{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:38:40Z","timestamp":1791157120284,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7ao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Biochemical Parasitology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.molbiopara.2012.02.008","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T11:28:08Z","timestamp":1330169288000},"page":"132-139","source":"Crossref","is-referenced-by-count":24,"title":["Effect of human TGF-\u03b2 on the gene expression profile of Schistosoma mansoni adult worms"],"prefix":"10.1016","volume":"183","author":[{"given":"Katia C.","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana L.P.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Verjovski-Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip T.","family":"LoVerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molbiopara.2012.02.008_bib0005","first-page":"186","article-title":"Global distribution of schistosomiasis: CEGET\/WHO atlas","volume":"37","author":"Doumenge","year":"1984","journal-title":"World Health Stat Q"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0010","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/356604a0","article-title":"Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice","volume":"356","author":"Amiri","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0015","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.1064462","article-title":"Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes","volume":"294","author":"Davies","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijpara.2003.10.010","article-title":"Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection","volume":"34","author":"Davies","year":"2004","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-genom-082908-150036","article-title":"Schistosoma genomics: new perspectives on schistosome biology and host\u2013parasite interaction","volume":"10","author":"Han","year":"2009","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0030","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1128\/IAI.67.8.4183-4190.1999","article-title":"Infection of mice lacking interleukin-7 (IL-7) reveals an unexpected role for IL-7 in the development of the parasite Schistosoma mansoni","volume":"67","author":"Wolowczuk","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0035","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1471-2148-7-150","article-title":"Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni","volume":"7","author":"Wu","year":"2007","journal-title":"BMC Evol Biol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0040","doi-asserted-by":"crossref","first-page":"e556","DOI":"10.1371\/journal.pntd.0000556","article-title":"Identification of the Schistosoma mansoni TNF-alpha receptor gene and the effect of human TNF-alpha on the parasite gene expression profile","volume":"3","author":"Oliveira","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0045","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1371\/journal.ppat.0020054","article-title":"Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene","volume":"2","author":"Osman","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0050","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1074\/jbc.273.18.11234","article-title":"A divergent member of the transforming growth factor beta receptor family from Schistosoma mansoni is expressed on the parasite surface membrane","volume":"273","author":"Davies","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0055","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bies.201000077","article-title":"Signalling pathways and the host\u2013parasite relationship: putative targets for control interventions against schistosomiasis: signalling pathways and future anti-schistosome therapies","volume":"33","author":"You","year":"2011","journal-title":"Bioessays"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0060","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.ijpara.2009.06.006","article-title":"Transcriptional profiles of adult male and female Schistosoma japonicum in response to insulin reveal increased expression of genes involved in growth and development","volume":"39","author":"You","year":"2009","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0065","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.pt.2005.09.013","article-title":"Parasite regulation by host hormones: an old mechanism of host exploitation?","volume":"21","author":"Escobedo","year":"2005","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0070","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0742-8413(96)00137-5","article-title":"Schistosoma mansoni: effect of recombinant tumor necrosis factor alpha on fecundity and [14C]-tyrosine uptake in females maintained in vitro","volume":"115","author":"Haseeb","year":"1996","journal-title":"Comp Biochem Physiol C Pharmacol Toxicol Endocrinol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0075","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0020-7519(03)00161-9","article-title":"Developmental plasticity in schistosomes and other helminths","volume":"33","author":"Davies","year":"2003","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0080","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1016\/j.febslet.2006.03.046","article-title":"Growth factor receptors in helminth parasites: signalling and host\u2013parasite relationships","volume":"580","author":"Dissous","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0085","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.ijpara.2010.02.013","article-title":"Growth factors and chemotactic factors from parasitic helminths: molecular evidence for roles in host\u2013parasite interactions versus parasite development","volume":"40","author":"Freitas","year":"2010","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/35043051","article-title":"How cells read TGF-beta signals","volume":"1","author":"Massague","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0095","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.cellbio.21.022404.142018","article-title":"Specificity and versatility in tgf-beta signaling through Smads","volume":"21","author":"Feng","year":"2005","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0166-6851(00)00307-8","article-title":"Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling","volume":"111","author":"Beall","year":"2000","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0105","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1111\/j.1742-4658.2007.05930.x","article-title":"Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni","volume":"274","author":"Carlo","year":"2007","journal-title":"FEBS J"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0110","doi-asserted-by":"crossref","first-page":"10072","DOI":"10.1074\/jbc.M005933200","article-title":"Identification and characterization of a Smad2 homologue from Schistosoma mansoni, a transforming growth factor-beta signal transducer","volume":"276","author":"Osman","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0115","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1074\/jbc.M310949200","article-title":"Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation","volume":"279","author":"Osman","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0120","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1371\/journal.ppat.0030052","article-title":"TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni","volume":"3","author":"Freitas","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0125","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijpara.2008.08.001","article-title":"A bone morphogenetic protein homologue in the parasitic flatworm, Schistosoma mansoni","volume":"39","author":"Freitas","year":"2009","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0130","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.molbiopara.2005.12.006","article-title":"Schistosoma mansoni CBP\/p300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1","volume":"146","author":"Bertin","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0135","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.exppara.2007.06.002","article-title":"Schistosoma mansoni: TGF-beta signaling pathways","volume":"117","author":"LoVerde","year":"2007","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0140","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.mib.2009.06.005","article-title":"Signal transduction regulates schistosome reproductive biology","volume":"12","author":"LoVerde","year":"2009","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0145","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.exppara.2007.04.006","article-title":"Tyrosine kinase and cooperative TGFbeta signaling in the reproductive organs of Schistosoma mansoni","volume":"117","author":"Knobloch","year":"2007","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0150","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"Duvall","year":"1967","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0155","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.exppara.2007.04.005","article-title":"Use of a 44k oligoarray to explore the transcriptome of Schistosoma mansoni adult worms","volume":"117","author":"Verjovski-Almeida","year":"2007","journal-title":"Exp Parasitol"},{"issue":"Suppl","key":"10.1016\/j.molbiopara.2012.02.008_bib0160","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/ng1032","article-title":"Microarray data normalization and transformation","volume":"32","author":"Quackenbush","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0165","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0170","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1109\/34.19039","article-title":"Leave-one-out procedures for nonparametric error-estimates","volume":"11","author":"Fukunaga","year":"1989","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0175","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/bioinformatics\/bth040","article-title":"Ontologizing gene-expression microarray data: characterizing clusters with Gene Ontology","volume":"20","author":"Robinson","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0180","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0185","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0190","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1251\/bpo126","article-title":"Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR","volume":"8","author":"Morey","year":"2006","journal-title":"Biol Proced Online"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0195","doi-asserted-by":"crossref","first-page":"e1043","DOI":"10.1371\/journal.pntd.0001043","article-title":"Gene Atlasing of digestive and reproductive tissues in Schistosoma mansoni","volume":"5","author":"Nawaratna","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0200","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ng1236","article-title":"Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource","volume":"35","author":"Hu","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0210","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/jcp.20359","article-title":"Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction","volume":"204","author":"Birukova","year":"2005","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0215","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1242\/jcs.01036","article-title":"Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42","volume":"117","author":"Edlund","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0220","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0736-0266(02)00020-7","article-title":"TGF-beta1 calcium signaling increases alpha5 integrin expression in osteoblasts","volume":"20","author":"Nesti","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0225","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/mrd.20597","article-title":"Differing mechanisms of cAMP-versus seawater-induced oocyte maturation in marine nemertean worms I. The roles of serine\/threonine kinases and phosphatases","volume":"73","author":"Stricker","year":"2006","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0230","doi-asserted-by":"crossref","first-page":"e1000769","DOI":"10.1371\/journal.ppat.1000769","article-title":"The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis","volume":"6","author":"Beckmann","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0235","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0240","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1590\/S0001-37652011000200026","article-title":"Non-coding RNAs in schistosomes: an unexplored world","volume":"83","author":"Oliveira","year":"2011","journal-title":"An Acad Bras Cienc"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0245","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000101316","article-title":"Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity","volume":"185","author":"Zavadil","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0250","doi-asserted-by":"crossref","first-page":"41328","DOI":"10.1074\/jbc.M110.146852","article-title":"MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}","volume":"285","author":"Louafi","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2012.02.008_bib0255","first-page":"8","article-title":"Smad-mediated miRNA processing: a critical role for a conserved RNA sequence","author":"Davis-Dusenbery","year":"2011","journal-title":"RNA Biol"}],"container-title":["Molecular and Biochemical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685112000503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685112000503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T02:19:01Z","timestamp":1593742741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166685112000503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0166685112000503"],"URL":"https:\/\/doi.org\/10.1016\/j.molbiopara.2012.02.008","relation":{},"ISSN":["0166-6851"],"issn-type":[{"value":"0166-6851","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}