{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:22:02Z","timestamp":1787383322835,"version":"build-2736575974"},"reference-count":140,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C53309\/A19702"],"award-info":[{"award-number":["C53309\/A19702"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["1609441.9"],"award-info":[{"award-number":["1609441.9"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.molcel.2021.08.026","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T01:15:03Z","timestamp":1632186903000},"page":"3731-3748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Supply and demand: Cellular nutrient uptake and exchange in cancer"],"prefix":"10.1016","volume":"81","author":[{"given":"Vasileios","family":"Papalazarou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver D.K.","family":"Maddocks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2021.08.026_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2021.08.026_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.4562","article-title":"Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival","volume":"237","author":"Baenke","year":"2015","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.molcel.2021.08.026_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09687688.2018.1448123","article-title":"Structural biology of solute carrier (SLC) membrane transport proteins","volume":"34","author":"Bai","year":"2017","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1042\/BST20150047","article-title":"Structural basis for the mechanism of ABC transporters","volume":"43","author":"Beis","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.molcel.2021.08.026_bib5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1039\/C6MD00043F","article-title":"Fatty Acid Transport Proteins: Targeting FATP2 as a Gatekeeper Involved in the Transport of Exogenous Fatty Acids","volume":"7","author":"Black","year":"2016","journal-title":"MedChemComm"},{"key":"10.1016\/j.molcel.2021.08.026_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cell.2016.05.042","article-title":"Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine","volume":"166","author":"Briggs","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib7","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1042\/BCJ20160822","article-title":"Amino acid homeostasis and signalling in mammalian cells and organisms","volume":"474","author":"Br\u00f6er","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.molcel.2021.08.026_bib8","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1074\/jbc.RA118.006378","article-title":"Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells","volume":"294","author":"Br\u00f6er","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2021.08.026_bib9","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1242\/jcs.088716","article-title":"P-type ATPases at a glance","volume":"124","author":"Bublitz","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fonc.2016.00044","article-title":"Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring","volume":"6","author":"Challapalli","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.molcel.2021.08.026_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1152\/physrev.1990.70.1.43","article-title":"Role of amino acid transport and countertransport in nutrition and metabolism","volume":"70","author":"Christensen","year":"1990","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.molcel.2021.08.026_bib12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1039\/C6MD00005C","article-title":"SLC Transporters: Structure, Function, and Drug Discovery","volume":"7","author":"Colas","year":"2016","journal-title":"MedChemComm"},{"key":"10.1016\/j.molcel.2021.08.026_bib13","doi-asserted-by":"crossref","first-page":"183341","DOI":"10.1016\/j.bbamem.2020.183341","article-title":"Regulation and function of V-ATPases in physiology and disease","volume":"1862","author":"Collins","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.molcel.2021.08.026_bib14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature12138","article-title":"Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells","volume":"497","author":"Commisso","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib15","doi-asserted-by":"crossref","first-page":"e53618","DOI":"10.7554\/eLife.53618","article-title":"Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth","volume":"9","author":"Contat","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2021.08.026_bib16","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1074\/jbc.RA117.001342","article-title":"The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)","volume":"293","author":"Cormerais","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2021.08.026_bib17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.ccell.2017.10.016","article-title":"Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma","volume":"32","author":"Cosset","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41569-020-0406-8","article-title":"SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control","volume":"17","author":"Cowie","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"6 Pt B","key":"10.1016\/j.molcel.2021.08.026_bib19","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.bbamcr.2015.11.016","article-title":"Calcium-ATPases: Gene disorders and dysregulation in cancer","volume":"1863","author":"Dang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molcel.2021.08.026_bib20","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.18632\/oncotarget.27758","article-title":"Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14","volume":"11","author":"Dejure","year":"2020","journal-title":"Oncotarget"},{"key":"10.1016\/j.molcel.2021.08.026_bib21","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1084\/jem.20182044","article-title":"Creatine uptake regulates CD8 T\u00a0cell antitumor immunity","volume":"216","author":"Di Biase","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2021.08.026_bib22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00018-017-2677-8","article-title":"Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters","volume":"75","author":"Edwards","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib23","doi-asserted-by":"crossref","first-page":"e140100","DOI":"10.1172\/JCI140100","article-title":"Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer","volume":"131","author":"Edwards","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.molcel.2021.08.026_bib24","doi-asserted-by":"crossref","first-page":"10627","DOI":"10.1158\/0008-5472.CAN-07-1805","article-title":"Targeting vacuolar H+-ATPases as a new strategy against cancer","volume":"67","author":"Fais","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2021.08.026_bib25","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2017.09.019","article-title":"Lactate Metabolism in Human Lung Tumors","volume":"171","author":"Faubert","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib26","first-page":"1231","article-title":"MRP and MDR1 gene expression in primary breast carcinomas","volume":"2","author":"Filipits","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.molcel.2021.08.026_bib27","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/nn.3510","article-title":"Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake","volume":"16","author":"Flavahan","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.molcel.2021.08.026_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2016.03.001","article-title":"ABC transporters as mediators of drug resistance and contributors to cancer cell biology","volume":"26","author":"Fletcher","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.molcel.2021.08.026_bib29","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/ncb2363","article-title":"Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes","volume":"13","author":"Florey","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib30","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1016\/j.febslet.2008.10.016","article-title":"The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families","volume":"582","author":"Fredriksson","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molcel.2021.08.026_bib31","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1038\/onc.2017.247","article-title":"Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia","volume":"36","author":"Gallagher","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2021.08.026_bib32","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41556-018-0118-z","article-title":"Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours","volume":"20","author":"Garcia-Bermudez","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrc706","article-title":"Multidrug resistance in cancer: role of ATP-dependent transporters","volume":"2","author":"Gottesman","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2021.08.026_bib34","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1158\/0008-5472.CAN-12-0448","article-title":"Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription","volume":"72","author":"Ha","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2021.08.026_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.celrep.2017.06.037","article-title":"Entosis Is Induced by Glucose Starvation","volume":"20","author":"Hamann","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2021.08.026_bib36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1158\/2159-8290.CD-19-1006","article-title":"Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer","volume":"10","author":"Hobbs","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2021.08.026_bib37","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/molbev\/msq350","article-title":"The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species","volume":"28","author":"H\u00f6glund","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.molcel.2021.08.026_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cellsig.2016.01.011","article-title":"Oncogenic activation of the PI3K\/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein","volume":"28","author":"Hong","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.molcel.2021.08.026_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/B978-0-12-800223-0.00004-9","article-title":"Biology of the major facilitative folate transporters SLC19A1 and SLC46A1","volume":"73","author":"Hou","year":"2014","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.molcel.2021.08.026_bib40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib41","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s41467-020-14928-3","article-title":"Macropinocytosis confers resistance to therapies targeting cancer anabolism","volume":"11","author":"Jayashankar","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2021.08.026_bib42","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1042\/BST20160055","article-title":"Transport mechanism of a glutamate transporter homologue GltPh","volume":"44","author":"Ji","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.molcel.2021.08.026_bib43","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.immuni.2019.06.007","article-title":"Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses","volume":"51","author":"Ji","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2021.08.026_bib44","first-page":"1","article-title":"Transporter proteins and its implication in human diseases","volume":"124","author":"Kabra","year":"2021","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib45","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/0008-5472.CAN-14-2211","article-title":"Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein","volume":"75","author":"Kamphorst","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2021.08.026_bib46","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.tibs.2018.05.003","article-title":"Amino acid transporters revisited: New views in health and disease","volume":"43","author":"Kandasamy","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib47","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1158\/1535-7163.MCT-17-0535","article-title":"MCT4 Expression Is a Potential Therapeutic Target in Colorectal Cancer with Peritoneal Carcinomatosis","volume":"17","author":"Kim","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.molcel.2021.08.026_bib48","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1158\/2159-8290.CD-17-1215","article-title":"PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells","volume":"8","author":"Kim","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2021.08.026_bib49","doi-asserted-by":"crossref","first-page":"20180158","DOI":"10.1098\/rstb.2018.0158","article-title":"The origins and evolution of macropinocytosis","volume":"374","author":"King","year":"2019","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib50","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gad.340661.120","article-title":"Yap\/Taz promote the scavenging of extracellular nutrients through macropinocytosis","volume":"34","author":"King","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2021.08.026_bib51","doi-asserted-by":"crossref","first-page":"32748","DOI":"10.18632\/oncotarget.4977","article-title":"Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells","volume":"6","author":"Koch","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.molcel.2021.08.026_bib52","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/s41467-020-15136-9","article-title":"A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer","volume":"11","author":"Kodama","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2021.08.026_bib53","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jphs.2017.01.006","article-title":"Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)","volume":"133","author":"Kongpracha","year":"2017","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib54","doi-asserted-by":"crossref","first-page":"14240","DOI":"10.1074\/jbc.M117.798405","article-title":"The glutamate\/cystine antiporter SLC7A11\/xCT enhances cancer cell dependency on glucose by exporting glutamate","volume":"292","author":"Koppula","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2021.08.026_bib55","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of fatty acid metabolism in cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.molcel.2021.08.026_bib56","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1073\/pnas.1018081108","article-title":"Molecular basis of substrate-induced permeation by an amino acid antiporter","volume":"108","author":"Kowalczyk","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2021.08.026_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neo.2018.09.006","article-title":"Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology","volume":"21","author":"Kurhanewicz","year":"2019","journal-title":"Neoplasia"},{"key":"10.1016\/j.molcel.2021.08.026_bib59","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.molcel.2015.04.015","article-title":"A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome","volume":"58","author":"Lee","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib60","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/ars.2011.4391","article-title":"The cystine\/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities","volume":"18","author":"Lewerenz","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.molcel.2021.08.026_bib61","doi-asserted-by":"crossref","first-page":"e1470","DOI":"10.1038\/cddis.2014.431","article-title":"Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2021.08.026_bib62","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/1878-0261.12530","article-title":"SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity","volume":"13","author":"Liu","year":"2019","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.molcel.2021.08.026_bib63","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/ng.890","article-title":"Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis","volume":"43","author":"Locasale","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2021.08.026_bib64","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2014.12.018","article-title":"Extracellular metabolic energetics can promote cancer progression","volume":"160","author":"Loo","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib65","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-019-1553-0","article-title":"SLC19A1 transports immunoreactive cyclic dinucleotides","volume":"573","author":"Luteijn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib66","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature11743","article-title":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells","volume":"493","author":"Maddocks","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib67","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature22056","article-title":"Modulating the therapeutic response of tumours to dietary serine and glycine starvation","volume":"544","author":"Maddocks","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib68","doi-asserted-by":"crossref","first-page":"17495","DOI":"10.1074\/jbc.M115.660498","article-title":"Signaling through the Phosphatidylinositol 3-Kinase (PI3K)\/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma","volume":"290","author":"Makinoshima","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2021.08.026_bib69","doi-asserted-by":"crossref","first-page":"a002188","DOI":"10.1101\/cshperspect.a002188","article-title":"Membrane transport in primitive cells","volume":"2","author":"Mansy","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib70","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2147\/OTT.S288709","article-title":"Aberrant SLC6A14 Expression Promotes Proliferation and Metastasis of Colorectal Cancer via Enhancing the JAK2\/STAT3 Pathway","volume":"14","author":"Mao","year":"2021","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.molcel.2021.08.026_bib71","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/nm.3686","article-title":"Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development","volume":"20","author":"Mayers","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2021.08.026_bib72","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/emboj\/21.4.580","article-title":"Activation of system L heterodimeric amino acid exchangers by intracellular substrates","volume":"21","author":"Meier","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2021.08.026_bib73","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jcp.21166","article-title":"Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75","volume":"214","author":"Meneses","year":"2008","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.molcel.2021.08.026_bib74","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.celrep.2020.01.080","article-title":"Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition","volume":"30","author":"Michalopoulou","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2021.08.026_bib75","doi-asserted-by":"crossref","first-page":"e27713","DOI":"10.7554\/eLife.27713","article-title":"Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition","volume":"6","author":"Muir","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2021.08.026_bib76","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021475118","article-title":"Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11","volume":"118","author":"Mukhopadhyay","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2021.08.026_bib77","doi-asserted-by":"crossref","first-page":"13989","DOI":"10.1038\/ncomms13989","article-title":"Starved epithelial cells uptake extracellular matrix for survival","volume":"8","author":"Muranen","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2021.08.026_bib78","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41588-020-00753-3","article-title":"The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer","volume":"53","author":"Najumudeen","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2021.08.026_bib79","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40170-019-0203-1","article-title":"SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia","volume":"7","author":"Nasiri","year":"2019","journal-title":"Cancer Metab."},{"key":"10.1016\/j.molcel.2021.08.026_bib80","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.tcb.2017.05.001","article-title":"Serine and Functional Metabolites in Cancer","volume":"27","author":"Newman","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib81","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1016\/j.molcel.2021.03.019","article-title":"Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells","volume":"81","author":"Newman","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib82","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s42255-019-0039-6","article-title":"Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression","volume":"1","author":"Ni","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.molcel.2021.08.026_bib83","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","article-title":"Bidirectional transport of amino acids regulates mTOR and autophagy","volume":"136","author":"Nicklin","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib84","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm.2492","article-title":"Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth","volume":"17","author":"Nieman","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2021.08.026_bib85","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.molcel.2017.08.011","article-title":"mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein","volume":"67","author":"Nofal","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib86","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1349-7006.2009.01386.x","article-title":"L-type amino acid transporter 1 inhibitors inhibit tumor cell growth","volume":"101","author":"Oda","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib87","doi-asserted-by":"crossref","first-page":"16031","DOI":"10.1038\/ncomms16031","article-title":"Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions","volume":"8","author":"Olivares","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2021.08.026_bib88","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cell.2015.06.017","article-title":"The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1","volume":"162","author":"Palm","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib89","doi-asserted-by":"crossref","first-page":"E8628","DOI":"10.1073\/pnas.1712726114","article-title":"Critical role for PI3-kinase in regulating the use of proteins as an amino acid source","volume":"114","author":"Palm","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2021.08.026_bib90","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s42255-019-0159-z","article-title":"The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis","volume":"2","author":"Papalazarou","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.molcel.2021.08.026_bib91","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1158\/2159-8290.CD-19-0959","article-title":"Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer","volume":"10","author":"Parker","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2021.08.026_bib92","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tips.2016.11.008","article-title":"Classification Systems of Secondary Active Transporters","volume":"38","author":"Perland","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib93","doi-asserted-by":"crossref","first-page":"25505","DOI":"10.1038\/srep25505","article-title":"The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin","volume":"6","author":"Peters","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2021.08.026_bib94","doi-asserted-by":"crossref","first-page":"13101","DOI":"10.1038\/s41598-017-13298-z","article-title":"MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism","volume":"7","author":"Petersen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2021.08.026_bib95","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1111\/febs.15531","article-title":"A guide to plasma membrane solute carrier proteins","volume":"288","author":"Pizzagalli","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.molcel.2021.08.026_bib96","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10350","article-title":"Functional genomics reveal that the serine synthesis pathway is essential in breast cancer","volume":"476","author":"Possemato","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib97","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrm.2015.25","article-title":"Understanding transport by the major facilitator superfamily (MFS): structures pave the way","volume":"17","author":"Quistgaard","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib98","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.celrep.2014.12.037","article-title":"Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration","volume":"10","author":"Rainero","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2021.08.026_bib99","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41586-019-1831-x","article-title":"Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis","volume":"576","author":"Ramirez","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrm2646","article-title":"ABC transporters: the power to change","volume":"10","author":"Rees","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib101","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41586-021-03442-1","article-title":"Cell-programmed nutrient partitioning in the tumour microenvironment","volume":"593","author":"Reinfeld","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib102","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.molcel.2019.05.006","article-title":"SLC19A1 Is an Importer of the Immunotransmitter cGAMP","volume":"75","author":"Ritchie","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib103","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrc.2016.89","article-title":"The multifaceted roles of fatty acid synthesis in cancer","volume":"16","author":"R\u00f6hrig","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2021.08.026_bib104","doi-asserted-by":"crossref","first-page":"e28083","DOI":"10.7554\/eLife.28083","article-title":"Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer","volume":"6","author":"Sayin","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2021.08.026_bib105","doi-asserted-by":"crossref","first-page":"E4111","DOI":"10.1073\/pnas.1511698112","article-title":"Functional expression of sodium-glucose transporters in cancer","volume":"112","author":"Scafoglio","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2021.08.026_bib106","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nm.4464","article-title":"Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models","volume":"24","author":"Schulte","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2021.08.026_bib107","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41467-017-02444-w","article-title":"Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2\/SLC1A5","volume":"9","author":"Scopelliti","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2021.08.026_bib108","doi-asserted-by":"crossref","first-page":"15074","DOI":"10.1038\/ncomms15074","article-title":"The glutamate\/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility","volume":"8","author":"Shin","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2021.08.026_bib109","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.celrep.2017.10.053","article-title":"PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly","volume":"21","author":"Shinde","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2021.08.026_bib110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1208\/s12248-017-0164-7","article-title":"The Na+\/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis","volume":"20","author":"Sikder","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.molcel.2021.08.026_bib111","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1042\/BCJ20200099","article-title":"SLC6A14, a Na+\/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling","volume":"477","author":"Sikder","year":"2020","journal-title":"Biochem. J."},{"key":"10.1016\/j.molcel.2021.08.026_bib112","doi-asserted-by":"crossref","first-page":"166087","DOI":"10.1016\/j.bbadis.2021.166087","article-title":"SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic syndrome but only under conditions of a high-fat diet","volume":"1867","author":"Sivaprakasam","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.molcel.2021.08.026_bib113","first-page":"3930","article-title":"Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice","volume":"118","author":"Sonveaux","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.molcel.2021.08.026_bib114","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature19084","article-title":"Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion","volume":"536","author":"Sousa","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.sbi.2013.11.013","article-title":"Rotary ATPases--dynamic molecular machines","volume":"25","author":"Stewart","year":"2014","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib116","doi-asserted-by":"crossref","first-page":"e44235","DOI":"10.7554\/eLife.44235","article-title":"Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability","volume":"8","author":"Sullivan","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2021.08.026_bib117","doi-asserted-by":"crossref","first-page":"e102147","DOI":"10.15252\/embj.2019102147","article-title":"SLC1A3 contributes to L-asparaginase resistance in solid tumors","volume":"38","author":"Sun","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2021.08.026_bib118","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.cmet.2018.07.005","article-title":"A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3","volume":"28","author":"Tajan","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2021.08.026_bib119","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/ncb3272","article-title":"Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma","volume":"17","author":"Tardito","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41586-019-1847-2","article-title":"Metabolic heterogeneity confers differences in melanoma metastatic potential","volume":"577","author":"Tasdogan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib121","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1186\/s12935-020-01582-4","article-title":"FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport","volume":"20","author":"Tian","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.molcel.2021.08.026_bib122","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1002\/jcp.30189","article-title":"Overexpression of GLUT3 promotes metastasis of triple-negative breast cancer by modulating the inflammatory tumor microenvironment","volume":"236","author":"Tsai","year":"2021","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.molcel.2021.08.026_bib123","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/j.1478-3231.2008.01889.x","article-title":"Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin","volume":"28","author":"Vander Borght","year":"2008","journal-title":"Liver Int."},{"key":"10.1016\/j.molcel.2021.08.026_bib124","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1158\/0008-5472.CAN-19-3204","article-title":"Raman Spectroscopy Reveals That Biochemical Composition of Breast Microcalcifications Correlates with Histopathologic Features","volume":"80","author":"Vanna","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2021.08.026_bib125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-019-1118-2","article-title":"Fatty acid transport protein 2 reprograms neutrophils in cancer","volume":"569","author":"Veglia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib126","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ccell.2016.09.008","article-title":"An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers","volume":"30","author":"Villa","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib127","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The Metabolism of Tumors in the Body","volume":"8","author":"Warburg","year":"1927","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.molcel.2021.08.026_bib128","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1091\/mbc.e06-07-0593","article-title":"Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase\/Akt regulation of Glut1 activity and trafficking","volume":"18","author":"Wieman","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib129","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1021\/acs.chemrev.0c00644","article-title":"Toward a Molecular Basis of Cellular Nucleoside Transport in Humans","volume":"121","author":"Wright","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.molcel.2021.08.026_bib130","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.molcel.2013.01.035","article-title":"AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1","volume":"49","author":"Wu","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2021.08.026_bib131","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1038\/s41467-020-18020-8","article-title":"GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer","volume":"11","author":"Wu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2021.08.026_bib132","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-019-1062-1","article-title":"Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer","volume":"568","author":"Yao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2021.08.026_bib133","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cmet.2019.11.020","article-title":"A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells","volume":"31","author":"Yoo","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2021.08.026_bib134","doi-asserted-by":"crossref","first-page":"e23205","DOI":"10.1371\/journal.pone.0023205","article-title":"Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in\u00a0vitro and in\u00a0vivo","volume":"6","author":"Young","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molcel.2021.08.026_bib135","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.mam.2012.05.007","article-title":"The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29","volume":"34","author":"Young","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.molcel.2021.08.026_bib136","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.3390\/ijms20133374","article-title":"Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy","volume":"20","author":"Zambrano","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molcel.2021.08.026_bib137","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/ncb2432","article-title":"Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia","volume":"14","author":"Zhang","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib138","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.chembiol.2019.01.008","article-title":"Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2021.08.026_bib139","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cmet.2021.03.009","article-title":"Creatine promotes cancer metastasis through activation of Smad2\/3","volume":"33","author":"Zhang","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2021.08.026_bib140","doi-asserted-by":"crossref","first-page":"e10250","DOI":"10.7554\/eLife.10250","article-title":"Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism","volume":"5","author":"Zhao","year":"2016","journal-title":"eLife"},{"issue":"1A","key":"10.1016\/j.molcel.2021.08.026_bib141","first-page":"119","article-title":"P-glycoprotein and MRP1 expression in axillary lymph node metastases of breast cancer patients","volume":"21","author":"Z\u00f6chbauer-M\u00fcller","year":"2001","journal-title":"Anticancer Res."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276521006936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276521006936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:11:48Z","timestamp":1777608708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276521006936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":140,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1097276521006936"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2021.08.026","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Supply and demand: Cellular nutrient uptake and exchange in cancer","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2021.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}