{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:44:08Z","timestamp":1790167448083,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.modpat.2025.100953","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:25:39Z","timestamp":1765931139000},"page":"100953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["MEG3 Promoter Methylation and F11 Receptor (F11R) Overexpression Define a High-Risk Subtype of Diabetic Pancreatic Cancer"],"prefix":"10.1016","volume":"39","author":[{"given":"Keisuke","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-582X","authenticated-orcid":false,"given":"Hiroki","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yota","family":"Tatara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Itaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanae","family":"Kushibiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ryuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidefumi","family":"Ruike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keinosuke","family":"Ishido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Hakamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.modpat.2025.100953_bib1","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"10.1016\/j.modpat.2025.100953_bib2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"19","key":"10.1016\/j.modpat.2025.100953_bib4","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N Engl J Med"},{"issue":"17","key":"10.1016\/j.modpat.2025.100953_bib5","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.modpat.2025.100953_bib6","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/sj.bjc.6602619","article-title":"Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies","volume":"92","author":"Huxley","year":"2005","journal-title":"Br J Cancer"},{"issue":"7","key":"10.1016\/j.modpat.2025.100953_bib7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/cas.12203","article-title":"Report of the Japan Diabetes Society\/Japanese Cancer Association Joint Committee on Diabetes and Cancer","volume":"104","author":"Kasuga","year":"2013","journal-title":"Cancer Sci"},{"issue":"1","key":"10.1016\/j.modpat.2025.100953_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-18438-z","article-title":"Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation","volume":"7","author":"Saito","year":"2017","journal-title":"Sci Rep"},{"issue":"21","key":"10.1016\/j.modpat.2025.100953_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111716","article-title":"Diabetes in humans activates pancreatic stellate cells via RAGE in pancreatic ductal adenocarcinoma","volume":"22","author":"Uchida","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.modpat.2025.100953_bib10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cjp2.326","article-title":"Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis","volume":"9","author":"Hara","year":"2023","journal-title":"J Pathol Clin Res"},{"issue":"12","key":"10.1016\/j.modpat.2025.100953_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.187424","article-title":"Type 2 diabetes alters quiescent pancreatic stellate cells to tumor-prone state","volume":"10","author":"Hara","year":"2025","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.modpat.2025.100953_bib12","doi-asserted-by":"crossref","first-page":"716","DOI":"10.5858\/2010-0566-RA.1","article-title":"Molecular signatures of pancreatic cancer","volume":"135","author":"Hong","year":"2011","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"10.1016\/j.modpat.2025.100953_bib13","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1038\/s41467-019-11812-7","article-title":"Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine","volume":"10","author":"Lomberk","year":"2019","journal-title":"Nat Commun"},{"issue":"7847","key":"10.1016\/j.modpat.2025.100953_bib14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41586-020-03147-x","article-title":"A gene-environment-induced epigenetic program initiates tumorigenesis","volume":"590","author":"Alonso-Curbelo","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.modpat.2025.100953_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCRESAHA.115.306424","article-title":"Differential promoter methylation of macrophage genes is associated with impaired vascular growth in ischemic muscles of hyperlipidemic and type 2 diabetic mice: genome-wide promoter methylation study","volume":"117","author":"Babu","year":"2015","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.modpat.2025.100953_bib16","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/emboj.2011.503","article-title":"DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients","volume":"31","author":"Volkmar","year":"2012","journal-title":"EMBO J"},{"issue":"11","key":"10.1016\/j.modpat.2025.100953_bib17","doi-asserted-by":"crossref","first-page":"E1491","DOI":"10.1210\/jc.2015-3204","article-title":"Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels","volume":"100","author":"Nilsson","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.modpat.2025.100953_bib18","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/JME-12-0008","article-title":"MEG3 noncoding RNA: a tumor suppressor","volume":"48","author":"Zhou","year":"2012","journal-title":"J Mol Endocrinol"},{"issue":"42","key":"10.1016\/j.modpat.2025.100953_bib19","doi-asserted-by":"crossref","first-page":"73282","DOI":"10.18632\/oncotarget.19931","article-title":"Potential applications of MEG3 in cancer diagnosis and prognosis","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.modpat.2025.100953_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbrc.2016.01.169","article-title":"Fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of LncRNA MEG3","volume":"471","author":"Hu","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.modpat.2025.100953_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41419-018-0305-7","article-title":"Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting \u03b2-catenin by activating PKM2 and inactivating PTEN","volume":"9","author":"Zheng","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.modpat.2025.100953_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109129","article-title":"Maternally expressed gene 3 (MEG3): a tumor suppressor long non coding RNA","volume":"118","author":"Ghafouri-Fard","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.modpat.2025.100953_bib23","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1210\/jc.2004-1848","article-title":"Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors","volume":"90","author":"Zhao","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.modpat.2025.100953_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3816\/CLM.2008.n.021","article-title":"Promoter hypermethylation of the MEG3 (DLK1\/MEG3) imprinted gene in multiple myeloma","volume":"8","author":"Benetatos","year":"2008","journal-title":"Clin Lymphoma Myeloma"},{"issue":"5","key":"10.1016\/j.modpat.2025.100953_bib25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.2040-1124.2010.00074.x","article-title":"Report of the committee on the classification and diagnostic criteria of diabetes mellitus","volume":"1","author":"Seino","year":"2010","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.modpat.2025.100953_bib26","first-page":"322","article-title":"WHO classification of tumours of the digestive system","volume":"5","author":"Hruban","year":"2019"},{"issue":"13","key":"10.1016\/j.modpat.2025.100953_bib27","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1245\/s10434-012-2381-8","article-title":"Low expression of junctional adhesion molecule A is associated with metastasis and poor survival in pancreatic cancer","volume":"19","author":"Fong","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"18","key":"10.1016\/j.modpat.2025.100953_bib28","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.modpat.2025.100953_bib29","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41598-020-57883-1","article-title":"Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation","volume":"10","author":"Umetsu","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.modpat.2025.100953_bib55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.modpat.2025.100953_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11010-021-04259-2","article-title":"The F11 receptor (F11R)\/junctional adhesion molecule-A (JAM-A) (F11R\/JAM-A) in cancer progression","volume":"477","author":"Czubak-Prowizor","year":"2022","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10.1016\/j.modpat.2025.100953_bib31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4049\/jimmunol.178.2.663","article-title":"Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK","volume":"178","author":"Sherry","year":"2007","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.modpat.2025.100953_bib32","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/hc0702.104183","article-title":"Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses","volume":"105","author":"Basta","year":"2002","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.modpat.2025.100953_bib33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1\u03b2 in type 2 diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat Immunol"},{"issue":"12","key":"10.1016\/j.modpat.2025.100953_bib34","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.2337\/dc06-1134","article-title":"Improved glycemic control in poorly controlled patients with type 1 diabetes using real-time continuous glucose monitoring","volume":"29","author":"Deiss","year":"2006","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.modpat.2025.100953_bib35","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2337\/db08-0063","article-title":"Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients","volume":"57","author":"Ceriello","year":"2008","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.modpat.2025.100953_bib36","doi-asserted-by":"crossref","first-page":"e3990","DOI":"10.1210\/clinem\/dgac459","article-title":"The importance of continuous glucose monitoring-derived metrics beyond HbA1c for optimal individualized glycemic control","volume":"107","author":"Yoshii","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.modpat.2025.100953_bib37","doi-asserted-by":"crossref","first-page":"953","DOI":"10.20892\/j.issn.2095-3941.2019.0427","article-title":"Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma","volume":"17","author":"Han","year":"2020","journal-title":"Cancer Biol Med"},{"key":"10.1016\/j.modpat.2025.100953_bib38","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1038\/ncomms8743","article-title":"MEG3 long noncoding RNA regulates the TGF-\u03b2 pathway genes through formation of RNA-DNA triplex structures","volume":"6","author":"Mondal","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.modpat.2025.100953_bib39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.cellbio.22.010305.104219","article-title":"Tight junctions and cell polarity","volume":"22","author":"Shin","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.modpat.2025.100953_bib40","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0955-0674(97)80121-4","article-title":"Interendothelial junctions: structure, signalling and functional roles","volume":"9","author":"Lampugnani","year":"1997","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"10.1016\/j.modpat.2025.100953_bib41","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/scdb.2000.0177","article-title":"Transmembrane proteins of tight junctions","volume":"11","author":"Balda","year":"2000","journal-title":"Semin Cell Dev Biol"},{"issue":"10","key":"10.1016\/j.modpat.2025.100953_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077571","article-title":"F11R is a novel monocyte prognostic biomarker for malignant glioma","volume":"8","author":"Pong","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.modpat.2025.100953_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbrc.2009.01.100","article-title":"Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma","volume":"380","author":"Gutwein","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.modpat.2025.100953_bib44","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/ijc.24498","article-title":"JAM-A expression positively correlates with poor prognosis in breast cancer patients","volume":"125","author":"McSherry","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.modpat.2025.100953_bib45","article-title":"Effect of F11R Gene knockdown on malignant biological behaviours of pancreatic cancer cells","volume":"2022","author":"Zhang","year":"2022","journal-title":"J Oncol"},{"key":"10.1016\/j.modpat.2025.100953_bib46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1479-5876-9-98","article-title":"Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines","volume":"9","author":"Azari","year":"2011","journal-title":"J Transl Med"},{"key":"10.1016\/j.modpat.2025.100953_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150213","article-title":"F11R RNA trinucleotide over-edited by ADAR in gastric and colorectal cancers: cross-cohort validation, gene expression regulation, and diagnostic significance","volume":"726","author":"Bao","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10.1016\/j.modpat.2025.100953_bib48","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.3390\/biomedicines12071423","article-title":"Identification and validation of JAM-A as a novel prognostic and immune factor in human tumors","volume":"12","author":"Ren","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.modpat.2025.100953_bib49","doi-asserted-by":"crossref","DOI":"10.1007\/s13304-025-02382-z","article-title":"Predictive factors for long-term survival in pancreatic ductal adenocarcinoma that underwent surgery: a systematic review and meta-analysis of literature","author":"D'Ambra","year":"2025","journal-title":"Updates Surg"},{"issue":"3","key":"10.1016\/j.modpat.2025.100953_bib50","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12022-020-09626-1","article-title":"Long non-coding RNAs in pulmonary neuroendocrine neoplasms","volume":"31","author":"Narayanan","year":"2020","journal-title":"Endocr Pathol"},{"issue":"10","key":"10.1016\/j.modpat.2025.100953_bib51","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.phymed.2015.05.071","article-title":"Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer","volume":"22","author":"Zamani","year":"2015","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.modpat.2025.100953_bib52","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00280-017-3238-4","article-title":"Curcumin suppresses cisplatin resistance development partly via modulating extracellular vesicle-mediated transfer of MEG3 and miR-214 in ovarian cancer","volume":"79","author":"Zhang","year":"2017","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.modpat.2025.100953_bib53","doi-asserted-by":"crossref","first-page":"10305","DOI":"10.2147\/IJN.S282107","article-title":"Aptamer-functionalized dendrimer delivery of plasmid-encoding lncRNA MEG3 enhances gene therapy in castration-resistant prostate cancer","volume":"15","author":"Tai","year":"2020","journal-title":"Int J Nanomedicine"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225002510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395225002510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:04:09Z","timestamp":1771391049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395225002510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0893395225002510"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100953","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MEG3 Promoter Methylation and F11 Receptor (F11R) Overexpression Define a High-Risk Subtype of Diabetic Pancreatic Cancer","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2025.100953","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}],"article-number":"100953"}}