{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:28:47Z","timestamp":1790674127793,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Laura and Isaac Perlmutter Cancer Center","award":["P30CA016087"],"award-info":[{"award-number":["P30CA016087"]}]},{"DOI":"10.13039\/100007313","name":"MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of Research Infrastructure of the NIH","award":["S10OD018522"],"award-info":[{"award-number":["S10OD018522"]}]},{"name":"ISMMS Cancer Center Support Grant","award":["P30CA196521"],"award-info":[{"award-number":["P30CA196521"]}]},{"name":"NIH\/NCI","award":["R01CA174793"],"award-info":[{"award-number":["R01CA174793"]}]},{"name":"NIH\/NCI","award":["R01CA155234"],"award-info":[{"award-number":["R01CA155234"]}]},{"name":"NIH\/NCI","award":["R01CA163891"],"award-info":[{"award-number":["R01CA163891"]}]},{"name":"NIH\/NCI","award":["R01CA154683"],"award-info":[{"award-number":["R01CA154683"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.molcel.2017.11.004","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T14:50:54Z","timestamp":1510843854000},"page":"731-744.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"title":["Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene"],"prefix":"10.1016","volume":"68","author":[{"given":"Barbara","family":"Fontanals-Cirera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Hasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vardabasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Di Micco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Gantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"de Pablos-Aragoneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Morgenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Filipescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Valle-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farbod","family":"Darvishian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seok","family":"Roe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Vakoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2017.11.004_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature14289","article-title":"Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice","volume":"521","author":"Adam","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.11.004_bib2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ccell.2017.05.007","article-title":"A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis","volume":"31","author":"Agrawal","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib3","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1126\/science.1217277","article-title":"Epigenomic enhancer profiling defines a signature of colon cancer","volume":"336","author":"Akhtar-Zaidi","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.11.004_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nbt.2776","article-title":"Genome-wide localization of small molecules","volume":"32","author":"Anders","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2017.11.004_bib5","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4161\/cc.7.12.6032","article-title":"Novel anticancer compounds induce apoptosis in melanoma cells","volume":"7","author":"Bhat","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.molcel.2017.11.004_bib6","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2017.11.004_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib8","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic Classification of Cutaneous Melanoma","volume":"161","author":"Cancer Genome Atlas","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature09806","article-title":"The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset","volume":"471","author":"Ceol","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.11.004_bib10","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","article-title":"Improved survival with vemurafenib in melanoma with BRAF V600E mutation","volume":"364","author":"Chapman","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.molcel.2017.11.004_bib11","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1158\/0008-5472.CAN-13-2775","article-title":"A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma","volume":"74","author":"Chen","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2017.11.004_bib12","doi-asserted-by":"crossref","first-page":"21931","DOI":"10.1073\/pnas.1016071107","article-title":"Histone H3K27ac separates active from poised enhancers and predicts developmental state","volume":"107","author":"Creyghton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.11.004_bib13","doi-asserted-by":"crossref","first-page":"eaag2611","DOI":"10.1126\/scitranslmed.aag2611","article-title":"A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions","volume":"9","author":"Damelin","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molcel.2017.11.004_bib14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10509","article-title":"Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia","volume":"478","author":"Dawson","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.11.004_bib15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1755-148X.2012.00994.x","article-title":"Development of five new melanoma low passage cell lines representing the clinical and genetic profile of their tumors of origin","volume":"25","author":"de Miera","year":"2012","journal-title":"Pigment Cell Melanoma Res."},{"issue":"20 Pt A","key":"10.1016\/j.molcel.2017.11.004_bib16","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1016\/j.febslet.2015.08.044","article-title":"Structural and functional diversity of Topologically Associating Domains","volume":"589","author":"Dekker","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molcel.2017.11.004_bib83","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.celrep.2014.08.055","article-title":"Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes","volume":"9","author":"Di\u00a0Micco","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2017.11.004_bib17","doi-asserted-by":"crossref","first-page":"e1003047","DOI":"10.1371\/journal.pgen.1003047","article-title":"A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation","volume":"8","author":"Draker","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.molcel.2017.11.004_bib18","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/bioinformatics\/btg307","article-title":"Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles","volume":"19","author":"Eichler","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2017.11.004_bib19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1634\/theoncologist.2012-0483","article-title":"Ipilimumab and its toxicities: a multidisciplinary approach","volume":"18","author":"Fecher","year":"2013","journal-title":"Oncologist"},{"key":"10.1016\/j.molcel.2017.11.004_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrd4286","article-title":"Targeting bromodomains: epigenetic readers of lysine acetylation","volume":"13","author":"Filippakopoulos","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.molcel.2017.11.004_bib21","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.11.004_bib22","doi-asserted-by":"crossref","first-page":"17186","DOI":"10.1038\/srep17186","article-title":"MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells","volume":"5","author":"Fu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2017.11.004_bib23","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1038\/jid.2014.243","article-title":"The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells","volume":"134","author":"Gallagher","year":"2014","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.molcel.2017.11.004_bib24","doi-asserted-by":"crossref","first-page":"20970","DOI":"10.1074\/jbc.M111.237669","article-title":"Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects","volume":"286","author":"Golubkov","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2017.11.004_bib25","doi-asserted-by":"crossref","first-page":"24238","DOI":"10.1074\/jbc.M114.574459","article-title":"Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis","volume":"289","author":"Golubkov","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2017.11.004_bib26","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/ncb3573","article-title":"Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in\u00a0vivo","volume":"19","author":"Hanssen","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nsmb.2562","article-title":"The octamer is the major form of CENP-A nucleosomes at human centromeres","volume":"20","author":"Hasson","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrm3949","article-title":"The selection and function of cell type-specific enhancers","volume":"16","author":"Heinz","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.molcel.2017.02.027","article-title":"The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries","volume":"66","author":"Hsu","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/his.12909","article-title":"Prognostic significance of forkhead box M1 (FoxM1) expression and antitumour effect of FoxM1 inhibition in melanoma","volume":"69","author":"Ito","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.molcel.2017.11.004_bib33","doi-asserted-by":"crossref","first-page":"43567","DOI":"10.1038\/srep43567","article-title":"Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases","volume":"7","author":"Kanda","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2017.11.004_bib34","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nature09590","article-title":"The histone variant macroH2A suppresses melanoma progression through regulation of CDK8","volume":"468","author":"Kapoor","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.11.004_bib35","doi-asserted-by":"crossref","first-page":"aad2197","DOI":"10.1126\/science.aad2197","article-title":"A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation","volume":"351","author":"Kaufman","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molcel.2017.11.004_bib36","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1200\/JCO.2012.43.5966","article-title":"Phase II study of the MEK1\/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor","volume":"31","author":"Kim","year":"2013","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.molcel.2017.11.004_bib37","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1083\/jcb.200209074","article-title":"AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats","volume":"160","author":"Kuja-Panula","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib38","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2017.11.004_bib39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yexmp.2013.06.012","article-title":"Impact of LIF (leukemia inhibitory factor) expression in malignant melanoma","volume":"95","author":"Kuphal","year":"2013","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.molcel.2017.11.004_bib40","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1002\/jcb.23263","article-title":"Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes","volume":"112","author":"Ku\u017eelov\u00e1","year":"2011","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.molcel.2017.11.004_bib41","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib42","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.cell.2012.07.033","article-title":"Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma","volume":"150","author":"Lian","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib43","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/nm.3392","article-title":"Tumor adaptation and resistance to RAF inhibitors","volume":"19","author":"Lito","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2017.11.004_bib44","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2013.03.036","article-title":"Selective inhibition of tumor oncogenes by disruption of super-enhancers","volume":"153","author":"Lov\u00e9n","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature02677","article-title":"PTK7\/CCK-4 is a novel regulator of planar cell polarity in vertebrates","volume":"430","author":"Lu","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2017.11.004_bib46","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nmeth.2557","article-title":"The CRAPome: a contaminant repository for affinity purification-mass spectrometry data","volume":"10","author":"Mellacheruvu","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2017.11.004_bib47","doi-asserted-by":"crossref","first-page":"16669","DOI":"10.1073\/pnas.1108190108","article-title":"Targeting MYC dependence in cancer by inhibiting BET bromodomains","volume":"108","author":"Mertz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2017.11.004_bib48","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1021\/jm401088k","article-title":"Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains","volume":"56","author":"Mirguet","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.molcel.2017.11.004_bib49","doi-asserted-by":"crossref","first-page":"e0144241","DOI":"10.1371\/journal.pone.0144241","article-title":"Investigation of FOXM1 as a Potential New Target for Melanoma","volume":"10","author":"Miyashita","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2017.11.004_bib50","doi-asserted-by":"crossref","first-page":"25001","DOI":"10.1074\/jbc.M112.348904","article-title":"The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and \u03b3-secretase, enhances cell proliferation and migration in colon cancer cells","volume":"287","author":"Na","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2017.11.004_bib51","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1523\/JNEUROSCI.23-13-05887.2003","article-title":"Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons","volume":"23","author":"Ono","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.molcel.2017.11.004_bib52","doi-asserted-by":"crossref","first-page":"12983","DOI":"10.1038\/ncomms12983","article-title":"Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity","volume":"7","author":"Ooi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2017.11.004_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.onc.1209759","article-title":"Transcription factors control invasion: AP-1 the first among equals","volume":"26","author":"Ozanne","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2017.11.004_bib54","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1158\/1535-7163.MCT-09-0743","article-title":"Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set","volume":"9","author":"Park","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.molcel.2017.11.004_bib55","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.201503113","article-title":"AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation","volume":"211","author":"Park","year":"2015","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib56","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1158\/0008-5472.CAN-12-3686","article-title":"miR-214 coordinates melanoma progression by upregulating ALCAM through TFAP2 and miR-148b downmodulation","volume":"73","author":"Penna","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2017.11.004_bib57","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1056\/NEJMoa1414428","article-title":"Nivolumab and ipilimumab versus ipilimumab in untreated melanoma","volume":"372","author":"Postow","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.molcel.2017.11.004_bib58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2015.08.036","article-title":"Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest","volume":"163","author":"Prescott","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib59","doi-asserted-by":"crossref","first-page":"921","DOI":"10.18632\/oncotarget.626","article-title":"Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity","volume":"3","author":"Prud\u2019homme","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.molcel.2017.11.004_bib60","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1158\/2159-8290.CD-12-0418","article-title":"Targeting MYCN in neuroblastoma by BET bromodomain inhibition","volume":"3","author":"Puissant","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2017.11.004_bib61","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2017.11.004_bib62","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1038\/sj.onc.1207681","article-title":"DEGA\/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion\/migration and tumorigenicity","volume":"23","author":"Rabenau","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2017.11.004_bib63","doi-asserted-by":"crossref","first-page":"W187-91","DOI":"10.1093\/nar\/gku365","article-title":"deepTools: a flexible platform for exploring deep-sequencing data","volume":"42","author":"Ram\u00edrez","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2017.11.004_bib64","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1038\/jid.2013.197","article-title":"Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis","volume":"133","author":"Raskin","year":"2013","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.molcel.2017.11.004_bib65","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.molcel.2015.04.011","article-title":"BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia","volume":"58","author":"Roe","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib66","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1158\/0008-5472.CAN-13-0122-T","article-title":"BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy","volume":"73","author":"Segura","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2017.11.004_bib67","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nm.4092","article-title":"An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation","volume":"22","author":"Souroullas","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2017.11.004_bib68","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.celrep.2015.12.100","article-title":"H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs","volume":"14","author":"Surface","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2017.11.004_bib69","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-61779-376-9_7","article-title":"Two-step cross-linking for analysis of protein-chromatin interactions","volume":"809","author":"Tian","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib70","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molcel.2017.11.004_bib71","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.cell.2014.01.040","article-title":"Serpins promote cancer cell survival and vascular co-option in brain metastasis","volume":"156","author":"Valiente","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib73","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molcel.2015.05.009","article-title":"Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma","volume":"59","author":"Vardabasso","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib74","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1038\/ncomms7683","article-title":"Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state","volume":"6","author":"Verfaillie","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2017.11.004_bib75","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s13277-012-0480-6","article-title":"The role of CCND1 alterations during the progression of cutaneous malignant melanoma","volume":"33","author":"V\u00edzkeleti","year":"2012","journal-title":"Tumour Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib76","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jid.2016.01.035","article-title":"The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031","volume":"136","author":"Whiteman","year":"2016","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.molcel.2017.11.004_bib77","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2017.11.004_bib78","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1007\/s13277-015-3676-8","article-title":"TGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer","volume":"36","author":"Xiang","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib79","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1158\/1541-7786.MCR-07-0344","article-title":"Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases","volume":"6","author":"Xu","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.molcel.2017.11.004_bib80","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2017.11.004_bib81","doi-asserted-by":"crossref","first-page":"9834","DOI":"10.18632\/oncotarget.3383","article-title":"Cordycepin (3\u2032-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.molcel.2017.11.004_bib82","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1038\/ncomms7051","article-title":"The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors","volume":"6","author":"Zingg","year":"2015","journal-title":"Nat. Commun."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276517308390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276517308390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T20:48:31Z","timestamp":1603313311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276517308390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1097276517308390"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2017.11.004","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732125001.793539188","asserted-by":"object"}]},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2017.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}