{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:46:46Z","timestamp":1777366006570,"version":"3.51.4"},"reference-count":85,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U41HG007355"],"award-info":[{"award-number":["U41HG007355"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Berlin Institute of Health","award":["1.1.2.a.3"],"award-info":[{"award-number":["1.1.2.a.3"]}]},{"DOI":"10.13039\/501100003246","name":"NWO","doi-asserted-by":"publisher","award":["836.09.001"],"award-info":[{"award-number":["836.09.001"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["281622 PDControl"],"award-info":[{"award-number":["281622 PDControl"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/B"],"award-info":[{"award-number":["SFRH\/B"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["D\/51009\/2010"],"award-info":[{"award-number":["D\/51009\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alumni chapter Gooische Groningers"},{"name":"Groningen University Institute for Drug Exploration"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.molcel.2017.02.022","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T12:15:54Z","timestamp":1489666554000},"page":"1096-1108.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation"],"prefix":"10.1016","volume":"65","author":[{"given":"Olga","family":"Sin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Mata-Cabana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Kudron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Amr","family":"Zaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco A.","family":"Aprile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e I.","family":"Seinstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Stroo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rom\u00e9o Willinge","family":"Prins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line N.","family":"Martineau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wytse","family":"Hogewerf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Steinhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich E.","family":"Wanker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Vendruscolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis F.","family":"Calkhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Reinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Guryev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen A.A.","family":"Nollen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2017.02.022_bib1","doi-asserted-by":"crossref","first-page":"e85648","DOI":"10.1371\/journal.pone.0085648","article-title":"RNA polymerase III transcriptomes in human embryonic stem cells and induced pluripotent stem cells, and relationships with pluripotency transcription factors","volume":"9","author":"Alla","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2017.02.022_bib2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.02.022_bib3","doi-asserted-by":"crossref","first-page":"W202","DOI":"10.1093\/nar\/gkp335","article-title":"MEME SUITE: tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2017.02.022_bib4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nmeth.f.260","article-title":"MAQGene: software to facilitate C. elegans mutant genome sequence analysis","volume":"6","author":"Bigelow","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2017.02.022_bib5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1021\/cb1001203","article-title":"ANS binding reveals common features of cytotoxic amyloid species","volume":"5","author":"Bolognesi","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.bbagrm.2014.04.009","article-title":"The many faces of small nucleolar RNAs","volume":"1839","author":"Bratkovi\u010d","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molcel.2017.02.022_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.molcel.2017.02.022_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.sbi.2005.01.006","article-title":"Zinc finger proteins: getting a grip on RNA","volume":"15","author":"Brown","year":"2005","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib9","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1126\/science.287.5457.1485","article-title":"Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death","volume":"287","author":"Chen","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nchembio.131","article-title":"Amyloid formation by globular proteins under native conditions","volume":"5","author":"Chiti","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib11","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1093\/hmg\/ddr178","article-title":"Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions","volume":"20","author":"Davranche","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib12","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1242\/dev.125.16.3213","article-title":"A tissue-specific knock-out strategy reveals that lin-26 is required for the formation of the somatic gonad epithelium in Caenorhabditis elegans","volume":"125","author":"den Boer","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.molcel.2017.02.022_bib13","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1074\/jbc.M705306200","article-title":"RNA-binding protein TLS is a major nuclear aggregate-interacting protein in\u00a0huntingtin exon 1 with expanded polyglutamine-expressing cells","volume":"283","author":"Doi","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2017.02.022_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neures.2009.10.004","article-title":"The RNA-binding protein FUS\/TLS is a common aggregate-interacting protein in polyglutamine diseases","volume":"66","author":"Doi","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.molcel.2017.02.022_bib15","series-title":"WormBook","first-page":"1","article-title":"Immunohistochemistry","author":"Duerr","year":"2006"},{"key":"10.1016\/j.molcel.2017.02.022_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/genetics\/152.1.221","article-title":"lir-2, lir-1 and lin-26 encode a new class of zinc-finger proteins and are organized in two overlapping operons both in Caenorhabditis elegans and in Caenorhabditis briggsae","volume":"152","author":"Dufourcq","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.molcel.2017.02.022_bib17","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington\u2019s disease","volume":"296","author":"Dunah","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/1073858410390378","article-title":"Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease","volume":"17","author":"Ehrnhoefer","year":"2011","journal-title":"Neuroscientist"},{"key":"10.1016\/j.molcel.2017.02.022_bib19","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.cell.2012.02.022","article-title":"The amyloid state of proteins in human diseases","volume":"148","author":"Eisenberg","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.celrep.2012.06.012","article-title":"SERF protein is a direct modifier of amyloid fiber assembly","volume":"2","author":"Falsone","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2017.02.022_bib21","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1101\/gad.1575307","article-title":"Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells","volume":"21","author":"Garcia","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2017.02.022_bib22","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.1196914","article-title":"Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project","volume":"330","author":"Gerstein","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib23","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1124514","article-title":"Progressive disruption of cellular protein folding in models of polyglutamine diseases","volume":"311","author":"Gidalevitz","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib24","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.neuron.2009.11.020","article-title":"Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice","volume":"64","author":"Gu","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.molcel.2017.02.022_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.ge.22.120188.002131","article-title":"Spliceosomal snRNAs","volume":"22","author":"Guthrie","year":"1988","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.sbi.2005.04.004","article-title":"Multiple modes of RNA recognition by zinc finger proteins","volume":"15","author":"Hall","year":"2005","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib27","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1073\/pnas.0711018105","article-title":"Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson\u2019s disease model","volume":"105","author":"Hamamichi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.02.022_bib28","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1126\/science.1083701","article-title":"Regulation of aging and age-related disease by DAF-16 and heat-shock factor","volume":"300","author":"Hsu","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0022-2836(02)00969-5","article-title":"Intrinsic disorder in cell-signaling and cancer-associated proteins","volume":"323","author":"Iakoucheva","year":"2002","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib30","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.molcel.2013.08.001","article-title":"Integral nuclear pore proteins bind to Pol III-transcribed genes and are required for Pol III transcript processing in C. elegans","volume":"51","author":"Ikegami","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib31","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/gb-2010-11-12-r120","article-title":"Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2","volume":"11","author":"Ikegami","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib32","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1074\/jbc.M412042200","article-title":"Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes","volume":"280","author":"Jana","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2017.02.022_bib33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrg794","article-title":"The art and design of genetic screens: caenorhabditis elegans","volume":"3","author":"Jorgensen","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.devcel.2014.09.015","article-title":"The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally required for piRNA abundance","volume":"31","author":"Kasper","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib35","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis","volume":"300","author":"Kayed","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib36","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib37","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1073\/pnas.0900604106","article-title":"Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs","volume":"106","author":"Kosugi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.02.022_bib38","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/nar\/gkg161","article-title":"Structural classification of zinc fingers: survey and summary","volume":"31","author":"Krishna","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2017.02.022_bib39","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/hmg\/ddn198","article-title":"A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans","volume":"17","author":"Kuwahara","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib40","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1242\/dev.122.9.2579","article-title":"The Caenorhabditis elegans LIN-26 protein is required to specify and\/or maintain all non-neuronal ectodermal cell fates","volume":"122","author":"Labouesse","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.molcel.2017.02.022_bib41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0076-6879(99)09008-4","article-title":"Purification of paired helical filament tau and normal tau from human brain tissue","volume":"309","author":"Lee","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.molcel.2017.02.022_bib42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2164-13-91","article-title":"Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons","volume":"13","author":"Lejeune","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molcel.2017.02.022_bib43","doi-asserted-by":"crossref","first-page":"D302","DOI":"10.1093\/nar\/gkr931","article-title":"SMART 7: recent updates to the protein domain annotation resource","volume":"40","author":"Letunic","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2017.02.022_bib44","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1128\/MCB.22.5.1277-1287.2002","article-title":"Interaction of Huntington disease protein with transcriptional activator Sp1","volume":"22","author":"Li","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib45","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1021\/bi0602718","article-title":"Intrinsic disorder in transcription factors","volume":"45","author":"Liu","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.molcel.2017.02.022_bib46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.molcel.2017.02.022_bib47","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrc2539","article-title":"Non-coding RNA production by RNA polymerase III is implicated in cancer","volume":"8","author":"Marshall","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2017.02.022_bib48","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/sj.emboj.7600081","article-title":"Molecular clearance of ataxin-3 is regulated by a mammalian E4","volume":"23","author":"Matsumoto","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2017.02.022_bib49","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2017.02.022_bib50","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nchembio.694","article-title":"Identifying polyglutamine protein species in\u00a0situ that best predict neurodegeneration","volume":"7","author":"Miller","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib51","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jmb.2006.04.016","article-title":"Human transcription factors contain a high fraction of intrinsically disordered regions essential for transcriptional regulation","volume":"359","author":"Minezaki","year":"2006","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib52","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature14884","article-title":"Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation","volume":"524","author":"Nillegoda","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.02.022_bib53","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gr.114587.110","article-title":"Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans","volume":"21","author":"Niu","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2017.02.022_bib54","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1073\/pnas.0307697101","article-title":"Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation","volume":"101","author":"Nollen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.02.022_bib55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/jmbi.2000.4042","article-title":"T-Coffee: a novel method for fast and accurate multiple sequence alignment","volume":"302","author":"Notredame","year":"2000","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib56","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nsmb.1801","article-title":"Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors","volume":"17","author":"Oler","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib57","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cell.2010.11.050","article-title":"Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions","volume":"144","author":"Olzscha","year":"2011","journal-title":"Cell"},{"issue":"R1","key":"10.1016\/j.molcel.2017.02.022_bib58","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1093\/hmg\/ddn412","article-title":"Post-translational modifications of expanded polyglutamine proteins: impact on neurotoxicity","volume":"18","author":"Pennuto","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib59","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1093\/bioinformatics\/bti537","article-title":"FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded","volume":"21","author":"Prilusky","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2017.02.022_bib60","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1038\/emboj.2012.264","article-title":"Metazoan Hsp70 machines use Hsp110 to power protein disaggregation","volume":"31","author":"Rampelt","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2017.02.022_bib61","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/gb-2005-6-13-r110","article-title":"A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks","volume":"6","author":"Reece-Hoyes","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2017.02.022_bib62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2164-8-27","article-title":"Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns","volume":"8","author":"Reece-Hoyes","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molcel.2017.02.022_bib63","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2017.02.022_bib64","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2012.08.001","article-title":"A genome-scale resource for in\u00a0vivo tag-based protein function exploration in C. elegans","volume":"150","author":"Sarov","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib65","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0092-8674(00)80514-0","article-title":"Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in\u00a0vitro and in\u00a0vivo","volume":"90","author":"Scherzinger","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib66","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1101\/gad.1018902","article-title":"Recruitment of RNA polymerase III to its target promoters","volume":"16","author":"Schramm","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2017.02.022_bib67","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1073\/pnas.95.11.5857","article-title":"SMART, a simple modular architecture research tool: identification of signaling domains","volume":"95","author":"Schultz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.02.022_bib68","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1097\/NEN.0b013e31818e8951","article-title":"Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease","volume":"67","author":"Schwab","year":"2008","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.molcel.2017.02.022_bib69","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2017.02.022_bib70","doi-asserted-by":"crossref","first-page":"e1002438","DOI":"10.1371\/journal.pgen.1002438","article-title":"A genetic screening strategy identifies novel regulators of the proteostasis network","volume":"7","author":"Silva","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib71","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1007\/s00018-015-1985-0","article-title":"Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes","volume":"72","author":"Sin","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.molcel.2017.02.022_bib72","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1097-2765(00)80142-2","article-title":"SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates","volume":"2","author":"Sittler","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib73","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn1007","article-title":"Unfolding the role of protein misfolding in neurodegenerative diseases","volume":"4","author":"Soto","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.molcel.2017.02.022_bib74","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO modification of Huntingtin and Huntington\u2019s disease pathology","volume":"304","author":"Steffan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib75","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1074\/jbc.M311761200","article-title":"Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts","volume":"279","author":"Thomas","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2017.02.022_bib76","doi-asserted-by":"crossref","first-page":"19258","DOI":"10.1073\/pnas.1111684108","article-title":"Shared gene expression in distinct neurons expressing common selector genes","volume":"108","author":"Topalidou","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.02.022_bib77","doi-asserted-by":"crossref","first-page":"14912","DOI":"10.1073\/pnas.1203083109","article-title":"Delaying aging and the aging-associated decline in protein homeostasis by\u00a0inhibition of tryptophan degradation","volume":"109","author":"van der Goot","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.02.022_bib78","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2010.07.020","article-title":"Identification of MOAG-4\/SERF as a regulator of age-related proteotoxicity","volume":"142","author":"van Ham","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib79","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2015.03.032","article-title":"Widespread proteome remodeling and aggregation in aging C. elegans","volume":"161","author":"Walther","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.02.022_bib80","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0076-6879(99)09026-6","article-title":"Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates","volume":"309","author":"Wanker","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.molcel.2017.02.022_bib81","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrg3001","article-title":"Transcription by RNA polymerase III: more complex than we thought","volume":"12","author":"White","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib82","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/88878","article-title":"Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map","volume":"28","author":"Wicks","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2017.02.022_bib83","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1126\/science.aad2033","article-title":"Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA","volume":"351","author":"Woerner","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.02.022_bib84","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/acn3.176","article-title":"Anti-tau antibody reduces insoluble tau and decreases brain atrophy","volume":"2","author":"Yanamandra","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.molcel.2017.02.022_bib85","doi-asserted-by":"crossref","first-page":"e1000848","DOI":"10.1371\/journal.pgen.1000848","article-title":"Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4\/FOXA in development and environmental response","volume":"6","author":"Zhong","year":"2010","journal-title":"PLoS Genet."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276517301375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276517301375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T21:50:40Z","timestamp":1657403440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276517301375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":85,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1097276517301375"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2017.02.022","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727416619.793538190","asserted-by":"object"}]},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2017.02.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}