{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:36:49Z","timestamp":1791362209806,"version":"4.3.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Biochemical Parasitology"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.molbiopara.2014.06.002","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T07:46:13Z","timestamp":1403336773000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":357,"title":["Schistosomiasis control: praziquantel forever?"],"prefix":"10.1016","volume":"195","author":[{"given":"Donato","family":"Cioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Pica-Mattoccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Basso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Guidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molbiopara.2014.06.002_bib0005","first-page":"14","article-title":"The Paleoepidemiology of Schistosomiasis in Ancient Egypt","volume":"9","author":"Kloos","year":"2002","journal-title":"Human Ecol Rev"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","article-title":"The global status of schistosomiasis and its control","volume":"77","author":"Chitsulo","year":"2000","journal-title":"Acta Trop"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0001-706X(03)00029-9","article-title":"Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa","volume":"86","author":"van der Werf","year":"2003","journal-title":"Acta Trop"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0025","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)66457-4","article-title":"Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis","volume":"365","author":"King","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0030","first-page":"258","article-title":"Not by drugs alone: the fight against parasitic helminths","volume":"16","author":"Evans","year":"1995","journal-title":"World Health Forum"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0035","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0020-7519(97)00183-5","article-title":"From discovery to eradication of schistosomiasis in Japan: 1847\u20131996","volume":"27","author":"Tanaka","year":"1997","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4269\/ajtmh.1978.27.76","article-title":"Immunization of mice with cobalt-60 irradiated Schistosoma mansoni cercariae","volume":"27","author":"Minard","year":"1978","journal-title":"Am J Trop Med Hyg"},{"issue":"Suppl 1","key":"10.1016\/j.molbiopara.2014.06.002_bib0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/S0074-02762006000900004","article-title":"Schistosome vaccines: a critical appraisal","volume":"101","author":"Wilson","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0050","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1600-065X.2010.00976.x","article-title":"Vaccines to combat the neglected tropical diseases","volume":"239","author":"Bethony","year":"2011","journal-title":"Immunol Rev"},{"issue":"Suppl.","key":"10.1016\/j.molbiopara.2014.06.002_bib0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1590\/S0074-02762001000900003","article-title":"Schistosomiasis epidemiology and control: how did we get here and where should we go?","volume":"96","author":"Sturrock","year":"2001","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0060","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1179\/136485907X193833","article-title":"Angwafo F 3rd. Community acceptability of the use of low-dose niclosamide (Bayluscide), as a molluscicide in the control of human schistosomiasis in Sahelian Cameroon","volume":"101","author":"Takougang","year":"2007","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0065","series-title":"Biologically active natural products","author":"Hostettmann","year":"1988"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0070","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.actatropica.2013.12.013","article-title":"Regulation of laboratory populations of snails (Biomphalaria and Bulinus spp.) by river prawns, Macrobrachium spp. (Decapoda Palaemonidae): implications for control of schistosomiasis","volume":"132","author":"Sokolow","year":"2014","journal-title":"Acta Trop"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0163-7258(95)00026-7","article-title":"Antischistosomal drugs: past, present \u2026 and future?","volume":"68","author":"Cioli","year":"1995","journal-title":"Pharmacol Ther"},{"issue":"Suppl. 1","key":"10.1016\/j.molbiopara.2014.06.002_bib0080","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00436-002-0751-z","volume":"90","author":"Cioli","year":"2003","journal-title":"Praziquantel Parasitol Res"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0085","first-page":"309","article-title":"Praziquantel: too good to be replaced?","author":"Pica-Mattoccia","year":"2012"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/med.2610030204","volume":"3","author":"Andrews","year":"1983","journal-title":"Praziquantel Med Res Rev"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0095","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0169-4758(98)01315-5","article-title":"Is schistosomicidal chemotherapy sub-curative? Implications for drug resistance","volume":"14","author":"Doenhoff","year":"1998","journal-title":"Parasitol Today"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s13149-013-0289-6","article-title":"Comparaison de l\u2019efficacit\u00e9 th\u00e9rapeutique et de la tol\u00e9rance du praziquantel administr\u00e9 en prise unique \u00e0 la dose de 40 versus 60mg\/kg pour le traitement de la bilharziose urinaire en Mauritanie","volume":"106","author":"Ouldabdallahi","year":"2013","journal-title":"Bull Soc Pathol Exot"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00389899","article-title":"a new broad-spectrum antischistosomal agent","volume":"52","author":"G\u00f6nnert","year":"1977","journal-title":"Z Parasitenkd"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0110","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0014-4894(86)90184-0","article-title":"Schistosoma mansoni: chemotherapy of infections of different ages","volume":"61","author":"Sabah","year":"1986","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ijpara.2003.12.003","article-title":"Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment","volume":"34","author":"Pica-Mattoccia","year":"2004","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4269\/ajtmh.1995.53.167","article-title":"Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni","volume":"53","author":"Stelma","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0125","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0169-4758(98)01310-6","article-title":"An international initiative on praziquantel use","volume":"14","author":"Renganathan","year":"1998","journal-title":"Parasitol Today"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0130","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1365-3156.2000.00646.x","article-title":"Efficacy of praziquantel against Schistosoma mansoni with particular consideration for intensity of infection","volume":"5","author":"Utzinger","year":"2000","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0135","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4269\/ajtmh.1991.45.345","article-title":"Comparison of the therapeutic efficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica","volume":"45","author":"Wu","year":"1991","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0140","doi-asserted-by":"crossref","first-page":"e357","DOI":"10.1371\/journal.pntd.0000357","article-title":"Taste a new incentive to switch to (R)-praziquantel in schistosomiasis treatment","volume":"3","author":"Meyer","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0145","doi-asserted-by":"crossref","first-page":"e1260","DOI":"10.1371\/journal.pntd.0001260","article-title":"Resolution of praziquantel","volume":"5","author":"Woelfle","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3947\/ic.2013.45.1.32","article-title":"Praziquantel treatment in trematode and cestode infections: an update","volume":"45","author":"Chai","year":"2013","journal-title":"Infect Chemother"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0155","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00436-013-3303-9","article-title":"Application of praziquantel in schistosomiasis japonica control strategies in China","volume":"112","author":"Wu","year":"2013","journal-title":"Parasitol Res"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0160","doi-asserted-by":"crossref","first-page":"e1917","DOI":"10.1371\/journal.pntd.0001917","article-title":"Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium","volume":"6","author":"Coulibaly","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0165","doi-asserted-by":"crossref","first-page":"e1864","DOI":"10.1371\/journal.pntd.0001864","article-title":"Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children","volume":"6","author":"Sousa-Figueiredo","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0170","series-title":"Report of the WHO informal consultation on the use of praziquantel during pregnancy\/lactation and albendazole\/mebendazole in children under 24 months","author":"World Health Organization","year":"2003"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0175","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3347\/kjp.2011.49.1.73","article-title":"A paragonimiasis patient with allergic reaction to praziquantel and resistance to triclabendazole: successful treatment after desensitization to praziquantel","volume":"49","author":"Kyung","year":"2011","journal-title":"Korean J Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0180","first-page":"21","volume":"89","author":"World Health Organization","year":"2014","journal-title":"Weekly epidemiological record"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0185","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0035-9203(01)90034-3","article-title":"Development and validation of a \u2018tablet pole\u2019 for the administration of praziquantel in sub-Saharan Africa","volume":"95","author":"Montresor","year":"2001","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0190","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0140-6736(10)60879-3","article-title":"Africa is desperate for praziquantel","volume":"376","author":"Hotez","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0195","first-page":"55","article-title":"Refugia \u2013 overlooked as perhaps the most potent factor concerning the development of anthelmintic resistance","volume":"68","author":"van Wyk","year":"2001","journal-title":"Onderstepoort J Vet Res"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0200","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4269\/ajtmh.1996.55.214","article-title":"Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel","volume":"55","author":"Ismail","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0205","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ijpara.2005.02.005","article-title":"Current status of sensitivity to praziquantel in a focus of potential drug resistance in Egypt","volume":"35","author":"Botros","year":"2005","journal-title":"Int J Parasitol"},{"issue":"May (5)","key":"10.1016\/j.molbiopara.2014.06.002_bib0210","first-page":"614","article-title":"Praziquantel efficacy and long-term appraisal of schistosomiasis control in Pemba Island","volume":"15","author":"Guidi","year":"2010","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0215","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0014-4894(85)90041-4","article-title":"Schistosoma mansoni: reduced efficacy of chemotherapy in infected T-cell-deprived mice","volume":"60","author":"Sabah","year":"1985","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0220","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ijpara.2004.05.001","article-title":"Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates","volume":"34","author":"Cioli","year":"2004","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0225","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","article-title":"Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific","volume":"51","author":"Fallon","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0230","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.actatropica.2009.01.012","article-title":"Genetic analysis of decreased praziquantel sensitivity in a laboratory strain of Schistosoma mansoni","volume":"111","author":"Pica-Mattoccia","year":"2009","journal-title":"Acta Trop"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0235","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/S0074-02762011000200006","article-title":"Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails","volume":"106","author":"Couto","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpara.2004.09.004","article-title":"Are Ca2+ channels targets of praziquantel action?","volume":"35","author":"Greenberg","year":"2005","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0245","doi-asserted-by":"crossref","first-page":"e464","DOI":"10.1371\/journal.pntd.0000464","article-title":"A novel biological activity of praziquantel requiring voltage-operated Ca2+ channel beta subunits: subversion of flatworm regenerative polarity","volume":"3","author":"Nogi","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0250","doi-asserted-by":"crossref","first-page":"e1003942","DOI":"10.1371\/journal.ppat.1003942","article-title":"\u2018Death and axes\u2019: unexpected Ca2+ entry phenologs predict new anti-schistosomal agents","volume":"10","author":"Chan","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0255","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.exppara.2006.09.017","article-title":"Cytochalasin D abolishes the schistosomicidal activity of praziquantel","volume":"115","author":"Pica-Mattoccia","year":"2007","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0260","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.exppara.2008.03.012","article-title":"Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death","volume":"119","author":"Pica-Mattoccia","year":"2008","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0265","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.2174\/156802611796575939","article-title":"Macromolecular bases of antischistosomal therapy","volume":"11","author":"Angelucci","year":"2011","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0270","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1016\/j.bmcl.2007.05.063","article-title":"Praziquantel derivatives I: modification of the aromatic ring","volume":"17","author":"Ronketti","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0275","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bmcl.2010.03.001","article-title":"Praziquantel analogs with activity against juvenile Schistosoma mansoni","volume":"20","author":"Dong","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0280","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.bmcl.2011.11.108","article-title":"Synthesis of new praziquantel analogues: potential candidates for the treatment of schistosomiasis","volume":"22","author":"Sadhu","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0285","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/expr.1993.1104","article-title":"Schistosoma mansoni: genetic complementation analysis shows that two independent hycanthone\/oxamniquine-resistant strains are mutated in the same gene","volume":"77","author":"Pica-Mattoccia","year":"1993","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0290","first-page":"191","article-title":"Current and future antischistosomal drugs","volume":"vol. 10","author":"Cioli","year":"2005"},{"issue":"Suppl. 1","key":"10.1016\/j.molbiopara.2014.06.002_bib0295","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1590\/S0074-02762006000900048","article-title":"The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase","volume":"101","author":"Pica-Mattoccia","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0300","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1126\/science.1243106","article-title":"Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites","volume":"342","author":"Valentim","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0305","doi-asserted-by":"crossref","first-page":"e45867","DOI":"10.1371\/journal.pone.0045867","article-title":"Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis","volume":"7","author":"P\u00e9rez del Villar","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0310","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1128\/AAC.05371-11","article-title":"In vivo activity of aryl ozonides against Schistosoma species","volume":"56","author":"Keiser","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0315","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tmaid.2008.06.006","article-title":"Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice","volume":"6","author":"Van Nassauw","year":"2008","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0320","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-6851(02)00031-2","article-title":"The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase","volume":"121","author":"Alger","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0325","doi-asserted-by":"crossref","first-page":"32557","DOI":"10.1074\/jbc.M110.141960","article-title":"Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography","volume":"285","author":"Angelucci","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0330","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nm1737","article-title":"Identification of oxadiazoles as new drug leads for the control of schistosomiasis","volume":"14","author":"Sayed","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0335","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nrd2684","article-title":"Genomic-scale prioritization of drug targets: the TDR Targets database","volume":"7","author":"Ag\u00fcero","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0340","doi-asserted-by":"crossref","first-page":"e1003254","DOI":"10.1371\/journal.ppat.1003254","article-title":"Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII","volume":"9","author":"You","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.molbiopara.2014.06.002_bib0345","first-page":"302","volume":"35","author":"Paveley","year":"2013","journal-title":"Automated imaging and other developments in whole-organism anthelmintic screening, Parasite Immunol"}],"container-title":["Molecular and Biochemical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685114000759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685114000759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T03:03:17Z","timestamp":1597978997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166685114000759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0166685114000759"],"URL":"https:\/\/doi.org\/10.1016\/j.molbiopara.2014.06.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725849704.793510453","asserted-by":"object"}]},"ISSN":["0166-6851"],"issn-type":[{"value":"0166-6851","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schistosomiasis control: praziquantel forever?","name":"articletitle","label":"Article Title"},{"value":"Molecular and Biochemical Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molbiopara.2014.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}