.1016\/j.modpat.2025.100854_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cytogfr.2013.01.004","article-title":"The role of cytokines in the initiation and progression of myelofibrosis","volume":"24","author":"Hasselbalch","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"10.1016\/j.modpat.2025.100854_bib5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/bjh.16576","article-title":"Myelofibrosis biology and contemporary management","volume":"191","author":"Gangat","year":"2020","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.modpat.2025.100854_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.cancergen.2013.02.002","article-title":"Myelofibrosis in Philadelphia chromosome-negative myeloproliferative neoplasms is associated with aberrant karyotypes","volume":"206","author":"Hauck","year":"2013","journal-title":"Cancer Genet"},{"issue":"9","key":"10.1016\/j.modpat.2025.100854_bib7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/ajh.24442","article-title":"Prognostic impact of bone marrow fibrosis in primary myelofibrosis. A study of the AGIMM group on 490 patients","volume":"91","author":"Guglielmelli","year":"2016","journal-title":"Am J Hematol"},{"issue":"24","key":"10.1016\/j.modpat.2025.100854_bib8","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1182\/blood-2017-01-761999","article-title":"Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis","volume":"129","author":"Guglielmelli","year":"2017","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.modpat.2025.100854_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hon.2808","article-title":"Cytogenetic study in primary myelofibrosis at diagnosis: clinical and histological association and impact on survival according to WHO 2017 classification in an Italian multicenter series","volume":"39","author":"Iurlo","year":"2021","journal-title":"Hematol Oncol"},{"issue":"4","key":"10.1016\/j.modpat.2025.100854_bib10","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1200\/JCO.2017.76.4886","article-title":"MIPSS70: mutation-enhanced international prognostic score system for transplantation-age patients with primary myelofibrosis","volume":"36","author":"Guglielmelli","year":"2017","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.modpat.2025.100854_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41375-022-01773-0","article-title":"Continuous indexing of fibrosis (CIF): improving the assessment and classification of MPN patients","volume":"37","author":"Ryou","year":"2023","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.modpat.2025.100854_bib12","first-page":"1128","article-title":"European consensus on grading bone marrow fibrosis and assessment of cellularity","volume":"90","author":"Thiele","year":"2005","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.modpat.2025.100854_bib13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/his.13309","article-title":"Prognostic significance of a comprehensive histological evaluation of reticulin fibrosis, collagen deposition and osteosclerosis in primary myelofibrosis patients","volume":"71","author":"Gianelli","year":"2017","journal-title":"Histopathology"},{"issue":"6","key":"10.1016\/j.modpat.2025.100854_bib14","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/his.12871","article-title":"Problems and pitfalls in grading of bone marrow fibrosis, collagen deposition and osteosclerosis\u2014a consensus-based study","volume":"68","author":"Kvasnicka","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.modpat.2025.100854_bib15","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia","author":"Arber","year":"2016","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.modpat.2025.100854_bib16","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.modpat.2025.100854_bib17","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1309\/FP0N3LC8MBJUFFA6","article-title":"VEGF expression correlates with microvessel density in Philadelphia chromosome-negative chronic myeloproliferative disorders","volume":"128","author":"Gianelli","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.modpat.2025.100854_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00277-016-2890-9","article-title":"Bone marrow microvessel density and plasma angiogenic factors in myeloproliferative neoplasms: clinicopathological and molecular correlations","volume":"96","author":"Lekovic","year":"2017","journal-title":"Ann Hematol"},{"issue":"30","key":"10.1016\/j.modpat.2025.100854_bib19","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1002\/sim.5958","article-title":"Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks","volume":"32","author":"Blanche","year":"2013","journal-title":"Stat Med"},{"issue":"11","key":"10.1016\/j.modpat.2025.100854_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v050.i11","article-title":"Evaluating random forests for survival analysis using prediction error curves","volume":"50","author":"Mogensen","year":"2012","journal-title":"J Stat Softw"},{"issue":"5","key":"10.1016\/j.modpat.2025.100854_bib21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41375-018-0018-z","article-title":"Revised cytogenetic risk stratification in primary myelofibrosis: analysis based on 1002 informative patients","volume":"32","author":"Tefferi","year":"2018","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.modpat.2025.100854_bib22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41408-022-00713-6","article-title":"Differential prognostic impact of cytopenic phenotype in prefibrotic vs overt primary myelofibrosis","volume":"12","author":"Coltro","year":"2022","journal-title":"Blood Cancer J"},{"issue":"7","key":"10.1016\/j.modpat.2025.100854_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.clml.2020.01.008","article-title":"The myelodepletive phenotype in myelofibrosis: clinical relevance and therapeutic implication","volume":"20","author":"Marcellino","year":"2020","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"1","key":"10.1016\/j.modpat.2025.100854_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/2040620710394474","article-title":"JAK2 allele burden in the myeloproliferative neoplasms: effects on phenotype, prognosis and change with treatment","volume":"2","author":"Vannucchi","year":"2011","journal-title":"Ther Adv Hematol"},{"issue":"5","key":"10.1016\/j.modpat.2025.100854_bib25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3324\/haematol.2021.280320","article-title":"ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis-mediated neoplastic fibrocyte generation in myeloproliferative neoplasms","volume":"108","author":"Shi","year":"2023","journal-title":"Haematologica"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:30:30Z","timestamp":1779780630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395225001516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0893395225001516"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100854","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Prognostic Correlates of the Reticulin-Collagen-Osteosclerosis Score in Primary Myelofibrosis","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}],"article-number":"100854"}}