{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:28:48Z","timestamp":1792020528620,"version":"4.4.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["099276\/Z\/12\/Z"],"award-info":[{"award-number":["099276\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["222845\/Z\/21\/Z"],"award-info":[{"award-number":["222845\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20PJ1405500\/21DZ2210200"],"award-info":[{"award-number":["20PJ1405500\/21DZ2210200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000735","name":"University of Cambridge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 620-2016"],"award-info":[{"award-number":["ALTF 620-2016"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.molcel.2022.09.003","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T13:59:45Z","timestamp":1664546385000},"page":"3769-3780.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Chromatin jets define the properties of cohesin-driven in\u00a0vivo loop extrusion"],"prefix":"10.1016","volume":"82","author":[{"given":"Ya","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ediem","family":"Al-Jibury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Garcia-Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Ntagiantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.D.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Galjart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Lenhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rueckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Pruessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Merkenschlager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2022.09.003_bib1","doi-asserted-by":"crossref","first-page":"11202","DOI":"10.1093\/nar\/gks925","article-title":"Self-organization of domain structures by DNA-loop-extruding enzymes","volume":"40","author":"Alipour","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2022.09.003_bib2","doi-asserted-by":"crossref","first-page":"e65467","DOI":"10.7554\/eLife.65467","article-title":"A low SMC flux avoids collisions and facilitates chromosome organization in bacillus subtilis","volume":"10","author":"Anchimiuk","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.09.003_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41586-021-03193-z","article-title":"Loop extrusion as a mechanism for formation of DNA damage repair foci","volume":"590","author":"Arnould","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.09.003_bib4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2020.04.011","article-title":"Loop extrusion: theory meets single-molecule experiments","volume":"64","author":"Banigan","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.molcel.2022.09.003_bib5","article-title":"Transcription shapes 3D chromatin organization by interacting with loop-extruding cohesin complexes","author":"Banigan","year":"2022","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.molcel.2022.09.003_bib6","doi-asserted-by":"crossref","first-page":"e53558","DOI":"10.7554\/eLife.53558","article-title":"Chromosome organization by one-sided and two-sided loop extrusion","volume":"9","author":"Banigan","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.09.003_bib8","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.aaz3418","article-title":"DNA loop extrusion by human cohesin","volume":"366","author":"Davidson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.09.003_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.molcel.2015.09.023","article-title":"CTCF binding polarity determines chromatin looping","volume":"60","author":"de Wit","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib10","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2016.02.007","article-title":"The 3D genome as moderator of chromosomal communication","volume":"164","author":"Dekker","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cels.2016.07.002","article-title":"Juicer provides a one-click system for analyzing loop-resolution hi-c experiments","volume":"3","author":"Durand","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.molcel.2022.09.003_bib12","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/nprot.2012.101","article-title":"Identifying ChIP-seq enrichment using Macs","volume":"7","author":"Feng","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molcel.2022.09.003_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1101\/sqb.2017.82.034710","article-title":"Emerging evidence of chromosome folding by loop extrusion","volume":"82","author":"Fudenberg","year":"2017","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.molcel.2022.09.003_bib14","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.celrep.2016.04.085","article-title":"Formation of chromosomal domains by loop extrusion","volume":"15","author":"Fudenberg","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2022.09.003_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.aar7831","article-title":"Real-time imaging of DNA loop extrusion by condensin","volume":"360","author":"Ganji","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.09.003_bib16","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.cub.2006.06.068","article-title":"Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication","volume":"16","author":"Gerlich","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.molcel.2022.09.003_bib17","doi-asserted-by":"crossref","first-page":"e53885","DOI":"10.7554\/eLife.53885","article-title":"Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner","volume":"9","author":"Golfier","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.09.003_bib19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2009.02.035","article-title":"Recruitment of condensin to replication origin regions by ParB\/SpoOJ promotes chromosome segregation in B. subtilis","volume":"137","author":"Gruber","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2017.04.013","article-title":"The cohesin release factor Wapl restricts chromatin loop extension","volume":"169","author":"Haarhuis","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib21","doi-asserted-by":"crossref","first-page":"e25776","DOI":"10.7554\/eLife.25776","article-title":"CTCF and cohesin regulate chromatin loop stability with distinct dynamics","volume":"6","author":"Hansen","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.09.003_bib22","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1038\/emboj.2008.214","article-title":"CTCF regulates cell cycle progression of \u03b1\u03b2T cells in the thymus","volume":"27","author":"Heath","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2022.09.003_bib23","author":"Imakaev"},{"key":"10.1016\/j.molcel.2022.09.003_bib24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature09380","article-title":"Mediator and cohesin connect gene expression and chromatin architecture","volume":"467","author":"Kagey","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.09.003_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.molcel.2017.07.013","article-title":"Myc regulates chromatin decompaction and nuclear architecture during B cell activation","volume":"67","author":"Kieffer-Kwon","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib26","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.aaz4475","article-title":"Human cohesin compacts DNA by loop extrusion","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.09.003_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)81018-1","article-title":"13s condensin actively reconfigures DNA by introducing global positive writhe: implications for chromosome condensation","volume":"98","author":"Kimura","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molcel.2020.04.026","article-title":"Human condensin I and II drive extensive ATP-dependent compaction of nucleosome-bound DNA","volume":"79","author":"Kong","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib29","article-title":"Aligning short sequencing reads with Bowtie","volume":"Chapter 11","author":"Langmead","year":"2010","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.molcel.2022.09.003_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2022.09.003_bib31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","article-title":"A critical role for dnmt1 and DNA methylation in T\u00a0cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2022.09.003_bib32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41586-019-1910-z","article-title":"The structural basis for cohesin\u2013CTCF-anchored loops","volume":"578","author":"Li","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.09.003_bib74","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2022.09.003_bib33","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/s41588-021-00934-8","article-title":"Brd4 orchestrates genome folding to promote neural crest differentiation","volume":"53","author":"Linares-Saldana","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2022.09.003_bib34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41588-020-00744-4","article-title":"Wapl maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation","volume":"53","author":"Liu","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2022.09.003_bib35","article-title":"Rapid depletion of CTCF and cohesin proteins reveals dynamic features of chromosome architecture","author":"Liu","year":"2021","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.molcel.2022.09.003_bib36","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41419-019-1792-x","article-title":"The Cornelia de Lange syndrome-associated factor NIPBL interacts with Brd4 ET domain for transcription control of a common set of genes","volume":"10","author":"Luna-Pel\u00e1ez","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2022.09.003_bib37","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.molcel.2015.07.020","article-title":"Condensin- and replication-mediated bacterial chromosome folding and origin condensation revealed by Hi-C and super-resolution imaging","volume":"59","author":"Marbouty","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-genom-083115-022339","article-title":"CTCF and cohesin in genome folding and transcriptional gene regulation","volume":"17","author":"Merkenschlager","year":"2016","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.molcel.2022.09.003_bib39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ceb.2019.05.001","article-title":"Two major mechanisms of chromosome organization","volume":"58","author":"Mirny","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.molcel.2022.09.003_bib40","doi-asserted-by":"crossref","first-page":"eabb1455","DOI":"10.1126\/sciimmunol.abb1455","article-title":"The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells","volume":"5","author":"Miyazaki","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molcel.2022.09.003_bib41","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1146\/annurev.genet.35.102401.091334","article-title":"Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis","volume":"35","author":"Nasmyth","year":"2001","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.molcel.2022.09.003_bib42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev-genet-102108-134233","article-title":"Cohesin: its roles and mechanisms","volume":"43","author":"Nasmyth","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.molcel.2022.09.003_bib43","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1038\/s41467-020-19283-x","article-title":"Molecular basis of CTCF binding polarity in genome folding","volume":"11","author":"Nora","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2022.09.003_bib44","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.cell.2017.05.004","article-title":"Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization","volume":"169","author":"Nora","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41588-018-0042-y","article-title":"Brd4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange\u2013like syndrome","volume":"50","author":"Olley","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2022.09.003_bib46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-020-2244-6","article-title":"Convergent genes shape budding yeast pericentromeres","volume":"582","author":"Paldi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.09.003_bib47","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41556-021-00783-x","article-title":"Cohesin regulates homology search during recombinational DNA repair","volume":"23","author":"Piazza","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2022.09.003_bib48","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1073\/pnas.1911708117","article-title":"CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention","volume":"117","author":"Pugacheva","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2022.09.003_bib49","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","article-title":"A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping","volume":"159","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cell.2017.09.026","article-title":"Cohesin loss eliminates all loop domains","volume":"171","author":"Rao","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1098\/rstb.1990.0012","article-title":"DNA methylation and late replication probably aid cell memory, and type I DNA reeling could aid chromosome folding and enhancer function","volume":"326","author":"Riggs","year":"1990","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.molcel.2022.09.003_bib52","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cels.2018.01.001","article-title":"Juicebox.js provides a cloud-based visualization system for Hi-C data","volume":"6","author":"Robinson","year":"2018","journal-title":"Cell Syst."},{"key":"10.1016\/j.molcel.2022.09.003_bib53","doi-asserted-by":"crossref","first-page":"E6456","DOI":"10.1073\/pnas.1518552112","article-title":"Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes","volume":"112","author":"Sanborn","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2022.09.003_bib54","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature24281","article-title":"Two independent modes of chromatin organization revealed by cohesin removal","volume":"551","author":"Schwarzer","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.09.003_bib55","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1101\/gr.161620.113","article-title":"Cohesin-based chromatin interactions enable regulated gene expression within pre-existing architectural compartments","volume":"23","author":"Seitan","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2022.09.003_bib56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature10312","article-title":"A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation","volume":"476","author":"Seitan","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.09.003_bib57","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13059-015-0831-x","article-title":"HiC-Pro: an optimized and flexible pipeline for Hi-C data processing","volume":"16","author":"Servant","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2022.09.003_bib58","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1101\/gad.605910","article-title":"Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes","volume":"24","author":"Tachibana-Konwalski","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2022.09.003_bib59","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature12471","article-title":"Wapl is an essential regulator of chromatin structure and chromosome segregation","volume":"501","author":"Tedeschi","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2022.09.003_bib60","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1126\/science.aan6516","article-title":"The condensin complex is a mechanochemical motor that translocates along DNA","volume":"358","author":"Terakawa","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.09.003_bib61","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.celrep.2017.08.026","article-title":"SMC progressively aligns chromosomal arms in Caulobacter crescentus but is antagonized by convergent transcription","volume":"20","author":"Tran","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2022.09.003_bib62","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.neuron.2016.11.047","article-title":"Nipbl Interacts with Zfp609 and the Integrator complex to regulate cortical neuron migration","volume":"93","author":"van den Berg","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.molcel.2022.09.003_bib63","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.cell.2018.03.072","article-title":"The energetics and physiological impact of cohesin extrusion","volume":"173","author":"Vian","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib64","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.celrep.2015.02.004","article-title":"Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture","volume":"10","author":"Vietri Rudan","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2022.09.003_bib65","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1126\/science.aai8982","article-title":"Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus","volume":"355","author":"Wang","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.molcel.2022.09.003_bib66","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.molcel.2018.07.006","article-title":"In\u00a0vivo evidence for ATPase-dependent DNA translocation by the bacillus subtilis SMC condensin complex","volume":"71","author":"Wang","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2022.09.003_bib67","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1101\/gr.269860.120","article-title":"Chromatin architecture transitions from zebrafish sperm through early embryogenesis","volume":"31","author":"Wike","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2022.09.003_bib68","doi-asserted-by":"crossref","first-page":"e52091","DOI":"10.7554\/eLife.52091","article-title":"Esco1 and CTCF enable formation of long chromatin loops by protecting cohesin Stag1 from Wapl","volume":"9","author":"Wutz","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.09.003_bib73","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.15252\/embj.201798004","article-title":"Topologically associating domains and chromatin loops depend on cohesin are are regulated by CTCF, WAPL, and PDS5 proteins","volume":"36","author":"Wutz","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.molcel.2022.09.003_bib69","doi-asserted-by":"crossref","first-page":"e62243","DOI":"10.7554\/eLife.62243","article-title":"Cohesin architecture and clustering in\u00a0vivo","volume":"10","author":"Xiang","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2022.09.003_bib70","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/cr.2018.1","article-title":"Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers","volume":"28","author":"Yan","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2022.09.003_bib71","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-genet-112618-043633","article-title":"Organization of chromosomal DNA by SMC complexes","volume":"53","author":"Yatskevich","year":"2019","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.molcel.2022.09.003_bib72","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.200801157","article-title":"A handcuff model for the cohesin complex","volume":"183","author":"Zhang","year":"2008","journal-title":"J.\u00a0Cell Biol."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276522008541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276522008541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:43:31Z","timestamp":1778798611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276522008541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":72,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1097276522008541"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2022.09.003","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromatin jets define the properties of cohesin-driven in\u00a0vivo loop extrusion","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2022.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}