{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:12:38Z","timestamp":1792005158190,"version":"4.4.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.molcel.2020.10.041","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T15:35:50Z","timestamp":1605627350000},"page":"779-795.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":151,"title":["Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-6198","authenticated-orcid":false,"given":"Shireen A.","family":"Sarraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hetal V.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Kanfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8470-6056","authenticated-orcid":false,"given":"Alicia M.","family":"Pickrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-8992","authenticated-orcid":false,"given":"Lynne A.","family":"Holtzclaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5296-8051","authenticated-orcid":false,"given":"Michael E.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Youle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2020.10.041_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuron.2010.04.031","article-title":"Probing the biology of Alzheimer\u2019s disease in mice","volume":"66","author":"Ashe","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.molcel.2020.10.041_bib2","doi-asserted-by":"crossref","first-page":"aac4354","DOI":"10.1126\/science.aac4354","article-title":"In\u00a0vivo aspects of protein folding and quality control","volume":"353","author":"Balchin","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molcel.2020.10.041_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1523\/JNEUROSCI.4988-09.2010","article-title":"Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis","volume":"30","author":"Barmada","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.molcel.2020.10.041_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nchembio.1563","article-title":"Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models","volume":"10","author":"Barmada","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.molcel.2004.12.021","article-title":"Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation","volume":"17","author":"Bennett","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200507002","article-title":"p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death","volume":"171","author":"Bj\u00f8rk\u00f8y","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib7","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib8","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1074\/jbc.M807440200","article-title":"HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2\u03b1 phosphorylation","volume":"284","author":"Carra","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2020.10.041_bib9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4161\/auto.7.3.14046","article-title":"The ubiquitin-binding adaptor proteins p62\/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway","volume":"7","author":"Cemma","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2020.10.041_bib10","doi-asserted-by":"crossref","first-page":"732798","DOI":"10.1155\/2011\/732798","article-title":"Autophagy in inflammatory diseases","volume":"2011","author":"Choi","year":"2011","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib11","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI58656","article-title":"The immunology of neurodegeneration","volume":"122","author":"Czirr","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.molcel.2020.10.041_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","article-title":"Proteasomal and Autophagic Degradation Systems","volume":"86","author":"Dikic","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2020.10.041_bib13","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1091\/mbc.8.8.1559","article-title":"Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells","volume":"8","author":"Eggers","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2020.10.041_bib15","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1002\/cpcb.51","article-title":"Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons","volume":"79","author":"Fernandopulle","year":"2018","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2020.10.041_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2298\/CSIS0501103H","article-title":"FP-Outlier: Frequent Pattern Based Outlier Detection","volume":"2","author":"He","year":"2005","journal-title":"Comput. Sci. Inf. Syst."},{"key":"10.1016\/j.molcel.2020.10.041_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN\/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2020.10.041_bib20","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2016.07.001","article-title":"UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome","volume":"166","author":"Hjerpe","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/emboj.2008.5","article-title":"Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation","volume":"27","author":"Iha","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2020.10.041_bib22","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1097\/00005072-199709000-00002","article-title":"APPSw transgenic mice develop age-related A \u03b2 deposits and neuropil abnormalities, but no neuronal loss in CA1","volume":"56","author":"Irizarry","year":"1997","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.molcel.2020.10.041_bib23","doi-asserted-by":"crossref","first-page":"13135","DOI":"10.1073\/pnas.0505801102","article-title":"Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation","volume":"102","author":"Iwata","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2020.10.041_bib24","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1073\/pnas.0802082105","article-title":"A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity","volume":"105","author":"Johnson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2020.10.041_bib25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature14498","article-title":"Regulation of endoplasmic reticulum turnover by selective autophagy","volume":"522","author":"Khaminets","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2020.10.041_bib26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.molcel.2009.04.026","article-title":"A role for ubiquitin in selective autophagy","volume":"34","author":"Kirkin","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib27","doi-asserted-by":"crossref","first-page":"732","DOI":"10.4161\/auto.5.5.8566","article-title":"NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets","volume":"5","author":"Kirkin","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2020.10.041_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2020.10.041_bib29","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","article-title":"Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice","volume":"131","author":"Komatsu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib30","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0962-8924(00)01852-3","article-title":"Aggresomes, inclusion bodies and protein aggregation","volume":"10","author":"Kopito","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib31","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1242\/jcs.114926","article-title":"Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates","volume":"126","author":"Korac","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.molcel.2020.10.041_bib33","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1073\/pnas.97.4.1589","article-title":"Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins","volume":"97","author":"Krobitsch","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2020.10.041_bib34","doi-asserted-by":"crossref","first-page":"736905","DOI":"10.1155\/2012\/736905","article-title":"Aggrephagy: selective disposal of protein aggregates by macroautophagy","volume":"2012","author":"Lamark","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib35","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.4161\/cc.8.13.8892","article-title":"NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets","volume":"8","author":"Lamark","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.molcel.2020.10.041_bib36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2020.10.041_bib37","doi-asserted-by":"crossref","first-page":"16208","DOI":"10.1523\/JNEUROSCI.2911-10.2010","article-title":"Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy","volume":"30","author":"Liachko","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.molcel.2020.10.041_bib38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2015.02.002","article-title":"Neuronal aggregates: formation, clearance, and spreading","volume":"32","author":"Lim","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib39","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cell.2014.05.048","article-title":"Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family","volume":"158","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ceb.2010.10.010","article-title":"Protein misfolding disorders and macroautophagy","volume":"23","author":"Menzies","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib41","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1083\/jcb.200112104","article-title":"Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1","volume":"157","author":"Meriin","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib42","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib43","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fnins.2018.00464","article-title":"An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration","volume":"12","author":"Moreno-Garc\u00eda","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.molcel.2020.10.041_bib44","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1101\/gad.1657108","article-title":"Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging","volume":"22","author":"Morimoto","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2020.10.041_bib45","doi-asserted-by":"crossref","first-page":"e73205","DOI":"10.1371\/journal.pone.0073205","article-title":"Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice","volume":"8","author":"Nakano","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2020.10.041_bib46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1136\/jmg.36.10.739","article-title":"A molecular investigation of true dominance in Huntington\u2019s disease","volume":"36","author":"Narain","year":"1999","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.molcel.2020.10.041_bib47","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4161\/auto.6.8.13426","article-title":"p62\/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both","volume":"6","author":"Narendra","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2020.10.041_bib48","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1365-2443.2010.01426.x","article-title":"p62\/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria","volume":"15","author":"Okatsu","year":"2010","journal-title":"Genes Cells"},{"key":"10.1016\/j.molcel.2020.10.041_bib49","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2020.10.041_bib82","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/bioinformatics\/btq046","article-title":"EBImage--an R package for image processing with applications to cellular phenotypes.","volume":"26","author":"Pau","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2020.10.041_bib50","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2","article-title":"Probability-based protein identification by searching sequence databases using mass spectrometry data","volume":"20","author":"Perkins","year":"1999","journal-title":"Electrophoresis"},{"key":"10.1016\/j.molcel.2020.10.041_bib51","doi-asserted-by":"crossref","first-page":"e97858","DOI":"10.15252\/embj.201797858","article-title":"Attenuation of cGAS-STING signaling is mediated by a p62\/SQSTM1-dependent autophagy pathway activated by TBK1","volume":"37","author":"Prabakaran","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2020.10.041_bib52","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molcel.2020.10.041_bib53","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.molcel.2019.01.041","article-title":"The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria","volume":"74","author":"Ravenhill","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib54","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/hmg\/11.9.1107","article-title":"Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy","volume":"11","author":"Ravikumar","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2020.10.041_bib55","series-title":"R: A language and environment for statistical computing","year":"2018"},{"key":"10.1016\/j.molcel.2020.10.041_bib56","doi-asserted-by":"crossref","first-page":"e0146021","DOI":"10.1371\/journal.pone.0146021","article-title":"Dose-Response Analysis Using R","volume":"10","author":"Ritz","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2020.10.041_bib57","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1093\/hmg\/ddq093","article-title":"Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington\u2019s disease","volume":"19","author":"Rose","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2020.10.041_bib58","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2020.10.041_bib59","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1084\/jem.20150956","article-title":"Therapeutic targeting of autophagy in neurodegenerative and infectious diseases","volume":"212","author":"Rubinsztein","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2020.10.041_bib60","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1128\/MCB.01485-08","article-title":"Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress","volume":"29","author":"Salomons","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib61","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/hmg\/ddi032","article-title":"Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis","volume":"14","author":"Sang","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molcel.2020.10.041_bib62","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1111\/j.1742-4658.2008.06562.x","article-title":"Huntington\u2019s disease: degradation of mutant huntingtin by autophagy","volume":"275","author":"Sarkar","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.molcel.2020.10.041_bib63","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1074\/jbc.M609532200","article-title":"Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein","volume":"282","author":"Sarkar","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2020.10.041_bib64","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2020.10.041_bib65","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1038\/sj.emboj.7601823","article-title":"Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling","volume":"26","author":"Shembade","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2020.10.041_bib66","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ni.2066","article-title":"The kinase IKK\u03b1 inhibits activation of the transcription factor NF-\u03baB by phosphorylating the regulatory molecule TAX1BP1","volume":"12","author":"Shembade","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2020.10.041_bib67","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0896-6273(01)00177-5","article-title":"Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases","volume":"29","author":"Sherman","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.molcel.2020.10.041_bib68","doi-asserted-by":"crossref","first-page":"e1005174","DOI":"10.1371\/journal.ppat.1005174","article-title":"The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy","volume":"11","author":"Tumbarello","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2020.10.041_bib69","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4939-7477-1_5","article-title":"Measurement of chaperone-mediated effects on polyglutamine protein aggregation by the filter trap assay","volume":"1709","author":"van Waarde-Verhagen","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib70","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molcel.2019.02.010","article-title":"Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy","volume":"74","author":"Vargas","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2020.10.041_bib71","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4161\/auto.6.2.11118","article-title":"NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria","volume":"6","author":"von Muhlinen","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2020.10.041_bib72","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1460-9568.2011.07803.x","article-title":"Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis","volume":"34","author":"Wang","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.molcel.2020.10.041_bib81","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stemcr.2017.08.019","article-title":"Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.","volume":"9","author":"Wang","year":"2017","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.molcel.2020.10.041_bib73","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1073\/pnas.0912417107","article-title":"TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration","volume":"107","author":"Wils","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2020.10.041_bib74","doi-asserted-by":"crossref","first-page":"a006734","DOI":"10.1101\/cshperspect.a006734","article-title":"Integration of clearance mechanisms: the proteasome and autophagy","volume":"2","author":"Wong","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2020.10.041_bib75","doi-asserted-by":"crossref","first-page":"E4439","DOI":"10.1073\/pnas.1405752111","article-title":"Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation","volume":"111","author":"Wong","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2020.10.041_bib76","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.nbd.2010.08.015","article-title":"The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration","volume":"43","author":"Yamamoto","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.molcel.2020.10.041_bib77","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1080\/07391102.2014.951688","article-title":"Crystallographic and modelling studies suggest that the SKICH domains from different protein families share a common Ig-like fold but harbour substantial structural variations","volume":"33","author":"Yang","year":"2015","journal-title":"J.\u00a0Biomol. Struct. Dyn."},{"key":"10.1016\/j.molcel.2020.10.041_bib78","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.4049\/jimmunol.157.5.1823","article-title":"Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?","volume":"157","author":"Yewdell","year":"1996","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.molcel.2020.10.041_bib79","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.molcel.2020.10.041_bib80","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","article-title":"Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse","volume":"89","author":"Zhang","year":"2016","journal-title":"Neuron"}],"updated-by":[{"DOI":"10.1016\/j.molcel.2022.03.020","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000}}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276520307759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276520307759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T15:09:23Z","timestamp":1723907363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276520307759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1097276520307759"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2020.10.041","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.molcel.2022.03.020","asserted-by":"object"}]},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2020.10.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}