{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:57:35Z","timestamp":1781697455036,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010946","name":"School of Medicine, University of California, San Francisco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.modpat.2026.100996","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:53:20Z","timestamp":1775260400000},"page":"100996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic, Immunohistochemical and mRNA In Situ Hybridization Profiling of Condyloma with Concurrent Squamous Cell Carcinoma and High-Grade Squamous Intraepithelial Lesion"],"prefix":"10.1016","volume":"39","author":[{"given":"Peyman","family":"Samghabadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikka","family":"Khorsandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter Patrick","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-2337","authenticated-orcid":false,"given":"Cynthia","family":"Gasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.modpat.2026.100996_bib1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1073\/pnas.80.2.560","article-title":"Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers","volume":"80","author":"Gissmann","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.modpat.2026.100996_bib2","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski","year":"2015","journal-title":"MMWR Recomm Rep"},{"issue":"Suppl 3","key":"10.1016\/j.modpat.2026.100996_bib3","first-page":"S3\/35","article-title":"Chapter 4: Burden and management of non-cancerous HPV-related conditions: HPV-6\/11 disease","volume":"24","author":"Lacey","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.modpat.2026.100996_bib4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1086\/590560","article-title":"Human papillomavirus genotype distribution in external acuminata condylomata: a large French national study (EDiTH IV)","volume":"47","author":"Aubin","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.modpat.2026.100996_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000500908","article-title":"Distribution of human papillomavirus genotypes in condylomata acuminata: an Austrian cohort study","volume":"235","author":"Juelg","year":"2019","journal-title":"Dermatology"},{"key":"10.1016\/j.modpat.2026.100996_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12879-019-4005-4","article-title":"Association of HPV genotypes with external anogenital warts: a cross-sectional study","volume":"19","author":"Al-Awadhi","year":"2019","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.modpat.2026.100996_bib7","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1111\/codi.17099","article-title":"Risk of developing high-grade squamous intraepithelial lesions or anal cancer after anal condylomata treatment in people living with HIV","volume":"26","author":"Hewitt","year":"2024","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.modpat.2026.100996_bib8","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1097\/QAD.0000000000002975","article-title":"High-risk human papilloma virus, precancerous lesions and cancer in anal condylomas","volume":"35","author":"Albuquerque","year":"2021","journal-title":"AIDS"},{"key":"10.1016\/j.modpat.2026.100996_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/PAS.0b013e318263cda6","article-title":"Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: independent lesions due to different HPV types occurring in immunocompromised patients","volume":"37","author":"Maniar","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jss.2015.10.027","article-title":"Immune status does not predict high-risk HPV in anal condyloma","volume":"201","author":"Lee","year":"2016","journal-title":"J Surg Res"},{"key":"10.1016\/j.modpat.2026.100996_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.5858\/arpa.2018-0039-RA","article-title":"Verruciform and condyloma-like squamous proliferations in the anogenital region","volume":"143","author":"Chan","year":"2019","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.modpat.2026.100996_bib12","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/PAS.0b013e318265fb2b","article-title":"Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6\/E7 mRNA in situ hybridization method","volume":"36","author":"Bishop","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/PAS.0000000000000800","article-title":"HR-HPV E6\/E7 mRNA in situ hybridization: validation against PCR, DNA in situ hybridization, and p16 immunohistochemistry in 102 samples of cervical, vulvar, anal, and head and neck neoplasia","volume":"41","author":"Mills","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/PAS.0000000000000974","article-title":"HPV E6\/E7 mRNA In situ hybridization in the diagnosis of cervical low-grade squamous intraepithelial lesions (LSIL)","volume":"42","author":"Mills","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib15","unstructured":"Darragh TM, Colgan TJ, Cox JT, et al; Members of LAST Project Work Groups. The lower anogenital squamous terminology standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Arch Pathol Lab Med. 136(10):1266-1297. Erratum in: Arch Pathol Lab Med. 2013 Jun;137(6):738."},{"key":"10.1016\/j.modpat.2026.100996_bib16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000478-200004000-00004","article-title":"Warty (condylomatous) squamous cell carcinoma of the penis: a report of 11 cases and proposed classification of 'verruciform' penile tumors","volume":"24","author":"Cubilla","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib17","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/PAS.0000000000000454","article-title":"Squamous cell carcinoma of the vulva: a subclassification of 97 cases by clinicopathologic, immunohistochemical, and molecular features (p16, p53, and EGFR)","volume":"39","author":"Dong","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/PGP.0000000000000725","article-title":"The many uses of p53 immunohistochemistry in gynecological pathology: proceedings of the ISGyP companion society session at the 2020 USCAP Annual9 Meeting","volume":"40","author":"K\u00f6bel","year":"2021","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib19","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/LGT.0000000000000319","article-title":"Coexistent vulvar condyloma and high-grade squamous intraepithelial lesion in an immunocompetent woman: from the case consultation committee of the International Society for the Study of Vulvovaginal Disease","volume":"21","author":"Sulaiman","year":"2017","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.modpat.2026.100996_bib20","first-page":"61","article-title":"Progression of intravesical condyloma acuminata to locally advanced poorly differentiated squamous cell carcinoma","volume":"7","author":"Khambati","year":"2016","journal-title":"Urol Case Rep"},{"key":"10.1016\/j.modpat.2026.100996_bib21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1177\/0956462416635361","article-title":"Invasive squamous cell carcinoma originating from a giant penile condyloma","volume":"28","author":"Sir","year":"2017","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.modpat.2026.100996_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00384-008-0554-5","article-title":"Paraneoplastic hypercalcemia caused by an invasive squamous cell carcinoma arising from a giant anal condyloma acuminatum","volume":"24","author":"Hernandez","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.modpat.2026.100996_bib23","series-title":"International Agency for Research on Cancer, and World Health Organization. WHO Classification of Tumours: Female Genital Tumours","first-page":"429","article-title":"Squamous cell carcinoma, HPV-associated, of the vulva","author":"Bosse","year":"2020"},{"key":"10.1016\/j.modpat.2026.100996_bib24","series-title":"WHO Classification of Tumours Editorial Board. Urinary and male genital tumours","article-title":"Squamous cell carcinoma, HPV-associated, of the penis and scrotum","author":"Isabel Alvarado-Cabrero","year":"2022"},{"key":"10.1016\/j.modpat.2026.100996_bib25","series-title":"International agency for research on cancer, and World Health Organization. WHO Classification of Tumours of the Digestive System","article-title":"Anal squamous cell carcinoma","author":"Goldblum","year":"2019"},{"key":"10.1016\/j.modpat.2026.100996_bib26","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1128\/JCM.37.10.3316-3322.1999","article-title":"Detection of multiple human papillomavirus types in condylomata acuminata lesions from otherwise healthy and immunosuppressed patients","volume":"37","author":"Brown","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.modpat.2026.100996_bib27","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/infdis\/170.4.759","article-title":"Detection of multiple human papillomavirus types in condylomata acuminata from immunosuppressed patients","volume":"170","author":"Brown","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1016\/j.modpat.2026.100996_bib28","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/jmv.23646","article-title":"Distribution of genital wart human papillomavirus genotypes in China: a multi-center study","volume":"85","author":"Chang","year":"2013","journal-title":"J Med Virol"},{"key":"10.1016\/j.modpat.2026.100996_bib29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s40257-017-0262-4","article-title":"Immunostaining for high-risk human papillomavirus in condyloma lesions in immunocompromised patients","volume":"18","author":"Rodriguez","year":"2017","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.modpat.2026.100996_bib30","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1365-2559.2011.04169.x","article-title":"Transcriptionally active high-risk human papillomavirus is rare in oral cavity and laryngeal\/hypopharyngeal squamous cell carcinomas-a tissue microarray study utilizing E6\/E7 mRNA in situ hybridization","volume":"60","author":"Lewis","year":"2012","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.modpat.2026.100996_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091142","article-title":"HPV E6\/E7 RNA in situ hybridization signal patterns as biomarkers of three-tier cervical intraepithelial neoplasia grade","volume":"9","author":"Evans","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.modpat.2026.100996_bib32","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ygyno.2008.09.047","article-title":"HPV in situ hybridization signal patterns as a marker for cervical intraepithelial neoplasia progression","volume":"112","author":"De Marchi Triglia","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.modpat.2026.100996_bib33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13027-020-00310-x","article-title":"Multiplex HPV RNA in situ hybridization\/p16 immunohistochemistry: a novel approach to detect papillomavirus in HPV-related cancers. A novel multiplex ISH\/IHC assay to detect HPV","volume":"15","author":"Zito Marino","year":"2020","journal-title":"Infect Agent Cancer"},{"issue":"10","key":"10.1016\/j.modpat.2026.100996_bib34","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.3390\/ijms25105354","article-title":"High-risk HPV CISH detection in cervical biopsies with weak and\/or focal p16 immunohistochemical positivity","volume":"25","author":"Cabibi","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.modpat.2026.100996_bib35","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/PAS.0000000000000342","article-title":"Attributing oncogenic human papillomavirus genotypes to high-grade cervical neoplasia: which type causes the lesion?","volume":"39","author":"van der Marel","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"26","key":"10.1016\/j.modpat.2026.100996_bib36","doi-asserted-by":"crossref","first-page":"10516","DOI":"10.1073\/pnas.1202684109","article-title":"A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer","volume":"109","author":"Herfs","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.modpat.2026.100996_bib37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13000-023-01308-w","article-title":"CIN grades possessing different HPV RNA location patterns and RNAscope is helpful tool for distinguishing squamous intraepithelial lesions in difficult cervical cases","volume":"18","author":"Chen","year":"2023","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib38","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/annonc\/mdw152","article-title":"Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes","volume":"27","author":"Chung","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.modpat.2026.100996_bib39","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41379-020-00729-y","article-title":"Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 mutation status","volume":"34","author":"Zhu","year":"2021","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2026.100996_bib40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/bjc.2013.281","article-title":"Functional and cancer genomics of ASXL family members","volume":"109","author":"Katoh","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.modpat.2026.100996_bib41","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41379-020-00651-3","article-title":"Molecular characterization of invasive and in situ squamous neoplasia of the vulva and implications for morphologic diagnosis and outcome","volume":"34","author":"Tessier-Cloutier","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib42","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00432-021-03514-9","article-title":"TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features","volume":"147","author":"Kim","year":"2021","journal-title":"J Cancer Res Clin Oncol"},{"issue":"10","key":"10.1016\/j.modpat.2026.100996_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100250","article-title":"Different mutational landscapes in human papillomavirus-induced and human papillomavirus-independent invasive penile squamous cell cancers","volume":"36","author":"Ermakov","year":"2023","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.modpat.2026.100996_bib44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41379-021-00942-3","article-title":"Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma","volume":"35","author":"Salama","year":"2022","journal-title":"Mod Pathol"},{"issue":"5","key":"10.1016\/j.modpat.2026.100996_bib45","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/ijc.31412","article-title":"Distinct profiles of TERT promoter mutations and telomerase expression in head and neck cancer and cervical carcinoma","volume":"143","author":"Annunziata","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.modpat.2026.100996_bib46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/PGP.0000000000000556","article-title":"HPV 6-associated HSIL\/squamous carcinoma in the anogenital tract","volume":"38","author":"Liu","year":"2019","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.modpat.2026.100996_bib47","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/PAS.0000000000002367","article-title":"Clinicopathologic features and viral status of low-risk HPV6 and HPV11-associated squamous cell carcinoma of the uterine cervix and vulva","volume":"49","author":"Williams","year":"2025","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.modpat.2026.100996_bib48","first-page":"196","article-title":"A low-risk HPV-associated well-differentiated squamous cell carcinoma of the cervix with low-grade squamous intraepithelial lesion morphology: clinical and pathologic diagnostic difficulties and review of the literature","volume":"40","author":"Ates","year":"2024","journal-title":"Turk Patoloji Derg"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395226000396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395226000396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:32:16Z","timestamp":1781695936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395226000396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0893395226000396"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2026.100996","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic, Immunohistochemical and mRNA In Situ Hybridization Profiling of Condyloma with Concurrent Squamous Cell Carcinoma and High-Grade Squamous Intraepithelial Lesion","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2026.100996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100996"}}