{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:17:47Z","timestamp":1768677467958,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Biochemical Parasitology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.molbiopara.2004.08.003","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T18:27:57Z","timestamp":1095186477000},"page":"165-170","source":"Crossref","is-referenced-by-count":138,"title":["RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting"],"prefix":"10.1016","volume":"138","author":[{"given":"Sara","family":"Lustigman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Oksov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarwar","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molbiopara.2004.08.003_bib1","unstructured":"WHO. Onchocerciasis and its control. Report of a WHO Expert Committee on Onchocerciasis Control. World Health Organ Tech Rep Ser 1995;852:1\u2013104."},{"key":"10.1016\/j.molbiopara.2004.08.003_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2883-2-2","article-title":"Final report of the conference on the eradicability of Onchocerciasis","volume":"2","author":"Dadzie","year":"2003","journal-title":"Filaria J"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1179\/000349804225003253","article-title":"An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana","volume":"98","author":"Awadzi","year":"2004","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1471-4922(02)02310-3","article-title":"Future directions for vaccine-related onchocerciasis research","volume":"18","author":"Nutman","year":"2002","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib5","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1128\/IAI.68.6.3491-3501.2000","article-title":"Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of Onchocerca volvulus larval cDNA libraries","volume":"68","author":"Lizotte-Waniewski","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib6","first-page":"86","article-title":"The river blindness genome project","volume":"18","author":"Williams","year":"2002","journal-title":"Parasitol Today"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0035-9203(02)90224-5","article-title":"The Brugia malayi genome project: expressed sequence tags and gene discovery","volume":"96","author":"Blaxter","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1101\/gad.880001","article-title":"RNA interference\u20142001","volume":"15","author":"Sharp","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0166-6851(03)00092-6","article-title":"Use of RNA interference to investigate gene function in the human filarial nematode parasite Brugia malayi","volume":"129","author":"Aboobaker","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0166-6851(02)00068-3","article-title":"Suppression of secreted acetylcholinesterase expression in Nippostrongylus brasiliensis by RNA interference","volume":"122","author":"Hussein","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1094\/MPMI.2002.15.8.747","article-title":"Ingestion of double-stranded RNA by preparasitic juvenile cyst nematodes leads to RNA interference","volume":"15","author":"Urwin","year":"2002","journal-title":"Mol Plant Microbe Interact"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib12","doi-asserted-by":"crossref","first-page":"30181","DOI":"10.1074\/jbc.271.47.30181","article-title":"Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae","volume":"271","author":"Lustigman","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib13","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1074\/jbc.M106117200","article-title":"Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans","volume":"277","author":"Hashmi","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molbiopara.2004.03.015","article-title":"A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling","volume":"136","author":"Guiliano","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/expr.1993.1027","article-title":"Dirofilaria immitis: effect of fluoromethyl ketone cysteine protease inhibitors on the third- to fourth-stage molt","volume":"76","author":"Richer","year":"1993","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib16","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1074\/jbc.M312346200","article-title":"The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms\u2019 development","volume":"279","author":"Hashmi","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1051\/parasite\/1998051037","article-title":"New features on the moults and morphogenesis of the human filaria Loa loa by using rodent hosts consequences","volume":"5","author":"Bain","year":"1998","journal-title":"Parasite"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib18","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/IAI.68.9.5454-5458.2000","article-title":"Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine development","volume":"68","author":"Allen","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib19","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/27579","article-title":"Specific interference by ingested dsRNA","volume":"395","author":"Timmons","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib20","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib21","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1074\/jbc.M007528200","article-title":"Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals","volume":"276","author":"Liu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0169-4758(99)01411-8","article-title":"Do filarid nematodes have a vascular system?","volume":"15","author":"McKerrow","year":"1999","journal-title":"Parasitol Today"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib23","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/BF00928422","article-title":"Morphological demonstration of essential functional changes after in vitro and in vivo transition of infective Onchocerca volvulus to the post-infective stage","volume":"77","author":"Strote","year":"1991","journal-title":"Parasitol Res"},{"key":"10.1016\/j.molbiopara.2004.08.003_bib24","doi-asserted-by":"crossref","first-page":"52340","DOI":"10.1074\/jbc.M308858200","article-title":"An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site","volume":"278","author":"Brooks","year":"2003","journal-title":"J Biol Chem"}],"container-title":["Molecular and Biochemical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685104002166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685104002166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T23:29:35Z","timestamp":1549236575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166685104002166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0166685104002166"],"URL":"https:\/\/doi.org\/10.1016\/j.molbiopara.2004.08.003","relation":{},"ISSN":["0166-6851"],"issn-type":[{"value":"0166-6851","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}