{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:56:03Z","timestamp":1791564963037,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.modpat.2026.101044","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:43:35Z","timestamp":1785167015000},"page":"101044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["USP6 RNA Chromogenic In Situ Hybridization Is Useful in the Diagnosis of Nodular Fasciitis and Aneurysmal Bone Cyst"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7601-1756","authenticated-orcid":false,"given":"Timothy A.","family":"Dinh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hrycaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May P.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Bresler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-8215","authenticated-orcid":false,"given":"Douglas","family":"Rottmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.modpat.2026.101044_bib1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)63432-3","article-title":"USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts","volume":"165","author":"Oliveira","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/labinvest.2011.118","article-title":"Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion","volume":"91","author":"Erickson-Johnson","year":"2011","journal-title":"Lab Invest"},{"key":"10.1016\/j.modpat.2026.101044_bib3","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/his.13011","article-title":"USP6 gene rearrangement in nodular fasciitis and histological mimics","volume":"69","author":"Shin","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.modpat.2026.101044_bib4","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1158\/0008-5472.CAN-03-2827","article-title":"USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst","volume":"64","author":"Oliveira","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.modpat.2026.101044_bib5","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/sj.onc.1208506","article-title":"Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes","volume":"24","author":"Oliveira","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.modpat.2026.101044_bib6","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/modpathol.2017.78","article-title":"USP6 activation in nodular fasciitis by promoter-swapping gene fusions","volume":"30","author":"Patel","year":"2017","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib7","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/gcc.22366","article-title":"PPP6R3-USP6 amplification: novel oncogenic mechanism in malignant nodular fasciitis","volume":"55","author":"Guo","year":"2016","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.modpat.2026.101044_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/gcc.22742","article-title":"RNA sequencing identifies a novel USP9X-USP6 promoter swap gene fusion in a primary aneurysmal bone cyst","volume":"58","author":"Blackburn","year":"2019","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.modpat.2026.101044_bib9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/gcc.22836","article-title":"Novel ASAP1-USP6, FAT1-USP6, SAR1A-USP6, and TNC-USP6 fusions in primary aneurysmal bone cyst","volume":"59","author":"\u0160ekoranja","year":"2020","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.modpat.2026.101044_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00428-020-02961-y","article-title":"Atypical nodular fasciitis with a novel PAFAH1B1-USP6 fusion in a 22-month-old boy","volume":"479","author":"Qiu","year":"2021","journal-title":"Virchows Arch"},{"key":"10.1016\/j.modpat.2026.101044_bib11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jcp-2023-208768","article-title":"Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature","volume":"77","author":"Balko","year":"2024","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib12","doi-asserted-by":"crossref","first-page":"37111","DOI":"10.1074\/jbc.M110.175133","article-title":"TRE17\/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation","volume":"285","author":"Lau","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.modpat.2026.101044_bib13","doi-asserted-by":"crossref","first-page":"E2945","DOI":"10.1073\/pnas.1605691113","article-title":"USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds","volume":"113","author":"Madan","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.modpat.2026.101044_bib14","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1038\/onc.2011.520","article-title":"Atypical mechanism of NF-\u03baB activation by TRE17\/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis","volume":"31","author":"Pringle","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.modpat.2026.101044_bib15","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1158\/0008-5472.CAN-15-2391","article-title":"Jak1\u2013STAT3 signals are essential effectors of the USP6\/TRE17 oncogene in tumorigenesis","volume":"76","author":"Quick","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.modpat.2026.101044_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<265::AID-GCC12>3.0.CO;2-#","article-title":"Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts","volume":"26","author":"Panoutsakopoulos","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.modpat.2026.101044_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1098-2264(200006)28:2<233::AID-GCC13>3.0.CO;2-H","article-title":"Variant translocations involving 16q22 and 17p13 in solid variant and extraosseous forms of aneurysmal bone cyst","volume":"28","author":"Dal Cin","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.modpat.2026.101044_bib18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/gcc.22432","article-title":"Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst","volume":"56","author":"Guseva","year":"2017","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.modpat.2026.101044_bib19","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/his.14268","article-title":"Clinicopathological and molecular characterisation of USP6-rearranged soft tissue neoplasms: the evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity","volume":"78","author":"Wang","year":"2021","journal-title":"Histopathology"},{"key":"10.1016\/j.modpat.2026.101044_bib20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.anndiagpath.2018.01.006","article-title":"Myositis ossificans\u2014another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst","volume":"34","author":"Bekers","year":"2018","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/gcc.22335","article-title":"Gene fusions in soft tissue tumors: recurrent and overlapping pathogenetic themes","volume":"55","author":"Mertens","year":"2016","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.modpat.2026.101044_bib22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/PAT.0000000000000122","article-title":"STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics","volume":"46","author":"Cheah","year":"2014","journal-title":"Pathology"},{"key":"10.1016\/j.modpat.2026.101044_bib23","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/PAS.0000000000000137","article-title":"STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors","volume":"38","author":"Yoshida","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/modpathol.2013.164","article-title":"Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics","volume":"27","author":"Doyle","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.humpath.2014.01.020","article-title":"USP6 gene rearrangements occur preferentially in giant cell reparative granulomas of the hands and feet but not in gnathic location","volume":"45","author":"Agaram","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib26","first-page":"590","article-title":"Validation of fluorescence in situ hybridization testing of USP6 gene rearrangement for diagnosis of primary aneurysmal bone cyst","volume":"49","author":"Li","year":"2019","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.modpat.2026.101044_bib27","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/ajcp\/aqx094","article-title":"Rapid loss of RNA detection by in situ hybridization in stored tissue blocks and preservation by cold storage of unstained slides","volume":"148","author":"Baena-Del Valle","year":"2017","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/modpathol.2016.83","article-title":"USP6 genetic rearrangements in cellular fibroma of tendon sheath","volume":"29","author":"Carter","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib29","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/s41379-021-00836-4","article-title":"Fibroma of tendon sheath is defined by a USP6 gene fusion\u2014morphologic and molecular reappraisal of the entity","volume":"34","author":"Pi\u017eem","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41379-020-0621-1","article-title":"Characterization of novel USP6 gene rearrangements in a subset of so-called cellular fibroma of tendon sheath","volume":"34","author":"Mantilla","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.modpat.2026.101044_bib31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/his.15196","article-title":"Recurrent USP6 rearrangement in a subset of atypical myofibroblastic tumours of the soft tissues: low-grade myofibroblastic sarcoma or atypical\/malignant nodular fasciitis?","volume":"85","author":"Arcovito","year":"2024","journal-title":"Histopathology"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395226000876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395226000876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:50:00Z","timestamp":1791060600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395226000876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0893395226000876"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2026.101044","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP6 RNA Chromogenic In Situ Hybridization Is Useful in the Diagnosis of Nodular Fasciitis and Aneurysmal Bone Cyst","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2026.101044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}],"article-number":"101044"}}