{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:42:00Z","timestamp":1791348120160,"version":"4.3.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2299,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.molcel.2007.03.013","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T07:13:59Z","timestamp":1177658039000},"page":"231-243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":180,"title":["XPG Stabilizes TFIIH, Allowing Transactivation of Nuclear Receptors: Implications for Cockayne Syndrome in XP-G\/CS Patients"],"prefix":"10.1016","volume":"26","author":[{"given":"Shinsuke","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Kuraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chymkowitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Compe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arato","family":"Takedachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Ishigami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Coin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Egly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2007.03.013_bib1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mrfmmm.2005.04.004","article-title":"Transcription-coupled repair and premature ageing","volume":"577","author":"Andressoo","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.molcel.2007.03.013_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1101\/gad.14.3.349","article-title":"Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK","volume":"14","author":"Araujo","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2007.03.013_bib3","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1128\/MCB.21.7.2281-2291.2001","article-title":"Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome","volume":"21","author":"Araujo","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2007.03.013_bib4","doi-asserted-by":"crossref","first-page":"21896","DOI":"10.1074\/jbc.M001985200","article-title":"TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7","volume":"275","author":"Bastien","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.03.013_bib5","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/nar\/27.4.979","article-title":"Nucleotide excision repair 3\u2032 endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase","volume":"27","author":"Bessho","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2007.03.013_bib6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1097-2765(02)00678-0","article-title":"CSB is a component of RNA Pol I transcription","volume":"10","author":"Bradsher","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1097-2765(05)00004-3","article-title":"Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7","volume":"6","author":"Chen","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib8","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.biochi.2003.10.014","article-title":"The XPG story","volume":"85","author":"Clarkson","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.molcel.2007.03.013_bib9","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/emboj\/18.5.1357","article-title":"Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH","volume":"18","author":"Coin","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2007.03.013_bib10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/2491","article-title":"Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH","volume":"20","author":"Coin","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2007.03.013_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.molcel.2005.10.024","article-title":"p8\/TTD-A as a repair-specific TFIIH subunit","volume":"21","author":"Coin","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib12","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1128\/MCB.25.14.6065-6076.2005","article-title":"Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations","volume":"25","author":"Compe","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2007.03.013_bib13","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1074\/jbc.274.9.5637","article-title":"Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair","volume":"274","author":"Constantinou","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.03.013_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molcel.2004.10.007","article-title":"Selective regulation of vitamin D receptor-responsive genes by TFIIH","volume":"16","author":"Drane","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib15","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.1073\/pnas.93.13.6488","article-title":"Human cyclin-dependent kinase-activating kinase exists in three distinct complexes","volume":"93","author":"Drapkin","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2007.03.013_bib16","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/S1097-2765(03)00182-5","article-title":"Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients","volume":"11","author":"Dubaele","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib17","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1074\/jbc.M412228200","article-title":"The spacer region of XPG mediates recruitment to nucleotide excision repair complexes and determines substrate specificity","volume":"280","author":"Dunand-Sauthier","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.03.013_bib18","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1046\/j.1523-1747.2002.01782.x","article-title":"Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients","volume":"118","author":"Emmert","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.molcel.2007.03.013_bib19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/emboj\/16.3.625","article-title":"Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein","volume":"16","author":"Evans","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2007.03.013_bib20","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1093\/emboj\/16.21.6559","article-title":"Mechanism of open complex and dual incision formation by human nucleotide excision repair factors","volume":"16","author":"Evans","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2007.03.013_bib21","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1242\/jcs.02718","article-title":"Secrets of a double agent: CDK7 in cell-cycle control and transcription","volume":"118","author":"Fisher","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.molcel.2007.03.013_bib22","series-title":"DNA Repair and Mutagenesis","author":"Friedberg","year":"2006"},{"key":"10.1016\/j.molcel.2007.03.013_bib23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nsmb782","article-title":"TFIIH contains a PH domain involved in DNA nucleotide excision repair","volume":"11","author":"Gervais","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2007.03.013_bib24","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/ng1387","article-title":"A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A","volume":"36","author":"Giglia-Mari","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2007.03.013_bib25","doi-asserted-by":"crossref","first-page":"8949","DOI":"10.1038\/sj.onc.1206096","article-title":"Subpathways of nucleotide excision repair and their regulation","volume":"21","author":"Hanawalt","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2007.03.013_bib26","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1021\/bi9524124","article-title":"Interactions involving the human RNA polymerase II transcription\/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein","volume":"35","author":"Iyer","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.molcel.2007.03.013_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0092-8674(02)00692-X","article-title":"XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha","volume":"109","author":"Keriel","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1097-2765(00)80172-0","article-title":"Base excision repair of oxidative DNA damage activated by XPG protein","volume":"3","author":"Klungland","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0092-8674(02)00795-X","article-title":"Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome","volume":"109","author":"Lee","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib30","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.biochi.2003.09.010","article-title":"DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy","volume":"85","author":"Lehmann","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.molcel.2007.03.013_bib31","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1074\/jbc.270.6.2415","article-title":"Reconstitution of human DNA repair excision nuclease in a highly defined system","volume":"270","author":"Mu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.03.013_bib32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0076-6879(03)70037-8","article-title":"Immunoaffinity purification of mammalian protein complexes","volume":"370","author":"Nakatani","year":"2003","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.molcel.2007.03.013_bib33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/hmg\/3.6.963","article-title":"Mutations that disable the DNA repair gene XPG in a xeroderma pigmentosum group G patient","volume":"3","author":"Nouspikel","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2007.03.013_bib34","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/sj.emboj.7601071","article-title":"Cockayne syndrome B protein regulates the transcriptional program after UV irradiation","volume":"25","author":"Proietti-De-Santis","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2007.03.013_bib35","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1073\/pnas.93.13.6482","article-title":"Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2\/CAK and TFIIH","volume":"93","author":"Reardon","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2007.03.013_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0092-8674(00)80317-7","article-title":"Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7","volume":"90","author":"Rochette-Egly","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib37","doi-asserted-by":"crossref","first-page":"35328","DOI":"10.1074\/jbc.M105570200","article-title":"A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH","volume":"276","author":"Sandrock","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.03.013_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molcel.2005.09.022","article-title":"Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne syndrome","volume":"20","author":"Sarker","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.dnarep.2004.10.009","article-title":"Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg","volume":"4","author":"Shiomi","year":"2005","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.molcel.2007.03.013_bib40","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0968-0004(96)10046-3","article-title":"The multiple roles of transcription\/repair factor TFIIH","volume":"21","author":"Svejstrup","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molcel.2007.03.013_bib41","doi-asserted-by":"crossref","first-page":"10670","DOI":"10.1128\/MCB.24.24.10670-10680.2004","article-title":"Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage","volume":"24","author":"Thorel","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2007.03.013_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(00)80177-X","article-title":"Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7","volume":"3","author":"Tirode","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2007.03.013_bib43","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tig.2003.08.005","article-title":"The transcriptional complexity of the TFIIH complex","volume":"19","author":"Zurita","year":"2003","journal-title":"Trends Genet."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276507001761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276507001761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:06:00Z","timestamp":1761091560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276507001761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S1097276507001761"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2007.03.013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1082765.535681","asserted-by":"object"}]},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"XPG Stabilizes TFIIH, Allowing Transactivation of Nuclear Receptors: Implications for Cockayne Syndrome in XP-G\/CS Patients","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2007.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}