{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:27:01Z","timestamp":1791502021396,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:00:00Z","timestamp":1486166400000},"content-version":"vor","delay-in-days":369,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.molcel.2016.01.008","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T15:20:29Z","timestamp":1454599229000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":374,"title":["Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations"],"prefix":"10.1016","volume":"61","author":[{"given":"Florian","family":"Buhr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Thommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Mittelstaet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Kutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Schwalbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Rodnina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton A.","family":"Komar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2016.01.008_bib1","doi-asserted-by":"crossref","first-page":"e2189","DOI":"10.1371\/journal.pone.0002189","article-title":"Heterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host","volume":"3","author":"Angov","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2016.01.008_bib2","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.1073\/pnas.96.11.6161","article-title":"Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status","volume":"96","author":"Aslund","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2016.01.008_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pbiomolbio.2003.11.012","article-title":"Ageing and vision: structure, stability and function of lens crystallins","volume":"86","author":"Bloemendal","year":"2004","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/BC20070037","article-title":"Halting a cellular production line: responses to ribosomal pausing during translation","volume":"99","author":"Buchan","year":"2007","journal-title":"Biol. Cell"},{"key":"10.1016\/j.molcel.2016.01.008_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.sbi.2010.01.005","article-title":"Protein folding on the ribosome","volume":"20","author":"Cabrita","year":"2010","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0003-9861(69)90044-7","article-title":"The copper catalyzed oxidation of cysteine to cystine","volume":"130","author":"Cavallini","year":"1969","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.molcel.2016.01.008_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-biophys-060414-034333","article-title":"Roles for synonymous codon usage in protein biogenesis","volume":"44","author":"Chaney","year":"2015","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.molcel.2016.01.008_bib8","doi-asserted-by":"crossref","first-page":"e3412","DOI":"10.1371\/journal.pone.0003412","article-title":"Rare codons cluster","volume":"3","author":"Clarke","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2016.01.008_bib9","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1093\/nar\/gku646","article-title":"The effect of tRNA levels on decoding times of mRNA codons","volume":"42","author":"Dana","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2016.01.008_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1379\/CSC-139R.1","article-title":"Native folding of\u00a0aggregation-prone recombinant proteins in Escherichia coli by osmolytes, plasmid- or benzyl alcohol-overexpressed molecular chaperones","volume":"10","author":"de Marco","year":"2005","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.molcel.2016.01.008_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.1229017","article-title":"EF-P is essential for rapid synthesis of proteins containing consecutive proline residues","volume":"339","author":"Doerfel","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.molcel.2016.01.008_bib12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2008.05.042","article-title":"Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution","volume":"134","author":"Drummond","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2016.01.008_bib13","doi-asserted-by":"crossref","first-page":"03735","DOI":"10.7554\/eLife.03735","article-title":"Measurement of average decoding rates of the 61 sense codons in\u00a0vivo","volume":"3","author":"Gardin","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2016.01.008_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.sbi.2013.11.004","article-title":"Co-translational mechanisms of protein maturation","volume":"24","author":"Gloge","year":"2014","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.tibtech.2004.04.006","article-title":"Codon bias and heterologous protein expression","volume":"22","author":"Gustafsson","year":"2004","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.molcel.2016.01.008_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nsmb.1591","article-title":"Converging concepts of protein folding in\u00a0vitro and in\u00a0vivo","volume":"16","author":"Hartl","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib17","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0006-291X(87)90729-7","article-title":"cDNA clones encoding bovine gamma-crystallins","volume":"146","author":"Hay","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molcel.2016.01.008_bib18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.genet.42.110807.091442","article-title":"Selection on codon bias","volume":"42","author":"Hershberg","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.molcel.2016.01.008_bib19","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1126\/science.aad0344","article-title":"Cotranslational protein folding on the ribosome monitored in real time","volume":"350","author":"Holtkamp","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.molcel.2016.01.008_bib20","doi-asserted-by":"crossref","first-page":"30855","DOI":"10.1074\/jbc.M113.467977","article-title":"Genetic code-guided protein\u00a0synthesis and folding in Escherichia coli","volume":"288","author":"Hu","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2016.01.008_bib21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tig.2014.04.006","article-title":"Exposing synonymous mutations","volume":"30","author":"Hunt","year":"2014","journal-title":"Trends Genet."},{"key":"10.1016\/j.molcel.2016.01.008_bib22","first-page":"13","article-title":"Codon usage and tRNA content in unicellular and multicellular organisms","volume":"2","author":"Ikemura","year":"1985","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.molcel.2016.01.008_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrg3645","article-title":"Ribosome profiling: new views of translation, from single codons to genome scale","volume":"15","author":"Ingolia","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2016.01.008_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in\u00a0vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","author":"Ingolia","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.molcel.2016.01.008_bib25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0092-8674(00)80547-4","article-title":"Chaperone activity with a redox switch","volume":"96","author":"Jakob","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2016.01.008_bib26","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.febslet.2004.11.046","article-title":"The co-translational folding and interactions of nascent protein chains: a new approach using fluorescence resonance energy transfer","volume":"579","author":"Johnson","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molcel.2016.01.008_bib27","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1126\/science.1209740","article-title":"The ribosome modulates nascent protein folding","volume":"334","author":"Kaiser","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.molcel.2016.01.008_bib28","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.aaa3974","article-title":"Protein folding. Translational tuning optimizes nascent protein folding in cells","volume":"348","author":"Kim","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.molcel.2016.01.008_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.1135308","article-title":"A \u201csilent\u201d polymorphism in the MDR1 gene changes substrate specificity","volume":"315","author":"Kimchi-Sarfaty","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.molcel.2016.01.008_bib30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tibs.2008.10.002","article-title":"A pause for thought along the co-translational folding pathway","volume":"34","author":"Komar","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molcel.2016.01.008_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-5793(95)01275-0","article-title":"Kinetics of translation of gamma B crystallin and its circularly permutated variant in an in\u00a0vitro cell-free system: possible relations to codon distribution and protein folding","volume":"376","author":"Komar","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molcel.2016.01.008_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0014-5793(99)01566-5","article-title":"Synonymous codon substitutions affect ribosome traffic and protein folding during in\u00a0vitro translation","volume":"462","author":"Komar","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molcel.2016.01.008_bib33","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nsmb.1614","article-title":"The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins","volume":"16","author":"Kramer","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib34","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature10965","article-title":"The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria","volume":"484","author":"Li","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2016.01.008_bib35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1475-2859-11-56","article-title":"SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm","volume":"11","author":"Lobstein","year":"2012","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.molcel.2016.01.008_bib36","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1016\/j.jmb.2014.10.006","article-title":"Regional discrimination and propagation of local rearrangements along the ribosomal exit tunnel","volume":"426","author":"Lu","year":"2014","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib37","doi-asserted-by":"crossref","first-page":"17031","DOI":"10.1021\/ja407511q","article-title":"A kinetic safety gate controlling the delivery of unnatural amino acids to the ribosome","volume":"135","author":"Mittelstaet","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.molcel.2016.01.008_bib38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0076-6879(89)77005-1","article-title":"Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance","volume":"177","author":"Muchmore","year":"1989","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.molcel.2016.01.008_bib39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1107\/S0907444992007601","article-title":"Structure of the bovine eye lens protein gammaB(gammaII)-crystallin at 1.47 A","volume":"49","author":"Najmudin","year":"1993","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.molcel.2016.01.008_bib40","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1021\/ar5000117","article-title":"Understanding the influence of codon translation rates on cotranslational protein folding","volume":"47","author":"O\u2019Brien","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.molcel.2016.01.008_bib41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nsmb.2466","article-title":"Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding","volume":"20","author":"Pechmann","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib42","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.molcel.2013.01.020","article-title":"The ribosome as a hub for protein quality control","volume":"49","author":"Pechmann","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2016.01.008_bib43","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nsmb.2919","article-title":"Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in\u00a0vivo","volume":"21","author":"Pechmann","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jmb.2011.01.025","article-title":"The functional half-life of an mRNA depends on the ribosome spacing in an early coding region","volume":"407","author":"Pedersen","year":"2011","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2899","article-title":"Synonymous but not the same: the causes and consequences of codon bias","volume":"12","author":"Plotkin","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2016.01.008_bib46","doi-asserted-by":"crossref","first-page":"770","DOI":"10.15252\/msb.20145524","article-title":"Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation","volume":"10","author":"Pop","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib47","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2015.02.029","article-title":"Codon optimality is a major determinant of mRNA stability","volume":"160","author":"Presnyak","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2016.01.008_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1475-2859-8-41","article-title":"Rare codon content affects the solubility of recombinant proteins in a codon bias-adjusted Escherichia coli strain","volume":"8","author":"Rosano","year":"2009","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.molcel.2016.01.008_bib49","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1021\/ja411302m","article-title":"Expanding Anfinsen\u2019s principle: contributions of synonymous codon selection to rational protein design","volume":"136","author":"Sander","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.molcel.2016.01.008_bib50","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrg3051","article-title":"Understanding the contribution of synonymous mutations to human disease","volume":"12","author":"Sauna","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2016.01.008_bib51","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0003-2697(87)90587-2","article-title":"Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100\u00a0kDa","volume":"166","author":"Sch\u00e4gger","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.molcel.2016.01.008_bib52","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1128\/AEM.06923-11","article-title":"Disulfide bond formation and activation of Escherichia coli \u03b2-galactosidase under oxidizing conditions","volume":"78","author":"Seras-Franzoso","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.molcel.2016.01.008_bib53","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/nar\/15.3.1281","article-title":"The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications","volume":"15","author":"Sharp","year":"1987","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2016.01.008_bib54","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1098\/rstb.2009.0305","article-title":"Forces that influence the evolution of codon bias","volume":"365","author":"Sharp","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.molcel.2016.01.008_bib55","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jmb.2008.08.012","article-title":"Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima","volume":"383","author":"Tsai","year":"2008","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib56","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jmb.2013.09.013","article-title":"Transmembrane segments form tertiary hairpins in the folding vestibule of the ribosome","volume":"426","author":"Tu","year":"2014","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pnmrs.2013.07.003","article-title":"Protein folding on the ribosome studied using NMR spectroscopy","volume":"74","author":"Waudby","year":"2013","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.molcel.2016.01.008_bib58","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.sbi.2011.01.007","article-title":"The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling","volume":"21","author":"Wilson","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib59","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0092-8674(04)00169-2","article-title":"Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins","volume":"116","author":"Woolhead","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2016.01.008_bib60","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.molcel.2015.07.018","article-title":"Codon usage influences the local rate of translation elongation to regulate co-translational protein folding","volume":"59","author":"Yu","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2016.01.008_bib61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.sbi.2010.10.008","article-title":"Folding at the birth of the nascent chain: coordinating translation with co-translational folding","volume":"21","author":"Zhang","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib62","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nsmb.1554","article-title":"Transient ribosomal attenuation coordinates protein synthesis and co-translational folding","volume":"16","author":"Zhang","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2016.01.008_bib63","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature11833","article-title":"Non-optimal codon usage affects expression, structure and function of clock protein FRQ","volume":"495","author":"Zhou","year":"2013","journal-title":"Nature"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276516000095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276516000095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T14:50:27Z","timestamp":1537023027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276516000095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1097276516000095"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2016.01.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726123259.793519869","asserted-by":"object"}]},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2016.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}