{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:36:32Z","timestamp":1791185792473,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1993,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.molcel.2007.12.028","type":"journal-article","created":{"date-parts":[[2008,3,2]],"date-time":"2008-03-02T07:27:53Z","timestamp":1204442873000},"page":"525-531","source":"Crossref","is-referenced-by-count":259,"title":["MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG"],"prefix":"10.1016","volume":"29","author":[{"given":"Kok Lian","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain W.","family":"McNae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Schmiedeberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Klose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm D.","family":"Walkinshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2007.12.028_bib1","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1107\/S0907444902016657","article-title":"PHENIX: building new software for automated crystallographic structure determination","volume":"58","author":"Adams","year":"2002","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.molcel.2007.12.028_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2007.12.028_bib3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/1531-8249(200005)47:5<670::AID-ANA20>3.0.CO;2-F","article-title":"Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes","volume":"47","author":"Amir","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.molcel.2007.12.028_bib4","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1021\/bi0001271","article-title":"Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA","volume":"39","author":"Ballestar","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.molcel.2007.12.028_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0006-3495(92)81649-1","article-title":"The nucleic acid database. A comprehensive relational database of three-dimensional structures of nucleic acids","volume":"63","author":"Berman","year":"1992","journal-title":"Biophys. J."},{"key":"10.1016\/j.molcel.2007.12.028_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg1878","article-title":"Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized","volume":"7","author":"Bienvenu","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2007.12.028_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2007.12.028_bib8","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molcel.2007.12.028_bib9","doi-asserted-by":"crossref","first-page":"19280","DOI":"10.1074\/jbc.M602257200","article-title":"Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases","volume":"281","author":"Couture","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.12.028_bib10","series-title":"The PyMOL molecular graphics system","author":"DeLano","year":"2003"},{"key":"10.1016\/j.molcel.2007.12.028_bib11","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.molcel.2007.12.028_bib12","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1093\/nar\/gkg249","article-title":"The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties","volume":"31","author":"Fraga","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2007.12.028_bib13","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1074\/jbc.M007224200","article-title":"DNA recognition by the methyl-CpG binding domain of MeCP2","volume":"276","author":"Free","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.12.028_bib14","doi-asserted-by":"crossref","first-page":"D211","DOI":"10.1093\/nar\/gkh078","article-title":"E-MSD: an integrated data resource for bioinformatics","volume":"32","author":"Golovin","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2007.12.028_bib15","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.molcel.2007.12.028_bib16","doi-asserted-by":"crossref","first-page":"6538","DOI":"10.1128\/MCB.18.11.6538","article-title":"Identification and characterization of a family of mammalian methyl-CpG binding proteins","volume":"18","author":"Hendrich","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2007.12.028_bib17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"Jones","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2007.12.028_bib18","doi-asserted-by":"crossref","first-page":"46490","DOI":"10.1074\/jbc.M408284200","article-title":"MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex","volume":"279","author":"Klose","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2007.12.028_bib19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2005.07.021","article-title":"DNA binding selectivity of MeCP2 due to a requirement for A\/T sequences adjacent to methyl-CpG","volume":"19","author":"Klose","year":"2005","journal-title":"Mol. Cell"},{"issue":"Spec 2","key":"10.1016\/j.molcel.2007.12.028_bib20","doi-asserted-by":"crossref","first-page":"R221","DOI":"10.1093\/hmg\/ddg286","article-title":"DNA methylation and Rett syndrome","volume":"12","author":"Kriaucionis","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"Suppl 1","key":"10.1016\/j.molcel.2007.12.028_bib21","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1016\/S0387-7604(01)00345-X","article-title":"Functional analyses of MeCP2 mutations associated with Rett syndrome using transient expression systems","volume":"23","author":"Kudo","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.molcel.2007.12.028_bib22","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1093\/nar\/gkg680","article-title":"3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures","volume":"31","author":"Lu","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2007.12.028_bib23","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/nar\/29.13.2860","article-title":"Amino acid-base interactions: a three-dimensional analysis of protein-DNA interactions at an atomic level","volume":"29","author":"Luscombe","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2007.12.028_bib24","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation","volume":"302","author":"Martinowich","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molcel.2007.12.028_bib25","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1093\/emboj\/17.9.2709","article-title":"Hydration and recognition of methylated CpG steps in DNA","volume":"17","author":"Mayer-Jung","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2007.12.028_bib26","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1006\/jmbi.1994.1334","article-title":"Satisfying hydrogen bonding potential in proteins","volume":"238","author":"McDonald","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molcel.2007.12.028_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.molcel.2007.12.028_bib28","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1093\/nar\/21.21.4886","article-title":"Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2","volume":"21","author":"Nan","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2007.12.028_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"Nan","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2007.12.028_bib30","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2007.12.028_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1073858403260995","article-title":"Rett syndrome: a prototypical neurodevelopmental disorder","volume":"10","author":"Neul","year":"2004","journal-title":"Neuroscientist"},{"key":"10.1016\/j.molcel.2007.12.028_bib32","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1093\/emboj\/18.23.6653","article-title":"Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1","volume":"18","author":"Ohki","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2007.12.028_bib33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00324-5","article-title":"Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA","volume":"105","author":"Ohki","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2007.12.028_bib34","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1107\/S0907444902015391","article-title":"The CCP4 molecular-graphics project","volume":"58","author":"Potterton","year":"2002","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.molcel.2007.12.028_bib35","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1006\/jmbi.1999.3023","article-title":"The solution structure of the domain from MeCP2 that binds to methylated DNA","volume":"291","author":"Wakefield","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molcel.2007.12.028_bib36","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1006\/jmbi.1999.2552","article-title":"A natural grouping of motifs with an aspartate or asparagine residue forming two hydrogen bonds to residues ahead in sequence: their occurrence at \u03b1-helical N termini and in other situations","volume":"286","author":"Wan","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molcel.2007.12.028_bib37","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1006\/jmbi.1999.2551","article-title":"A recurring two-hydrogen-bond motif incorporating a serine or threonine residue is found both at \u03b1-helical N termini and in other situations","volume":"286","author":"Wan","year":"1999","journal-title":"J. Mol. Biol."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276508000968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276508000968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T07:21:43Z","timestamp":1546240903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276508000968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S1097276508000968"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2007.12.028","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}