{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:49:32Z","timestamp":1791157772751,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2299,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.molcel.2007.02.024","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T07:49:02Z","timestamp":1176450542000},"page":"63-74","source":"Crossref","is-referenced-by-count":403,"title":["Regulation of HIF-1\u03b1 Stability through S-Nitrosylation"],"prefix":"10.1016","volume":"26","author":[{"given":"Fang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sonveaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid N.","family":"Rabbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeljko","family":"Vujaskovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0W.","family":"Dewhirst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2007.02.024_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/0264-6021:3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.molcel.2007.02.024_bib2","first-page":"8984","article-title":"Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity","volume":"63","author":"Bisht","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib3","first-page":"5347","article-title":"Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas","volume":"56","author":"Brizel","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib4","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1158\/0008-5472.CAN-05-2714","article-title":"Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion","volume":"65","author":"Colombo","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4161\/cc.2.3.402","article-title":"A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function","volume":"2","author":"Cramer","year":"2003","journal-title":"Cell Cycle"},{"key":"10.1016\/j.molcel.2007.02.024_bib6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","article-title":"HIF-1alpha is essential for myeloid cell-mediated inflammation","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2007.02.024_bib7","doi-asserted-by":"crossref","first-page":"9211","DOI":"10.1158\/0008-5472.CAN-06-2181","article-title":"Inhibition of hsp90 compromises the DNA damage response to radiation","volume":"66","author":"Dote","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.1082504","article-title":"Tumor response to radiotherapy regulated by endothelial cell apoptosis","volume":"300","author":"Garcia-Barros","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molcel.2007.02.024_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1124\/mi.3.5.253","article-title":"S-nitrosylation signaling in cell biology","volume":"3","author":"Gaston","year":"2003","journal-title":"Mol. Interv."},{"key":"10.1016\/j.molcel.2007.02.024_bib10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrd1199","article-title":"HIF-1 as a target for drug development","volume":"2","author":"Giaccia","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.molcel.2007.02.024_bib11","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1128\/IAI.72.5.2956-2963.2004","article-title":"Role of macrophages in host resistance to group A streptococci","volume":"72","author":"Goldmann","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molcel.2007.02.024_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc704","article-title":"Hypoxia\u2013a key regulatory factor in tumour growth","volume":"2","author":"Harris","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2007.02.024_bib13","doi-asserted-by":"crossref","first-page":"16128","DOI":"10.1074\/jbc.M313342200","article-title":"Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway","volume":"279","author":"Isaacs","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.02.024_bib14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.molcel.2007.02.024_bib15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.molcel.2007.02.024_bib16","doi-asserted-by":"crossref","first-page":"PL1","DOI":"10.1126\/stke.2001.86.pl1","article-title":"The biotin switch method for the detection of S-nitrosylated proteins","volume":"2001","author":"Jaffrey","year":"2001","journal-title":"Sci. STKE"},{"key":"10.1016\/j.molcel.2007.02.024_bib17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0092-8674(02)01085-1","article-title":"Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation","volume":"111","author":"Jeong","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2007.02.024_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.RES.86.3.319","article-title":"Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes","volume":"86","author":"Jung","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib19","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1101\/gad.991402","article-title":"FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor","volume":"16","author":"Lando","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2007.02.024_bib20","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1068592","article-title":"Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch","volume":"295","author":"Lando","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.molcel.2007.02.024_bib21","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/(SICI)1096-9896(200003)190:4<430::AID-PATH538>3.0.CO;2-6","article-title":"Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer","volume":"190","author":"Leek","year":"2000","journal-title":"J. Pathol."},{"key":"10.1016\/j.molcel.2007.02.024_bib22","first-page":"1326","article-title":"Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer","volume":"62","author":"Leek","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0002-9440(10)62038-X","article-title":"Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies","volume":"167","author":"Lewis","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molcel.2007.02.024_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/386403a0","article-title":"Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT","volume":"386","author":"Maltepe","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2007.02.024_bib25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1471-4159.2004.02483.x","article-title":"HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion","volume":"90","author":"Matrone","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.molcel.2007.02.024_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2007.02.024_bib27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-1-4757-3401-0_24","article-title":"The pVHL-hIF-1 system. A key mediator of oxygen homeostasis","volume":"502","author":"Maxwell","year":"2001","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molcel.2007.02.024_bib28","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4161\/cc.3.2.689","article-title":"HIF-1: a target for cancer, ischemia and inflammation\u2013too good to be true?","volume":"3","author":"Melillo","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.molcel.2007.02.024_bib29","doi-asserted-by":"crossref","first-page":"12236","DOI":"10.1074\/jbc.272.18.12236","article-title":"Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine","volume":"272","author":"Melillo","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.02.024_bib30","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1091\/mbc.E02-12-0791","article-title":"Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases","volume":"14","author":"Metzen","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.molcel.2007.02.024_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1535-6108(04)00115-1","article-title":"Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules","volume":"5","author":"Moeller","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2007.02.024_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ccr.2005.06.016","article-title":"Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity","volume":"8","author":"Moeller","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2007.02.024_bib33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nm1196","article-title":"Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy","volume":"11","author":"Muller","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2007.02.024_bib34","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00001622-200311000-00003","article-title":"Heat shock protein 90","volume":"15","author":"Neckers","year":"2003","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.molcel.2007.02.024_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1517\/14728214.7.2.277","article-title":"Heat-shock protein 90 inhibitors as novel cancer chemotherapeutic agents","volume":"7","author":"Neckers","year":"2002","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.molcel.2007.02.024_bib36","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1124\/mol.58.6.1197","article-title":"Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides","volume":"58","author":"Palmer","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molcel.2007.02.024_bib37","doi-asserted-by":"crossref","first-page":"9533","DOI":"10.1073\/pnas.96.17.9533","article-title":"Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL\/elongin BC\/hCUL-2 complex with the ubiquitin ligase complex SKP1\/cullin\/F-box protein","volume":"96","author":"Pause","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2007.02.024_bib38","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1172\/JCI23865","article-title":"HIF-1alpha expression regulates the bactericidal capacity of phagocytes","volume":"115","author":"Peyssonnaux","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molcel.2007.02.024_bib39","first-page":"4316","article-title":"Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway","volume":"62","author":"Rapisarda","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1182\/blood.V97.4.1009","article-title":"Accumulation of HIF-1alpha under the influence of nitric oxide","volume":"97","author":"Sandau","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.molcel.2007.02.024_bib41","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S1471-4914(02)02317-1","article-title":"HIF-1 and tumor progression: pathophysiology and therapeutics","volume":"8","author":"Semenza","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.molcel.2007.02.024_bib42","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2007.02.024_bib43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/0-306-46825-5_12","article-title":"Hypoxia, HIF-1, and the pathophysiology of common human diseases","volume":"475","author":"Semenza","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molcel.2007.02.024_bib44","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4161\/cc.3.2.617","article-title":"Dead cells don't form tumors: HIF-dependent cytotoxins","volume":"3","author":"Sutphin","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.molcel.2007.02.024_bib45","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1073\/pnas.0400453101","article-title":"Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide","volume":"101","author":"Thomas","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2007.02.024_bib46","first-page":"3300","article-title":"Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor","volume":"57","author":"Thomsen","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib47","first-page":"471","article-title":"Monocyte\/macrophage recruitment, activation and differentiation modulate interleukin-8 production: a paracrine role of tumor-associated macrophages in tumor angiogenesis","volume":"16","author":"Varney","year":"2002","journal-title":"In Vivo"},{"key":"10.1016\/j.molcel.2007.02.024_bib48","first-page":"1957","article-title":"Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction","volume":"9","author":"Wachsberger","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.molcel.2007.02.024_bib49","doi-asserted-by":"crossref","first-page":"21513","DOI":"10.1016\/S0021-9258(20)80571-7","article-title":"Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia","volume":"268","author":"Wang","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2007.02.024_bib50","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.90.9.4304","article-title":"General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia","volume":"90","author":"Wang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2007.02.024_bib51","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1074\/jbc.270.3.1230","article-title":"Purification and characterization of hypoxia-inducible factor 1","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.02.024_bib52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-5793(03)00807-X","article-title":"S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity","volume":"549","author":"Yasinska","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molcel.2007.02.024_bib53","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/jnci\/95.7.516","article-title":"YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1","volume":"95","author":"Yeo","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.molcel.2007.02.024_bib54","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1158\/0008-5472.CAN-03-2301","article-title":"Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276507001244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276507001244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T08:55:05Z","timestamp":1683795305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276507001244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S1097276507001244"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2007.02.024","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}