{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:13:40Z","timestamp":1791573220673,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.molcel.2014.01.021","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T11:45:17Z","timestamp":1392291917000},"page":"1005-1019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":374,"title":["An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment"],"prefix":"10.1016","volume":"53","author":[{"given":"Nianwei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kung-Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Gates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zacharia\u00a0A.","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Shun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas\u00a0J.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven\u00a0R.","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg","family":"Duester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Duc Si","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq\u00a0M.","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2014.01.021_bib1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/sj.emboj.7601046","article-title":"Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes","volume":"25","author":"Angelov","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2014.01.021_bib2","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1101\/gad.176008.111","article-title":"Sequentially acting Sox transcription factors in neural lineage development","volume":"25","author":"Bergsland","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2014.01.021_bib3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature09531","article-title":"A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity","volume":"468","author":"Chia","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.01.021_bib4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2011.08.027","article-title":"Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions","volume":"44","author":"Chu","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2014.01.021_bib5","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1074\/jbc.274.2.1066","article-title":"G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, A role for G-G pairing in immunoglobulin switch recombination","volume":"274","author":"Dempsey","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2014.01.021_bib6","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2014.01.021_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.stem.2009.03.009","article-title":"A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity","volume":"4","author":"Ding","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molcel.2014.01.021_bib8","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1101\/gr.078378.108","article-title":"Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation","volume":"18","author":"Dinger","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2014.01.021_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.01.021_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1242\/dev.123.1.399","article-title":"Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva","volume":"123","author":"Granato","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.molcel.2014.01.021_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.01.021_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature10398","article-title":"lincRNAs act in the circuitry controlling pluripotency and differentiation","volume":"477","author":"Guttman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.01.021_bib13","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington\u2019s disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2014.01.021_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2010.06.040","article-title":"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response","volume":"142","author":"Huarte","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2014.01.021_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/stem.1279","article-title":"Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells","volume":"31","author":"Hutchins","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.molcel.2014.01.021_bib16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature04915","article-title":"Dissecting self-renewal in stem cells with RNA interference","volume":"442","author":"Ivanova","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.01.021_bib17","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1101\/gr.121095.111","article-title":"Synthetic spike-in standards for RNA-seq experiments","volume":"21","author":"Jiang","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2014.01.021_bib18","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.0904715106","article-title":"Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression","volume":"106","author":"Khalil","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2014.01.021_bib19","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.1231776","article-title":"Epigenetic regulation by long noncoding RNAs","volume":"338","author":"Lee","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.molcel.2014.01.021_bib20","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.710","article-title":"Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells","volume":"42","author":"Loewer","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2014.01.021_bib21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cell.2005.09.032","article-title":"hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage","volume":"123","author":"Moumen","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2014.01.021_bib22","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.4161\/cc.10.21.17903","article-title":"Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells","volume":"10","author":"Ohno","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.molcel.2014.01.021_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2014.01.021_bib24","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2014.01.021_bib25","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1096\/fasebj.13.14.1911","article-title":"Molecular dissection of nucleolin\u2019s role in growth and cell proliferation: new insights","volume":"13","author":"Srivastava","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.molcel.2014.01.021_bib26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2014.01.021_bib27","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.1192002","article-title":"Long noncoding RNA as modular scaffold of histone modification complexes","volume":"329","author":"Tsai","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.molcel.2014.01.021_bib37","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.cell.2011.11.055","article-title":"Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution","volume":"147","author":"Ulitsky","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2014.01.021_bib28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.molcel.2014.01.021_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.molcel.2014.01.021_bib30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nature09819","article-title":"A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.01.021_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1385\/SCR:1:2:131","article-title":"Cell cycle control of embryonic stem cells","volume":"1","author":"White","year":"2005","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.molcel.2014.01.021_bib32","series-title":"In situ hybridization: A Practical Approach","article-title":"Whole mount in\u00a0situ hybridization of vertebrate embryos","author":"Wilkinson","year":"1992"},{"key":"10.1016\/j.molcel.2014.01.021_bib33","first-page":"6068","article-title":"Purification and characterization of nucleolin and its identification as a transcription repressor","volume":"14","author":"Yang","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2014.01.021_bib34","doi-asserted-by":"crossref","first-page":"43370","DOI":"10.1074\/jbc.M111.225185","article-title":"Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathway","volume":"286","author":"Yang","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2014.01.021_bib35","doi-asserted-by":"crossref","first-page":"12690","DOI":"10.1074\/jbc.M411119200","article-title":"Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation","volume":"280","author":"Yano","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2014.01.021_bib36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nn.3026","article-title":"PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2","volume":"15","author":"Zheng","year":"2012","journal-title":"Nat. Neurosci."}],"updated-by":[{"DOI":"10.1016\/j.molcel.2014.03.013","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000}}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276514000823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276514000823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:17:02Z","timestamp":1761092222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276514000823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1097276514000823"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2014.01.021","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2014.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}