{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:12:28Z","timestamp":1788667948596,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HG006827"],"award-info":[{"award-number":["HG006827"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HG008935"],"award-info":[{"award-number":["HG008935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.molcel.2023.12.021","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T15:34:57Z","timestamp":1704987297000},"page":"596-610.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome"],"prefix":"10.1016","volume":"84","author":[{"given":"Xinran","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Sheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingluan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2023.12.021_bib1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3390\/biology3040670","article-title":"DNA modifications: function and applications in normal and disease states","volume":"3","author":"Liyanage","year":"2014","journal-title":"Biology"},{"key":"10.1016\/j.molcel.2023.12.021_bib2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tig.2021.12.003","article-title":"DNA N6-methyldeoxyadenosine in mammals and human disease","volume":"38","author":"Shen","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.molcel.2023.12.021_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41576-022-00456-x","article-title":"Means, mechanisms and consequences of adenine methylation in DNA","volume":"23","author":"Boulias","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2023.12.021_bib4","doi-asserted-by":"crossref","first-page":"eaay3335","DOI":"10.1126\/sciadv.aay3335","article-title":"No evidence for DNA N6-methyladenine in mammals","volume":"6","author":"Douvlataniotis","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2023.12.021_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1126\/science.abe7489","article-title":"Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution","volume":"375","author":"Kong","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.molcel.2023.12.021_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s12864-019-5754-6","article-title":"Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA","volume":"20","author":"O\u2019Brown","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molcel.2023.12.021_bib7","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.1002\/anie.201700424","article-title":"Quantitative LC-MS provides no evidence for m6dA or m4dC in the genome of mouse embryonic stem cells and tissues","volume":"56","author":"Schiffers","year":"2017","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.molcel.2023.12.021_bib8","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cell.2015.04.010","article-title":"N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas","volume":"161","author":"Fu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib9","doi-asserted-by":"crossref","first-page":"11659","DOI":"10.1093\/nar\/gky1104","article-title":"Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome","volume":"46","author":"Koh","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.molcel.2020.02.018","article-title":"N6-deoxyadenosine methylation in mammalian mitochondrial DNA","volume":"78","author":"Hao","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41592-018-0038-7","article-title":"A reassessment of DNA-immunoprecipitation-based genomic profiling","volume":"15","author":"Lentini","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2023.12.021_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0022-2836(78)90242-5","article-title":"Use of restriction enzymes to study eukaryotic DNA methylation","volume":"118","author":"Bird","year":"1978","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.molcel.2023.12.021_bib13","doi-asserted-by":"crossref","first-page":"11301","DOI":"10.1038\/ncomms11301","article-title":"Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing","volume":"7","author":"Luo","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.021_bib14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1039\/D0SC03509B","article-title":"Single-nucleotide resolution of N6-adenine methylation sites in DNA and RNA by nitrite sequencing","volume":"12","author":"Mahdavi-Amiri","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.molcel.2023.12.021_bib15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41576-018-0081-3","article-title":"Deciphering bacterial epigenomes using modern sequencing technologies","volume":"20","author":"Beaulaurier","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2023.12.021_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1101\/gr.136739.111","article-title":"Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases","volume":"23","author":"Schadt","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib17","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1101\/gr.231068.117","article-title":"Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing","volume":"28","author":"Zhu","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib18","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1021\/bi00717a013","article-title":"Effects of methylation on the stability of nucleic acid conformations: monomer level","volume":"13","author":"Engel","year":"1974","journal-title":"Biochemistry"},{"key":"10.1016\/j.molcel.2023.12.021_bib19","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0021-9258(17)38193-0","article-title":"Effects of methylation on the stability of nucleic acid conformations: studies at the polymer level","volume":"253","author":"Engel","year":"1978","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2023.12.021_bib20","doi-asserted-by":"crossref","first-page":"19079","DOI":"10.1021\/ja4105792","article-title":"Identification of a selective polymerase enables detection of N6-methyladenosine in RNA","volume":"135","author":"Harcourt","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.molcel.2023.12.021_bib21","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1093\/nar\/gki873","article-title":"The use of thymidine analogs to improve the replication of an extra DNA base pair: a synthetic biological system","volume":"33","author":"Sismour","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib22","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1021\/jacs.5b02074","article-title":"Processive incorporation of deoxynucleoside triphosphate analogs by single-molecule DNA polymerase I (Klenow fragment) nanocircuits","volume":"137","author":"Pugliese","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.molcel.2023.12.021_bib23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nprot.2006.93","article-title":"Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene delivery vehicles","volume":"1","author":"Koerber","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molcel.2023.12.021_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/abio.1995.1050","article-title":"Direct random mutagenesis of gene-sized DNA fragments using polymerase chain reaction","volume":"224","author":"Fromant","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.molcel.2023.12.021_bib25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2023.12.021_bib26","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1073\/pnas.1820574116","article-title":"Structural insights into FTO\u2019s catalytic mechanism for the demethylation of multiple RNA substrates","volume":"116","author":"Zhang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2023.12.021_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41422-019-0237-5","article-title":"Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA","volume":"30","author":"Zhang","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib28","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.cell.2018.10.006","article-title":"N6-methyladenine DNA modification in glioblastoma","volume":"175","author":"Xie","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib29","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1038\/ncomms8438","article-title":"Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes","volume":"6","author":"Beaulaurier","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.021_bib30","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41467-019-08289-9","article-title":"Single-molecule sequencing detection of N6-methyladenine in microbial reference materials","volume":"10","author":"McIntyre","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.021_bib31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/S0021-9258(17)34217-5","article-title":"Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease","volume":"254","author":"Geier","year":"1979","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2023.12.021_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0301-4622(02)00251-X","article-title":"Assembly of EcoKI DNA methyltransferase requires the C-terminal region of the HsdM modification subunit","volume":"103","author":"Powell","year":"2003","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.molcel.2023.12.021_bib33","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/gbe\/evw008","article-title":"Genome sequence and analysis of Escherichia coli MRE600, a colicinogenic, nonmotile strain that lacks RNase I and the Type I methyltransferase, EcoKI","volume":"8","author":"Kurylo","year":"2016","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.molcel.2023.12.021_bib34","author":"Tapella"},{"key":"10.1016\/j.molcel.2023.12.021_bib35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41586-020-2500-9","article-title":"N6-methyladenine in DNA antagonizes SATB1 in early development","volume":"583","author":"Li","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.021_bib36","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1038\/ncomms13052","article-title":"Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig","volume":"7","author":"Liu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.021_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature17640","article-title":"DNA methylation on N6-adenine in mammalian embryonic stem cells","volume":"532","author":"Wu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.021_bib38","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41593-019-0339-x","article-title":"The DNA modification N6-methyl-2\u2032-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction","volume":"22","author":"Li","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.molcel.2023.12.021_bib39","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.molcel.2019.03.018","article-title":"An adversarial DNA N6-methyladenine-sensor network preserves Polycomb silencing","volume":"74","author":"Kweon","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2018.06.015","article-title":"N6-methyladenine DNA modification in the human genome","volume":"71","author":"Xiao","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib41","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/s41467-017-01195-y","article-title":"DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress","volume":"8","author":"Yao","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.021_bib42","first-page":"354","article-title":"c-myc reverses neu-induced transformed morphology by transcriptional repression","volume":"11","author":"Suen","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2023.12.021_bib43","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/312513a0","article-title":"The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen","volume":"312","author":"Schechter","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.021_bib44","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/312545a0","article-title":"Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene","volume":"312","author":"Drebin","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.021_bib45","doi-asserted-by":"crossref","first-page":"37511","DOI":"10.18632\/oncotarget.16400","article-title":"Promoting oligodendroglial-oriented differentiation of glioma stem cell: a repurposing of quetiapine for the treatment of malignant glioma","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.molcel.2023.12.021_bib46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12192-018-00958-w","article-title":"Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy","volume":"24","author":"Reindl","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.molcel.2023.12.021_bib47","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cell.2018.12.012","article-title":"Environmental control of astrocyte pathogenic activities in CNS inflammation","volume":"176","author":"Wheeler","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib48","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s13577-015-0109-3","article-title":"The determination of sex type of the cultured murine cell with quantitative PCR technique","volume":"28","author":"Wan","year":"2015","journal-title":"Hum. Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib49","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3390\/genes11020192","article-title":"Pathogenic mitochondria DNA mutations: current detection tools and interventions","volume":"11","author":"Mustafa","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.molcel.2023.12.021_bib50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccr.2007.12.005","article-title":"Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells","volume":"13","author":"Lee","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib51","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mrrev.2008.02.004","article-title":"Epigenetic interplay between histone modifications and DNA methylation in gene silencing","volume":"659","author":"Vaissi\u00e8re","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1756-9966-31-52","article-title":"Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1","volume":"31","author":"Liu","year":"2012","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1039\/C6SC02271E","article-title":"Selective detection of N6-methyladenine in DNA via metal ion-mediated replication and rolling circle amplification","volume":"8","author":"Hong","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.molcel.2023.12.021_bib54","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/175336a0","article-title":"Occurrence of a new base in the deoxyribonucleic acid of a strain of bacterium coli","volume":"175","author":"Dunn","year":"1955","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2023.12.021_bib55","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.cell.2019.04.028","article-title":"Identification of a DNA N6-adenine methyltransferase complex and its impact on chromatin organization","volume":"177","author":"Beh","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib56","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/ng.3859","article-title":"Widespread adenine N6-methylation of active genes in fungi","volume":"49","author":"Mondo","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2023.12.021_bib57","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1038\/s41467-019-10202-3","article-title":"6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda","volume":"10","author":"He","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2023.12.021_bib58","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.cell.2015.04.018","article-title":"N6-methyladenine DNA modification in Drosophila","volume":"161","author":"Zhang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib59","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cell.2015.04.005","article-title":"DNA methylation on N6-adenine in C. elegans","volume":"161","author":"Greer","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2023.12.021_bib60","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nsmb.3412","article-title":"DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?","volume":"24","author":"Luo","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2023.12.021_bib61","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/bs.mie.2015.03.013","article-title":"Preparation of human nuclear RNA m6A methyltransferases and demethylases and biochemical characterization of their catalytic activity","author":"Liu","year":"2015"},{"key":"10.1016\/j.molcel.2023.12.021_bib62","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fmicb.2017.00494","article-title":"Comparative evaluation of four bacteria-specific primer pairs for 16S rRNA gene surveys","volume":"8","author":"Thijs","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.molcel.2023.12.021_bib63","doi-asserted-by":"crossref","first-page":"15007","DOI":"10.1523\/JNEUROSCI.1436-10.2010","article-title":"Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents","volume":"30","author":"Uchida","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.molcel.2023.12.021_bib64","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/15592294.2019.1649930","article-title":"Human rDNA copy number is unstable in metastatic breast cancers","volume":"15","author":"Valori","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.molcel.2023.12.021_bib65","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/gkw1110","article-title":"SPlinted Ligation Adapter Tagging (SPLAT), a novel library preparation method for whole genome bisulphite sequencing","volume":"45","author":"Raine","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2023.12.021_bib66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13293-017-0154-6","article-title":"Genetic sex determination of mice by simplex PCR","volume":"8","author":"Tunster","year":"2017","journal-title":"Biol. Sex Differ."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276523010407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276523010407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:45:14Z","timestamp":1734677114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276523010407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1097276523010407"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2023.12.021","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2023.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}