{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:38:08Z","timestamp":1790797088385,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2023YFC2306800"],"award-info":[{"award-number":["2023YFC2306800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2019YFA050880"],"award-info":[{"award-number":["2019YFA050880"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LR22C050002"],"award-info":[{"award-number":["LR22C050002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013807","name":"Wuhan University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130055"],"award-info":[{"award-number":["32130055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92353303\/32141004"],"award-info":[{"award-number":["92353303\/32141004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100959\/32371249\/82322070"],"award-info":[{"award-number":["32100959\/32371249\/82322070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000845"],"award-info":[{"award-number":["32000845"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32222038\/31971195"],"award-info":[{"award-number":["32222038\/31971195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.molcel.2023.12.020","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T10:39:59Z","timestamp":1704969599000},"page":"570-583.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Conformational transitions and activation of the adhesion receptor CD97"],"prefix":"10.1016","volume":"84","author":[{"given":"Chunyou","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Jia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Dan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Yu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Kun","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huibing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingya","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2023.12.020_bib1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1124\/pr.114.009647","article-title":"International union of basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors","volume":"67","author":"Hamann","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.molcel.2023.12.020_bib2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41573-019-0039-y","article-title":"Adhesion G protein-coupled receptors: opportunities for drug discovery","volume":"18","author":"Bassilana","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.molcel.2023.12.020_bib3","first-page":"1","article-title":"Adhesion G protein-coupled receptors-Structure and functions","volume":"195","author":"Thor","year":"2023","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.molcel.2023.12.020_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1124\/pharmrev.120.000011","article-title":"Mutations in G protein-coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches","volume":"73","author":"Sch\u00f6neberg","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.molcel.2023.12.020_bib5","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33432","article-title":"Gq activity- and beta-arrestin-1 scaffolding-mediated ADGRG2\/CFTR coupling are required for male fertility","volume":"7","author":"Zhang","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2023.12.020_bib6","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/s41589-022-01084-6","article-title":"Structures of the ADGRG2-Gs complex in apo and ligand-bound forms","volume":"18","author":"Lin","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib7","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1124\/mol.112.080309","article-title":"Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation","volume":"82","author":"Paavola","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molcel.2023.12.020_bib8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.molcel.2020.12.042","article-title":"Tethered agonist exposure in intact adhesion\/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain","volume":"81","author":"Beliu","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2023.12.020_bib9","doi-asserted-by":"crossref","first-page":"6194","DOI":"10.1073\/pnas.1421785112","article-title":"Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist","volume":"112","author":"Stoveken","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2023.12.020_bib10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41586-022-04575-7","article-title":"The tethered peptide activation mechanism of adhesion GPCRs","volume":"604","author":"Barros-\u00c1lvarez","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41586-022-04619-y","article-title":"Structural basis for the tethered peptide activation of adhesion GPCRs","volume":"604","author":"Ping","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41586-022-04590-8","article-title":"Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4","volume":"604","author":"Xiao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41586-022-04580-w","article-title":"Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1","volume":"604","author":"Qu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib14","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1016\/j.molcel.2022.10.009","article-title":"Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling","volume":"82","author":"Qian","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2023.12.020_bib15","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1038\/s41467-022-33173-4","article-title":"Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling","volume":"13","author":"Zhu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.020_bib16","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41586-020-03083-w","article-title":"Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex","volume":"589","author":"Ping","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib17","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41467-020-15423-5","article-title":"GPR56\/ADGRG1 is associated with response to antidepressant treatment","volume":"11","author":"Belzeaux","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.020_bib18","doi-asserted-by":"crossref","first-page":"eaaz0368","DOI":"10.1126\/sciadv.aaz0368","article-title":"Regulation of body length and bone mass by Gpr126\/Adgrg6","volume":"6","author":"Sun","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2023.12.020_bib19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.tips.2019.02.003","article-title":"Adhesion G protein-coupled receptors as drug targets for neurological diseases","volume":"40","author":"Folts","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.molcel.2023.12.020_bib20","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1158\/0008-5472.CAN-13-1049","article-title":"GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the G\u03b1q-p63RhoGEF-Rho GTPase pathway","volume":"73","author":"Tang","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2023.12.020_bib21","first-page":"1798","article-title":"CD97: a dedifferentiation marker in human thyroid carcinomas","volume":"57","author":"Aust","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2023.12.020_bib22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-pharmtox-010617-052933","article-title":"Adhesion G protein-coupled receptors as drug targets","volume":"58","author":"Purcell","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.molcel.2023.12.020_bib23","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1080\/17460441.2020.1791075","article-title":"Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions","volume":"15","author":"Bondarev","year":"2020","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.molcel.2023.12.020_bib24","doi-asserted-by":"crossref","first-page":"14065","DOI":"10.1074\/jbc.REV120.007423","article-title":"Mechanisms of adhesion G protein-coupled receptor activation","volume":"295","author":"Vizurraga","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2023.12.020_bib25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/bcpt.13831","article-title":"Structural clarity is brought to adhesion G protein-coupled receptor tethered agonism","volume":"133","author":"Gupta","year":"2023","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.molcel.2023.12.020_bib26","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.4049\/jimmunol.155.4.1942","article-title":"Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain","volume":"155","author":"Hamann","year":"1995","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.molcel.2023.12.020_bib27","doi-asserted-by":"crossref","first-page":"100776","DOI":"10.1016\/j.jbc.2021.100776","article-title":"Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs","volume":"296","author":"Niu","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2023.12.020_bib28","doi-asserted-by":"crossref","first-page":"7301","DOI":"10.1158\/0008-5472.CAN-11-2381","article-title":"LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells","volume":"71","author":"Ward","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2023.12.020_bib29","doi-asserted-by":"crossref","first-page":"eabi5965","DOI":"10.1126\/science.abi5965","article-title":"CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells","volume":"375","author":"Liu","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.molcel.2023.12.020_bib30","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1084\/jem.20190598","article-title":"CD97 is a critical regulator of acute myeloid leukemia stem cell function","volume":"216","author":"Martin","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.molcel.2023.12.020_bib31","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1002\/hep.30068","article-title":"CD97 promotes tumor aggressiveness through the traditional G protein-coupled receptor-mediated signaling in hepatocellular carcinoma","volume":"68","author":"Yin","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.molcel.2023.12.020_bib32","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1182\/blood-2004-07-2878","article-title":"CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells","volume":"105","author":"Wang","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.molcel.2023.12.020_bib33","doi-asserted-by":"crossref","first-page":"e58464","DOI":"10.7554\/eLife.58464","article-title":"Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling","volume":"9","author":"Tsutsumi","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2023.12.020_bib34","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1038\/s41467-022-32125-2","article-title":"Fusion protein strategies for cryo-EM study of G protein-coupled receptors","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.020_bib35","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.neuron.2016.08.022","article-title":"Structural basis for regulation of GPR56\/ADGRG1 by its alternatively spliced extracellular domains","volume":"91","author":"Salzman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.molcel.2023.12.020_bib36","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41467-019-14040-1","article-title":"Structural basis for adhesion G protein-coupled receptor Gpr126 function","volume":"11","author":"Leon","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.020_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17219","article-title":"Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta","volume":"5","author":"Wang","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2023.12.020_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175642","article-title":"Mini-G proteins: novel tools for studying GPCRs in their active conformation","volume":"12","author":"Nehm\u00e9","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.molcel.2023.12.020_bib39","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.cell.2020.08.024","article-title":"Structure of a hallucinogen-activated Gq-coupled 5-HT2A serotonin receptor","volume":"182","author":"Kim","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.020_bib40","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1038\/s41467-020-17933-8","article-title":"Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy","volume":"11","author":"Duan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.020_bib41","doi-asserted-by":"crossref","first-page":"e50279","DOI":"10.7554\/eLife.50279","article-title":"Common activation mechanism of class A GPCRs","volume":"8","author":"Zhou","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2023.12.020_bib42","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/endrev\/bnac033","article-title":"New insights into the structure and function of class B1 GPCRs","volume":"44","author":"Cary","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.molcel.2023.12.020_bib43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib44","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1107\/S2052252519013137","article-title":"Toward G protein-coupled receptor structure-based drug design using X-ray lasers","volume":"6","author":"Ishchenko","year":"2019","journal-title":"IUCrJ"},{"key":"10.1016\/j.molcel.2023.12.020_bib45","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s41467-020-14934-5","article-title":"Full-length human GLP-1 receptor structure without orthosteric ligands","volume":"11","author":"Wu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.020_bib46","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature18934","article-title":"Structural basis of smoothened regulation by its extracellular domains","volume":"535","author":"Byrne","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib47","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cell.2017.07.009","article-title":"How ligands illuminate GPCR molecular pharmacology","volume":"170","author":"Wacker","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.020_bib48","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41392-020-00435-w","article-title":"G protein-coupled receptors: structure- and function-based drug discovery","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.molcel.2023.12.020_bib49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/ci800324m","article-title":"Identifying and characterizing binding sites and assessing druggability","volume":"49","author":"Halgren","year":"2009","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.molcel.2023.12.020_bib50","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1073\/pnas.1221585110","article-title":"Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations","volume":"110","author":"Wootten","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U SA"},{"key":"10.1016\/j.molcel.2023.12.020_bib51","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.tips.2022.01.002","article-title":"Structural perspective of class B1 GPCR signaling","volume":"43","author":"Cong","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.molcel.2023.12.020_bib52","doi-asserted-by":"crossref","first-page":"eabn0067","DOI":"10.1126\/sciadv.abn0067","article-title":"Structure of S1PR2-heterotrimeric G13 signaling complex","volume":"8","author":"Chen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2023.12.020_bib53","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.chembiol.2023.08.003","article-title":"Structural basis of CD97 activation and G-protein coupling","volume":"30","author":"Wang","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib54","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature10361","article-title":"Crystal structure of the beta2 adrenergic receptor-Gs protein complex","volume":"477","author":"Rasmussen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib55","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature22394","article-title":"Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein","volume":"546","author":"Zhang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib56","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/s41589-020-0646-2","article-title":"Sterols in an intramolecular channel of smoothened mediate Hedgehog signaling","volume":"16","author":"Qi","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib57","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2023.12.020_bib58","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2015.08.008","article-title":"CTFFIND4: fast and accurate defocus estimation from electron micrographs","volume":"192","author":"Rohou","year":"2015","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsb.2015.11.003","article-title":"Gctf: real-time CTF determination and correction","volume":"193","author":"Zhang","year":"2016","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib60","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1042\/BCJ20210708","article-title":"New tools for automated cryo-EM single-particle analysis in RELION-4.0.","volume":"478","author":"Kimanius","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.molcel.2023.12.020_bib61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nmeth.2727","article-title":"Quantifying the local resolution of cryo-EM density maps","volume":"11","author":"Kucukelbir","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2023.12.020_bib62","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.molcel.2023.12.020_bib63","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.molcel.2023.12.020_bib64","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s42003-021-02399-1","article-title":"DeepEMhancer: a deep learning solution for cryo-EM volume post-processing","volume":"4","author":"Sanchez-Garcia","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"Phenix: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.molcel.2023.12.020_bib66","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.molcel.2023.12.020_bib67","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.molcel.2023.12.020_bib68","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s10482-018-1048-2","article-title":"Bird feathers as potential sources of pathogenic microorganisms: a new look at old diseases","volume":"111","author":"Miskiewicz","year":"2018","journal-title":"Antonie Leeuwenhoek"},{"key":"10.1016\/j.molcel.2023.12.020_bib69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J.\u00a0Mol. Graph."},{"key":"10.1016\/j.molcel.2023.12.020_bib70","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/ci500020m","article-title":"g_mmpbsa\u2013a GROMACS tool for high-throughput MM-PBSA calculations","volume":"54","author":"Kumari","year":"2014","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.molcel.2023.12.020_bib71","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.1219218","article-title":"Structural basis for allosteric regulation of GPCRs by sodium ions","volume":"337","author":"Liu","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.molcel.2023.12.020_bib72","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41589-020-0535-8","article-title":"TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome","volume":"16","author":"Olsen","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib73","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/bs.mie.2016.04.012","article-title":"Processing of structurally heterogeneous cryo-EM data in RELION","volume":"579","author":"Scheres","year":"2016","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.molcel.2023.12.020_bib74","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2023.12.020_bib75","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jsb.2018.07.003","article-title":"Single particle reconstruction and validation using Bsoft for the map challenge","volume":"204","author":"Heymann","year":"2018","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.molcel.2023.12.020_bib76","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: meeting modern challenges in visualization and analysis","volume":"27","author":"Goddard","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.molcel.2023.12.020_bib77","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nature17154","article-title":"The conformational signature of beta-arrestin2 predicts its trafficking and signalling functions","volume":"531","author":"Lee","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib78","doi-asserted-by":"crossref","first-page":"16226","DOI":"10.1074\/jbc.RA118.004175","article-title":"Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation","volume":"293","author":"Yang","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2023.12.020_bib79","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature17198","article-title":"Beta-arrestin biosensors reveal a rapid, receptor-dependent activation\/deactivation cycle","volume":"531","author":"Nuber","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib80","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nmeth.4067","article-title":"CHARMM36m: an improved force field for folded and intrinsically disordered proteins","volume":"14","author":"Huang","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2023.12.020_bib81","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-021-04077-y","article-title":"Structure, function and pharmacology of human itch receptor complexes","volume":"600","author":"Yang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.020_bib82","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.jctc.5b00935","article-title":"CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM\/OpenMM simulations using the CHARMM36 additive force field","volume":"12","author":"Lee","year":"2016","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.molcel.2023.12.020_bib83","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/01621459.1949.10483310","article-title":"The Monte Carlo method","volume":"44","author":"Metropolis","year":"1949","journal-title":"J.\u00a0Am. Stat. Assoc."},{"key":"10.1016\/j.molcel.2023.12.020_bib84","doi-asserted-by":"crossref","first-page":"126601","DOI":"10.1088\/0034-4885\/71\/12\/126601","article-title":"Metadynamics: a method to simulate rare events and reconstruct the free energy in biophysics, chemistry and material science","volume":"71","author":"Laio","year":"2008","journal-title":"Rep. Prog. Phys."},{"key":"10.1016\/j.molcel.2023.12.020_bib85","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.cpc.2013.09.018","article-title":"PLUMED 2: New feathers for an old bird","volume":"185","author":"Tribello","year":"2014","journal-title":"Comput. Phys. Commun."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276523010390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276523010390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:54:30Z","timestamp":1778590470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276523010390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1097276523010390"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2023.12.020","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conformational transitions and activation of the adhesion receptor CD97","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2023.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}