{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T05:49:06Z","timestamp":1793512146885,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.molcel.2022.04.033","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T01:31:00Z","timestamp":1652664660000},"page":"2385-2400.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":151,"title":["Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells"],"prefix":"10.1016","volume":"82","author":[{"given":"R\u00e9mi","family":"Plan\u00e8s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Santoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Hessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Passemar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Paillette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Luiza Chaves","family":"Valad\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Samirah","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Fadrique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pericat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salimata","family":"Bagayoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Adonai","family":"Leon-Icaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Rombouts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Perouzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Tiraby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Cicuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Jouanguy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Neyrolles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres R.","family":"Floto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Goujon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin Zhong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Martin-Blondel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cougoule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reversade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Marcoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Ravet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2022.04.033_bib1","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1038\/srep16836","article-title":"A modular assembly platform for rapid generation of DNA constructs","volume":"6","author":"Akama-Garren","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2022.04.033_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.2020006520","article-title":"COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection","volume":"136","author":"Al-Samkari","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.molcel.2022.04.033_bib3","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.1085658","article-title":"Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs","volume":"300","author":"Anand","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/sciimmunol.abl4348","article-title":"X-linked recessive TLR7 deficiency in \u223c1% of men under 60 years old with life-threatening COVID-19","volume":"6","author":"Asano","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib5","doi-asserted-by":"crossref","first-page":"e55070","DOI":"10.7554\/eLife.55070","article-title":"Co-regulation and function of FOXM1\/ RHNO1 bidirectional genes in cancer","volume":"10","author":"Barger","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.04.033_bib6","doi-asserted-by":"crossref","first-page":"eabl4340","DOI":"10.1126\/sciimmunol.abl4340","article-title":"Autoantibodies neutralizing type I IFNs are present in \u223c4% of uninfected individuals over 70 years old and account for \u223c20% of COVID-19 deaths","volume":"6","author":"Bastard","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1084\/jem.20210554","article-title":"Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1","volume":"218","author":"Bastard","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib8","doi-asserted-by":"crossref","first-page":"eabd4585","DOI":"10.1126\/science.abd4585","article-title":"Autoantibodies against type I IFNs in patients with life-threatening COVID-19","volume":"370","author":"Bastard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5802\/crbiol.36","article-title":"Insufficient type I IFN immunity underlieslife-threatening COVID-19 pneumonia life-threatening COVID-19 pneumonia","volume":"344","author":"Bastard","year":"2021","journal-title":"C.\u00a0R. Biol."},{"key":"10.1016\/j.molcel.2022.04.033_bib10","doi-asserted-by":"crossref","first-page":"eabd0811","DOI":"10.1126\/science.abd0811","article-title":"Human NLRP1 is a sensor for double-stranded RNA","volume":"371","author":"Bauernfried","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib11","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1056\/NEJMcp2009575","article-title":"Severe Covid-19","volume":"383","author":"Berlin","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib12","doi-asserted-by":"crossref","first-page":"e20190295","DOI":"10.1084\/jem.20190295","article-title":"Cytokines Focus Type III interferons: balancing tissue tolerance and resistance to pathogen invasion","volume":"217","author":"Broggi","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41577-020-0308-3","article-title":"COVID-19: immunopathology and its implications for therapy","volume":"20","author":"Cao","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41577-021-00522-1","article-title":"The first 12\u00a0months of COVID-19: a timeline of immunological insights","volume":"21","author":"Carvalho","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib16","doi-asserted-by":"crossref","first-page":"18951","DOI":"10.1073\/pnas.2009017117","article-title":"Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19","volume":"117","author":"Cauchois","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2022.04.033_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(21)00035-7","article-title":"The right place for IL-1 inhibition in COVID-19","volume":"9","author":"Cavalli","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib18","doi-asserted-by":"crossref","first-page":"e1006052","DOI":"10.1371\/journal.ppat.1006052","article-title":"Functional and evolutionary analyses identify proteolysis as a general mechanism for NLRP1 inflammasome activation","volume":"12","author":"Chavarr\u00eda-Smith","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2022.04.033_bib19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.aau1208","article-title":"N-terminal degradation activates the NLRP1B inflammasome","volume":"364","author":"Chui","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib20","doi-asserted-by":"crossref","first-page":"2000045","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","article-title":"Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR","volume":"25","author":"Corman","year":"2020","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.molcel.2022.04.033_bib21","first-page":"1","article-title":"ASC filament formation serves as a signal amplification mechanism for inflammasomes","volume":"71","author":"Dick","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2022.04.033_bib22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41594-019-0291-1","article-title":"Degradation of proteins with N-terminal glycine","volume":"26","author":"Eldeeb","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2022.04.033_bib23","doi-asserted-by":"crossref","first-page":"e50829","DOI":"10.15252\/embr.202050829","article-title":"Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response","volume":"21","author":"Eren","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2022.04.033_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-1-4939-7471-9_15","article-title":"Primary airway epithelial cell gene editing using CRISPR-Cas9","volume":"1706","author":"Everman","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.molcel.2022.04.033_bib25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ni.2913","article-title":"ASC has extracellular and prionoid activities that propagate inflammation","volume":"15","author":"Franklin","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41590-020-00840-x","article-title":"Untuned antiviral immunity in COVID-19 revealed by temporal type I\/III interferon patterns and flu comparison","volume":"22","author":"Galani","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib27","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.abc6027","article-title":"Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients","volume":"369","author":"Hadjadj","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib28","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/j.cell.2021.04.036","article-title":"Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions","volume":"184","author":"Hansen","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.04.033_bib29","doi-asserted-by":"crossref","first-page":"e202000735","DOI":"10.26508\/lsa.202000735","article-title":"Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD","volume":"3","author":"Heilig","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.molcel.2022.04.033_bib30","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-021-03350-4","article-title":"DPP9 sequesters the C\u00a0terminus of NLRP1 to repress inflammasome activation","volume":"592","author":"Hollingsworth","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.04.033_bib31","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41591-018-0082-y","article-title":"DPP8\/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia","volume":"24","author":"Johnson","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib32","article-title":"SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release","author":"Junqueira","year":"2021","journal-title":"Res. Sq."},{"key":"10.1016\/j.molcel.2022.04.033_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-021-03218-7","article-title":"NINJ1 mediates plasma membrane rupture during lytic cell death","volume":"591","author":"Kayagaki","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.04.033_bib34","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.04.033_bib35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2105-5-72","article-title":"Coronavirus 3CLpro proteinase cleavage sites: possible relevance to SARS virus pathology","volume":"5","author":"Kiemer","year":"2004","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.molcel.2022.04.033_bib36","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s00134-021-06392-4","article-title":"Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients","volume":"47","author":"Koning","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib37","doi-asserted-by":"crossref","first-page":"eaau4643","DOI":"10.1126\/sciimmunol.aau4643","article-title":"Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium","volume":"4","author":"Lee","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01069-17","article-title":"Enterovirus 71 inhibits pyroptosis through cleavage of gasdermin D","volume":"91","author":"Lei","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.molcel.2022.04.033_bib39","first-page":"1","article-title":"SARS-CoV-2 cell tropism and multiorgan infection","volume":"71","author":"Liu","year":"2021","journal-title":"Cell Discov."},{"key":"10.1016\/j.molcel.2022.04.033_bib40","article-title":"Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs","volume":"218","author":"Lopez","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib41","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent Inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.04.033_bib42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41586-020-2588-y","article-title":"Longitudinal analyses reveal immunological misfiring in severe COVID-19","volume":"584","author":"Lucas","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.04.033_bib43","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.chom.2021.08.010","article-title":"Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection","volume":"29","author":"Luchetti","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.molcel.2022.04.033_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coi.2019.04.015","article-title":"The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries","volume":"60","author":"Mitchell","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib45","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.chembiol.2017.12.013","article-title":"Inhibition of Dpp8\/9 activates the Nlrp1b inflammasome","volume":"25","author":"Okondo","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2022.04.033_bib46","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.immuni.2021.04.012","article-title":"Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes gasdermin-E-dependent pyroptosis in barrier epithelial cells","volume":"54","author":"Orzalli","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2022.04.033_bib47","first-page":"1","article-title":"SARS-CoV-2\u00a0N protein promotes NLRP3 inflammasome activation to induce hyperinflammation","volume":"12","author":"Pan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2022.04.033_bib48","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.tibs.2021.06.001","article-title":"Cell entry by SARS-CoV-2","volume":"46","author":"Peng","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molcel.2022.04.033_bib49","doi-asserted-by":"crossref","first-page":"e02415","DOI":"10.1128\/JVI.02415-20","article-title":"SARS-CoV-2 triggers an MDA-5-Dependent interferon response which is unable to control replication in lung epithelial cells","volume":"95","author":"Rebendenne","year":"2021","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.molcel.2022.04.033_bib50","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints12","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.molcel.2022.04.033_bib51","doi-asserted-by":"crossref","first-page":"e0237420","DOI":"10.1128\/JVI.02374-20","article-title":"Inhibitors of coronavirus 3CL proteases protect cells from protease-mediated cytotoxicity","volume":"95","author":"Resnick","year":"2021","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.molcel.2022.04.033_bib52","doi-asserted-by":"crossref","first-page":"eaay2002","DOI":"10.1126\/science.aay2002","article-title":"Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia","volume":"370","author":"Robinson","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib53","doi-asserted-by":"crossref","first-page":"e20201707","DOI":"10.1084\/jem.20201707","article-title":"Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients","volume":"218","author":"Rodrigues","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib54","doi-asserted-by":"crossref","first-page":"eaau1330","DOI":"10.1126\/science.aau1330","article-title":"Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes","volume":"364","author":"Sandstrom","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib55","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2022.04.033_bib56","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.cell.2021.02.029","article-title":"COVID-19 and the human innate immune system","volume":"184","author":"Schultze","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.04.033_bib57","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.04.033_bib58","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.chembiol.2017.03.009","article-title":"Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages","volume":"24","author":"Taabazuing","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2022.04.033_bib59","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.60609","article-title":"Diverse viral proteases activate the nlrp1 inflammasome","volume":"10","author":"Tsu","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.04.033_bib61","first-page":"1","article-title":"Caspase-1 initiates apoptosis in the absence of gasdermin D.","volume":"101","author":"Tsuchiya","year":"2019","journal-title":"Nat. Commun"},{"key":"10.1016\/j.molcel.2022.04.033_bib62","doi-asserted-by":"crossref","first-page":"e192","DOI":"10.1016\/S1473-3099(20)30483-7","article-title":"A minimal common outcome measure set for COVID-19 clinical research","volume":"20","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.molcel.2022.04.033_bib63","doi-asserted-by":"crossref","first-page":"eabh2624","DOI":"10.1126\/scitranslmed.abh2624","article-title":"Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19","volume":"13","author":"Wijst","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molcel.2022.04.033_bib64","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.chom.2020.04.004","article-title":"An infectious cDNA clone of SARS-CoV-2","volume":"27","author":"Xie","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.molcel.2022.04.033_bib65","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.virol.2022.01.003","article-title":"SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway","volume":"568","author":"Xu","year":"2022","journal-title":"Virology"},{"key":"10.1016\/j.molcel.2022.04.033_bib66","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4049\/jimmunol.2000513","article-title":"Inflammasomes and pyroptosis as therapeutic targets for COVID-19","volume":"205","author":"Yap","year":"2020","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.molcel.2022.04.033_bib67","first-page":"1","article-title":"Pyroptosis: mechanisms and diseases","volume":"61","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.molcel.2022.04.033_bib68","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.coviro.2021.08.004","article-title":"Interfering with SARS-CoV-2: are interferons friends or foes in COVID-19?","volume":"50","author":"Zanoni","year":"2021","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.molcel.2022.04.033_bib69","doi-asserted-by":"crossref","first-page":"eabd4570","DOI":"10.1126\/science.abd4570","article-title":"Inborn errors of type I IFN immunity in patients with life-threatening COVID-19","volume":"370","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.04.033_bib70","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/j.jinf.2020.04.021","article-title":"Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis","volume":"81","author":"Zheng","year":"2020","journal-title":"J.\u00a0Infectol."},{"key":"10.1016\/j.molcel.2022.04.033_bib71","doi-asserted-by":"crossref","first-page":"18864","DOI":"10.1074\/jbc.RA118.004350","article-title":"Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding","volume":"293","author":"Zhong","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2022.04.033_bib72","doi-asserted-by":"crossref","first-page":"108998","DOI":"10.1016\/j.celrep.2021.108998","article-title":"Gasdermin E permits interleukin-1beta release in distinct sublytic and pyroptotic phases","volume":"35","author":"Zhou","year":"2021","journal-title":"Cell Rep."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276522004336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276522004336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:44:43Z","timestamp":1761093883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276522004336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":72,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1097276522004336"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2022.04.033","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2022.04.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}