{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:06:17Z","timestamp":1789985177821,"version":"4.0.1"},"reference-count":114,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":388,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.molcel.2014.03.029","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T15:48:21Z","timestamp":1398354501000},"page":"297-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases"],"prefix":"10.1016","volume":"54","author":[{"given":"Gregory\u00a0R.","family":"Robbins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny\u00a0P.-Y.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2014.03.029_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-065X.2008.00624.x","article-title":"IL-1, IL-18, and IL-33 families of cytokines","volume":"223","author":"Arend","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molcel.2014.03.029_bib3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2337\/dc12-2625","article-title":"Economic costs of diabetes in the U.S. in 2012","volume":"36","author":"Association","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.molcel.2014.03.029_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2337\/diabetes.54.2.452","article-title":"Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells","volume":"54","author":"Cardozo","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.molcel.2014.03.029_bib6","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/S0021-9258(18)61655-2","article-title":"The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene","volume":"262","author":"Cladaras","year":"1987","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2014.03.029_bib7","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.1073\/pnas.092324399","article-title":"Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size","volume":"99","author":"Devlin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2014.03.029_bib8","doi-asserted-by":"crossref","first-page":"e56100","DOI":"10.1371\/journal.pone.0056100","article-title":"Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis","volume":"8","author":"Dixon","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2014.03.029_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib10","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib11","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.molcel.2014.03.029_bib12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0008-6363(03)00343-2","article-title":"Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice","volume":"59","author":"Elhage","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.molcel.2014.03.029_bib13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/01.CIR.97.3.242","article-title":"Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice","volume":"97","author":"Elhage","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.molcel.2014.03.029_bib14","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1210\/jcem.87.8.8781","article-title":"Weight loss reduces interleukin-18 levels in obese women","volume":"87","author":"Esposito","year":"2002","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.molcel.2014.03.029_bib15","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1007\/s00125-013-3023-9","article-title":"Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue","volume":"56","author":"Esser","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.molcel.2014.03.029_bib16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1086\/341357","article-title":"Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes","volume":"71","author":"Feldmann","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molcel.2014.03.029_bib17","doi-asserted-by":"crossref","first-page":"18055","DOI":"10.1073\/pnas.1109176108","article-title":"Inflammasome activation and IL-1\u03b2 target IL-1\u03b1 for secretion as opposed to surface expression","volume":"108","author":"Fettelschoss","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl 1","key":"10.1016\/j.molcel.2014.03.029_bib18","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1073\/pnas.0909606106","article-title":"Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition","volume":"107","author":"Finch","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2014.03.029_bib19","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1073\/pnas.0707370105","article-title":"Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms","volume":"105","author":"Fink","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2014.03.029_bib20","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/eji.201041316","article-title":"Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis","volume":"41","author":"Freigang","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib21","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ni.2704","article-title":"Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1\u03b1 and sterile vascular inflammation in atherosclerosis","volume":"14","author":"Freigang","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s11926-011-0162-1","article-title":"The role of uric acid as an endogenous danger signal in immunity and inflammation","volume":"13","author":"Ghaemi-Oskouie","year":"2011","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.molcel.2014.03.029_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/ard.2007.082222","article-title":"Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process","volume":"68","author":"Giamarellos-Bourboulis","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molcel.2014.03.029_bib24","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1194\/jlr.M038638","article-title":"Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis","volume":"54","author":"Giordano","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.molcel.2014.03.029_bib25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.molimm.2012.01.005","article-title":"Expression of NLRP3 inflammasome and T\u00a0cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans","volume":"50","author":"Goossens","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11926-012-0313-z","article-title":"Cholesterol crystals and inflammation","volume":"15","author":"Grebe","year":"2013","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.molcel.2014.03.029_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.immuni.2012.01.018","article-title":"Inflammasome activators induce interleukin-1\u03b1 secretion via distinct pathways with differential requirement for the protease function of caspase-1","volume":"36","author":"Gross","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2014.03.029_bib31","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1002\/art.27456","article-title":"Role of the leucine-rich repeat domain of cryopyrin\/NALP3 in monosodium urate crystal-induced inflammation in mice","volume":"62","author":"Hoffman","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molcel.2014.03.029_bib32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11882-010-0109-z","article-title":"Inflammasome and IL-1beta-mediated disorders","volume":"10","author":"Hoffman","year":"2010","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.molcel.2014.03.029_bib33","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib34","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2014.03.029_bib35","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1073\/pnas.0802726105","article-title":"A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide","volume":"105","author":"Hsu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2014.03.029_bib36","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/01.ATV.0000127025.48140.a3","article-title":"Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice","volume":"24","author":"Isoda","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molcel.2014.03.029_bib37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","article-title":"Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation","volume":"39","author":"Iyer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbrc.2012.07.011","article-title":"Oxidized low-density lipoprotein induces secretion of interleukin-1\u03b2 by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation","volume":"425","author":"Jiang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molcel.2014.03.029_bib39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature05286","article-title":"The plant immune system","volume":"444","author":"Jones","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib40","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/art.27667","article-title":"Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1\u03b2 production via the ASC\/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis","volume":"62","author":"Joosten","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molcel.2014.03.029_bib41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2014.03.029_bib42","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1210\/en.2010-1480","article-title":"The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue","volume":"152","author":"Koenen","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.molcel.2014.03.029_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"Lamkanfi","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2014.03.029_bib44","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"Larsen","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.molcel.2014.03.029_bib45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.coi.2009.12.004","article-title":"The inflammasomes: mechanisms of activation and function","volume":"22","author":"Latz","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib47","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2337\/db12-0420","article-title":"Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes","volume":"62","author":"Lee","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.molcel.2014.03.029_bib48","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2014.03.029_bib49","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.immuni.2013.06.009","article-title":"Immune effector mechanisms implicated in atherosclerosis: from mice to humans","volume":"38","author":"Libby","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib50","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.2337\/db12-1095","article-title":"Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice","volume":"62","author":"Lindegaard","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.molcel.2014.03.029_bib51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fimmu.2013.00285","article-title":"Unsolved Mysteries in NLR Biology","volume":"4","author":"Lupfer","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.molcel.2014.03.029_bib52","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.molcel.2014.03.029_bib53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.immuni.2013.07.017","article-title":"Autophagy and cellular immune responses","volume":"39","author":"Ma","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib54","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","article-title":"Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets","volume":"110","author":"Maedler","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.molcel.2014.03.029_bib55","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1053\/jhep.2003.50161","article-title":"Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome","volume":"37","author":"Marchesini","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.molcel.2014.03.029_bib56","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib57","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2014.03.029_bib58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib59","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1\u03b2 in type 2 diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib60","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1038\/cddis.2011.18","article-title":"Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome","volume":"2","author":"Menu","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2014.03.029_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature04946","article-title":"Intracellular pattern recognition receptors in the host response","volume":"442","author":"Meylan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib62","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ni1344","article-title":"Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf","volume":"7","author":"Miao","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib63","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ni.2550","article-title":"Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome","volume":"14","author":"Misawa","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib64","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.micinf.2011.12.005","article-title":"Anthrax and the inflammasome","volume":"14","author":"Moayeri","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.molcel.2014.03.029_bib65","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/gut.2010.214577","article-title":"Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression","volume":"59","author":"Moschen","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.molcel.2014.03.029_bib66","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/ar3898","article-title":"Enhanced interleukin-1\u03b2 production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals","volume":"14","author":"Mylona","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molcel.2014.03.029_bib67","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib68","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nm1415","article-title":"Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance","volume":"12","author":"Netea","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2014.03.029_bib69","doi-asserted-by":"crossref","first-page":"e1000906","DOI":"10.1371\/journal.ppat.1000906","article-title":"Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1","volume":"6","author":"Newman","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2014.03.029_bib70","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.immuni.2008.09.013","article-title":"Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells","volume":"29","author":"Ng","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib71","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.191.2.303","article-title":"Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene","volume":"191","author":"Nicklin","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2014.03.029_bib72","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000070824","article-title":"Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population","volume":"60","author":"Olusi","year":"2003","journal-title":"Horm. Res."},{"key":"10.1016\/j.molcel.2014.03.029_bib73","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2012.07.005","article-title":"Thioredoxin-interacting protein mediates ER stress-induced \u03b2 cell death through initiation of the inflammasome","volume":"16","author":"Oslowski","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2014.03.029_bib74","doi-asserted-by":"crossref","first-page":"16374","DOI":"10.1074\/jbc.M110.207738","article-title":"Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression","volume":"286","author":"Piantadosi","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2014.03.029_bib75","doi-asserted-by":"crossref","first-page":"e11765","DOI":"10.1371\/journal.pone.0011765","article-title":"Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation","volume":"5","author":"Rajam\u00e4ki","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2014.03.029_bib76","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cmet.2012.02.011","article-title":"Autophagy links inflammasomes to atherosclerotic progression","volume":"15","author":"Razani","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2014.03.029_bib77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/rheumatology\/kep306","article-title":"The modern management of gout","volume":"49","author":"Rider","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.molcel.2014.03.029_bib78","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrrheum.2012.143","article-title":"Uric acid as a danger signal in gout and its comorbidities","volume":"9","author":"Rock","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.molcel.2014.03.029_bib79","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.0901698","article-title":"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation","volume":"185","author":"Rodr\u00edguez-Prados","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib80","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.molcel.2014.03.029_bib81","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature07383","article-title":"Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production","volume":"456","author":"Saitoh","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1074\/jbc.M110.139048","article-title":"Sodium overload and water influx activate the NALP3 inflammasome","volume":"286","author":"Schorn","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2014.03.029_bib83","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.4049\/jimmunol.177.9.6370","article-title":"Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals","volume":"177","author":"Scott","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib84","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/ni.2639","article-title":"CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation","volume":"14","author":"Sheedy","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib85","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.0105-2896.2009.00851.x","article-title":"Monosodium urate crystals in inflammation and immunity","volume":"233","author":"Shi","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molcel.2014.03.029_bib86","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ni.1836","article-title":"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer","volume":"11","author":"Stewart","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib87","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2014.03.029_bib88","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2011.10.011","article-title":"The inflammasome puts obesity in the danger zone","volume":"15","author":"Stienstra","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2014.03.029_bib89","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2014.03.029_bib90","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib91","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2337\/db11-1389","article-title":"The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue","volume":"61","author":"Sun","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.molcel.2014.03.029_bib92","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2006.02.004","article-title":"Critical role for NALP3\/CIAS1\/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1","volume":"24","author":"Sutterwala","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib93","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2014.03.029_bib94","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib95","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.semarthrit.2013.04.007","article-title":"P2X7R: a potential key regulator of acute gouty arthritis","volume":"43","author":"Tao","year":"2013","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.molcel.2014.03.029_bib96","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.immunol.23.021704.115616","article-title":"CATERPILLER: a novel gene family important in immunity, cell death, and diseases","volume":"23","author":"Ting","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib97","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1475-2840-9-11","article-title":"The role of interleukin-18 in the metabolic syndrome","volume":"9","author":"Tr\u00f8seid","year":"2010","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.molcel.2014.03.029_bib98","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbrc.2012.07.058","article-title":"Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice","volume":"425","author":"Usui","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molcel.2014.03.029_bib99","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2014.03.029_bib100","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s10495-010-0498-4","article-title":"IL-1beta induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells","volume":"15","author":"Verma","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.molcel.2014.03.029_bib101","doi-asserted-by":"crossref","first-page":"e36044","DOI":"10.1371\/journal.pone.0036044","article-title":"Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome","volume":"7","author":"Vyleta","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2014.03.029_bib102","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2014.03.029_bib103","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2010.10.004","article-title":"Cellular metabolic stress: considering how cells respond to nutrient excess","volume":"40","author":"Wellen","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2014.03.029_bib104","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib105","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.immuni.2013.08.037","article-title":"Mechanisms of NOD-like receptor-associated inflammasome activation","volume":"39","author":"Wen","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2014.03.029_bib106","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.molcel.2014.03.029_bib107","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1084\/jem.191.8.1437","article-title":"Infectious agents are not necessary for murine atherogenesis","volume":"191","author":"Wright","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2014.03.029_bib108","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cmet.2010.04.005","article-title":"Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance","volume":"11","author":"Yang","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2014.03.029_bib109","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1411543","article-title":"Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E","volume":"258","author":"Zhang","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.molcel.2014.03.029_bib110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2014.03.029_bib111","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2014.03.029_bib112","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/art.30520","article-title":"Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008","volume":"63","author":"Zhu","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molcel.2014.03.029_bib113","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ijo.2008.109","article-title":"Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus","volume":"32","author":"Zilverschoon","year":"2008","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.molcel.2014.03.029_bib114","doi-asserted-by":"crossref","first-page":"11097","DOI":"10.1073\/pnas.0611523104","article-title":"Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency","volume":"104","author":"Zorrilla","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276514002627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276514002627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T05:22:01Z","timestamp":1716700921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276514002627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":114,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1097276514002627"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2014.03.029","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2014.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}