{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:47:46Z","timestamp":1792205266485,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Institute for Basic Science from the Ministry of Science"},{"DOI":"10.13039\/100011273","name":"ICT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011273","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Future Planning of Korea and Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government Ministry of Science"},{"DOI":"10.13039\/100011273","name":"ICT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011273","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Future Planning","award":["NRF-2016R1C1B2009886"],"award-info":[{"award-number":["NRF-2016R1C1B2009886"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.molcel.2018.07.029","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T10:50:55Z","timestamp":1535626255000},"page":"1051-1063.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":262,"title":["PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs"],"prefix":"10.1016","volume":"71","author":[{"given":"Yoosik","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joha","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MinA","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong-Gyun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulhwan","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjeong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baekgyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Woo","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Narry","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2018.07.029_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature21715","article-title":"DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome","volume":"544","author":"Akta\u015f","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2018.07.029_bib2","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1073\/pnas.68.8.1757","article-title":"Symmetrical in\u00a0vivo transcription of mitochondrial DNA in HeLa cells","volume":"68","author":"Aloni","year":"1971","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2018.07.029_bib3","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1371\/journal.pbio.0020391","article-title":"Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome","volume":"2","author":"Athanasiadis","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.molcel.2018.07.029_bib4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1146\/annurev.biochem.71.110601.135501","article-title":"RNA editing by adenosine deaminases that act on RNA","volume":"71","author":"Bass","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2018.07.029_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/emboj\/16.3.611","article-title":"Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR","volume":"16","author":"Benkirane","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2018.07.029_bib6","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.molcel.2014.02.007","article-title":"TAIL-seq: Genome-wide determination of poly(A) tail length and 3\u2032 end modifications","volume":"53","author":"Chang","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/JAD-140429","article-title":"Metabolic profiling of CHO-A\u03b2PP695 cells revealed mitochondrial dysfunction prior to amyloid-\u03b2 pathology and potential therapeutic effects of both PPAR\u03b3 and PPAR\u03b1 agonisms for Alzheimer\u2019s disease","volume":"44","author":"Chang","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.molcel.2018.07.029_bib8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.cell.2012.10.019","article-title":"LIN28A is a suppressor of ER-associated translation in embryonic stem cells","volume":"151","author":"Cho","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib9","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2017.12.038","article-title":"Human ADAR1 prevents endogenous RNA from triggering translational shutdown","volume":"172","author":"Chung","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib10","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.3390\/v4112598","article-title":"dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection","volume":"4","author":"Dabo","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.molcel.2018.07.029_bib11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bcp.2013.12.012","article-title":"Brain metabolic dysfunction at the core of Alzheimer\u2019s disease","volume":"88","author":"de la Monte","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molcel.2018.07.029_bib57","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41586-018-0363-0","article-title":"Mitochondrial double-stranded RNA triggers antiviral signalling in humans","volume":"560","author":"Dhir","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2018.07.029_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2018.07.029_bib13","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1101\/gad.220962.113","article-title":"STAU1 binding 3\u2032 UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown","volume":"27","author":"Elbarbary","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2018.07.029_bib14","doi-asserted-by":"crossref","first-page":"aac7247","DOI":"10.1126\/science.aac7247","article-title":"Retrotransposons as regulators of gene expression","volume":"351","author":"Elbarbary","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molcel.2018.07.029_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1009664109241","article-title":"Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): Mechanism of action","volume":"5","author":"Gil","year":"2000","journal-title":"Apoptosis"},{"key":"10.1016\/j.molcel.2018.07.029_bib16","doi-asserted-by":"crossref","first-page":"W70","DOI":"10.1093\/nar\/gkn188","article-title":"The Vienna RNA websuite","volume":"36","author":"Gruber","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2018.07.029_bib17","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.3892\/ijo.2013.1911","article-title":"Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells","volume":"42","author":"Haneji","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.molcel.2018.07.029_bib18","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.1261253","article-title":"Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase","volume":"346","author":"Harbauer","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.molcel.2018.07.029_bib19","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: The reference human genome annotation for The ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2018.07.029_bib20","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1101\/gad.242644.114","article-title":"PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator","volume":"28","author":"Kim","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2018.07.029_bib21","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.celrep.2014.09.039","article-title":"Deletion of human tarbp2 reveals cellular microRNA targets and cell-cycle function of TRBP","volume":"9","author":"Kim","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2018.07.029_bib22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.molcel.2017.03.013","article-title":"Genome-wide mapping of DROSHA cleavage sites on primary MicroRNAs and noncanonical substrates","volume":"66","author":"Kim","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib23","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1126\/science.1382315","article-title":"Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase","volume":"257","author":"Koromilas","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.molcel.2018.07.029_bib24","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2018.07.029_bib25","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.celrep.2016.04.064","article-title":"APEX fingerprinting reveals the subcellular localization of proteins of interest","volume":"15","author":"Lee","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.molcel.2018.07.029_bib26","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1021\/jacs.6b10418","article-title":"Architecture mapping of the inner mitochondrial membrane proteome by chemical tools in live cells","volume":"139","author":"Lee","year":"2017","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.molcel.2018.07.029_bib27","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature07488","article-title":"HITS-CLIP yields genome-wide insights into brain alternative RNA processing","volume":"456","author":"Licatalosi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2018.07.029_bib28","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.cell.2014.10.055","article-title":"Uridylation by TUT4 and TUT7 marks mRNA for degradation","volume":"159","author":"Lim","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","article-title":"Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib30","first-page":"611","article-title":"Detection of double-stranded RNA-protein interactions by methylene blue-mediated photo-crosslinking","volume":"2","author":"Liu","year":"1996","journal-title":"RNA"},{"key":"10.1016\/j.molcel.2018.07.029_bib31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s13238-017-0448-9","article-title":"Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2","volume":"8","author":"Liu","year":"2017","journal-title":"Protein Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2011.06.051","article-title":"The human mitochondrial transcriptome","volume":"146","author":"Mercer","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib33","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1128\/JVI.66.10.5805-5814.1992","article-title":"Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth","volume":"66","author":"Meurs","year":"1992","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.molcel.2018.07.029_bib34","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cell.2010.01.001","article-title":"Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis","volume":"140","author":"Nakamura","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.celrep.2015.03.021","article-title":"A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2\u03b1 phosphorylation in obesity","volume":"11","author":"Nakamura","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2018.07.029_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fnmol.2014.00022","article-title":"Roles of eIF2\u03b1 kinases in the pathogenesis of Alzheimer\u2019s disease","volume":"7","author":"Ohno","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.molcel.2018.07.029_bib37","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/290470a0","article-title":"tRNA punctuation model of RNA processing in human mitochondria","volume":"290","author":"Ojala","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2018.07.029_bib38","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.molcel.2018.07.029_bib39","doi-asserted-by":"crossref","first-page":"8283","DOI":"10.1073\/pnas.92.18.8283","article-title":"The interferon-inducible double-stranded RNA-activated protein kinase self-associates in\u00a0vitro and in\u00a0vivo","volume":"92","author":"Patel","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2018.07.029_bib40","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: A flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2018.07.029_bib41","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.1230593","article-title":"Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging","volume":"339","author":"Rhee","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.molcel.2018.07.029_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nsmb.2739","article-title":"Staufen1 senses overall transcript secondary structure to regulate translation","volume":"21","author":"Ricci","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2018.07.029_bib43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1083\/jcb.201404097","article-title":"Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division","volume":"207","author":"Ro\u0161i\u0107","year":"2014","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2018.07.029_bib44","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cell.2015.07.056","article-title":"DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts","volume":"162","author":"Roulois","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2018.07.029_bib45","doi-asserted-by":"crossref","first-page":"41620","DOI":"10.1074\/jbc.M103674200","article-title":"Translation inhibition in apoptosis: Caspase-dependent PKR activation and eIF2-alpha phosphorylation","volume":"276","author":"Saelens","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2018.07.029_bib46","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1093\/nar\/19.11.2993","article-title":"Monoclonal antibodies to double-stranded RNA as probes of RNA structure in crude nucleic acid extracts","volume":"19","author":"Sch\u00f6nborn","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2018.07.029_bib47","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13059-016-1083-0","article-title":"Transcriptome-wide effects of inverted SINEs on gene expression and their impact on RNA polymerase II activity","volume":"17","author":"Tajaddod","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2018.07.029_bib48","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/sj.onc.1209906","article-title":"Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44\/p42 MAPK and p38 MAPK activation","volume":"26","author":"Takada","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2018.07.029_bib49","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.celrep.2015.04.026","article-title":"Apoptosis triggers specific, rapid, and global mRNA decay with 3\u2032 uridylated intermediates degraded by DIS3L2","volume":"11","author":"Thomas","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2018.07.029_bib50","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1093\/bioinformatics\/bts569","article-title":"Site\u00a0identification in high-throughput RNA-protein interaction data","volume":"28","author":"Uren","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2018.07.029_bib51","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nmeth.3810","article-title":"Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)","volume":"13","author":"Van Nostrand","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2018.07.029_bib52","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis\u2217","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.molcel.2018.07.029_bib53","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature05584","article-title":"14-3-3sigma controls mitotic translation to facilitate cytokinesis","volume":"446","author":"Wilker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2018.07.029_bib54","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0006-291X(75)80357-3","article-title":"Characterization of double-stranded RNA from HeLa cell mitochondria","volume":"65","author":"Young","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molcel.2018.07.029_bib55","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1073\/pnas.1424044112","article-title":"Potential role for snoRNAs in PKR activation during metabolic stress","volume":"112","author":"Youssef","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2018.07.029_bib56","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.cell.2011.11.029","article-title":"Suppression of PKR promotes network excitability and enhanced cognition by interferon-\u03b3-mediated disinhibition","volume":"147","author":"Zhu","year":"2011","journal-title":"Cell"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276518305987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276518305987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T09:26:45Z","timestamp":1604827605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276518305987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1097276518305987"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2018.07.029","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733936635.793559960","asserted-by":"object"}]},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2018.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}