{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:59:32Z","timestamp":1791331172501,"version":"4.3.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Biochemical Parasitology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.molbiopara.2008.02.005","type":"journal-article","created":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T19:54:58Z","timestamp":1203450898000},"page":"85-91","source":"Crossref","is-referenced-by-count":144,"title":["Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells"],"prefix":"10.1016","volume":"159","author":[{"given":"Emma","family":"Ringqvist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E. Daniel","family":"Palm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Skarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian B.","family":"Hehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Weiland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Davids","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Eckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances D.","family":"Gillin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan G.","family":"Sv\u00e4rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molbiopara.2008.02.005_bib1","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1126\/science.1143837","article-title":"Genomic minimalism in the early diverging intestinal parasite Giardia lamblia","volume":"317","author":"Morrison","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.14.3.447-475.2001","article-title":"Biology of Giardia lamblia","volume":"14","author":"Adam","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00005176-199701000-00018","article-title":"The molecular pathogenesis of giardiasis","volume":"24","author":"Farthing","year":"1997","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pt.2005.11.005","article-title":"Giardia immunity\u2014an update","volume":"22","author":"Roxstrom-Lindquist","year":"2006","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S0031182001008629","article-title":"Identification and characterization of an excretory\u2013secretory product from Giardia lamblia","volume":"123","author":"Kaur","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(08)60548-5","article-title":"Giardia and giardiasis","volume":"17","author":"Meyer","year":"1979","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2036.1994.tb00277.x","article-title":"Activity of metronidazole, azithromycin and three benzimidazoles on Giardia lamblia growth and attachment to a human intestinal cell line","volume":"8","author":"Katelaris","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib8","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1128\/IAI.73.12.8204-8208.2005","article-title":"Giardia lamblia-induced changes in gene expression in differentiated Caco-2 human intestinal epithelial cells","volume":"73","author":"Roxstr\u00f6m-Lindquist","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/AAC.50.1.162-170.2006","article-title":"In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells","volume":"50","author":"M\u00fcller","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI117676","article-title":"A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion","volume":"95","author":"Jung","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib11","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1128\/AEM.67.11.5037-5042.2001","article-title":"Inhibition of Giardia intestinalis by extracellular factors from Lactobacilli: an in vitro study","volume":"67","author":"Perez","year":"2001","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib12","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1128\/IAI.00596-07","article-title":"Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis","volume":"75","author":"Li","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib13","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.4049\/jimmunol.177.9.6281","article-title":"Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia","volume":"177","author":"Davids","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1574-695X.2007.00304.x","article-title":"Caspase-dependent apoptosis of the HCT-8 epithelial cell line induced by the parasite Giardia intestinalis","volume":"51","author":"Panaro","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1590\/S0074-02762006000600020","article-title":"Giardia duodenalis: analysis of secreted proteases upon trophozoite\u2013epithelial cell interaction in vitro","volume":"101","author":"Rodriguez-Fuentes","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib16","first-page":"800","article-title":"Giardia lamblia rearranges F-actin and alpha-actinin in human colonic and duodenal monolayers and reduces transepithelial electrical resistance","volume":"86","author":"Teoh","year":"2000","journal-title":"J Parasitol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib17","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/gast.2002.36002","article-title":"Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion","volume":"123","author":"Scott","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib18","first-page":"BR248","article-title":"Biochemical characterization of the arginine degrading enzymes arginase and arginine deiminase and their effect on nitric oxide production","volume":"8","author":"Dillon","year":"2002","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib19","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.4049\/jimmunol.164.3.1478","article-title":"Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia","volume":"164","author":"Eckmann","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0014-4894(03)00054-7","article-title":"A potentially important excretory\u2013secretory product of Giardia lamblia","volume":"102","author":"Shant","year":"2002","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib21","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1128\/IAI.70.7.3673-3680.2002","article-title":"Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in a caspase-3-dependent manner","volume":"70","author":"Chin","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/gut.2006.107771","article-title":"Mechanisms of epithelial dysfunction in giardiasis","volume":"56","author":"Buret","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/gut.2006.100198","article-title":"Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum","volume":"56","author":"Troeger","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib24","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1086\/375356","article-title":"Identification of immunoreactive proteins during acute human giardiasis","volume":"187","author":"Palm","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-3024.2005.00758.x","article-title":"Secretory antibodies against Giardia intestinalis in lactating Nicaraguan women","volume":"27","author":"Tellez","year":"2005","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib26","doi-asserted-by":"crossref","first-page":"24837","DOI":"10.1074\/jbc.M302082200","article-title":"An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis","volume":"278","author":"Marti","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib27","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1074\/jbc.273.8.4470","article-title":"Cloning and expression of a prokaryotic enzyme, arginine deiminase, from a primitive eukaryote Giardia intestinalis","volume":"273","author":"Knodler","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0020-7519(97)00172-0","article-title":"Anaerobic bacterial metabolism in the ancient eukaryote Giardia duodenalis","volume":"28","author":"Brown","year":"1998","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib29","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/PL00000910","article-title":"Multifunctional alpha-enolase: its role in diseases","volume":"58","author":"Pancholi","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-2958.2002.03029.x","article-title":"Surface antigenic variation in Giardia lamblia","volume":"45","author":"Nash","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib31","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.4049\/jimmunol.131.4.2004","article-title":"Excretory\u2013secretory products of Giardia lamblia","volume":"131","author":"Nash","year":"1983","journal-title":"J Immunol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib32","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/infdis\/152.6.1166","article-title":"Differences in excretory\u2013secretory products and surface antigens among 19 isolates of Giardia","volume":"152","author":"Nash","year":"1985","journal-title":"J Infect Dis"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib33","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1645\/0022-3395(2000)086[0859:IAPCOE]2.0.CO;2","article-title":"Identification and partial characterization of excretory\/secretory products with proteolytic activity in Giardia intestinalis","volume":"86","author":"Jimenez","year":"2000","journal-title":"J Parasitol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib34","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/CDLI.11.1.152-160.2004","article-title":"Systemic and mucosal responses to oral administration of excretory and secretory antigens from Giardia intestinalis","volume":"11","author":"Jimenez","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1600-0854.2005.00302.x","article-title":"Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells","volume":"6","author":"Nickel","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/infdis\/169.2.452","article-title":"A subset of proteins found in culture supernatants of Candida albicans includes the abundant, immunodominant, glycolytic enzyme enolase","volume":"169","author":"Sundstrom","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib37","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s10096-004-1229-y","article-title":"Identification and immunoreactivity of proteins released from Streptococcus agalactiae","volume":"23","author":"Fluegge","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib38","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1074\/jbc.273.23.14503","article-title":"Alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci","volume":"273","author":"Pancholi","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib39","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1128\/IAI.72.11.6748-6752.2004","article-title":"Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen","volume":"72","author":"Ge","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib40","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.bjc.6600681","article-title":"Arginine deprivation, growth inhibition and tumour cell death. Part 2. Enzymatic degradation of arginine in normal and malignant cell cultures","volume":"88","author":"Philip","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib41","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/00006454-200208000-00007","article-title":"Enteric pathogens, intestinal permeability and nitric oxide production in acute gastroenteritis","volume":"21","author":"Kukuruzovic","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.molbiopara.2008.02.005_bib42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1016-8478(23)15015-1","article-title":"Characterization of mycoplasma arginine deiminase expressed in E. coli and its inhibitory regulation of nitric oxide synthesis","volume":"13","author":"Noh","year":"2002","journal-title":"Mol Cells"}],"container-title":["Molecular and Biochemical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016668510800056X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016668510800056X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T12:46:24Z","timestamp":1708605984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016668510800056X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S016668510800056X"],"URL":"https:\/\/doi.org\/10.1016\/j.molbiopara.2008.02.005","relation":{},"ISSN":["0166-6851"],"issn-type":[{"value":"0166-6851","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}