{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:07:18Z","timestamp":1780420038516,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"FOCEM"},{"name":"Agencia Nacional de Investigacion e Innovaci\u00f3n"},{"DOI":"10.13039\/501100001688","name":"ICGEB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Biochemical Parasitology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.molbiopara.2016.03.002","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T17:47:40Z","timestamp":1457718460000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host"],"prefix":"10.1016","volume":"206","author":[{"given":"Mariana","family":"Bonilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Krull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Irigo\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo A.","family":"Comini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molbiopara.2016.03.002_bib0005","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1083516","article-title":"Characterization of mammalian selenoproteomes","volume":"300","author":"Kryukov","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0010","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0015","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/ars.2015.6391","article-title":"Update on selenoprotein biosynthesis","volume":"23","author":"Bulteau","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0020","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/nar\/gkj450","article-title":"The plasmodium selenoproteome","volume":"34","author":"Lobanov","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0025","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1093\/nar\/gkl541","article-title":"Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a kinetoplastida-specific selenoprotein","volume":"34","author":"Lobanov","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0030","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1073\/pnas.0901575106","article-title":"The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes","volume":"106","author":"Aeby","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0035","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1016\/j.bbagen.2013.01.013","article-title":"Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids","volume":"1830","author":"Manta","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0040","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/ars.2009.2865","article-title":"Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins","volume":"12","author":"Shchedrina","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0045","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1210\/en.2013-1167","article-title":"The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human \u03b2-cells and its targeted inactivation impairs glucose tolerance","volume":"154","author":"Prevost","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0050","doi-asserted-by":"crossref","first-page":"16478","DOI":"10.1073\/pnas.1417176111","article-title":"Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6\/selenoprotein K complex","volume":"111","author":"Fredericks","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molbiopara.2009.08.007","article-title":"The selenoproteome is dispensable in bloodstream forms of Trypanosoma brucei","volume":"168","author":"Aeby","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molbiopara.2008.08.009","article-title":"Selenocysteine incorporation in kinetoplastid: selenophosphate synthetase (SELD) from Leishmania major and Trypanosoma brucei","volume":"162","author":"Sculaccio","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molbiopara.2011.04.007","article-title":"Oxidative stress protection of Trypanosomes requires selenophosphate synthase","volume":"180","author":"Costa","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0070","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkr1032","article-title":"GeneDB\u2014an annotation database for pathogens","volume":"40","author":"Logan-Klumpler","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0075","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkp851","article-title":"TriTrypDB: a functional genomic resource for the Trypanosomatidae","volume":"38","author":"Aslett","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0080","doi-asserted-by":"crossref","first-page":"D270","DOI":"10.1093\/nar\/gku1152","article-title":"MBGD update 2015: microbial genome database for flexible ortholog analysis utilizing a diverse set of genomic data","volume":"43","author":"Uchiyama","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0085","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/BJ20061341","article-title":"Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes","volume":"402","author":"Comini","year":"2007","journal-title":"Biochem. J"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0090","doi-asserted-by":"crossref","first-page":"27785","DOI":"10.1074\/jbc.M802010200","article-title":"Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes","volume":"283","author":"Comini","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0095","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1083\/jcb.105.6.2649","article-title":"Import of fructose bisphosphate aldolase into the glycosomes of Trypanosoma brucei","volume":"105","author":"Clayton","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0166-6851(99)00002-X","article-title":"A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei","volume":"99","author":"Wirtz","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0105","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2958.2011.07721.x","article-title":"Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei","volume":"81","author":"Rold\u00e1n","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/cc2955","article-title":"Statistics review 12: survival analysis","volume":"8","author":"Bewick","year":"2004","journal-title":"Crit. Care"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0115","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1186\/1471-2164-9-594","article-title":"Insights into the genome sequence of a free-living Kinetoplastid: bodo saltans (Kinetoplastida: Euglenozoa)","volume":"9","author":"Jackson","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0120","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1017\/S0031182014000894","article-title":"Genome evolution in trypanosomatid parasites","volume":"142","author":"Jackson","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0125","first-page":"457","article-title":"Staphylococcus aureus CstB is a novel multidomain persulfide dioxygenase-sulfurtransferase involved in hydrogen sulfide detoxification","volume":"11","author":"Shen","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nchembio.1834","article-title":"Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways","volume":"11","author":"Mishanina","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0135","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molbiopara.2006.05.009","article-title":"The glucose-6-phosphate dehydrogenase from Trypanosoma cruzi: its role in the defense of the parasite against oxidative stress","volume":"149","author":"Igoillo-Esteve","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0140","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1089\/ars.2012.4859","article-title":"Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity","volume":"19","author":"Manta","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0145","doi-asserted-by":"crossref","first-page":"22209","DOI":"10.1074\/jbc.M401240200","article-title":"Glyoxalase II of African trypanosomes is trypanothione-dependent","volume":"279","author":"Irsch","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0150","series-title":"Carbohydrate Metabolism in Cultured Cells","first-page":"183","author":"Fairlamb","year":"1986"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1432-1033.1993.tb17638.x","article-title":"The formation of methylglyoxal from triose phosphates: investigation using a specific assay for methylglyoxal","volume":"212","author":"Phillips","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0009-2797(97)00157-9","article-title":"Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors","volume":"11","author":"Thornalley","year":"1998","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molbiopara.2008.09.005","article-title":"Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes","volume":"163","author":"Wendler","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0170","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1016\/S0021-9258(18)42403-9","article-title":"Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase","volume":"267","author":"Bj\u00f6rnstedt","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0175","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1432-1033.1992.tb17068.x","article-title":"Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen","volume":"207","author":"Kumar","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0180","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.3390\/nu7053536","article-title":"Redox-active selenium compounds\u2014from toxicity and cell death to cancer treatment","volume":"7","author":"Misra","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0185","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.exppara.2013.07.016","article-title":"Effects of dietary selenium supplementation on parasitemia, anemia and serum proteins of Trypanosoma brucei infected rats","volume":"135","author":"Eze","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0190","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1590\/S0074-02762010000600003","article-title":"The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice","volume":"105","author":"Souza","year":"2010","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0195","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00436-010-1794-1","article-title":"The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection","volume":"106","author":"de Souza","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0200","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1515\/BC.2003.069","article-title":"Kinetics and redox-sensitive oligomerisation reveal negative subunit cooperativity in tryparedoxin peroxidase of Trypanosoma brucei","volume":"384","author":"Budde","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0205","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1091\/mbc.E12-09-0648","article-title":"Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation","volume":"24","author":"Haunhorst","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0210","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nchembio.1892","article-title":"N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin","volume":"11","author":"Banci","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0215","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1083\/jcb.137.6.1369","article-title":"Survival of Trypanosoma brucei in the tsetse fly is enhanced by the expression of specific forms of procyclin","volume":"137","author":"Ruepp","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molbiopara.2016.03.002_bib0220","doi-asserted-by":"crossref","first-page":"37388","DOI":"10.1074\/jbc.M110.123323","article-title":"Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite","volume":"285","author":"Buchholz","year":"2010","journal-title":"J. Biol. Chem."}],"container-title":["Molecular and Biochemical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685116300184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166685116300184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:30:05Z","timestamp":1655253005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166685116300184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":44,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0166685116300184"],"URL":"https:\/\/doi.org\/10.1016\/j.molbiopara.2016.03.002","relation":{},"ISSN":["0166-6851"],"issn-type":[{"value":"0166-6851","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host","name":"articletitle","label":"Article Title"},{"value":"Molecular and Biochemical Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molbiopara.2016.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}