{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:54:25Z","timestamp":1778950465401,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017507","name":"Department of Laboratory Medicine and Pathology, University of Washington","doi-asserted-by":"publisher","award":["9362"],"award-info":[{"award-number":["9362"]}],"id":[{"id":"10.13039\/100017507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005895","name":"Fred Hutchinson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.modpat.2025.100879","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T15:33:51Z","timestamp":1756740831000},"page":"100879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Digital Spatial Profiling Demonstrates Differences Between Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans and Its Conventional Counterparts"],"prefix":"10.1016","volume":"38","author":[{"given":"Nicholas","family":"Frazzette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvrajit","family":"Maji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ata S.","family":"Moshiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Ricciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreeram","family":"Akilesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-6459","authenticated-orcid":false,"given":"Jose G.","family":"Mantilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.modpat.2025.100879_bib1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00000478-199805000-00009","article-title":"Fibrosarcomatous (\u201chigh-grade\u201d) dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance","volume":"22","author":"Mentzel","year":"1998","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.1016\/j.modpat.2025.100879_bib2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/DAD.0b013e3182014631","article-title":"Dermatofibrosarcoma protuberans with unusual sarcomatous transformation: a series of 4 cases with molecular confirmation","volume":"33","author":"Swaby","year":"2011","journal-title":"Am J Dermatopathol"},{"issue":"1","key":"10.1016\/j.modpat.2025.100879_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13023-021-01698-4","article-title":"Clinicopathological features of fibrosarcomatous dermatofibrosarcoma protuberans and the construction of a back-propagation neural network recognition model","volume":"16","author":"Li","year":"2021","journal-title":"Orphanet J Rare Dis"},{"issue":"3","key":"10.1016\/j.modpat.2025.100879_bib4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jaad.2010.06.020","article-title":"Dermatofibrosarcoma protuberans: a clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors","volume":"65","author":"Llombart","year":"2011","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.modpat.2025.100879_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-74556-5","article-title":"PRAME expression in fibrosarcomatous dermatofibrosarcoma protuberans","volume":"14","author":"Ichiki","year":"2024","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.modpat.2025.100879_bib6","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3390\/jcm9061752","article-title":"Dermatofibrosarcoma protuberans: update on the diagnosis and treatment","volume":"9","author":"Hao","year":"2020","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.modpat.2025.100879_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00428-022-03297-5","article-title":"Coamplification of 12q15 and 12p13 and homozygous CDKN2A\/2B deletion: synergistic role of fibrosarcomatous transformation in dermatofibrosarcoma protuberans with a cryptic COL1A1-PDGFB fusion","volume":"481","author":"Lu","year":"2022","journal-title":"Virchows Arch"},{"issue":"9","key":"10.1016\/j.modpat.2025.100879_bib8","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1158\/1541-7786.MCR-16-0068","article-title":"Evolution of dermatofibrosarcoma protuberans to DFSP-derived fibrosarcoma: an event marked by epithelial-mesenchymal transition-like process and 22q loss","volume":"14","author":"Stacchiotti","year":"2016","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.modpat.2025.100879_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cancergen.2019.12.001","article-title":"Genomic and transcriptomic features of dermatofibrosarcoma protuberans: unusual chromosomal origin of the COL1A1-PDGFB fusion gene and synergistic effects of amplified regions in tumor development","volume":"241","author":"K\u00f6ster","year":"2020","journal-title":"Cancer Genet"},{"key":"10.1016\/j.modpat.2025.100879_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2025.104190","article-title":"Rigor and reproducibility of spatial transcriptomics performed on clinically sourced human tissues","volume":"105","author":"Smith","year":"2025","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.modpat.2025.100879_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000538344","article-title":"Challenges and opportunities for the clinical translation of spatial transcriptomics technologies","volume":"4","author":"Smith","year":"2024","journal-title":"Glomerular Dis"},{"issue":"17","key":"10.1016\/j.modpat.2025.100879_bib12","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.3390\/cancers13174456","article-title":"Best practices for spatial profiling for breast cancer research with the GeoMx(\u00ae) Digital Spatial Profiler","volume":"13","author":"Bergholtz","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.modpat.2025.100879_bib13","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3390\/ijms25031582","article-title":"PRAME updated: diagnostic, prognostic, and therapeutic role in skin cancer","volume":"25","author":"Cassalia","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.modpat.2025.100879_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/DAD.0000000000002932","article-title":"Clinicopathologic features of PRAME-positive common melanocytic nevi: a case-control study","volume":"47","author":"Knittel","year":"2025","journal-title":"Am J Dermatopathol"},{"issue":"11","key":"10.1016\/j.modpat.2025.100879_bib15","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1097\/PAS.0000000000001134","article-title":"PRAME expression in melanocytic tumors","volume":"42","author":"Lezcano","year":"2018","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2025.100879_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00428-023-03606-6","article-title":"PRAME immunohistochemistry in soft tissue tumors and mimics: a study of 350 cases highlighting its imperfect specificity but potentially useful diagnostic applications","volume":"483","author":"Cammareri","year":"2023","journal-title":"Virchows Arch"},{"issue":"12","key":"10.1016\/j.modpat.2025.100879_bib17","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/cup.13812","article-title":"Diffuse PRAME expression is highly specific for malignant melanoma in the distinction from clear cell sarcoma","volume":"47","author":"Raghavan","year":"2020","journal-title":"J Cutan Pathol"},{"issue":"7","key":"10.1016\/j.modpat.2025.100879_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70750","article-title":"Expression of cancer-testis antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in bone and soft tissue sarcomas: the experience from a single center in China","volume":"14","author":"Chen","year":"2025","journal-title":"Cancer Med"},{"issue":"11","key":"10.1016\/j.modpat.2025.100879_bib19","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1097\/PAS.0000000000001944","article-title":"PRAME expression in cancer. A systematic immunohistochemical study of >5800 epithelial and nonepithelial tumors","volume":"46","author":"Kaczorowski","year":"2022","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"10.1016\/j.modpat.2025.100879_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70020","article-title":"NY-ESO-1 antigen: a promising frontier in cancer immunotherapy","volume":"14","author":"Alsalloum","year":"2024","journal-title":"Clin Transl Med"},{"issue":"2","key":"10.1016\/j.modpat.2025.100879_bib21","first-page":"1268","article-title":"NY-ESO-1 as a diagnostic and prognostic marker for myxoid liposarcoma","volume":"14","author":"Jo","year":"2022","journal-title":"Am J Transl Res"},{"issue":"9","key":"10.1016\/j.modpat.2025.100879_bib22","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/modpathol.2013.65","article-title":"NY-ESO-1 is a sensitive and specific immunohistochemical marker for myxoid and round cell liposarcomas among related mesenchymal myxoid neoplasms","volume":"26","author":"Hemminger","year":"2013","journal-title":"Mod Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2025.100879_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2024.103645","article-title":"Investigating the prognostic impact of NY-ESO-1 expression and HLA subtypes in metastatic synovial sarcoma","volume":"9","author":"Dufresne","year":"2024","journal-title":"ESMO Open"},{"issue":"2","key":"10.1016\/j.modpat.2025.100879_bib24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00428-024-03846-0","article-title":"Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study","volume":"485","author":"Forchhammer","year":"2024","journal-title":"Virchows Arch"},{"issue":"6","key":"10.1016\/j.modpat.2025.100879_bib25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/modpathol.2012.31","article-title":"NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis","volume":"25","author":"Lai","year":"2012","journal-title":"Mod Pathol"},{"issue":"23","key":"10.1016\/j.modpat.2025.100879_bib26","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1158\/1078-0432.CCR-12-2189","article-title":"Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients","volume":"18","author":"Sabbatini","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"8","key":"10.1016\/j.modpat.2025.100879_bib27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/CJI.0000000000000183","article-title":"First-in-human treatment with a dendritic cell-targeting lentiviral vector-expressing NY-ESO-1, LV305, induces deep, durable response in refractory metastatic synovial sarcoma patient","volume":"40","author":"Pollack","year":"2017","journal-title":"J Immunother"},{"issue":"15","key":"10.1016\/j.modpat.2025.100879_bib28","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1073\/pnas.1117208109","article-title":"Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients","volume":"109","author":"Odunsi","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"232","key":"10.1016\/j.modpat.2025.100879_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008068","article-title":"Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205","volume":"6","author":"Dhodapkar","year":"2014","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.modpat.2025.100879_bib30","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1078-0432.CCR-14-2708","article-title":"A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response","volume":"21","author":"Robbins","year":"2015","journal-title":"Clin Cancer Res"},{"issue":"24","key":"10.1016\/j.modpat.2025.100879_bib31","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1158\/1078-0432.CCR-23-1456","article-title":"Safety and efficacy of NY-ESO-1 antigen-specific T-cell receptor gene-transduced T lymphocytes in patients with synovial sarcoma: a phase I\/II clinical trial","volume":"29","author":"Kawai","year":"2023","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.modpat.2025.100879_bib32","article-title":"Phase 1 study of IMCnyeso, a T cell receptor bispecific ImmTAC targeting NY-ESO-1-expressing malignancies","volume":"6","author":"Lopez","year":"2025","journal-title":"Cell Rep Med"},{"issue":"2","key":"10.1016\/j.modpat.2025.100879_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1365-2230.1999.00431.x","article-title":"Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders","volume":"24","author":"Thewes","year":"1999","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.modpat.2025.100879_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111899","article-title":"The paradoxical role of matrix metalloproteinase-11 in cancer","volume":"141","author":"Ma","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.modpat.2025.100879_bib35","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12967-023-04052-3","article-title":"Identification of the MMP family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma","volume":"21","author":"Liu","year":"2023","journal-title":"J Transl Med"},{"issue":"3","key":"10.1016\/j.modpat.2025.100879_bib36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/cas.16418","article-title":"Cancer-associated fibroblast-derived MMP11 promotes tumor progression in pancreatic cancer","volume":"116","author":"Wang","year":"2025","journal-title":"Cancer Sci"},{"issue":"1","key":"10.1016\/j.modpat.2025.100879_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13046-025-03299-6","article-title":"Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-\u03b21 signaling mechanism","volume":"44","author":"Gorodetska","year":"2025","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.modpat.2025.100879_bib38","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.jid.2024.10.612","article-title":"The influence of melanoma extracellular vesicles on benign melanocytes: a role for PRAME in modulation of the tumor microenvironment","volume":"145","author":"Liu","year":"2025","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.modpat.2025.100879_bib39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2133.2007.08033.x","article-title":"Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34","volume":"157","author":"Kim","year":"2007","journal-title":"Br J Dermatol"},{"issue":"10","key":"10.1016\/j.modpat.2025.100879_bib40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.kjms.2012.04.017","article-title":"Expression of MMP-2, MMP-9 and MMP-11 in dermatofibroma and dermatofibrosarcoma protuberans","volume":"28","author":"Chen","year":"2012","journal-title":"Kaohsiung J Med Sci"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225001772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:00:13Z","timestamp":1772863213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395225001772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0893395225001772"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100879","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Digital Spatial Profiling Demonstrates Differences Between Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans and Its Conventional Counterparts","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100879","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100879"}}