{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:36:48Z","timestamp":1789879008673,"version":"4.0.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust","award":["084175"],"award-info":[{"award-number":["084175"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Biochemical Parasitology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.molbiopara.2014.01.002","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T04:16:16Z","timestamp":1390450576000},"page":"17-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert"],"prefix":"10.1016","volume":"193","author":[{"given":"M\u00f4nica C.O.","family":"Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor L.","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molbiopara.2014.01.002_bib0005","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1086\/605091","article-title":"An estimate of the burden of Chagas disease in the United States","volume":"49","author":"Bern","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0010","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: a computational simulation model","volume":"13","author":"Lee","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"31","key":"10.1016\/j.molbiopara.2014.01.002_bib0015","first-page":"1","article-title":"Trypanocidal drugs: mechanisms, resistance and new targets","volume":"11","author":"Wilkinson","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0020","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1191\/0960327106het653oa","article-title":"Toxic side effects of drugs used to treat Chagas\u2019 disease (American trypanosomiasis)","volume":"25","author":"Castro","year":"2006","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0025","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1073\/pnas.0711014105","article-title":"A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes","volume":"105","author":"Wilkinson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0030","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/AAC.05135-11","article-title":"Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation","volume":"56","author":"Hall","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0035","doi-asserted-by":"crossref","first-page":"13088","DOI":"10.1074\/jbc.M111.230847","article-title":"Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites","volume":"286","author":"Hall","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0040","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/infdis\/jis331","article-title":"Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population","volume":"206","author":"Mejia","year":"2012","journal-title":"J Inf Dis"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-6851(98)00037-1","article-title":"Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox","volume":"93","author":"Murta","year":"1998","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0050","doi-asserted-by":"crossref","first-page":"75575","DOI":"10.1016\/0035-9203(87)90020-4","article-title":"Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease","volume":"81","author":"Filardi","year":"1987","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0055","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1007\/s00436-013-3398-z","article-title":"P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance","volume":"112","author":"Campos","year":"2013","journal-title":"Parasitol Res"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1101\/gr.2895105","article-title":"Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16kb GC-rich transcriptional strand-switch domain as a major feature","volume":"15","author":"Obado","year":"2005","journal-title":"Genome Res"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0065","doi-asserted-by":"crossref","first-page":"e23042","DOI":"10.1371\/journal.pone.0023042","article-title":"Genome size, karyotype polymorphism and chromosomal evolution in Trypanosoma cruzi","volume":"6","author":"Souza","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0070","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10771","article-title":"High-throughput decoding of antitrypanosomal drug efficacy and resistance","volume":"482","author":"Alsford","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0075","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1002\/j.1460-2075.1990.tb07462.x","article-title":"Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase does not conform to the hotspot topogenic signal model","volume":"9","author":"Kendall","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.molbiopara.2014.01.002_bib0080","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1021\/jm000159m","article-title":"Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme","volume":"43","author":"Parkinson","year":"2000","journal-title":"J Med Chem"}],"updated-by":[{"DOI":"10.1016\/j.molbiopara.2015.05.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000}}],"container-title":["Molecular and Biochemical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685114000036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685114000036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T14:50:34Z","timestamp":1589208634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166685114000036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0166685114000036"],"URL":"https:\/\/doi.org\/10.1016\/j.molbiopara.2014.01.002","relation":{},"ISSN":["0166-6851"],"issn-type":[{"value":"0166-6851","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert","name":"articletitle","label":"Article Title"},{"value":"Molecular and Biochemical Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molbiopara.2014.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}