{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:52:46Z","timestamp":1791665566858,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2025-I2M-C &amp;T-B-048"],"award-info":[{"award-number":["2025-I2M-C &amp;T-B-048"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403804"],"award-info":[{"award-number":["2023YFC3403804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473407"],"award-info":[{"award-number":["82473407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.modpat.2026.101096","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:21:30Z","timestamp":1791588090000},"page":"101096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reproducible and Interpretable H&amp;E-based Histopathological Subtypes of Non-metastatic Lymph Nodes Refine Risk Stratification in Colorectal Cancer"],"prefix":"10.1016","author":[{"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-9739","authenticated-orcid":false,"given":"Yueyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.modpat.2026.101096_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"10.1016\/j.modpat.2026.101096_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4240\/wjgs.v8.i3.179","article-title":"Assessment of lymph node involvement in colorectal cancer","volume":"8","author":"Ong","year":"2016","journal-title":"World J Gastrointest Surg"},{"key":"10.1016\/j.modpat.2026.101096_bib3","article-title":"Excessive dissection of non-metastatic tumor-draining lymph nodes impairs immunotherapy efficacy in recurrent biliary tract cancer","author":"Long","year":"2025","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.modpat.2026.101096_bib4","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41577-023-00965-8","article-title":"Same yet different - how lymph node heterogeneity affects immune responses","volume":"24","author":"Cruz de Casas","year":"2024","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.modpat.2026.101096_bib5","doi-asserted-by":"crossref","first-page":"7834","DOI":"10.1038\/s41467-025-63200-z","article-title":"Lymph nodes molecular subtypes unravel lymph nodes heterogeneity and clinical implications in colorectal cancer","volume":"16","author":"Guan","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.modpat.2026.101096_bib6","unstructured":"Medeiros LJ. Ioachim\u2019s Lymph Node Pathology, 5e. Lippincott Williams & Wilkins, a Wolters Kluwer business; 2022."},{"issue":"3","key":"10.1016\/j.modpat.2026.101096_bib7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0022-5347(17)59166-1","article-title":"Prognostic significance of regional lymph node histology in cancer of the bladder","volume":"115","author":"Herr","year":"1976","journal-title":"J Urol"},{"issue":"5","key":"10.1016\/j.modpat.2026.101096_bib8","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1016\/S1470-2045(19)30154-8","article-title":"Digital pathology and artificial intelligence","volume":"20","author":"Niazi","year":"2019","journal-title":"Lancet Oncol"},{"issue":"9","key":"10.1016\/j.modpat.2026.101096_bib9","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s43018-022-00436-4","article-title":"Artificial intelligence in histopathology: enhancing cancer research and clinical oncology","volume":"3","author":"Shmatko","year":"2022","journal-title":"Nat Cancer"},{"issue":"10","key":"10.1016\/j.modpat.2026.101096_bib10","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.15997","article-title":"Machine Learning Approaches to Predict 6-Month Mortality Among Patients With Cancer","volume":"2","author":"Parikh","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.modpat.2026.101096_bib11","article-title":"Magnetic resonance imaging radiomics predicts preoperative axillary lymph node metastasis to support surgical decisions and is associated with tumor microenvironment in invasive breast cancer: A machine learning, multicenter study","volume":"69","author":"Yu","year":"2021","journal-title":"EBioMedicine (11205)"},{"key":"10.1016\/j.modpat.2026.101096_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ebiom.2019.07.049","article-title":"Radiomic analysis for pretreatment prediction of response to neoadjuvant chemotherapy in locally advanced cervical cancer: A multicentre study","volume":"46","author":"Sun","year":"2019","journal-title":"EBioMedicine (11205)"},{"issue":"10","key":"10.1016\/j.modpat.2026.101096_bib13","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1093\/bioinformatics\/btac166","article-title":"Analysing high-throughput sequencing data in Python with HTSeq 2.0","volume":"38","author":"Putri","year":"2022","journal-title":"BIOINFORMATICS (6931)"},{"issue":"1","key":"10.1016\/j.modpat.2026.101096_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.7326\/M18-1376","article-title":"PROBAST: A Tool to Assess the Risk of Bias and Applicability of Prediction Model Studies","volume":"170","author":"Wolff","year":"2019","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.modpat.2026.101096_bib15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41698-024-00553-6","article-title":"All models are wrong and yours are useless: making clinical prediction models impactful for patients","volume":"8","author":"Markowetz","year":"2024","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.modpat.2026.101096_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-078378","article-title":"TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods","volume":"385","author":"Collins","year":"2024","journal-title":"Bmj"},{"issue":"18","key":"10.1016\/j.modpat.2026.101096_bib17","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1093\/bioinformatics\/btac503","article-title":"ShinySyn: a Shiny\/R application for the interactive visualization and integration of macro- and micro-synteny data","volume":"38","author":"Xiao","year":"2022","journal-title":"BIOINFORMATICS (6931)"},{"key":"10.1016\/j.modpat.2026.101096_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/gpbjnl\/qzaf072","article-title":"The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data","author":"Zhang","year":"2025","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"D1","key":"10.1016\/j.modpat.2026.101096_bib19","doi-asserted-by":"crossref","first-page":"D30","DOI":"10.1093\/nar\/gkae978","article-title":"Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025","volume":"53","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.modpat.2026.101096_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008026","article-title":"Tumor-draining lymph nodes: opportunities, challenges, and future directions in colorectal cancer immunotherapy","volume":"12","author":"Wang","year":"2024","journal-title":"J Immunother Cancer"},{"issue":"63","key":"10.1016\/j.modpat.2026.101096_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg3551","article-title":"Tumor-draining lymph nodes: At the crossroads of metastasis and immunity","volume":"6","author":"du Bois","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.modpat.2026.101096_bib22","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-26-0046","article-title":"Influence of tumor-draining lymph nodes on immunotherapy: lymphadenectomy may have its limits","author":"Vonderheide","year":"2026","journal-title":"Clin Cancer Res"},{"issue":"5795","key":"10.1016\/j.modpat.2026.101096_bib23","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","article-title":"Type, density, and location of immune cells within human colorectal tumors predict clinical outcome","volume":"313","author":"Galon","year":"2006","journal-title":"SCIENCE (63714)"},{"issue":"10135","key":"10.1016\/j.modpat.2026.101096_bib24","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/S0140-6736(18)30789-X","article-title":"International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study","volume":"391","author":"Pag\u00e8s","year":"2018","journal-title":"LANCET 202731"},{"issue":"4","key":"10.1016\/j.modpat.2026.101096_bib25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1309\/AJCPWHUEFTGBWKE4","article-title":"Objective criteria for crohn-like lymphoid reaction in colorectal cancer","volume":"139","author":"Ueno","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.modpat.2026.101096_bib26","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.3389\/fimmu.2019.01884","article-title":"The Crohn's-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and Potentially Therapeutic Relevance in Colorectal Cancer","volume":"10","author":"Maoz","year":"2019","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.modpat.2026.101096_bib27","doi-asserted-by":"crossref","DOI":"10.1097\/AS9.0000000000000336","article-title":"The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review","volume":"4","author":"Pennings","year":"2023","journal-title":"Ann Surg Open"},{"issue":"1","key":"10.1016\/j.modpat.2026.101096_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2025.100948","article-title":"Quantitative Histology of Nonmetastatic Regional Lymph Nodes as a Novel Prognostic Indicator in Microsatellite Instability-High Colorectal Cancer","volume":"39","author":"Moon","year":"2026","journal-title":"Mod Pathol"},{"issue":"8","key":"10.1016\/j.modpat.2026.101096_bib29","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1200\/JCO.21.02538","article-title":"Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update","volume":"40","author":"Baxter","year":"2022","journal-title":"J Clin Oncol"},{"issue":"24","key":"10.1016\/j.modpat.2026.101096_bib30","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1056\/NEJMoa2200075","article-title":"Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer","volume":"386","author":"Tie","year":"2022","journal-title":"N Engl J Med"},{"issue":"10221","key":"10.1016\/j.modpat.2026.101096_bib31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(19)32998-8","article-title":"Deep learning for prediction of colorectal cancer outcome: a discovery and validation study","volume":"395","author":"Skrede","year":"2020","journal-title":"LANCET 202731"},{"issue":"1","key":"10.1016\/j.modpat.2026.101096_bib32","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/S2589-7500(23)00208-X","article-title":"End-to-end prognostication in colorectal cancer by deep learning: a retrospective, multicentre study","volume":"6","author":"Jiang","year":"2024","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.modpat.2026.101096_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.landig.2025.100961","article-title":"Artificial intelligence-based pathological model for pan-cancer lymph node metastasis detection: a multicentre diagnostic study with retrospective and prospective validation","author":"Wu","year":"2026","journal-title":"Lancet Digit Health"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395226001390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395226001390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:43:32Z","timestamp":1791665012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395226001390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":33,"alternative-id":["S0893395226001390"],"URL":"https:\/\/doi.org\/10.1016\/j.modpat.2026.101096","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reproducible and Interpretable H&E-based Histopathological Subtypes of Non-metastatic Lymph Nodes Refine Risk Stratification in Colorectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.modpat.2026.101096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101096"}}